Articles tagged with Antibiotics
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Researchers at University of Queensland developed a new supercharged antibiotic called vancapticins that target bacterial membranes, potentially revitalizing old antibiotics. The rebooted vancomycin has the potential to treat MRSA and VRE, addressing the growing threat of multi-drug resistant bacteria.
Researchers at TUM and Harvard University discovered a substance that interferes with the formation of Mycobacterium tuberculosis' mycomembrane. Combining this beta-lactone inhibitor with known antibiotics increases effectiveness by up to 100-fold, making it a promising new therapy for TB.
Researchers propose alternative therapies for mild infections to slow antibiotic resistance development, maintaining effectiveness for severe infections. This approach involves targeting milder bugs that can indirectly hinder the spread of resistant strains.
Researchers have identified 'sleeper cells' that can survive antibiotics and lie in a dormant state. These cells can evade detection using traditional methods, making them a significant public health concern.
A study by the Dairy Herd Health Group at the University of Nottingham's School of Veterinary Medicine and Science found that 25% of UK dairy farms used over half of all antibiotics in the sample. The research also identified factors associated with high antibiotic use, including oral antibiotics and digital dermatitis treatments.
Researchers developed a mouse model where the FXN gene defect causing Friedreich’s ataxia can be turned on or off, revealing that many early symptoms are reversible. The study found that reducing frataxin levels led to symptoms similar to those seen in humans with the disease, which disappeared when frataxin levels returned to normal.
Scientists at the University of Leeds have found that an old antibiotic candidate, pentyl pantothenamide, can stop E. coli growth but not kill it, making it effective against a specific type of bacteria. The discovery opens up the possibility of designing new drugs using the same mechanism to attack other disease-causing bacteria.
Scientists from Friedrich Schiller University Jena have developed nanoparticles that transport antibiotics more efficiently to their destination, killing off pathogens without problems. The particles are able to penetrate thick layers of mucus and biofilms, making them a promising solution against antibiotic resistance.
A recent study published in PLOS ONE and American Journal of Pathology suggests that Lyme bacteria can survive a 28-day course of antibiotics for months after infection. The study found living B. burgdorferi spirochetes in ticks and multiple organs of primates treated with doxycycline, as well as persistent infections in some subjects.
MIT researchers discovered a way to make bacteria more vulnerable to quinolones, enabling existing drugs to kill bacteria that cause chronic infections. Delivering quinolones along with glucose and fumarate can eliminate several types of bacteria, including Pseudomonas aeruginosa and Staphylococcus aureus.
Researchers found that certain bacterial strains can produce factors that increase or decrease the susceptibility of another bacterium to antibiotics. The study identified three specific factors: LasA, rhamnolipids, and HQNO, which could be used to create new antibiotics or develop genetic tests to detect antibiotic resistance
Researchers at University of Warwick and Francis Crick Institute discovered a deeper understanding of how D-cycloserine works against bacteria, opening up possibility of developing new antibiotic drugs. The study highlights the need for more effective antibiotics to fight drug-resistant bacterial infections.
Researchers used computer simulations to study the dynamics of efflux pumps in bacteria, which create drug resistance. Understanding how these pumps work could lead to finding ways to deactivate them, potentially making antibiotics effective again against life-threatening diseases.
A recent study found that antibiotics like ciprofloxacin can directly alter the biochemical environment of mouse immune cells during infection, making it harder for them to kill bacteria. This change in environment also led to increased resistance to antibiotics in E. coli bacteria.
A clinical trial shows FMT capsules are 96-per-cent effective in treating C. difficile infections, similar to colonoscopy. The pill-based treatment is non-invasive, inexpensive, and has no risks associated with sedation.
Bacteria resistant to ampicillin emerged several years before its widespread use in humans, according to a new study published in The Lancet Infectious Diseases. Low doses of penicillin added to animal feed in the 1950s and 60s may have encouraged antibiotic-resistant bacteria to evolve and spread.
Researchers found that antibiotic-resistant bacteria evolved and spread decades before the widespread use of ampicillin. The study suggests that low doses of penicillin fed to livestock may have triggered this evolution.
A new study published in the Journal of the American Medical Association shows that Fecal Microbiota Transplant capsules are just as effective as colonoscopy in treating C. difficile infections. The capsule delivery method is non-invasive, less expensive, and has no risks associated with sedation.
Researchers at the University of Bristol created a new platform for producing desperately needed antibiotics by combining synthetic biology with biology and chemistry. The team successfully generated a semi-synthetic pleuromutilin derivative with enhanced antibiotic activity, addressing the growing resistance to existing antibiotics.
