A new study by UCLA Jonsson Comprehensive Cancer Center identifies the DNA roots of resistance to targeted cancer therapy. The researchers found that a protein called DNA-PK plays a crucial role in the process of chromothripsis, which can lead to gene amplification and therapy resistance.
SourceUniversity of California - Los Angeles Health Sciences·JournalCancer Discovery·TypeExperimental study·DateJan 26, 2023
Researchers developed a translational step forward in treating brain tumors using intraventricular immunovirotherapy, which has shown safety and efficacy in recent clinical trials. This approach uses oncolytic herpes simplex virus type-1 to target high-grade glioma with promising results.
SourceImpact Journals LLC·JournalOncotarget·TypeCommentary/editorial·DateJan 26, 2023
A new study led by Mayo Clinic researchers found that women carrying specific genetic changes, such as BRCA1 and BRCA2, have a twofold increased risk of developing contralateral breast cancer. Premenopausal women with these mutations are more likely to develop cancer in both breasts.
SourceMayo Clinic·JournalJournal of Clinical Oncology·DateJan 20, 2023
Researchers developed a multimodal imaging-based tool, the active biopsy guidance system (ABGS), to improve oral cancer diagnosis. The ABGS provides clinically actionable direct visible guidance for biopsies, enhancing precision and potentially saving lives.
SourceSPIE--International Society for Optics and Photonics·JournalJournal of Biomedical Optics·DateJan 19, 2023
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Researchers found a protein called Rac1 that triggers milk production in breast cells when lactation stops and the breast returns to its pre-pregnancy state. This process involves cell death and autophagy, but can be reversed upon suckling, providing a fail-safe mechanism for mammalian survival.
SourceUniversity of Sheffield·JournalPLOS Biology·TypeExperimental study·DateJan 19, 2023
Researchers found poor adherence to surgical quality metrics in lung cancer patients, with only 40% receiving minimally invasive surgery and one-third receiving adequate lymph node sampling. Adherence to guidelines was associated with improved overall survival rates.
SourceWashington University in St. Louis·JournalJAMA Surgery·TypeData/statistical analysis·DateJan 18, 2023
Research found that nonablative fractional lasers (NAFL) reduce the risk of subsequent keratinocyte carcinoma development. NAFL-treated patients had about half the risk of developing a new facial keratinocyte carcinoma compared to untreated controls.
SourceMassachusetts General Hospital·JournalDermatologic Surgery·TypeObservational study·DateJan 18, 2023
A new study suggests that acupressure before surgery can reduce anxiety, while acupuncture during surgery may provide additional relief from severe pain. The research found that patients who received these treatments had better recovery scores and lower levels of pain and anxiety compared to those who received standard care.
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C)
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C) keeps Macs, tablets, and meters powered during extended observing runs and remote surveys.
A new study standardizes the use of optical genome mapping (OGM) for patients with blood cancers, demonstrating its potential as a frontline test for diagnosing hematologic malignancies. OGM outperforms existing tests in detecting cancer-causing gene variants and identifying additional information that can improve patient outcomes.
SourceMedical College of Georgia at Augusta University·JournalJournal of Molecular Diagnostics·DateJan 17, 2023
A study of 184 grade I and II meningiomas found associations between specific tumor mutations and increased or decreased recurrence rates. Mutations in ATM and CREBBP were linked to accelerated recurrence, while POLE mutations showed protective effects, highlighting potential targets for intervention.
SourceImpact Journals LLC·JournalOncoscience·TypeObservational study·DateJan 17, 2023
A study by Mayo Clinic researchers found a specific colonization of microbes in the reproductive tract is commonly found in women with ovarian cancer. The discovery strengthens evidence that the bacterial component of the microbiome is an important indicator for early detection, diagnosis, and prognosis of ovarian cancer.
SourceMayo Clinic·JournalScientific Reports·DateJan 16, 2023
Meta Quest 3 512GB
Meta Quest 3 512GB enables immersive mission planning, terrain rehearsal, and interactive STEM demos with high-resolution mixed-reality experiences.
