Fewer cases of children’s cancer picked up during COVID pandemic
A study found that COVID-19 reduced childhood cancer diagnoses by 17%, but increased intensive care admissions before diagnosis.
Cancer Treatments
Articles tagged with Cancer Treatments
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An innovative imaging technique for dynamic optical nanothermometry
A new imaging technique called single-shot photoluminescence lifetime imaging thermometry (SPLIT) measures temperature in 2D, without contact, and in real-time. This technology could improve photothermal therapy and help detect skin cancers.
WVCTSI to steer ‘medical clinic on wheels’ to West Virginia communities
The WVCTSI will deploy a mobile clinical trials unit in West Virginia, addressing health disparities and increasing participation in clinical research. The 39-foot Winnebago will provide on-site clinical trials and follow-up visits to rural residents.
High cell membrane tension constrains the spread of cancer
Research reveals that cancer cells have softer membranes than normal cells, but stiffening them can prevent abnormal changes in structure and motility. Stiffened breast cancer cells lost the ability to spread to the lungs in mouse experiments, suggesting a potential strategy for cancer treatments.
Pilot study reveals the benefits of ‘whole genome sequencing’ for children with cancer
A pilot study reveals that whole genome sequencing can refine diagnoses and provide new treatment options for children with cancer. The study found genetic variants that could change prognosis or suggest hereditary causes of the cancers, as well as treatments that may be effective but were not previously considered.
Prostate cancer urine test identifies good prognosis patients
A new pilot study reveals a prostate cancer urine test can identify men with intermediate-risk disease, allowing them to opt for active surveillance instead of immediate treatment. The test assesses the amount of aggressive cancer in the prostate without needing a biopsy.
Engineers devise a way to selectively turn on RNA therapies in human cells
Researchers at MIT and Harvard University have developed a way to selectively turn on gene therapies in target cells by detecting specific messenger RNA sequences. This technology can fine-tune gene therapies for applications ranging from regenerative medicine to cancer treatment, potentially reducing side effects and increasing efficacy.
Serial radiation therapy is safe and effective as alternative treatment to systemic therapy for kidney cancer
Researchers at MD Anderson Cancer Center reported that serial stereotactic body radiation therapy (SBRT) is a safe and effective treatment for oligometastatic renal cell carcinoma. The study showed promising results, with a median progression-free survival of 22.7 months and minimal toxicity.
Targeting cancer at the nanoscale
Scientists at Osaka University developed a novel system for targeted cancer radiation therapy using gold nanoparticles labeled with astatine-211. The nanoparticles are highly toxic to cancer cells while remaining localized, minimizing damage to healthy tissues.
Metastatic breast cancer: new ESMO Guideline with evidence-based recommendations
The new ESMO Clinical Practice Guideline provides comprehensive guidance on diagnosing, staging, and treating patients with metastatic breast cancer. The guideline incorporates recent clinical trial data to inform treatment choices, taking into account tumour biology and emerging targeted therapies.
New discovery may pave the way for more targeted treatment of cancer patients
Researchers at the University of Copenhagen have discovered that the BRCA2 gene requires a specific enzyme, PP2A-B56, to repair DNA damage. This finding may pave the way for more targeted treatment of cancer patients with certain mutations.
Oncotarget: Technology for the identification of MYC:TRRAP inhibitors
The study proposes a new approach to inhibit MYC's essential interaction with TRRAP, a protein required for efficient histone acetylation. This disruption could lead to cancer-specific targeted therapies with minimal effects on normal cells.
Many adults with breast cancer use cannabis but don’t tell their doctors
A survey of breast cancer patients found that nearly half use cannabis to alleviate pain, fatigue, and other symptoms while undergoing treatment. Physicians are often unaware of patients' cannabis use, highlighting the need for informed conversations about its potential benefits and risks.
Oncotarget: TAK1-inhibitors are cytotoxic for multiple myeloma cells
Researchers found that TAK1-inhibitors NG25 and 5Z-7 reduce the viability of multiple myeloma cell lines and primary cells, inducing apoptosis through various mechanisms. The combination of TAK1 inhibitors with DNA-damaging agents increases cytotoxicity in a synergistic or additive manner.
UH engineer reports advance in rapid cancer detection and monitoring
Researchers at the University of Houston have developed a new, label-free biosensing platform for detecting cancer biomarkers in exosomes. The technology uses gold nanodisks to capture and analyze surface proteins on exosomes with high sensitivity.
Percutaneous image-guided microwave and cryoablation for lung sarcoma
A retrospective cohort study of 27 patients with sarcoma lung metastases found high primary technical success rates for percutaneous image-guided microwave and cryoablation. The treatment modality and tumor location did not affect local progression, and smaller tumors showed lower cumulative incidence of local progression.