Babies exposed to antibiotics for GBS developmentally delayed gut bacteria, which recovered by 12 weeks of age. Long-term effects on infant health are unclear.
Research suggests that antibiotic use in mothers may alter the microbiome of their offspring, increasing the risk for inflammatory bowel disease. The study, published in Nature Microbiology, found that exposure to antibiotics can change the mix of bacterial species in maternal microbes, which are then passed on to their children.
Researchers found that bacteria can quickly share genes to maintain resistance, making it unlikely that reducing antibiotic use will reverse the trend. However, conjugation rates can be disrupted and reversed using existing drugs, paving the way for future development of new treatments.
A large study found that testing for fever, high pulse rate, crackly breath sounds, and low oxygen levels could help distinguish pneumonia from less serious infections. The researchers suggest using these four measures to identify patients who need treatment with antibiotics, while reducing unnecessary prescriptions.
Physicians at Kaiser Permanente reduced antibiotic prescriptions for sinusitis by 22% using computer alerts, finding a substantial decrease in acute sinusitis diagnoses while no increase in prescribing for other upper respiratory diagnoses was observed. The intervention's effect was not sustained over time.
A new review examines veterinary antibiotic use and its impact on soil resistance, highlighting the need for tighter controls. Recent studies show increased concentrations of antibiotics and diversity of resistant genes in animal manure and treated soils.
Researchers have identified specific chemical receptors in cells that could deceive bacteria and improve patient response to drugs. The study's findings suggest that targeting these receptors could help adapt antibiotics to better attack infections.
Researchers at Queen's University Belfast have made a breakthrough in treating antibiotic-resistant bacteria Klebsiella pneumoniae. They discovered that the body's natural defences, specifically interferons, can fight back against the infection, offering new avenues for therapy.
Researchers at the University of Birmingham identified two previously unknown mechanisms that bacteria use to protect themselves from antibiotics. The discovery provides new insights into how bacteria develop resistance and could lead to the development of new drugs to combat bacterial infections.
A report by the University of Birmingham calls for policymakers to focus on measurable objectives and simple language in their action plans. The current EU and UK plans have been criticized for lacking specificity and consistency, making it difficult to track progress and evaluate success.
Researchers have discovered that a cellular pump can move drugs like antibiotics into E. coli bacteria, contradicting the long-held assumption of strict proton and drug movement in opposite directions. This finding opens up new avenues for exploring antibiotic entry mechanisms to combat bacterial resistance.
Researchers at the University of Lincoln have developed two simplified synthetic versions of teixobactin, a natural antibiotic effective against superbugs like MRSA. The new forms retain identical potency as the natural form and can be produced on a commercial scale, overcoming previous limitations.
Two studies reveal that gut bacteria play a crucial role in cancer treatment response, with certain beneficial microbes linked to improved survival and efficacy of immunotherapy. Patients with healthier gut flora tend to have more immune cells that can target tumors.
A team of CSIC scientists has designed new molecules capable of destroying resistance to conventional antibiotics in bacteria. By targeting the cellular mechanisms that lead to antibiotic resistance, these molecules can break down the proteins responsible for making bacteria resistant to multiple drugs.
A new study found that most antibiotics decrease bacterial motility in multidrug-resistant Salmonella, but kanamycin increased swarming in one strain. Researchers hope to identify the accessory genes responsible for this effect to inform antibiotic choice.
Researchers identified two key proteins that allow mycobacterium tuberculosis to evade cell destruction, leading to potential new anti-microbial strategies. Deleting these proteins could inhibit repair mechanisms, making TB more susceptible to treatment.
A recent Vanderbilt University Medical Center study found that combination therapy with azithromycin is unnecessary in most cases of pediatric pneumonia. The study of 1418 children showed no significant differences in outcomes between patients treated with a single antibiotic versus a combination of antibiotics. The researchers argue t...
Researchers found that insects reared on contaminated diets or irrigated with antibiotics exhibit increased mortality rates and altered development times. This study has implications for integrated pest management and the use of reclaimed wastewater in agriculture.
A Wayne State University research team has received a $1.85 million NIH grant to investigate non-Shine-Dalgarno translation initiation in bacteria. The goal is to identify new antibiotic targets effective against pathogens lacking Shine-Dalgarno sites.
The study found that nonoperative management is associated with a significantly higher risk of dying during hospitalization for appendicitis. Patients receiving nonoperative management were, on average, eight years older and had more coexisting illnesses than those who underwent early operations.
A new study confirms outpatient antibiotic use is a primary risk factor for acquiring C. difficile infection in the community, and recent emergency department visits may also pose a risk. The study found that patients with community-associated C. difficile infections were more likely to have prior health care visits and taken antibiotics.
