Articles tagged with Cancer Treatments
A recent study found that MRI-guided adaptive radiation therapy, also known as SMART, has shown promising safety and patient outcomes data for treating locally advanced and borderline resectable pancreatic cancer. The study, led by Henry Ford Health, reported no incidence of acute grade 3 or higher gastrointestinal toxicity, with preli...
A new study analyzed tumor biopsies from patients with newly-diagnosed germinal center B cell lymphoma and found that CREBBP mutations were associated with lower disease-free survival rates. The researchers identified CLMA as a practical tool to translate experimental findings into clinical applications.
The Andrew Sabin Family Foundation has donated $10 million to the James P. Allison Institute, a research and innovation hub aiming to unlock cancer cures. The gift will support elite scientists and post-doctoral programs to accelerate breakthroughs in immunobiology.
Researchers at Clinica Universidad de Navarra found that ultrasound-guided surgery (IOUS) is more effective and quicker than traditional wire-localisation methods for treating ductal carcinoma in situ (DCIS). This technique reduces the risk of positive margins, a common cause of second operations.
Researchers have discovered that targeting a specific mutation in fibrolamellar tumors can reduce tumor growth in mice, offering a promising approach to treating this nearly incurable cancer. The findings highlight the potential for novel therapies against an intractable disease.
Researchers found that MK256 induced differentiation and maturation in leukemia stem cells, inhibiting proliferation of AML cell lines. The study also showed dose-dependent inhibition of the STAT pathway in both in vitro and in vivo studies.
A retrospective study found that tumor hyaluronan levels are associated with improved time to progression in non-small cell lung cancer patients. HA-high tumors showed a trend towards improved clinical benefit, suggesting its potential as a prognostic biomarker and therapeutic target.
Researchers at UVA Cancer Center have identified interleukin-1 as a crucial contributor to the development of myelofibrosis, a potentially deadly bone marrow cancer. Targeting this cytokine could prevent myelofibrosis from progressing and spare bone marrow scarring.
Researchers have discovered two novel drugs that can block the growth and shrink the size of schwannoma tumors, a type of nerve sheath tumor found in the nervous system. The treatment works by inhibiting the Hippo signaling pathway, which is dysregulated in multiple types of cancer.
A study has identified a subset of early-stage melanoma patients with almost no risk of death, potentially contributing to overdiagnosis. The researchers used cancer registry data and developed models to identify patients with a very low risk of mortality.
A recent study published in Oncotarget reveals that Nectin-4 is widely expressed in head and neck squamous cell carcinoma (HNSCC), with significant correlations to clinico-pathological parameters. Non-smokers and p16-positive HNSCC showed higher expression of Nectin-4, leading to better survival rates for positive tumors.
Researchers found that rapamycin treatment during developmental growth phase decelerates aging rate and extends lifespan in animals. A transient late-life treatment is not effective, but a transient early-life treatment can reprogram aging.
A study published in the Journal of the National Comprehensive Cancer Network found that breast cancer survivorship has doubled among Canadian women, with 2.1% of adult females diagnosed with breast cancer and 86% surviving by 2022. The prevalence varies by age group, with senior women having a higher rate of survival.
A study analyzing 16,083 colorectal biopsies found that 2.65% of rectal adenocarcinoma patients have mismatch repair deficiency, challenging earlier estimates. The analysis also highlighted the importance of screening at all ages for this condition.
A new technique improves tumour targeting efficiency by fixing partial cell membrane coating on nanoparticles. The method increases immune escape and specific cancer targeting capability, enhancing therapeutic outcomes and reducing adverse effects.
Filopodia contribute to building a barrier surrounding breast tumours, blocking their escape. Cancer cells lacking Myosin-10 cannot maintain this barrier, making it easier for them to spread.
A new study suggests that chlorhexidine gluconate (CHG) is the most effective irrigation solution for killing bone tumor cells after surgery. CHG shows highest cytotoxicity against chondrosarcoma and giant cell tumors, potentially making it a useful chemical adjuvant during intralesional curettage.
The TRIDENT-1 trial suggests that repotrectinib could be effective for treating ROS1 positive non-small cell lung cancer (NSCLC) in patients who have received other targeted treatments and those who have not. The drug showed promising results, with an objective response rate of 79% in patients not previously treated with a ROS TKI.
Researchers at Kyoto University have developed a prodrug form of curcumin called TBP1901, which has shown anti-tumor effects without causing harm. The study found that TBP1901's conversion to active curcumin is dependent on the enzyme GUSB, suggesting its potential therapeutic targets.
Researchers have successfully treated six children with relapsed and treatment-resistant B-ALL using CRISPR-edited T cells, achieving deep remission in four patients. The treatment has shown promise as a viable alternative to currently available treatments.
