Articles tagged with Antibiotics
Researchers identified powerful antimicrobial agents in some ant species but found that many others don't produce them, challenging conventional wisdom. The study suggests ants could be a future source of new antibiotics to fight human diseases.
A new study reveals that millions of unapproved antibiotics are sold in India each year, posing a significant threat to global antibiotic resistance control. Multinational pharmaceutical companies manufacture dozens of unapproved formulations, contributing to the country's high rates of antimicrobial resistance.
A new study found that millions of unapproved antibiotics are being sold in India, with multinational companies manufacturing nearly 20% of the unapproved formulations. The researchers argue that banning the sale of unapproved FDC antibiotics and improving access to healthcare are crucial steps to controlling antimicrobial resistance.
A study published in Infection Control & Hospital Epidemiology found that patient age, insurance, and race are associated with risk of receiving an unneeded antibiotic prescription. Advanced practice providers were 15% more likely to prescribe antibiotics than physician providers, highlighting the need for tailored education.
Researchers have re-evaluated an overlooked antibiotic, increasing its effectiveness against extensively drug-resistant bacteria. Octapeptin showed superior antimicrobial activity to colistin against resistant Gram-negative bacteria.
A study by MUSC Health found that using a mechanical ISDD and educating staff led to a nearly four-fold decrease in contaminated blood cultures. This reduction resulted in improved accurate diagnoses, decreased antibiotic use, and cost savings.
The DRIVE-AB consortium recommends a market entry reward of $1 billion per antibiotic globally to increase innovative antibiotic development and sustainable use. The report estimates up to 16-20 new antibiotics could be developed in the next 30 years, addressing priority pathogens identified by the WHO.
Researchers at the University of Freiburg have identified a specific position on TatC that can be chemically altered by DCCD, inhibiting contact with the Tat substrate. This finding reveals the mechanism of how TatC and TatB components assemble into an active transporter, creating a cavity for protein insertion.
A recent study published in BMC Medicine suggests that premature births are associated with an imbalance of bacteria in the mother's reproductive tract. The researchers found that subtle changes in vaginal microbiota were strongly linked to early water breakage and preterm birth, which can increase the risk of sepsis for newborns.
A team of computer scientists developed an algorithm called VarQuest to rapidly search massive databases for new antibiotic variants, discovering over a thousand new variants.
A new algorithm, VarQuest, has been developed to identify naturally occurring antibiotics, revealing an order of magnitude more compounds than previous studies. This breakthrough could lead to the discovery of new medicines and help combat rising antibiotic resistance.
Researchers at Aarhus University have determined a fundamental mechanism by which staphylococci bacteria handle stress when exposed to antibiotics. The discovery reveals that bacteria produce an enzyme capable of modifying DNA building blocks into signal molecules, allowing them to survive antibiotic treatment.
A recent study found that one in five nursing home residents received antibiotics within the last 30 days, with urinary tract infections accounting for 40% of all infections treated. New or worsening confusion was a strong factor associated with antibiotic treatment for suspected UTI.
A team of scientists has developed SAAP-148, a compound that effectively targets and eliminates drug-resistant bacteria in biofilms. The peptide-based treatment shows promise in treating MRSA and Acinetobacter baumannii infections, with plans for a clinical trial in 2018.
A survey of 1,728 participants found that most preferred surgical treatment over antibiotics for appendicitis. This contradicts the idea that antibiotics alone can be a suitable alternative to surgery for many patients.
Researchers at the University of Texas at Austin have developed a novel method called SLAY to screen hundreds of thousands of potential antibiotics. The method involves genetically engineering bacteria to produce and test molecules that are potentially toxic to themselves, allowing for rapid screening and efficient testing.
Scientists have discovered predictable sensitivities to other classes of antibiotics in Pseudomonas infections, paving the way for personalized treatment strategies. The findings suggest that targeting specific mutations could lead to more effective treatments for cystic fibrosis patients.
Researchers at University of Queensland developed a new supercharged antibiotic called vancapticins that target bacterial membranes, potentially revitalizing old antibiotics. The rebooted vancomycin has the potential to treat MRSA and VRE, addressing the growing threat of multi-drug resistant bacteria.
Researchers propose alternative therapies for mild infections to slow antibiotic resistance development, maintaining effectiveness for severe infections. This approach involves targeting milder bugs that can indirectly hinder the spread of resistant strains.
Researchers at TUM and Harvard University discovered a substance that interferes with the formation of Mycobacterium tuberculosis' mycomembrane. Combining this beta-lactone inhibitor with known antibiotics increases effectiveness by up to 100-fold, making it a promising new therapy for TB.
