Articles tagged with Cancer Medication
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A team of UNC scientists has received a $2,308,800 grant to develop targeted nano-particle technology for early detection and more effective treatments of pancreatic cancer. The goal is to design nanoscale metal-organic frameworks capable of carrying imaging and therapeutic cargoes or multiple drugs.
Researchers have found a new drug combination that enhances anti-tumor efficacy and protects the heart from damage caused by doxorubicin, a powerful anti-cancer drug. The combination of Viagra and doxorubicin significantly reduces tumor size in prostate cancer patients without harming healthy cells.
A Mayo Clinic collaboration identified four genetic variants on chromosome 14 associated with aromatase inhibitor-induced arthritis. These findings provide a new clue for identifying women at risk and developing treatments, allowing more women to take lifesaving breast cancer therapy.
Researchers at UCLA's Jonsson Comprehensive Cancer Center have discovered a new cell signaling pathway that controls cell growth and development. This pathway, part of a global DNA damage response, turns off 136 genes that can promote aberrant cell division and cancer.
Scientists have developed a new form of methotrexate as nose drops to treat brain cancer, showing promise in bypassing the blood-brain barrier. In initial testing on laboratory rats with brain cancer, the nose drop drug reduced tumor weight by almost one-third compared to injectable treatment.
Researchers found that genes in a signaling network, not just individual molecules, contribute to resistance. Most genes were not mutated, but rather altered their function to evade treatment. The study's findings highlight the need for new therapeutic approaches targeting the complex interactions within cancer cell networks.
Researchers at Fox Chase Cancer Center identified over 60 proteins necessary for cancer cells to survive with EGFR inhibitors, demonstrating a two-hit strategy that increases tumor cell death. This approach will open the door for future therapies and has already led to two clinical trials testing innovative drug combinations.
A new study at Duke University Medical Center found that nearly 30% of Americans with voice problems have never received treatment, highlighting a need for better awareness and advocacy. The study also highlights the importance of early detection and personalized treatment plans to manage chronic conditions.
Researchers at Mayo Clinic found that pazopanib significantly decreased progression rate in patients with metastatic, rapidly progressive differentiated thyroid cancers. The median progression-free survival time was 11.7 months, with an overall survival rate of 81 percent at one year.
A phase 2 trial found that pazopanib, an antiangiogenetic drug, significantly improved outcomes for patients with advanced differentiated thyroid cancers. Approximately 49% of patients experienced a partial response, with two-thirds likely to have a lasting response over 1 year.
Research published online in journal Gut found that taking even a very low dose of regular aspirin (75 mg) can reduce the risk of developing bowel cancer. After one year, daily low-dose aspirin was associated with a 22% reduced risk of developing bowel cancer, which increased to 30% after five years.
Researchers at Washington University School of Medicine discovered a new drug target that can improve the effectiveness of radiation therapy for hard-to-treat cancers. The enzyme cytosolic phospholipase A2 (cPLA2) promotes tumor angiogenesis, enabling tumors to overcome radiation effects.
A multicenter trial found that childhood cancer survivors who took methylphenidate showed improved sustained attention and social skills, with benefits lasting a year after treatment. The study offers hope and reassurance for survivors and their families.
Researchers find a crucial protein involved in immune response also plays a role in T-cell acute lymphoblastic leukemia (T-ALL) progression. Suppressing the protein's activity eliminates leukemic cells, paving the way for potential new treatments.
A team of UC Davis scientists discovered a novel mechanism behind Vioxx's link to heart attacks and strokes, finding that the drug increases a regulatory lipid that contributes to cardiovascular events. The research may pave the way for safer coxibs for millions of arthritis patients.
Ipilimumab shows significant survival benefits in stage IV melanoma patients, with a median survival of 10 months. The FDA grants priority review status to this cancer treatment, providing new hope for those with devastating disease.
Researchers at the University of Illinois have identified a new target for cancer therapy in dogs and tested a compound that arrested tumor growth and induced partial remission. The study suggests that the treatment could be effective and safe, potentially adding to existing lymphoma treatments.
Researchers at Purdue University have developed a new type of pump for drug-delivery patches that uses arrays of microneedles to deliver a wider range of medications. The pump is activated by touch and can exert pressure to force drugs through the needles, with prototypes exerting pressures of up to 4.87 psi.
A new targeted therapy called PLX4032 has been linked to an 80% response rate in treating advanced melanoma. The treatment, which targets the BRAF protein, has shown significant tumor shrinkage and improved quality of life for some patients.
A phase 1 clinical trial showed that PLX4032 significantly shrinks tumors in over 80% of patients with metastatic melanoma and the mutated BRAF gene. The drug has also improved quality of life by reducing symptoms such as pain and fatigue within a week.
