Articles tagged with Antibiotics
A recent study found that consistent use of nasal saline and corticosteroid sprays can significantly reduce the need for antibiotics and oral steroids in individuals with chronic rhinosinusitis (CRS). This reduction can lead to fewer side effects associated with these medications, such as gastric issues and mood disturbances. By using ...
A new study published in Pediatrics found that eight in 10 children who reported being allergic to non-beta-lactam antibiotics were not truly allergic, highlighting the need for improved and timely access to formal allergy evaluations. This can prevent lifelong avoidance of certain antibiotic classes and help combat antibiotic resistance.
A team of scientists has modified an approved cancer drug to create a new antibiotic effective against multi-resistant bacteria, including MRSA. The new agent, PK150, targets unconventional structures within the bacteria and has shown promising results in mice, with no observed resistance development.
A new study found that children in LMICs receive an average of 25 antibiotic prescriptions during their first five years of life, which could exacerbate resistance. The excessive use of antibiotics worldwide poses a significant threat to global health and development.
A study published in BMJ found that 18% of outpatient antibiotic prescriptions lacked a documented indication, highlighting the need for improved antibiotic stewardship. The research identified groups most likely to receive unnecessary prescriptions, including adult males and patients with chronic conditions.
Researchers at Rice University and Texas A&M University developed molecular drills that target and kill antibiotic-resistant bacteria. The drills, which can be activated with light, increase the effectiveness of existing antibiotics, offering a potential solution to superbug infections.
Researchers estimate that up to 43% of antibiotic prescriptions in the US are potentially inappropriate, highlighting the importance of proper documentation. The study found that patients with chronic conditions and those who spent more time with a physician were more likely to receive antibiotics without an indication.
A new study investigates online sales of fish antibiotics and finds that consumers are purchasing these medications for human use, raising concerns about unintended consequences. The research highlights the potential risks of self-medication and the need for healthcare professionals to educate patients on safe medication use.
Researchers found that vancomycin alters the gut microbiome to improve the function of dendritic cells, which can help the immune system fight tumors more effectively. The approach has potential implications for a wide variety of cancer types and could lead to a new treatment strategy.
The discovery of LiaX, a secret protein that alerts bacteria to antibiotic and immune system attacks, opens doors for future treatment options against antibiotic-resistant superbugs. The protein's activation causes restructuring of the bacterial cell, preventing antibiotics from destroying it.
Researchers have developed 'clever drugs for slimy bugs' to combat staph infections by destroying biofilms that prevent conventional antibiotics from working. Hybrid antibiotics have been shown to kill bacteria directly or leave them susceptible to killing in lab-grown biofilms.
A multi-drug resistant Staphylococcus aureus lineage known as the Bengal Bay clone has spread globally, causing severe disease and raising concerns about antibiotic resistance. The bacteria combines high virulence potential with multi-drug resistance, making it a significant public health issue.
Researchers at McMaster University have discovered a potent new antimicrobial that works against the toughest infectious disease strains, including MRSA. The compound, MAC-545496, cripples MRSA's ability to cause infection by diminishing its tolerance to the immune system and blocking its resistance to antibiotics.
Researchers at Martin-Luther-Universität Halle-Wittenberg have developed biodegradable rods containing an antibiotic to treat periodontal disease, reducing side effects and inflammation. The innovative treatment uses a combination of minocycline and magnesium stearate, releasing the antibiotic slowly and locally in the mouth.
Researchers have discovered that Pseudomonas aeruginosa bacteria send out warning signals when attacked by antibiotics or viruses, allowing them to survive and potentially evade treatment. This communication mechanism may hold the key to developing new treatments and improving existing ones.
Researchers have discovered a novel peptide, Darobactin, effective against antibiotic-resistant gram-negative bacteria. The substance binds to the BamA protein, disrupting the bacterial external membrane and leading to its death. This finding presents a promising lead for developing a new antibiotic.
A team of scientists has discovered 79 new types of bacteria with potential to produce unique antibiotics. The researchers, led by Christian Jogler, found that these Planctomycetes have complex lifestyles and the ability to produce small molecules like antibiotics.
Researchers at Martin-Luther-Universität Halle-Wittenberg have developed new active ingredients that target the pyruvate kinase enzyme in pathogenic bacteria. These substances were shown to be effective against staphylococcus and MRSA, potentially offering a solution to the growing problem of antibiotic resistance.
Researchers at McGill University have made significant strides in understanding the functioning of enzymes that produce antibiotics and therapeutics. The study found a surprising level of flexibility in the assembly line of nonribosomal peptide synthetases (NRPSs), which could lead to new therapeutic design possibilities.
A new poll finds that half of older Americans have taken leftover antibiotics without guidance, while one in five expect doctors to prescribe them for colds. Despite widespread awareness of antibiotic resistance, many older adults engage in risky practices, highlighting opportunities for education and improved prescribing.
