Articles tagged with Cancer Treatments
A retrospective cohort study of 27 patients with sarcoma lung metastases found high primary technical success rates for percutaneous image-guided microwave and cryoablation. The treatment modality and tumor location did not affect local progression, and smaller tumors showed lower cumulative incidence of local progression.
Researchers developed a gel made of fibrin that improved the effectiveness of CAR-T cell immunotherapy for glioblastoma by enhancing T cell distribution and preventing tumor recurrence. In mouse studies, the gel showed promising results, with 64% of treated mice being tumor-free after 94 days.
Researchers have discovered the molecular mechanisms behind stem cell rolling in blood vessels, a complex process that slows down cells using long tethers. The findings offer new insights into improving stem cell transplantations and developing treatments for metastasizing cancers.
MUSC researcher Haizhen Wang receives R37 grant to investigate CDK6's role in T-cell acute lymphoblastic leukemia, a aggressive cancer. The research aims to understand how the immune system can be used to reduce leukemia progression.
Researchers found that high CD39 expression is associated with human bladder cancer, particularly in the non-muscle-invasive phenotype. CD39's involvement in tumor development and progression is still unclear, but its overexpression in early-stage tumors suggests a potential role in bladder cancer progression.
Researchers developed a fluorescence quenching assay to probe the integrity of cell membrane coating on biomimetic nanoparticles. The study found that only 20% of particles were fully coated, indicating significant limitations in current coating protocols.
The MAP Virtual Congress 2021 focuses on integrating tumour sample analysis into daily practice, enabling personalized treatment. Key findings include actionable mutations in patient DNA and the role of the tumour microenvironment in metastasis.
A new study found that a healthy gut microbiome is essential for skeletal muscles to grow after exercise. Researchers used mice with antibiotics to disrupt the microbiome, showing reduced muscle growth compared to healthy mice. The findings support previous studies linking the gut microbiome to muscle health.
New targeted therapies are being developed to target genetic alterations in cancer cells, such as the ARID1A mutation found in 10-50% of solid tumours. Early clinical trials suggest that these agents may be effective in treating multiple cancers, including breast, ovarian, and gastric cancer.
Researchers identified two subtypes of metastatic prostate cancer that respond differently to hormone treatment. Luminal tumors responded better to testosterone-blocking treatments, while basal tumors did not benefit as much from this hormone treatment.
The VCU Massey Cancer Center has established a Translational Research Center in Lung Cancer Disparities (TRACER) to address racial disparities in lung cancer. TRACER will investigate the interaction between stress, smoking, and gene expression to raise lung cancer risk in Black men.
The report reveals a high risk of preventable cancers among Hispanic/Latino population, with 2-fold higher rates of liver and stomach cancers. Access to quality prevention, early detection, and treatment services is crucial for reducing the cancer burden in this population.
Researchers at Johns Hopkins Medicine have identified promising new targets for pancreatic cancer treatment and early detection, including glycosylated proteins that could be captured in the blood for diagnosis. The study also suggests new ways to improve immune response to these tumors.
Researchers at St. Jude Children's Research Hospital found that the tumor suppressor gene PTEN controls rhabdomyosarcoma cell identity and that enhancing PAX7 expression can maintain tumor cell existence, providing a potential treatment target for rhabdomyosarcoma.
Researchers at the University of Basel have discovered a novel combination therapy approach that combines inhibiting JAK2 with targeting the MAPK signaling pathway. This dual targeting strategy has shown promising results in improving leukemia treatment outcomes by reducing blood cell production and altering disease course.
Researchers develop a novel cell reprogramming strategy to transform glioma cells into non-proliferative neurons. This approach shows promise in slowing down the growth of GBMs and overcoming harmful side effects of conventional treatments.
Researchers at Max-Planck-Gesellschaft engineered synthetic exosomes that regulate cellular signaling during wound closure, leading to faster healing and improved formation of new blood vessels. The study provides a systematic understanding of extracellular vesicle communication and its potential therapeutic application.
Researchers identified DNA mutations from platinum-based chemotherapies in AML patients, suggesting treatment-associated cancer development. The study's findings imply that clonal hematopoiesis precedes chemotherapy exposure.
Recent study by Okayama University researchers reveals three photoinitiators cause faster increase in breast tumor growth in mice, with tamoxifen pretreatment reducing toxicity. The findings suggest photoinitiators could act as hormonal disruptions, raising concerns for patients and healthy individuals.
Researchers at USC Viterbi School of Engineering have discovered a way to boost the effectiveness of CAR T-cell therapy for treating solid tumors, including breast and melanoma. By engineering CAR T-cells to produce an enzyme called adenosine deaminase, they break down an immune-suppressive microenvironment, allowing cancer-killing cel...