Researchers at Tel Aviv University have developed a nano-sized vehicle that can deliver chemotherapy drugs directly into cancer cells while avoiding interaction with healthy cells. This technology has the potential to increase the efficiency of chemotherapeutic treatments while reducing their debilitating side effects.
Researchers developed new 'stapled peptides' to block key cancer proteins, showing promise for treating cancer, diabetes, and other diseases. The advances could lead to a new generation of medicines, overcoming the shortcomings of previous drugs.
Researchers at the University of Minnesota have identified two FDA-approved drugs, decitabine and gemcitabine, which, when combined, may be an effective treatment for HIV. The drug combination forces the virus to mutate itself to death, a phenomenon dubbed 'lethal mutagenesis.'
Researchers have identified two effective treatments for neuroblastoma in mice using existing medications DECA-14 and rapamycin. The study used cancer stem cells directly isolated from children's tumors to test the drugs' efficacy without harming healthy cells.
A study by Yale University researchers found that a combination of four herbs reduced gastrointestinal side effects of chemotherapy in mice while increasing the effectiveness of cancer treatment. The herbal formula PHY906 enhanced anti-tumor activity and promoted intestinal cell regeneration.
Palliative care significantly improved the lives of lung cancer patients, extending their survival by an average of 11.6 months compared to those receiving standard care alone. Quality-of-life assessments also showed substantial improvement in the palliative care group.
A CSHL-led team found that increased IL-6 secretion can lead to decreased sensitivity to Tarceva, a targeted therapy for lung cancer. They also discovered that tumor cells with up-regulated TGF-β and increased IL-6 secretion were resistant to treatment independently of the EGFR pathway.
The study found that depleting SIK2 from ovarian cancers sensitized the cells to paclitaxel, making it more effective in stopping cancer growth. Levels of SIK2 protein are increased in approximately 30 percent of ovarian cancers and associated with poorer survival rates.
Researchers at VCU Massey Cancer Center have discovered a new link between chronic inflammation and cancer, highlighting the importance of sphingosine-1-phosphate (S1P) in regulating inflammation. S1P is found to be a missing cofactor required for TRAF2's activity, which controls inflammation and cancer.
A study by the University of Houston team suggests that higher exposure to estrogens may be connected to gallbladder cancer. The research found that eliminating estrogens prevents tumor development in a specific animal model, leading to potential new drugs and understanding individual risks.
Researchers at Beth Israel Deaconess Medical Center discovered that the MDM2 oncogene is regulated by a complex signaling pathway involving enzymes CKI and beta-TRCP1. This finding suggests a 'dimmer switch' control mechanism, which could lead to new drug targets for killing tumors.
Researchers have developed a way to deliver drugs directly to tumors using nanoparticles, reducing the risk of severe side effects. The new approach uses immune cells to target tumors, allowing for more effective cancer treatment.
The international community must prioritize cancer care as a global health issue, with stark disparities between low- and high-income countries. Implementing evidence-based interventions can prevent or ease suffering from many malignancies, reducing the gap in access to care.
Despite high burden of disease, many cancers are preventable or treatable with generic drugs, education, and training. Initiatives like vaccination against HPV and hepatitis B virus can significantly impact cancer mortality. GTF.CCC aims to support existing initiatives and improve health systems in LMICs.
Assistant Professor Annelise Nguyen receives $370,000 grant to study cell communication in cancer cells, potentially leading to enhanced drug treatments. Her work also has potential applications for colon and prostate cancers.
A study of over 80,000 patients in the UK found no significant association between oral bisphosphonate use and an increased risk of esophageal or gastric cancer. The analysis excluded patients with less than 6 months follow-up, resulting in 41,826 members in each group.
BGU Professor Ron N. Apte received the 2010 Samuel and Paula Elkeles Prize for Outstanding Scientist in the Field of Medicine. His research focuses on inflammation in malignant processes, with a major emphasis on IL-1-mediated inflammation in tumor invasiveness and metastasis.
Scientists create a new system that utilizes porous nanomaterials driven by a magnetic core to release drugs inside living cancer cells, improving targeted drug delivery and imaging in cancer treatment. The system has the potential to deliver anti-cancer drugs only to cancer cells while leaving healthy cells unharmed.
The UK government's £50 million emergency cancer fund is under fire for its potential to favor patients based on geographical location rather than medical need. The Lancet Editorial argues that this policy undermines the principles of evidence-based medicine and rational healthcare resource allocation.
The University of Louisville has received a $3.15 million grant from the Helmsley Charitable Trust to support its cancer research program in Owensboro. The funding will be used to create new faculty positions and expand the research program, with a focus on developing plant-based pharmaceuticals.