A new study found that early involvement of an infectious disease specialist in patients with severe sepsis leads to a 40% lower risk of death. The study, which included 248 ER patients, also found that antibiotic prescriptions were stopped more quickly when an ID consult happened early.
Research gaps exist in antibiotic stewardship programs aimed at reducing unnecessary antibiotic use, with a need for standardized processes and outcome metrics. The Society for Healthcare Epidemiology of America calls for additional clinical evidence to inform optimal antibiotic prescribing practices.
A simple questionnaire and skin test can identify non-allergic reactions to penicillin, allowing patients to switch to safer and cheaper antibiotics. This could save the US millions of dollars annually and reduce antibiotic-resistant infections.
Researchers have discovered a mechanism behind bacterial evolution of drug resistance, exploiting collateral sensitivity for novel and sustainable treatments. The study found that certain drugs can be used in combination to eliminate bacterial populations or prevent the emergence of multidrug resistance.
The American Dental Association recommends against prescribing antibiotics for healthy adults with toothaches, citing evidence that they do not alleviate symptoms and can cause harm. In cases where dental treatment is delayed or signs of infection are present, antibiotics may be considered, but only in specific scenarios.
A nationally representative survey found that nursing homes with certified infection preventionists were nearly five times more likely to have comprehensive antibiotic stewardship programs. The study highlights the importance of well-trained IPs in reducing the risk of infections and improving patient safety.
Researchers at the University of Zurich have discovered a new family of synthetic antibiotics that target essential outer membrane proteins in Gram-negative bacteria, disrupting their synthesis and leading to cell bursting.
Researchers at the University of Pittsburgh have developed a novel electrochemical therapy to treat metal-based implant infections, which are a persistent problem with five to 10 percent failure rates. The new approach damages the microbe cell membrane, increasing susceptibility to antibiotics and eradicating drug-resistant cells.
Researchers tracked the disruption of gut microbes after antibiotics, finding that some individuals experienced long-term changes to their microbiome. The study used bioinformatic tools to analyze fecal samples from 30 young adults who received single or triple antibiotic treatments.
A new study finds that antibiotic resistance to H. pylori has more than doubled in 20 years, from 9.9% in 1998 to 21.6% last year. This increase is particularly concerning for countries like Southern Italy and Greece, where rates of primary clarithromycin resistance are highest.
A novel approach to tackle superbugs has been discovered using nanocapsules made of natural ingredients, which can prevent bacteria from attaching to stomach cells. The research aims to reduce antibiotic-resistant strains and is a potential preventative measure.
Aarhus University researchers have found that ants inhibit at least 14 different plant diseases through the secretion of antibiotics and pheromones. The discovery has sparked hope for new biological control agents in agriculture, which could be used to combat resistant plant diseases.
Researchers at Flinders University have discovered a nanomesh drug delivery system that can effectively treat antibiotic-resistant bacteria. The system, which uses electrospinning and gold nanoparticles, was tested with antibiotics Colistin and Vancomycin and showed promising results.
Researchers at the University of Oregon found that low-dose antibiotic exposure can cause significant changes in gut bacterial communities, leading to severe drops in bacterial populations. The study used zebrafish as a model organism and showed that the physical activity of the intestine amplifies the effects of weak antibiotics.
A new study by Colorado State University researchers found that exposure to manure from cows administered antibiotics alters the soil microbiome and ecosystem functions, reduces soil carbon storage, and changes how plants allocate carbon below ground. The findings suggest that widespread use of antibiotics in livestock production has s...
CRISPR-BEST addresses the challenge of genetic instability caused by double-stranded breaks in genome editing. The new tool creates mutations in actinomycetes without DNA breakage, enabling efficient targeting of genes for bioactive compound production.
The occurrence of antibiotic resistance in disease-causing bacteria from animals to humans has nearly tripled since 2000. Researchers found that antibiotics showing rates of resistance above 50% increased in chickens and pigs in developing countries between 2000 and 2018.
Researchers have discovered a new antibiotic, phazolicin, produced by a soil bacterium from a Mexican tropical forest that can prevent harmful bacteria from growing in plant roots. The findings suggest the potential for using this bacterium as a 'plant probiotic' to improve crop health and resistance to disease.
A systematic review suggests that published studies on burnout and patient care quality may exaggerate the magnitude of the effect. The review analyzed 145 study populations and found that many results were due to biases in measurement and analysis, leading to overestimation of the relationship between burnout and poor quality care.
A new analysis found that the current annual US sales of new antibiotics to treat carbapenem-resistant Enterobacteriaceae (CRE) is $101 million, significantly short of the needed $1 billion. This shortfall threatens the financial viability of new antibiotic development and may lead to reduced treatment options for patients. Researchers...