Researchers identified a minimal set of defined factors that can convert normal human fibroblast cells to liver cancer cells, providing a mechanistic proof-of-principle for understanding why certain mutations cause cancer in particular tissues.
Researchers have found that hormone profiles before and after treatment play a significant role in the success of therapy for breast cancer. This finding could lead to improved treatment options and better outcomes for patients.
A new combination treatment has shown significant tumor shrinkage and prolonged survival in patients with metastatic uveal melanoma. The treatment, which targets HDAC and PD-1 proteins, was found to work better in tumors with active BAP1 genes, a key discovery that may lead to improved survival rates.
Researchers developed a new cancer therapy combining sulforaphane (SFN) and acetazolamide (AZ), which inhibits the PI3K/Akt/mTOR survival pathway and reduces 5-HT secretion in carcinoid syndrome. The combination therapy induces apoptosis in tumor cells, upregulates the p21 cell cycle inhibitor, and downregulates the PI3K/Akt/mTOR pathway.
Researchers have uncovered a weakness in the key enzyme that solid tumour cancer cells rely on to adapt and survive when oxygen levels are low. Inhibiting this enzyme, called Carbonic Anhydrase IX (CAIX), can effectively stop cancer cell growth.
Researchers compared the accuracy of two types of fecal tests for detecting colorectal cancer, finding that both types are reliable when thresholds are adjusted. The study suggests that health providers should select the best type of test based on specific demands in screening settings.
A population-based cohort study in Canada identified mortality patterns for different types of neuroendocrine tumors (NETs), revealing varying risks of cancer-related and non-cancer death. The study found that small NETs can be safely monitored, while larger tumors may require more aggressive treatment.
Researchers from Okayama University conducted a randomized trial to assess the benefits of interventions for early cancer screening in patients with schizophrenia. The study found that 47.1% of counseled patients underwent colorectal cancer screening, compared to 11.8% of those receiving only usual treatment.
Monash University researchers have established a vast collection of living prostate cancer tumors from patients, enabling the testing of new treatments and advancing patient care. The PDX collection comprises 59 tumors collected from 30 patients between 2012-2020, providing a unique resource for scientists and pharmaceutical companies.
Researchers uncover a neuro-immune process by which brain signals instruct immune function in visceral fat stores, providing new approaches for fighting obesity and related illness. The study identifies a critical mediator of neuro-immune communication, mesenchymal cells, and reveals the molecular messages exchanged across all steps.
A research team from Okayama University has reported the potential of a berry-producing vine, Vitis coignetiae Pulliat (Yamabudo), against lung cancer in mice. The study found that extracts from Yamabudo and its chemical compounds display tumor-suppressing properties by repairing DNA damage and suppressing growth signaling pathways.
Recent studies demonstrate the applications of LC-MS in characterizing Traditional Chinese Medicine formulations, real-time drug measurement, and bioactive compounds from Osmanthus fragrans. These techniques offer high sensitivity, robustness, and ease of use for quality assessment and characterization.
Black, Hispanic, Indigenous and Asian Americans remain underrepresented in pancreatic cancer clinical trials, despite federal mandates. The lack of diversity hurts patients and science alike, with racial and ethnic minorities accounting for a disproportionate burden of pancreatic cancer cases.
A single-center retrospective study found that AI-CAD reduced recall rates and improved accuracy compared to digital mammography (DM) and DBT. The study showed lower recall rates and higher accuracy for DM with AI-CAD, indicating a practical addition to lowering false-positive findings.
Researchers developed a 'frameshifting' therapy that alters mRNA to reduce mast cell tumor size and prevent organ infiltration. The treatment, targeting the c-KIT gene, shows promise in reducing KIT protein expression, signaling, and function.
A phase II clinical trial of remetinostat gel found a 69.7% response rate to the topical treatment, with complete responses observed across multiple BCC subtypes, and a durable response in nodular BCCs.
A new study analyzes 377 severe harm and death incidents in acute medical units across England and Wales between 2005-2015. The most common incident types were diagnostic errors, medication-related errors, and failures in monitoring patients. Implementing electronic prescribing systems and checklists can reduce diagnostic errors, while...
A big data study from UNSW Sydney found that Australian cancer patients kept up their pharmaceutical treatments during last year's COVID-19 lockdowns. The researchers attribute the good news to relatively low rates of COVID-19 infections in Australia, which minimally impacted cancer treatment patterns.
A new droplet digital PCR-based assay for HPV16 circulating tumor DNA was developed to predict treatment response in metastatic head and neck squamous cell carcinoma. Longitudinal changes of HPV16 ctDNA correlate with treatment response, allowing for early identification of treatment failure.
Moffitt researchers identify PARP16 as a novel functionally relevant target for talazoparib, which enhances anti-cancer effects in small cell lung cancer and Ewing sarcoma. Combination treatment with talazoparib and adavosertib results in enhanced anti-cancer activity.