Gel enhances CAR-T immunotherapy benefits in brains surgically treated for glioblastoma
Researchers developed a gel made of fibrin that improved the effectiveness of CAR-T cell immunotherapy for glioblastoma by enhancing T cell distribution and preventing tumor recurrence. In mouse studies, the gel showed promising results, with 64% of treated mice being tumor-free after 94 days.
The complex dynamics of stem cell tethers and slings
Researchers have discovered the molecular mechanisms behind stem cell rolling in blood vessels, a complex process that slows down cells using long tethers. The findings offer new insights into improving stem cell transplantations and developing treatments for metastasizing cancers.
Early-stage Hollings investigator awarded R37 grant to study new leukemia target
MUSC researcher Haizhen Wang receives R37 grant to investigate CDK6's role in T-cell acute lymphoblastic leukemia, a aggressive cancer. The research aims to understand how the immune system can be used to reduce leukemia progression.
Oncotarget: High CD39 expression is associated with human bladder cancer
Researchers found that high CD39 expression is associated with human bladder cancer, particularly in the non-muscle-invasive phenotype. CD39's involvement in tumor development and progression is still unclear, but its overexpression in early-stage tumors suggests a potential role in bladder cancer progression.
Novel fluorescence imaging assay gives new insight to develop biomimetic nanoparticles for targeted cancer therapy
Researchers developed a fluorescence quenching assay to probe the integrity of cell membrane coating on biomimetic nanoparticles. The study found that only 20% of particles were fully coated, indicating significant limitations in current coating protocols.
Molecular Analysis for Precision Oncology Virtual Congress 2021
The MAP Virtual Congress 2021 focuses on integrating tumour sample analysis into daily practice, enabling personalized treatment. Key findings include actionable mutations in patient DNA and the role of the tumour microenvironment in metastasis.
Using the microbiome to promote muscle growth in muscle loss conditions such as ageing and cancer
A new study found that a healthy gut microbiome is essential for skeletal muscles to grow after exercise. Researchers used mice with antibiotics to disrupt the microbiome, showing reduced muscle growth compared to healthy mice. The findings support previous studies linking the gut microbiome to muscle health.
Early signs of efficacy of new targeted agents and immunotherapies reported for multiple cancers at ESMO Congress 2021
New targeted therapies are being developed to target genetic alterations in cancer cells, such as the ARID1A mutation found in 10-50% of solid tumours. Early clinical trials suggest that these agents may be effective in treating multiple cancers, including breast, ovarian, and gastric cancer.
Metastatic prostate cancer comes in two forms, which could guide treatment
Researchers identified two subtypes of metastatic prostate cancer that respond differently to hormone treatment. Luminal tumors responded better to testosterone-blocking treatments, while basal tumors did not benefit as much from this hormone treatment.
$3 million grant establishes center to combat racial inequities in lung cancer
The VCU Massey Cancer Center has established a Translational Research Center in Lung Cancer Disparities (TRACER) to address racial disparities in lung cancer. TRACER will investigate the interaction between stress, smoking, and gene expression to raise lung cancer risk in Black men.
High burden of liver, stomach and cervical cancers among the Hispanic/Latino population highlights access to care challenges
The report reveals a high risk of preventable cancers among Hispanic/Latino population, with 2-fold higher rates of liver and stomach cancers. Access to quality prevention, early detection, and treatment services is crucial for reducing the cancer burden in this population.
Unique aspects of pancreatic cancer proteins could lead to early detection, new treatments
Researchers at Johns Hopkins Medicine have identified promising new targets for pancreatic cancer treatment and early detection, including glycosylated proteins that could be captured in the blood for diagnosis. The study also suggests new ways to improve immune response to these tumors.
Control of rhabdomyosarcoma cell identity provides clues to possible treatments
Researchers at St. Jude Children's Research Hospital found that the tumor suppressor gene PTEN controls rhabdomyosarcoma cell identity and that enhancing PAX7 expression can maintain tumor cell existence, providing a potential treatment target for rhabdomyosarcoma.
Improving leukemia therapy with targeted treatment approaches
Researchers at the University of Basel have discovered a novel combination therapy approach that combines inhibiting JAK2 with targeting the MAPK signaling pathway. This dual targeting strategy has shown promising results in improving leukemia treatment outcomes by reducing blood cell production and altering disease course.