A computational model predicts brain tumour growth using MRI data, providing valuable insights for clinicians. The study uses anonymous patient data to develop a predictive model for glioblastoma multiforme (GBM) growth, which can be used to inform treatment decisions.
SourceUniversity of Waterloo·JournalJournal of Theoretical Biology·DateJan 16, 2023
A study of 4,768 patients with cancer found that SARS-CoV-2 infection led to delayed or discontinued cancer treatment, exacerbating existing survival inequities. Racial and area-level social determinants were associated with these delays.
SourceJAMA Network·JournalJAMA Network Open·DateJan 13, 2023
A genetically engineered bacterium has enabled the biosynthesis of melanin nanoparticles with excellent biocompatibility, stability, and photothermal conversion efficiency. The resulting nanoparticles showed strong absorption in the near-infrared region and high antitumor efficacy for photoacoustic imaging-guided photothermal therapy.
SourceChinese Academy of Sciences Headquarters·JournalSmall·DateJan 12, 2023
A phase II study found that posoleucel, an off-the-shelf T-cell therapy, demonstrated promising antiviral efficacy and safety in patients with blood cancers and other hematologic disorders. The therapy reduced viral load by an average of 97% and showed limited rates of graft-versus-host disease.
SourceAmerican Association for Cancer Research·JournalClinical Cancer Research·DateJan 11, 2023
Researchers at Iowa State University have identified a metabolic switch that can be modified to control fat production, which could lead to more effective treatments for childhood obesity and cancer. The discovery involves altering the acetylation levels of fatty acid synthase, an enzyme critical to de novo lipogenesis.
SourceIowa State University·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateJan 11, 2023
Sony Alpha a7 IV (Body Only)
Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
Researchers are working to understand the events contributing to pancreatic cancer development by studying gene abnormalities and their effects on the disease. Dr. Krushna Patra's lab is focused on understanding how genetic mutations like GNAS contribute to pancreatic cancer growth.
Researchers from prominent institutions discuss hepatocellular carcinoma's pathogenesis, genomic heterogeneity, and targeted therapy options. The review aims to characterize HCC's complexities and develop clinically relevant biomarkers for better management.
SourceImpact Journals LLC·JournalGenes & Cancer·TypeLiterature review·DateJan 6, 2023
African patients with chronic hepatitis B face limited access to treatment due to inadequate guidelines. Researchers propose lower treatment thresholds and better adapted guidelines for the African population.
SourceUniversity of Liverpool·JournalNature Communications·TypeSystematic review·DateJan 5, 2023
A new Northwestern Medicine study found that all U.S. OB-GYN subspecialties lack racial and ethnic representation in clinical trials and research publications. This absence has negative consequences, including biased tools for diagnosing endometrial cancer and unacceptably low sensitivity in the Black female population.
SourceNorthwestern University·JournalJAMA Surgery·DateDec 21, 2022
Langerhans' Cell Histiocytosis (LCH) is a serious disease affecting children that can be fatal in severe cases. Researchers have identified the origin of LCH cells, which are derived from both dendritic and monocyte cells.
SourceKarolinska Institutet·JournalScience Immunology·DateDec 16, 2022
Kestrel 3000 Pocket Weather Meter
Kestrel 3000 Pocket Weather Meter measures wind, temperature, and humidity in real time for site assessments, aviation checks, and safety briefings.
Researchers have discovered that calcitriol, a form of activated vitamin D3, inhibits arsenic-mediated carcinogenesis in human skin cells. The treatment significantly reduced arsenic levels and suppressed anchorage-independent growth in both keratinocytes and lung epithelial cells.
SourceShibaura Institute of Technology·TypeExperimental study·DateDec 15, 2022
Researchers investigate how lung cancers evade the immune system to develop more effective immunotherapy treatments. The study aims to uncover a new way lung cancers disguise themselves from the immune system, potentially leading to improved treatment outcomes.
A new study from Edith Cowan University found that a single bout of exercise can significantly suppress tumour growth in people with late-stage prostate cancer. The researchers observed increased levels of anti-cancer myokines after high-intensity exercise, which helped fight cancerous cells and stimulated anti-cancer processes.