The ASMBS Foundation has awarded two research grants totaling $50,000 to investigate the impact of COVID-19 on adolescents with obesity and the effects of cannabis use after bariatric surgery. The studies will help improve the understanding of these conditions and develop effective therapies.
A team from UNIGE and HUG used information theory to study the molecular regulations behind cancer cell adaptation to targeted therapies. They found that a large reversible component of resistance exists, which can be modulated by therapeutic combinations.
Scientists from UCLA Jonsson Comprehensive Cancer Center identified TAF12 as critical to the formation of preinitiation complexes, which are necessary for gene transcription. Eliminating TAF12 destroys preinitiation complexes and drastically reduces genome-wide transcription.
Luay Nakhleh's team will use single-cell DNA data from the University of Texas MD Anderson Cancer Center to identify mutations at the root of the disease and how they evolve in tumors. By building open-source models and tools, they aim to refine cancer treatments and predict patient outcomes.
A new robotic neck brace designed by Columbia Engineering can precisely detect changes in patient neck movements during routine clinical visits. The device can help identify patients who may have issues with neck movement, enabling targeted physical therapy interventions to improve recovery outcomes.
Severe PES is characterized by high fever, rash, diarrhea, and increased transplant-related mortality. A study revealed that monocytes derived from cord blood produce proinflammatory cytokines, leading to PES. Tocilizumab treatment significantly controlled clinical symptoms and reduced mortality in patients with severe PES
Researchers identified that macrophages from different types of monocytes respond to inflammation in opposing ways, with CD14+monocytes being more prone to a pro-inflammatory response. This could lead to targeted activation of macrophages for cancer treatment by choosing the most suitable monocyte subset.
A new study by CNIO researchers has found that blocking the RagC protein's signals can delay the onset of follicular lymphoma in animal models. The strategy may also be effective in treating autoimmune diseases.
A new study found that a stunning virtual reality setting can reduce pain caused by uncomfortable medical procedures, such as cystoscopies. The research used VR headsets to present patients with a calming Icelandic landscape, resulting in lower pain scores and reduced anxiety.
Scientists have found that short-chain fatty acids can increase the efficiency of tumor therapies by boosting the activity of killer cells. The researchers identified pentanoate, produced by Megasphaera massiliensis bacteria, as a key player in this process.
Research found nearly two-thirds of patients with non-muscle-invasive bladder cancer had multiple co-existing chronic conditions, leading to a mean treatment burden of 8.9 days. Rural patients consistently had higher treatment burden than urban counterparts.
Researchers analyzed molecular analysis data from a pediatric melanoma registry, identifying diverse subgroups and their characteristics. The study found that spitzoid melanomas often have gene fusions and benign clinical courses, while conventional melanoma patients with advanced disease had poorer outcomes.
Research at Kumamoto University found that LSD1 produces unique metabolic profiles depending on the type of acute myeloid leukemia cells. LSD1 inhibitors may be effective in treating erythroleukemia (EL) with high LSD1 expression levels, and could lead to personalized therapies for various leukemia types.
Researchers discovered that laminins, specifically laminin γ1, play a crucial role in mediating cell attachment and penetration for oncolytic viruses like H-1PV. This finding may lead to the development of more efficient clinical trials with reduced costs and approval times.
The partnership aims to reduce the risk of relapse in Stage 2 melanoma patients using BRAF and MEK targeted therapies. EORTC and Pierre Fabre will conduct a large Phase 3 study to advance research in melanoma.
A new study found that a double stimulation approach, known as DuoStim, is as efficient as conventional two cycles of ovarian stimulation and reduces the time to pregnancy in predicted poor responders. This strategy recruits multiple follicles on any day of the cycle, benefiting patients with low egg collection and high treatment failu...
A team of researchers has identified a protein complex that promotes breast cancer growth, which can be disrupted to hinder tumor development. Non-toxic peptides were developed to prevent the abnormal interaction between RBM39 and MLL1 proteins in breast cancer cells.
Researchers have developed a novel synthesis method using peptides to create green gold nanoparticles, which can target and destroy cancer cells using near-infrared light. The findings provide an easy and eco-friendly protocol for Au nanoparticle synthesis, opening doors to non-toxic nanoparticle therapeutic agents.
The study investigated the association of the IGF/CTP score with overall survival and progression-free survival in CTP class A patients with advanced HCC treated with sorafenib. In these patients, IGF/CTP score B was associated with shorter PFS and OS, indicating a more accurate predictive tool for treatment outcomes.
A study by the American Cancer Society found a 10.2% decline in real-time electronic pathology reports from population-based cancer registries in 2020 compared to 2019. The study suggests substantial delays in diagnosis and treatment services for cancers during the pandemic.