Researchers found ubiquitous presence of antibiotic resistant genes (ARGs) in groundwater samples, despite advanced treatment facility reducing ARGs to below detection limits. The study highlights the need for interdisciplinary approaches to address the global spread of antibiotic resistance and ensure clean water supply.
Scientists have elucidated the structure of the ClpX-ClpP proteolytic complex, a key to developing innovative antibiotics that target bacterial degradation processes. The complex's unique mechanism of action has considerable innovation potential in the fight against pathogenic bacteria.
A study analyzing prescribing data from over 8,000 English general practitioners reveals substantial variation in the adoption of new prescribing guidance, with some practices changing much later than others. This variation can lead to avoidable health service costs and poorer patient care.
Researchers discovered a novel weapon in bacteria arsenal that mimics common antibiotics, potentially filling gap left by antibiotic resistance. The 'toxic arrowhead' VgrG2b targets cell envelope and prevents division, causing cells to bulge and explode.
The new guideline offers evidence-based recommendations for diagnosing and treating community-acquired pneumonia in adults, with a focus on outpatient settings. It suggests using amoxicillin as first-line empiric therapy, while also recommending more microscopic studies of respiratory tract samples to avoid unnecessary antibiotic use.
The Global Antibiotic Research and Development Partnership (GARDP) and Entasis Therapeutics have partnered to develop a new oral antibiotic, zoliflodacin, for treating uncomplicated gonorrhea. The phase 3 trial will assess the treatment's efficacy in preventing persistent infections.
Researchers at Imperial College London developed microneedle biosensors that accurately detect changing antibiotic concentrations in patients' bodies. The technology enables real-time monitoring with similar results to blood tests.
Researchers at RUDN University have created non-toxic derivatives of chitosan with enhanced antibacterial activity, comparable to modern antibiotics. These novel materials can be used as preservatives in food coatings, providing a safer and more sustainable solution.
Researchers at MIPT have identified a promising class of antibiotics, 2-pyrazol-1-yl-thiazole derivatives, which exhibit antibacterial properties and inhibit protein synthesis. The discovery was made possible by a semi-automatic analysis method that enabled the screening of over 125,000 molecules.
Researchers at Newcastle University have confirmed that bacteria can lose their cell wall to avoid detection by antibiotics, leading to recurring urinary tract infections. The study found that L-form switching allows bacteria to survive and re-form their cell wall, making it harder for the immune system to target them.
A new compound derived from eushearilide has shown significant antibacterial properties against various disease-causing bacteria, including MRSA. This finding offers relief for immunocompromised people who are susceptible to life-threatening fungal and bacterial infections.
Only half of patients with sinus, throat, ear infections received recommended first-line antibiotics, a rate below industry standard. Retail clinics and emergency departments had higher rates, while urgent care centers lagged.
Researchers at University of Warwick have made a breakthrough in understanding the functions and structures of key enzymes in assembling an antibiotic with activity against Acinetobacter baumannii, a highly resistant pathogen. Understanding these enzymes could enable more effective versions of the antibiotic to be created.
Scientists at the University of Surrey discovered that green tea's EGCG can restore antibiotic activity against antibiotic-resistant bacteria Pseudomonas aeruginosa. The study found that combining EGCG with aztreonam significantly reduced bacterial numbers and improved survival rates in infected larvae.
Researchers mapped global trends in antimicrobial resistance rates among food animals in low- and middle-income countries between 2000 and 2018. The study found that antibiotic-resistant bacteria are on the rise, with high rates of resistance identified in antibiotics commonly used in food production.
Researchers identified six genes responsible for producing plant antibiotics that control fungal disease resistance in maize. This breakthrough could lead to improved disease resistance in rice and other crops using the same genetic pathways.
A new study has found that initiating antibiotics immediately before obtaining blood cultures significantly affects their sensitivity and ability to diagnose bacterial and fungal infections. This change in guidelines may reduce mortality rates from sepsis, a life-threatening condition with a 20% mortality rate.
Scientists engineer a plasmid that removes antibiotic resistance genes from Enterococcus faecalis, reducing its abundance by threefold in mouse models. The technology uses CRISPR-Cas9 and aims to combat antimicrobial resistance in hospitals.
Researchers found that 2.5% of women and 12.1% of men without established CVD could derive net benefit from aspirin treatment for 5 years. The study used data from a well-characterized web-based decision support program in New Zealand, identifying persons likely to benefit from aspirin treatment based on personalized benefit-harm analy...
A new antibiotic-coated shunt has been shown to significantly reduce infection rates in patients with hydrocephalus. The BASICS trial found that the innovative treatment saved the NHS approximately £130K per infection averted, resulting in estimated annual savings of £7 million.