Changing the fate: Converting glioma cells into neurons may treat glioblastoma
Researchers develop a novel cell reprogramming strategy to transform glioma cells into non-proliferative neurons. This approach shows promise in slowing down the growth of GBMs and overcoming harmful side effects of conventional treatments.
Programming synthetic exosomes to optimize wound healing
Researchers at Max-Planck-Gesellschaft engineered synthetic exosomes that regulate cellular signaling during wound closure, leading to faster healing and improved formation of new blood vessels. The study provides a systematic understanding of extracellular vesicle communication and its potential therapeutic application.
Scientists reveal how the impact of chemotherapy on healthy cells affects the development of blood cells
Researchers identified DNA mutations from platinum-based chemotherapies in AML patients, suggesting treatment-associated cancer development. The study's findings imply that clonal hematopoiesis precedes chemotherapy exposure.
Hormonal hazard: Chemicals used in paints and plastics can promote breast tumor growth
Recent study by Okayama University researchers reveals three photoinitiators cause faster increase in breast tumor growth in mice, with tamoxifen pretreatment reducing toxicity. The findings suggest photoinitiators could act as hormonal disruptions, raising concerns for patients and healthy individuals.
A T-cell power-up for tumor treatments
Researchers at USC Viterbi School of Engineering have discovered a way to boost the effectiveness of CAR T-cell therapy for treating solid tumors, including breast and melanoma. By engineering CAR T-cells to produce an enzyme called adenosine deaminase, they break down an immune-suppressive microenvironment, allowing cancer-killing cel...
Researchers identified factors that turn normal cells into liver cancer cells
Researchers identified a minimal set of defined factors that can convert normal human fibroblast cells to liver cancer cells, providing a mechanistic proof-of-principle for understanding why certain mutations cause cancer in particular tissues.
Hormone profiling could be used to improve survival rates for breast cancer
Researchers have found that hormone profiles before and after treatment play a significant role in the success of therapy for breast cancer. This finding could lead to improved treatment options and better outcomes for patients.
Increased survival with eye melanoma in clinical trial
A new combination treatment has shown significant tumor shrinkage and prolonged survival in patients with metastatic uveal melanoma. The treatment, which targets HDAC and PD-1 proteins, was found to work better in tumors with active BAP1 genes, a key discovery that may lead to improved survival rates.
Oncotarget: Disabling the PI3K/Akt/mTOR survival pathway and inducing apoptosis
Researchers developed a new cancer therapy combining sulforaphane (SFN) and acetazolamide (AZ), which inhibits the PI3K/Akt/mTOR survival pathway and reduces 5-HT secretion in carcinoid syndrome. The combination therapy induces apoptosis in tumor cells, upregulates the p21 cell cycle inhibitor, and downregulates the PI3K/Akt/mTOR pathway.
New study examines ‘Achilles heel’ of cancer tumours, paving the way for new treatment strategies
Researchers have uncovered a weakness in the key enzyme that solid tumour cancer cells rely on to adapt and survive when oxygen levels are low. Inhibiting this enzyme, called Carbonic Anhydrase IX (CAIX), can effectively stop cancer cell growth.
Qualitative fecal test: Empowering colorectal cancer screening
Researchers compared the accuracy of two types of fecal tests for detecting colorectal cancer, finding that both types are reliable when thresholds are adjusted. The study suggests that health providers should select the best type of test based on specific demands in screening settings.
JNCCN study reveals neuroendocrine tumor mortality patterns to inform treatment decisions
A population-based cohort study in Canada identified mortality patterns for different types of neuroendocrine tumors (NETs), revealing varying risks of cancer-related and non-cancer death. The study found that small NETs can be safely monitored, while larger tumors may require more aggressive treatment.
A “helping hand”: Intervention for early cancer screening in patients with mental illness
Researchers from Okayama University conducted a randomized trial to assess the benefits of interventions for early cancer screening in patients with schizophrenia. The study found that 47.1% of counseled patients underwent colorectal cancer screening, compared to 11.8% of those receiving only usual treatment.
Patients helping researchers to advance treatments for prostate cancer
Monash University researchers have established a vast collection of living prostate cancer tumors from patients, enabling the testing of new treatments and advancing patient care. The PDX collection comprises 59 tumors collected from 30 patients between 2012-2020, providing a unique resource for scientists and pharmaceutical companies.
Scientists decipher how neuro-immune interactions burn deep fat
Researchers uncover a neuro-immune process by which brain signals instruct immune function in visceral fat stores, providing new approaches for fighting obesity and related illness. The study identifies a critical mediator of neuro-immune communication, mesenchymal cells, and reveals the molecular messages exchanged across all steps.