A peptide derived from bee venom can deliver liposomes bearing drugs or diagnostic dyes to specific cells or tissues, improving the effectiveness of cancer treatment. This 'smart bomb' technology may help design personalized treatment regimens that can selectively target tumors and other diseases.
Researchers have made a groundbreaking discovery that challenges scientists' understanding of programmed cell death and its role in tumour formation. The study found that the body's natural cell-suicide program can fuel tumour development under certain conditions.
Researchers at Rensselaer Polytechnic Institute are developing new technology to push drugs through the blood-brain barrier, directly targeting brain tumors. The goal is to deliver treatments for diffuse malignant glioma, a lethal type of brain cancer with no cure.
A UNC physician authored an editorial on a cost-effectiveness study comparing colonoscopy and computed tomographic colonography (CTC) for colon cancer screening. The analysis concluded that CTC is not cost-effective compared to colonoscopy if reimbursed at the same rate.
Researchers identified a way to predict which cancer patients will respond to everolimus, a treatment targeting the protein mTOR. The presence of KRAS gene mutations is associated with lack of response to treatment, suggesting that looking for PIK3CA and KRAS mutations can help predict patient outcomes.
A study of 601 childhood cancer survivors found that 27% had abnormal cardiac function, with no evidence that sex or certain treatments were risk factors. The study highlights the need for continued monitoring of these patients to prevent further deterioration of cardiac function.
Researchers have developed a new drug that targets peripheral CB1 cannabinoid receptors to improve cardiometabolic risk in mouse models of obesity. The drug inhibits the same protein as rimonabant, but without neurological side effects. This approach may reduce health risks associated with obesity and type 2 diabetes.
Researchers discovered a non-human sialic acid sugar in biotech drugs that can provoke a strong immune response in some individuals, worsening chronic inflammation. A simple modification to the drug-making process could solve this problem by adding human sialic acid.
A new study published in The Lancet found that women who underwent radiation therapy as children are more likely to experience stillbirths or baby deaths when attempting to conceive. In contrast, no increased risk was found for men exposed to similar levels of radiation. The authors suggest that uterine damage may be the primary factor...
Researchers at Tel Aviv University are developing a new clinical approach to prevent cancer recurrence after surgery by blocking stress responses. The treatment involves combining two widely available medications to boost the immune system and prevent tumor metastasis, with promising results in animal studies.
Researchers found that mice lacking MTOR in their heart muscle cells developed a fatal heart condition, highlighting the potential adverse effects of MTOR inhibitors on heart health. Deletion of 4E-BP1 improved heart function and survival, suggesting a new therapeutic strategy for improving heart function in patients with heart failure.
A meta-analysis of published evidence reveals painters are at significantly increased risk of developing bladder cancer. The risk increases with length of employment as a painter, and persists even after accounting for smoking and other risk factors.
A study found that drugs inhibiting the protein MTOR can impair heart function in patients with ongoing heart dysfunction. Additionally, researchers discovered that deleting the protein 4E-BP1 improved heart function and survival in mice. These findings suggest a potential new therapeutic strategy for improving heart health.
The largest study of its kind has released its first results, providing a wealth of information on how genetic mutations affect cancer responses to treatments. The research aims to improve patient care by tailoring treatment to individual tumour characteristics.
Researchers at Northwestern University developed a new arsenic nanoparticle that effectively targets and blocks aggressive triple negative breast cancer. The nanoparticles deliver the toxic cargo directly to tumor cells while shielding normal tissue from harm, making it a promising lead for improving chemotherapy drugs.
Long-term follow-up study reveals increased mortality rates in childhood cancer survivors due to second primary cancers and cardiac deaths. Risk persists beyond 45 years after initial diagnosis, likely attributed to late complications of treatment.
A new study has found that centralized telephone-based care management can significantly reduce pain and depression in cancer patients. The INCPAD study combined automated calls with follow-up calls from nurse care managers, and the results showed improved outcomes for patients with all types of cancers.
Researchers from the John Theurer Cancer Center have made exciting progress in elucidating the mechanisms of bortezomib in mantle cell lymphoma. The study identified biomarkers that can help guide patient selection and speed up the development of targeted cancer drugs.
A Stanford study found that arsenic trioxide can block the Hedgehog pathway, a signaling cascade involved in various cancers. The compound inhibits the expression of certain genes, making it harder for cancer cells to mutate and evade treatment.
A genetically reprogrammed herpes virus and an anti-vascular drug combination shrinks spreading distant sarcomas in mice, with significant tumor reduction and improved survival rates. Researchers achieved these results by using the virus systemically via injection, overcoming a major stumbling block in previous cancer treatments.