A study published in European Journal of Nuclear Medicine and Molecular Imaging identified specific genetic markers associated with high risk of head and neck cancer. The research used DNA sequencing, artificial intelligence, and positron emission tomography to analyze cellular characteristics of tumors. These markers can facilitate mo...
A meta-analysis of 410 articles from 68 countries found that patients in lower-income countries take up to four times longer to initiate care for cancer treatment. Cancers causing non-specific symptoms, such as myeloma and colorectal cancer, typically take the longest to diagnose.
A new study has discovered that MTCH2, a protein essential in various cellular processes, acts as a 'door' for proteins to access the mitochondrial membrane. The finding opens up potential avenues for cancer treatments by harnessing apoptosis, a programmed cell death mechanism.
A study found that patients receiving CAR T-cell therapy were more likely to develop neurological side effects, including ICANS, when they had hypophosphatemia. The researchers suggest that serum phosphate measurements could be used to predict the onset of ICANS in these patients.
USC Norris Comprehensive Cancer Center is partnering with the Chinatown Service Center to address disparities in cervical cancer screening and treatment. The partnership aims to optimize access, shorten diagnosis-to-treatment timeframes, and enhance quality of care for Chinese and Latina women in Los Angeles.
Scientists at NTU Singapore have found that a stress response in cells, when 'switched on' at a post-reproductive age, could be the key to slowing down aging. The study showed that this stress response extended the lifespan of roundworms fed a high-glucose diet.
Researchers have identified a key enzyme in muscle that contributes to cancer-induced muscle wasting. Targeting this enzyme, UBR2, may help preserve muscle mass and function in cancer patients. The study's findings offer new hope for the treatment of cancer cachexia, a complication affecting 60% of all cancer patients.
Researchers propose an optical imaging system for real-time hypoxia imaging in cancer treatment. The technique utilizes protoporphyrin IX to enhance contrast between tumors and healthy tissues, allowing for more effective surgical removal.
Researchers discovered that animal models with germline alteration rs55705857 developed gliomas significantly faster than those without the alteration. The study offers new insights into tumor formation and may lead to novel therapies targeting this specific change.
A new study reveals that different SCLC subtypes have specific molecular characteristics, leading to varying responses to cancer treatment. The research provides a basis for developing targeted and personalized treatment approaches tailored to each subtype.
A new genetic test called PancreaSeq accurately classifies pancreatic cysts as potentially cancerous or benign, improving the accuracy of diagnoses compared to current guidelines. The test distinguishes between different types of cysts with higher accuracy than traditional forms of surveillance and current pancreatic cyst guidelines.
A new study has uncovered a previously unknown genetic process that could inform the development of novel treatment options for glioblastoma (GBM), a virtually incurable brain tumor. The epidermal growth factor receptor (EGFR) signaling pathway and long non-coding RNA molecules, such as lncEPAT, play critical roles in GBM tumorigenesis.
Researchers found that certain fungal species in tumors are linked to inflammation and reduced cell-to-cell adhesion, features associated with late-stage cancer spread. High levels of these fungi may serve as biomarkers for metastasis risk and lead to more effective treatment choices.
A team of researchers at Nagoya University has developed a novel tissue-mimicking phantom using konjac, enabling surgeons to practice fluorescence-guided cancer surgery. The model's use of indocyanine green and konjac jelly makes it suitable for training with electrocautery, promoting safer and more reliable surgical techniques.
Researchers identified a specific gut bacterium responsible for antibiotic-induced GVHD after stem cell transplants. A sugar supplement was found to improve gut health by distracting the bacteria from attacking mucin in the intestinal lining, reducing complications such as GVHD.
A new CAR NK cell engineering approach requires two signals to eliminate target cells, improving tumor specificity and enhancing anti-tumor activity. This strategy mitigates NK cell exhaustion and fratricide, leading to better focus on and attack of only the tumor cells.
Researchers compare Monte Carlo simulations and Loevinger formula for beta radiation dosimetry in cancer treatment, finding the latter to be a quick yet accurate method. The study suggests using the Loevinger formula as a basis for dosimetry software in simple geometries.
A novel PET radiotracer has been developed to assess tumor aggressiveness in neuroendocrine neoplasms, providing valuable information for personalized care. High uPAR expression was associated with a worse prognosis, making it a potential target for therapy.
Researchers developed a computational platform to identify metabolic vulnerabilities in ovarian cancer genes, suggesting opportunities for targeted therapies. The study found that certain genetic alterations can create vulnerabilities in cancer cell metabolism, which can be exploited to selectively kill cancer cells.
Researchers uncovered crucial interactions between XPA and RPA proteins in NER, essential for repairing UV-damaged DNA. These findings hold promise for improving cancer therapy outcomes by targeting the NER pathway.