SourceEdith Cowan University·JournalProstate Cancer and Prostatic Diseases·TypeObservational study·DateDec 13, 2022
The USC Norris Comprehensive Cancer Center will receive funding from the American Cancer Society Institutional Research Grant (IRG) to support pilot work, training, and career development for junior faculty members. The grant aims to address cancer disparities in Los Angeles and beyond.
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
A recent study by City of Hope found that only 30% of patients with advanced neuroendocrine tumors prioritize living longer as their top goal. Instead, 70% focus on addressing pain, fatigue, and losing function. The research highlights the need for better communication between care providers and patients to develop personalized treatme...
SourceNational Comprehensive Cancer Network·JournalJournal of the National Comprehensive Cancer Network·DateDec 12, 2022
Researchers found that lncRNA MVIH is overexpressed in cervical cancer tumors and associated with younger age, lymph node metastasis, tumor invasion depth, and squamous cell type. This suggests its potential as a diagnostic biomarker for cervical cancer.
SourceImpact Journals LLC·JournalGenes & Cancer·TypeObservational study·DateDec 9, 2022
Dr. Keith Chan joins Houston Methodist to enhance chemoimmunotherapy responses in bladder cancer, while also expanding research into pancreatic and skin cancers. He will lead translational research and mentor next-generation cancer researchers.
Sky & Telescope Pocket Sky Atlas, 2nd Edition
Sky & Telescope Pocket Sky Atlas, 2nd Edition is a durable star atlas for planning sessions, identifying targets, and teaching celestial navigation.
Tricia King's project aims to create personalized treatment plans for brain cancer survivors by identifying environmental, clinical, and genetic risk factors. The research has the potential to improve treatment outcomes for patients with various types of cancer.
The updated guideline provides recommendations on the use of radiation therapy and systemic therapy after surgery to treat patients with endometrial cancer. It considers the role of surgical staging and molecular profiling techniques in determining whether a patient should receive post-operative therapy.
SourceAmerican Society for Radiation Oncology·JournalPractical Radiation Oncology·DateDec 7, 2022
A study published in the Journal of Medical Imaging and Radiation Sciences found that hospital parking fees significantly correlate with cancer center address transit score and city cost of living across Western Canada. Cities with higher cost of living have less free parking, exacerbating economic burdens on patients.
SourceElsevier·JournalJournal of Medical Imaging and Radiation Sciences·TypeData/statistical analysis·DateDec 7, 2022
The study suggests a significant decrease in US melanoma mortality rates, thanks to the availability of effective therapies and new pharmacological treatments. These findings are encouraging and support the continued development of such therapies.
SourceJAMA Network·JournalJAMA Network Open·DateDec 6, 2022
NUS researchers have developed a low-cost, non-invasive cancer testing method that sequences clinical samples heated to isolate cancer-specific signatures in patient blood. The Heatrich-BS assay has high sensitivity comparable to gold standard CT scans and costs around US$35 from start to finish.
SourceNational University of Singapore·JournalScience Advances·DateDec 5, 2022
GoPro HERO13 Black
GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
A study using spatial single-cell transcriptomics reveals the spatial organization of cancer cells in patient tissues across ages and locations. The research highlights age- and location-dependent differences in tumor biology, suggesting that kids and adults with diffuse midline gliomas may need different treatments.
SourceBoston Children's Hospital·JournalNature Genetics·DateDec 5, 2022
A new review paper discusses the role of CDK4 in regulating the cell cycle and its involvement in cancer. The study highlights the importance of CDK4/6 inhibitors as treatments for ER+ breast cancer and their potential utility in multiple tumor types.
SourceImpact Journals LLC·JournalGenes & Cancer·TypeLiterature review·DateDec 2, 2022
A Texas A&M team will leverage single-cell sequencing technology to improve cancer diagnosis, treatment, and prevention. The project aims to develop novel statistical methods for analyzing single-cell RNA-sequencing data to reveal medically important information about cancer.