Austrian scientists identify critical enterotoxin tilivalline and its potent metabolite tilimycin, produced by penicillin-resistant bacteria. The discovery provides insights into antibiotic side reactions and potential new approaches for producing anticancer drugs.
A project in rural China has successfully reduced the over-prescription of antibiotics for children's upper respiratory tract infections by half. The collaboration between UK, Canadian, and Chinese scientists introduced clinical guidelines to help doctors decide when antibiotics are necessary, resulting in a significant decrease in ant...
Researchers at Rutgers University have identified a protein complex called TldD that activates the antibiotic microcin B17 by removing its protective coating. This discovery could lead to the development of new antibacterial agents and drugs to combat toxins.
Researchers have developed novel antimicrobial compounds that can treat multidrug-resistant bacteria, enhancing the effectiveness of traditional antibiotics. The combination of colistin and a manganese tricarbonyl complex showed significant antibacterial activity in killing multidrug-resistant bacteria.
Researchers have made significant breakthroughs in understanding and combating antibiotic resistance, particularly through the development of β-lactamase inhibitors. These enzyme inhibitors have shown promise in reversing resistance to certain antibiotics, offering new hope in treating previously untreatable infections.
A Wayne State research team is developing a novel approach to treat bacterial endophthalmitis with Resolvin D1, which has shown promise in reducing inflammation and preventing tissue damage. The study aims to identify new anti-inflammatory therapeutics for the prevention and treatment of blinding ocular infections.
A team of researchers from Newcastle University discovered the MlaA protein, which removes lipids from the outer membrane to increase permeability for toxic compounds. This process could be exploited by drugs to decrease bacterial virulence and enhance antibiotic effectiveness.
A new meta-analysis shows that procalcitonin reduces relative mortality by 14% and antibiotic side effects by 25% in patients with respiratory infections. This biomarker can help medical experts diagnose infectious diseases and tailor treatment strategies.
A new study reveals that C-section births in mice result in less developed gut microbiota and significant weight gain. Vaginal-born mice demonstrated a leaner body type and normal microbiome maturity, while C-section born mice showed no major changes in microbiome structure but gained 33% more weight after weaning.
Researchers at OIST have identified genetic manipulation tools for B. bacteriovorus, a type of predatory bacteria that can be used as a living antibiotic to treat various infections. The study also explores potential applications in organic food production and industry.
A study published in JAMA found that stopping behavioral interventions aimed at reducing inappropriate antibiotic prescribing led to an increase in such prescribing practices, despite previous effectiveness of the interventions. The randomized trial, which included 47 primary care practices and 248 clinicians, showed a decrease in appr...
Researchers found that two psychological approaches, peer comparison and accountable justification, significantly reduced inappropriate antibiotic prescribing rates. However, when these interventions were removed after a year, some clinicians' bad habits returned, highlighting the need for long-term adoption of nudges to maintain bette...
A large-scale study found that patients who receive antibiotics before certain types of low-risk operations have the same risk for developing antibiotic-resistant infections as those who don't. The study analyzed data from over 22,000 patients and found no association between prophylactic antibiotic use and postoperative antibiotic res...
A study found that patients with recorded penicillin allergy were more likely to develop surgical site infections, but only if they received alternative antibiotics. The risk was 50% higher in these patients, highlighting the need for reevaluation of penicillin allergy testing guidelines.
The sale of unapproved antibiotics in India is increasing at the fastest rate, driven by fixed-dose formulations and contributing to rising antimicrobial resistance. Researchers urge the Indian government to take effective action to stop the sales and implement regulations.
A study found that antibiotics prescribed by dentists may contribute to Clostridium difficile infections, a serious and potentially deadly infection. The research highlights the importance of using antibiotics only when needed and notes that many unnecessary prescriptions are likely.
Sloan Siegrist, a UMass Amherst microbiologist, has received a five-year, $2.3 million NIH New Innovator Award to study Mycobacterium tuberculosis (Mtb) growth rates and develop new antibiotic therapies.
Researchers discovered a simple chemical mimic of host defense peptides can cure bacterial infections, either alone or in combination with traditional antibiotics. The study suggests new alternatives for treating life-threatening bacterial threats.
A new test developed at Caltech can identify antibiotic-resistant bacteria in as little as 30 minutes, allowing doctors to choose the most effective antibiotics. The test has been proven accurate with a 95% match rate, and researchers hope to expand its use to other types of infections.
New research reveals light-activated nanoparticles can re-potentiate existing antibiotics for certain clinical isolate infections. The nanoparticles release superoxide, making bacteria more susceptible to the original antibiotic and reducing effective resistance by a factor of 1,000.