OU-MRU: A berry vine found in Asia proves useful in combating lung cancer
A research team from Okayama University has reported the potential of a berry-producing vine, Vitis coignetiae Pulliat (Yamabudo), against lung cancer in mice. The study found that extracts from Yamabudo and its chemical compounds display tumor-suppressing properties by repairing DNA damage and suppressing growth signaling pathways.
Way forward: Quantitative analytical tools in medicine and clinical research
Recent studies demonstrate the applications of LC-MS in characterizing Traditional Chinese Medicine formulations, real-time drug measurement, and bioactive compounds from Osmanthus fragrans. These techniques offer high sensitivity, robustness, and ease of use for quality assessment and characterization.
Pancreatic cancer trials are no more diverse now than over a decade ago
Black, Hispanic, Indigenous and Asian Americans remain underrepresented in pancreatic cancer clinical trials, despite federal mandates. The lack of diversity hurts patients and science alike, with racial and ethnic minorities accounting for a disproportionate burden of pancreatic cancer cases.
AI DBT impact on mammography post-breast therapy
A single-center retrospective study found that AI-CAD reduced recall rates and improved accuracy compared to digital mammography (DM) and DBT. The study showed lower recall rates and higher accuracy for DM with AI-CAD, indicating a practical addition to lowering false-positive findings.
‘Frameshifting’ therapy for mast cell cancers reduces size, spread
Researchers developed a 'frameshifting' therapy that alters mRNA to reduce mast cell tumor size and prevent organ infiltration. The treatment, targeting the c-KIT gene, shows promise in reducing KIT protein expression, signaling, and function.
First-in-class histone deacetylase inhibitor gel shows promise for the treatment of patients with basal cell carcinoma
A phase II clinical trial of remetinostat gel found a 69.7% response rate to the topical treatment, with complete responses observed across multiple BCC subtypes, and a durable response in nodular BCCs.
New 10-year patient safety analysis highlights areas for improvement in acute medical units
A new study analyzes 377 severe harm and death incidents in acute medical units across England and Wales between 2005-2015. The most common incident types were diagnostic errors, medication-related errors, and failures in monitoring patients. Implementing electronic prescribing systems and checklists can reduce diagnostic errors, while...
Cancer treatments didn’t falter in Australia during 2020 COVID-19 lockdowns
A big data study from UNSW Sydney found that Australian cancer patients kept up their pharmaceutical treatments during last year's COVID-19 lockdowns. The researchers attribute the good news to relatively low rates of COVID-19 infections in Australia, which minimally impacted cancer treatment patterns.
Oncotarget: DNA assay predicts treatment response in head and neck carcinoma
A new droplet digital PCR-based assay for HPV16 circulating tumor DNA was developed to predict treatment response in metastatic head and neck squamous cell carcinoma. Longitudinal changes of HPV16 ctDNA correlate with treatment response, allowing for early identification of treatment failure.
Moffitt researchers identify new relevant target for PARP inhibitor talazoparib
Moffitt researchers identify PARP16 as a novel functionally relevant target for talazoparib, which enhances anti-cancer effects in small cell lung cancer and Ewing sarcoma. Combination treatment with talazoparib and adavosertib results in enhanced anti-cancer activity.
ASMBS Foundation awards research grants for studies related to COVID-19 & obesity
The ASMBS Foundation has awarded two research grants totaling $50,000 to investigate the impact of COVID-19 on adolescents with obesity and the effects of cannabis use after bariatric surgery. The studies will help improve the understanding of these conditions and develop effective therapies.
Cancer: Information theory to fight resistance to treatments
A team from UNIGE and HUG used information theory to study the molecular regulations behind cancer cell adaptation to targeted therapies. They found that a large reversible component of resistance exists, which can be modulated by therapeutic combinations.
Scientists provide new insight on how to stop transcription of cancer cells
Scientists from UCLA Jonsson Comprehensive Cancer Center identified TAF12 as critical to the formation of preinitiation complexes, which are necessary for gene transcription. Eliminating TAF12 destroys preinitiation complexes and drastically reduces genome-wide transcription.
Scientists seek details of cancer's evolutionary tree
Luay Nakhleh's team will use single-cell DNA data from the University of Texas MD Anderson Cancer Center to identify mutations at the root of the disease and how they evolve in tumors. By building open-source models and tools, they aim to refine cancer treatments and predict patient outcomes.
Robotic neck brace can help analyze cancer treatment impacts
A new robotic neck brace designed by Columbia Engineering can precisely detect changes in patient neck movements during routine clinical visits. The device can help identify patients who may have issues with neck movement, enabling targeted physical therapy interventions to improve recovery outcomes.