Researchers have identified 'sleeper cells' that can survive antibiotics and lie in a dormant state. These cells can evade detection using traditional methods, making them a significant public health concern.
A study by the Dairy Herd Health Group at the University of Nottingham's School of Veterinary Medicine and Science found that 25% of UK dairy farms used over half of all antibiotics in the sample. The research also identified factors associated with high antibiotic use, including oral antibiotics and digital dermatitis treatments.
Researchers developed a mouse model where the FXN gene defect causing Friedreich’s ataxia can be turned on or off, revealing that many early symptoms are reversible. The study found that reducing frataxin levels led to symptoms similar to those seen in humans with the disease, which disappeared when frataxin levels returned to normal.
Scientists at the University of Leeds have found that an old antibiotic candidate, pentyl pantothenamide, can stop E. coli growth but not kill it, making it effective against a specific type of bacteria. The discovery opens up the possibility of designing new drugs using the same mechanism to attack other disease-causing bacteria.
Scientists from Friedrich Schiller University Jena have developed nanoparticles that transport antibiotics more efficiently to their destination, killing off pathogens without problems. The particles are able to penetrate thick layers of mucus and biofilms, making them a promising solution against antibiotic resistance.
A recent study published in PLOS ONE and American Journal of Pathology suggests that Lyme bacteria can survive a 28-day course of antibiotics for months after infection. The study found living B. burgdorferi spirochetes in ticks and multiple organs of primates treated with doxycycline, as well as persistent infections in some subjects.
MIT researchers discovered a way to make bacteria more vulnerable to quinolones, enabling existing drugs to kill bacteria that cause chronic infections. Delivering quinolones along with glucose and fumarate can eliminate several types of bacteria, including Pseudomonas aeruginosa and Staphylococcus aureus.
Researchers at University of Warwick and Francis Crick Institute discovered a deeper understanding of how D-cycloserine works against bacteria, opening up possibility of developing new antibiotic drugs. The study highlights the need for more effective antibiotics to fight drug-resistant bacterial infections.
Researchers found that certain bacterial strains can produce factors that increase or decrease the susceptibility of another bacterium to antibiotics. The study identified three specific factors: LasA, rhamnolipids, and HQNO, which could be used to create new antibiotics or develop genetic tests to detect antibiotic resistance
Researchers used computer simulations to study the dynamics of efflux pumps in bacteria, which create drug resistance. Understanding how these pumps work could lead to finding ways to deactivate them, potentially making antibiotics effective again against life-threatening diseases.
A recent study found that antibiotics like ciprofloxacin can directly alter the biochemical environment of mouse immune cells during infection, making it harder for them to kill bacteria. This change in environment also led to increased resistance to antibiotics in E. coli bacteria.
A clinical trial shows FMT capsules are 96-per-cent effective in treating C. difficile infections, similar to colonoscopy. The pill-based treatment is non-invasive, inexpensive, and has no risks associated with sedation.
Bacteria resistant to ampicillin emerged several years before its widespread use in humans, according to a new study published in The Lancet Infectious Diseases. Low doses of penicillin added to animal feed in the 1950s and 60s may have encouraged antibiotic-resistant bacteria to evolve and spread.
Researchers found that antibiotic-resistant bacteria evolved and spread decades before the widespread use of ampicillin. The study suggests that low doses of penicillin fed to livestock may have triggered this evolution.
A new study published in the Journal of the American Medical Association shows that Fecal Microbiota Transplant capsules are just as effective as colonoscopy in treating C. difficile infections. The capsule delivery method is non-invasive, less expensive, and has no risks associated with sedation.
Researchers at the University of Bristol created a new platform for producing desperately needed antibiotics by combining synthetic biology with biology and chemistry. The team successfully generated a semi-synthetic pleuromutilin derivative with enhanced antibiotic activity, addressing the growing resistance to existing antibiotics.
Babies exposed to antibiotics for GBS developmentally delayed gut bacteria, which recovered by 12 weeks of age. Long-term effects on infant health are unclear.
Research suggests that antibiotic use in mothers may alter the microbiome of their offspring, increasing the risk for inflammatory bowel disease. The study, published in Nature Microbiology, found that exposure to antibiotics can change the mix of bacterial species in maternal microbes, which are then passed on to their children.
Researchers found that bacteria can quickly share genes to maintain resistance, making it unlikely that reducing antibiotic use will reverse the trend. However, conjugation rates can be disrupted and reversed using existing drugs, paving the way for future development of new treatments.
A large study found that testing for fever, high pulse rate, crackly breath sounds, and low oxygen levels could help distinguish pneumonia from less serious infections. The researchers suggest using these four measures to identify patients who need treatment with antibiotics, while reducing unnecessary prescriptions.