A study found that concerns about colonoscopy, lack of opportunity to discuss next steps with a medical provider, and assumptions about personal risk are common reasons patients don't follow up after a positive at-home test. Researchers also developed two simple risk measurement tools to predict COVID-19 mortality rates, which could he...
SourceAmerican Academy of Family Physicians·JournalThe Annals of Family Medicine·DateNov 30, 2022
Researchers at VCU Massey Cancer Center discovered the inactivation of NF1 as a potential genetic driver for pancreatic cancer. The study suggests that targeting NF1 could create vulnerabilities for therapeutic advantage in mutant KRAS-bearing tumors.
SourceVirginia Commonwealth University·JournalCell Reports·DateNov 30, 2022
Aranet4 Home CO2 Monitor
Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.
A study published in Trends in Cancer suggests that targeting vulnerabilities in glioblastoma cancer cells, which maintain resemblance to the cells of origin, may lead to effective therapies. The research aims to identify ways to block these identity shifts and develop personalized treatments.
SourceFlinders University·JournalTrends in Cancer·TypeObservational study·DateNov 29, 2022
A new study found that less frequent CT scans may reduce health-care costs and patient anxiety without compromising patient outcomes. The researchers analyzed medical records of over 6,000 patients with stage 1 non-small cell lung cancer who underwent surgery between 2006 and 2016.
SourceWashington University in St. Louis·TypeData/statistical analysis·DateNov 28, 2022
Researchers at University of Chicago Medical Center have identified biomarker predicting response to combined RT and ICB treatment in mNSCLC. High tumor aneuploidy associated with improved survival when RT is added to ICB, while low aneuploidy shows no survival benefit.
SourceUniversity of Chicago Medical Center·JournalNature Cancer·DateNov 28, 2022
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
A trial found that extending anti-clotting treatment after a blood clot in the lower leg reduced further clot risk up to two years. Rivaroxaban administered for three months effectively and safely reduced venous thromboembolism compared to six weeks of treatment.
SourceBMJ Group·JournalThe BMJ·TypeRandomized controlled/clinical trial·DateNov 23, 2022
A new study published in JAMA Surgery compares robotic liver resection with open liver resection for treating hepatocellular carcinoma. Robotic liver resection is found to be a safe treatment option for patients with compromised liver function, achieving comparable oncologic efficacy to traditional open surgery.
A study published in Oncotarget found that APOE genotype is associated with the presence and severity of cancer treatment-related side effects and symptoms, as well as the response to exercise-based interventions in cancer survivors. ApoE4 carriers showed a lower fall rate after exercise intervention compared to non-carriers.
SourceImpact Journals LLC·JournalOncotarget·TypeObservational study·DateNov 22, 2022
UVA researchers developed a new tool to analyze genetic data, reducing noise and bias in cancer diagnosis. The tool uses mathematical modeling to identify patterns in chromatin, helping scientists detect tiny numbers of disease cells.
A recent study found that MRI-guided adaptive radiation therapy, also known as SMART, has shown promising safety and patient outcomes data for treating locally advanced and borderline resectable pancreatic cancer. The study, led by Henry Ford Health, reported no incidence of acute grade 3 or higher gastrointestinal toxicity, with preli...
Sky-Watcher EQ6-R Pro Equatorial Mount
Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
A new study analyzed tumor biopsies from patients with newly-diagnosed germinal center B cell lymphoma and found that CREBBP mutations were associated with lower disease-free survival rates. The researchers identified CLMA as a practical tool to translate experimental findings into clinical applications.
SourceImpact Journals LLC·JournalOncotarget·TypeExperimental study·DateNov 17, 2022
The Andrew Sabin Family Foundation has donated $10 million to the James P. Allison Institute, a research and innovation hub aiming to unlock cancer cures. The gift will support elite scientists and post-doctoral programs to accelerate breakthroughs in immunobiology.
SourceUniversity of Texas M. D. Anderson Cancer Center·DateNov 16, 2022
Researchers at Clinica Universidad de Navarra found that ultrasound-guided surgery (IOUS) is more effective and quicker than traditional wire-localisation methods for treating ductal carcinoma in situ (DCIS). This technique reduces the risk of positive margins, a common cause of second operations.