The TTUHSC team will provide no-cost colorectal cancer screening and colonoscopies to underinsured and uninsured people living in South Plains region counties. The FIT-STOP program aims to find signs of early-stage colorectal cancer to prevent treatment needs, leveraging existing relationships with partners.
A cohort study found that endoscopists performing colonoscopies in FIT-based screening programs should aim for markedly higher ADRs compared to primary colonoscopy screening. The study suggests that high ADRs are associated with lower colorectal cancer incidence and mortality. Researchers recommend using ADR targets, including differen...
Scientists successfully inhibited cancer cell growth using a modified pyrrolizidine alkaloid that avoids liver damage. The approach uses 'on-site synthesis' near cancer cells to limit toxicity.
Researchers at Mayo Clinic Comprehensive Cancer Center have identified a gene marker that may lead to more effective precision treatment for pancreatic ductal adenocarcinoma. The protein METTL16 is correlated with accumulated DNA damage and suppresses DNA repair, suggesting it as a potential biomarker for PARPi treatment.
Research from UVA Cancer Center finds that an unhealthy gut microbiome can trigger changes in normal breast tissue, facilitating cancer's spread to other parts of the body. The study suggests that targeting the gut-mast cell relationship could help prevent breast cancer recurrence and metastasis.
Scientists at St. Jude Children's Research Hospital have created a tool to identify 'safe harbor' sites for gene therapies, balancing safety and therapeutic expression. The tool uses genomic and epigenetic information to find regions with high variability among healthy individuals, reducing the risk of cancer or other problems.
A recent study led by Drexel University's College of Nursing and Health Professions highlights the importance of nutrition and physical activity for both cancer patients and their caregivers. The research found similarities in beliefs about physical activity and barriers faced by both groups, including fatigue and time constraints.
African American men are twice as likely to have more aggressive disease compared to non-African American men. Genomic biomarker tests like the Decipher score can identify patients with higher-risk disease, enabling tailored treatment approaches.
Researchers at UMC Utrecht will investigate how intestinal microbiota impacts cancer immunotherapy and therapy side effects. The project aims to develop microbiota-targeted therapies to improve ICI treatment effectiveness and reduce severe inflammation.
A team from The Institute of Industrial Science at The University of Tokyo has developed a new platform that uses organorhodium(III) phthalocyanine complexes to achieve the combination of traits necessary for photodynamic therapy. The new system shows toxicity to HeLa cells, indicating its potential as a cancer treatment.
Researchers at Mayo Clinic Comprehensive Cancer Center found that metabolic imaging, combined with traditional treatment response assessment methods, can provide critical information to guide therapy for pancreatic cancer patients. The use of positron emission tomography (PET) with 18-fluorodeoxyglucose (FDG) tracer adds significant pr...
A study led by researchers at the University of Arizona Health Sciences has uncovered a possible path for improving T cell therapies. The study found that the CD4 molecule plays a more active role in regulating T cell receptor signaling, allowing for even more powerful versions of T cell therapy.
Researchers found that combining BCL-2 inhibitors can selectively eliminate senescent cells, improving efficacy and reducing toxicity by targeting high-MCL-1 expressing subpopulation of cells. This synergistic approach enables lower doses of drugs to be used, overcoming resistance to monotherapy.
SAFER Ukraine successfully evacuated over 900 patients and families to reestablish medical care abroad. The effort demonstrates the importance of collaborative networks in global health and provides a model for future international emergency responses.
Researchers developed a light-based therapy, photodynamic therapy (aPDT), to combat antibiotic-resistant bacteria. The treatment showed promise in weakening bacteria, allowing lower doses of current antibiotics to effectively eliminate them.
A KAUST-led research team identified two drug treatments that boost the activity of molecules involved in cell adhesion, enhancing the ability of blood-forming stem cells to enter the bloodstream and produce new blood. This breakthrough could lead to improved bone marrow transplant success for leukemia patients.
Researchers have identified a potential new therapeutic approach for angioimmunoblastic T-cell lymphoma (AITL) by understanding the mechanism of its development. A team from the University of Tsukuba found that B cells accumulate mutations in genes controlling genetic material packaging, leading to AITL.
Researchers identified high-risk patients with stage 3A disease and microscopic lymph node metastases who would benefit from adjuvant therapy. Patients with larger metastases had poorer outcomes, while those with smaller metastases had better survival rates similar to stage 1A disease.
Researchers at Karolinska Institutet have developed a potential curative treatment for neuroblastoma, using DHODH blockers in combination with chemotherapy to cure mice with the disease. The treatment has shown promising results and could improve survival rates for children with neuroblastoma.
Researchers captured first image of antigen-bound T-cell receptor complex with bound antigen at atomic resolution. The study reveals no significant structural changes in the receptor after antigen binding, sparking further investigation into the signaling pathway activation mechanism.