Physicians at Kaiser Permanente reduced antibiotic prescriptions for sinusitis by 22% using computer alerts, finding a substantial decrease in acute sinusitis diagnoses while no increase in prescribing for other upper respiratory diagnoses was observed. The intervention's effect was not sustained over time.
A new review examines veterinary antibiotic use and its impact on soil resistance, highlighting the need for tighter controls. Recent studies show increased concentrations of antibiotics and diversity of resistant genes in animal manure and treated soils.
Researchers have identified specific chemical receptors in cells that could deceive bacteria and improve patient response to drugs. The study's findings suggest that targeting these receptors could help adapt antibiotics to better attack infections.
Researchers at Queen's University Belfast have made a breakthrough in treating antibiotic-resistant bacteria Klebsiella pneumoniae. They discovered that the body's natural defences, specifically interferons, can fight back against the infection, offering new avenues for therapy.
Researchers at the University of Birmingham identified two previously unknown mechanisms that bacteria use to protect themselves from antibiotics. The discovery provides new insights into how bacteria develop resistance and could lead to the development of new drugs to combat bacterial infections.
A report by the University of Birmingham calls for policymakers to focus on measurable objectives and simple language in their action plans. The current EU and UK plans have been criticized for lacking specificity and consistency, making it difficult to track progress and evaluate success.
Researchers have discovered that a cellular pump can move drugs like antibiotics into E. coli bacteria, contradicting the long-held assumption of strict proton and drug movement in opposite directions. This finding opens up new avenues for exploring antibiotic entry mechanisms to combat bacterial resistance.
Researchers at the University of Lincoln have developed two simplified synthetic versions of teixobactin, a natural antibiotic effective against superbugs like MRSA. The new forms retain identical potency as the natural form and can be produced on a commercial scale, overcoming previous limitations.
Two studies reveal that gut bacteria play a crucial role in cancer treatment response, with certain beneficial microbes linked to improved survival and efficacy of immunotherapy. Patients with healthier gut flora tend to have more immune cells that can target tumors.
A team of CSIC scientists has designed new molecules capable of destroying resistance to conventional antibiotics in bacteria. By targeting the cellular mechanisms that lead to antibiotic resistance, these molecules can break down the proteins responsible for making bacteria resistant to multiple drugs.
A recent Vanderbilt University Medical Center study found that combination therapy with azithromycin is unnecessary in most cases of pediatric pneumonia. The study of 1418 children showed no significant differences in outcomes between patients treated with a single antibiotic versus a combination of antibiotics. The researchers argue t...
A new study found that most antibiotics decrease bacterial motility in multidrug-resistant Salmonella, but kanamycin increased swarming in one strain. Researchers hope to identify the accessory genes responsible for this effect to inform antibiotic choice.
Researchers identified two key proteins that allow mycobacterium tuberculosis to evade cell destruction, leading to potential new anti-microbial strategies. Deleting these proteins could inhibit repair mechanisms, making TB more susceptible to treatment.
Researchers found that insects reared on contaminated diets or irrigated with antibiotics exhibit increased mortality rates and altered development times. This study has implications for integrated pest management and the use of reclaimed wastewater in agriculture.
A new study confirms outpatient antibiotic use is a primary risk factor for acquiring C. difficile infection in the community, and recent emergency department visits may also pose a risk. The study found that patients with community-associated C. difficile infections were more likely to have prior health care visits and taken antibiotics.
A Wayne State University research team has received a $1.85 million NIH grant to investigate non-Shine-Dalgarno translation initiation in bacteria. The goal is to identify new antibiotic targets effective against pathogens lacking Shine-Dalgarno sites.
The study found that nonoperative management is associated with a significantly higher risk of dying during hospitalization for appendicitis. Patients receiving nonoperative management were, on average, eight years older and had more coexisting illnesses than those who underwent early operations.
A project in rural China has successfully reduced the over-prescription of antibiotics for children's upper respiratory tract infections by half. The collaboration between UK, Canadian, and Chinese scientists introduced clinical guidelines to help doctors decide when antibiotics are necessary, resulting in a significant decrease in ant...
Austrian scientists identify critical enterotoxin tilivalline and its potent metabolite tilimycin, produced by penicillin-resistant bacteria. The discovery provides insights into antibiotic side reactions and potential new approaches for producing anticancer drugs.
Researchers at Rutgers University have identified a protein complex called TldD that activates the antibiotic microcin B17 by removing its protective coating. This discovery could lead to the development of new antibacterial agents and drugs to combat toxins.