SourceEuropean Organisation for Research and Treatment of Cancer·TypeExperimental study·DateNov 16, 2022
Nikon Monarch 5 8x42 Binoculars
Nikon Monarch 5 8x42 Binoculars deliver bright, sharp views for wildlife surveys, eclipse chases, and quick star-field scans at dark sites.
Researchers have discovered that targeting a specific mutation in fibrolamellar tumors can reduce tumor growth in mice, offering a promising approach to treating this nearly incurable cancer. The findings highlight the potential for novel therapies against an intractable disease.
SourceRockefeller University·JournalClinical Cancer Research·DateNov 10, 2022
Researchers found that MK256 induced differentiation and maturation in leukemia stem cells, inhibiting proliferation of AML cell lines. The study also showed dose-dependent inhibition of the STAT pathway in both in vitro and in vivo studies.
SourceImpact Journals LLC·JournalOncotarget·TypeExperimental study·DateNov 10, 2022
A retrospective study found that tumor hyaluronan levels are associated with improved time to progression in non-small cell lung cancer patients. HA-high tumors showed a trend towards improved clinical benefit, suggesting its potential as a prognostic biomarker and therapeutic target.
SourceImpact Journals LLC·JournalOncotarget·TypeObservational study·DateNov 9, 2022
AmScope B120C-5M Compound Microscope
AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.
Researchers at UVA Cancer Center have identified interleukin-1 as a crucial contributor to the development of myelofibrosis, a potentially deadly bone marrow cancer. Targeting this cytokine could prevent myelofibrosis from progressing and spare bone marrow scarring.
SourceUniversity of Virginia Health System·JournalNature Communications·DateNov 9, 2022
Researchers have discovered two novel drugs that can block the growth and shrink the size of schwannoma tumors, a type of nerve sheath tumor found in the nervous system. The treatment works by inhibiting the Hippo signaling pathway, which is dysregulated in multiple types of cancer.
SourceUniversity of Plymouth·JournalBrain·TypeExperimental study·DateNov 8, 2022
A study has identified a subset of early-stage melanoma patients with almost no risk of death, potentially contributing to overdiagnosis. The researchers used cancer registry data and developed models to identify patients with a very low risk of mortality.
A recent study published in Oncotarget reveals that Nectin-4 is widely expressed in head and neck squamous cell carcinoma (HNSCC), with significant correlations to clinico-pathological parameters. Non-smokers and p16-positive HNSCC showed higher expression of Nectin-4, leading to better survival rates for positive tumors.
SourceImpact Journals LLC·JournalOncotarget·TypeExperimental study·DateNov 3, 2022
DJI Air 3 (RC-N2)
DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
Researchers found that rapamycin treatment during developmental growth phase decelerates aging rate and extends lifespan in animals. A transient late-life treatment is not effective, but a transient early-life treatment can reprogram aging.
SourceImpact Journals LLC·JournalAging-US·TypeCommentary/editorial·DateNov 3, 2022
A study published in the Journal of the National Comprehensive Cancer Network found that breast cancer survivorship has doubled among Canadian women, with 2.1% of adult females diagnosed with breast cancer and 86% surviving by 2022. The prevalence varies by age group, with senior women having a higher rate of survival.
SourceUniversity of Toronto·JournalJournal of the National Comprehensive Cancer Network·TypeData/statistical analysis·DateNov 3, 2022
A study analyzing 16,083 colorectal biopsies found that 2.65% of rectal adenocarcinoma patients have mismatch repair deficiency, challenging earlier estimates. The analysis also highlighted the importance of screening at all ages for this condition.
SourceBrigham and Women's Hospital·JournalNew England Journal of Medicine·TypeObservational study·DateNov 2, 2022
A new technique improves tumour targeting efficiency by fixing partial cell membrane coating on nanoparticles. The method increases immune escape and specific cancer targeting capability, enhancing therapeutic outcomes and reducing adverse effects.
SourceUniversity of Eastern Finland·JournalNature Communications·DateOct 31, 2022