Articles tagged with Cancer Treatments
Researchers at Osaka University discovered that liver cancer cells induce autophagy in nearby stromal cells, leading to the secretion of GDF15, which enhances tumor growth. High levels of GDF15 are associated with a poorer prognosis in HCC patients.
Researchers at H. Lee Moffitt Cancer Center have identified SATB1 as a potential new drug target for treating cutaneous T cell lymphoma. Decreased expression of this protein contributes to the development of CTCL, and drugs that restore its expression may be effective against the disease.
Researchers have developed reconstituted in-vitro human organs called assembloids, which precisely mimic the structure and function of human tissues. The new technology surpasses current organoid technology by modeling complex diseases like cancer and neurological disorders.
This study investigated SARS-CoV-2 infection among patients with cancer receiving antitumor treatment in Italy. The results show a notable rate of SARS-CoV-2 infection, highlighting the vulnerability of cancer patients to COVID-19.
Researchers discovered that cancer cells resistant to adult leukemia treatment are already present in tumors before diagnosis, according to a new study published by IRB Barcelona. The study analyzed genome sequencing data from 19 adult patients and found that these resistant cells were undetectable at the time of diagnosis.
Researchers developed inhibitors targeting mitochondrial DNA, affecting only rapidly dividing cells like cancer cells. Treatment stopped cell proliferation and reduced tumour growth without harming healthy cells.
The Patient Researcher Forum allows patients and researchers to learn from each other, fostering interdisciplinary collaboration. The program has a positive impact on perspectives of both parties, with patients gaining insight into the importance of cancer research and researchers becoming more patient-centered in their work.
Post-neoadjuvant therapy changes in metabolic metrics from PET/MRI and morphologic metrics from CT were associated with pathologic response and overall survival in patients with pancreatic ductal adenocarcinoma. Serum CA 19-9 levels did not predict pathologic response or survival.
Researchers discovered that melatonin may regulate gene expression and intensify tumor suppressor genes, leading to increased tumor cell death and reduced proliferation. The study identified target genes for melatonin, which could guide personalized therapies for breast cancer patients.
Researchers at Children's Hospital Colorado have characterized the development of Natural Killer cells and innate lymphoid cells, crucial components in human health and disease. The findings pave the way for tailored therapies for children and adults undergoing cancer treatments.
A study by researchers at Dartmouth's Geisel School of Medicine found that active surveillance can be successfully implemented in patients with low-risk thyroid cancer. The study shows that 91% of patients adhered to the prescribed ultrasonography schedule and retention rates were high, with only 4.5% choosing surgery after two years.
Research reveals Aspergillus fumigatus activates inflammasome through galactosaminogalactan, increasing inflammation. The fungal pathogen's GAG is essential for NLRP3 inflammasome activation.
The Oncotarget journal has launched a special collection on breast cancer, featuring newly published scientific papers on prognostic markers, risk factors, therapies, and gene studies. This free-to-read resource aims to promote a better understanding of the latest breast cancer research.
Researchers have re-engineered human adenovirus to evade liver and innate immune systems, enabling systemic delivery without triggering life-threatening toxicities. The modified virus can selectively kill tumor cells while sparing healthy tissue, offering a new avenue for metastatic cancer treatment.
A fundamental way cells interpret signals from their environment has been revealed by researchers at Johns Hopkins Bloomberg School of Public Health. The Hippo pathway, which constrains cell division and regulates organ size, can be activated by multiple signaling inputs.
Researchers found that CRYM protein binds to hormone T3 and blocks cell membrane formation, inhibiting tumour growth. Lower CRYM levels are associated with poor prognosis.
A recent study published in Medical Cannabis and Cannabinoids found that CBD oils are equally or less effective than pure CBD at inhibiting the growth of certain cancer cells. The researchers tested different types of CBD oil against pure CBD on various cancer cell lines, including brain, skin, and colorectal cancers.
A new outpatient procedure has been shown to provide significant pain relief for patients with moderate to severe osteoarthritis in their hip and shoulder joints. Treatment involves the placement of needles where sensory nerves exist, followed by a low-grade current that 'stuns' them, slowing pain transmission to the brain.
A new diagnostic tool has been developed to predict which cancer patients are most likely to benefit from immunotherapy treatments. The tool analyzes the interactions between immune cells and tumor cells, as well as the activation state of immune checkpoints.
Researchers found that cold atmospheric plasma can kill the novel coronavirus on surfaces such as plastic, metal, and leather within 30 seconds. The treatment uses argon-fed plasma and has been shown to be effective against other viruses like SARS-CoV-2.
A recent study found that racial/ethnic minorities comprise only a small percentage of patients with AL amyloidosis, despite being theoretically at higher risk. Younger age and more severe illness were observed among minority patients, who were also less likely to undergo aggressive treatment with stem cell transplantation.
Researchers found that higher health literacy is associated with higher rates of PSA screening, despite guidelines recommending against it. The study also identified a dynamic interplay between health literacy and shared decision-making.
Researchers at Ludwig Institute for Cancer Research developed a protocol to overcome difficulties in engineering and expanding mouse T cells for CAR-T cell therapies. The new method showed improved tumor control, proliferation, and persistence of CAR-T cells, as well as enhanced reprogramming of the tumor microenvironment.
A screening program for COVID-19 in asymptomatic cancer patients prior to each cycle of anticancer therapy was implemented at a UAE hospital. The study found the program's effectiveness in detecting COVID-19 cases among these patients.
Researchers found that Medicaid expansion is associated with earlier stage of diagnosis, leading to decreased mortality rates for patients with newly diagnosed breast, lung, or colorectal cancer. In states with expanded Medicaid programs, mortality rates were significantly lower than in non-expansion states.
Researchers found that Trop-2 expression is a predictive biomarker for sacituzumab govitecan efficacy in triple-negative breast cancer. Increasing Trop-2 expression improved SG efficacy in mice with HRR-proficient tumors, suggesting a potential clinical benefit for patients with high Trop-2 levels.
A new study demonstrates that pooling treatment recommendations from multiple prescribers using the 'wisdom of crowds' concept can improve decisions on antibiotic prescribing and reduce overuse. Using international survey data, researchers found that groups of three or more prescribers showed significant benefits in guideline compliance.
A study by Massachusetts General Hospital found that patients with significant decision conflict prior to cancer surgery are less active after surgery. The researchers used a smartphone app and sensor data to measure physical activity levels at 30, 60, and 90 days after surgery.
A study published in STEM CELLS revealed that fibulin 5 plays a crucial role in the development of Schwann cells, which produce the myelin sheath surrounding neuronal axons. The research suggests that fibulin 5 may be used to treat Charcot-Marie-Tooth disease and other demyelinating disorders.
A proof-of-concept study shows cerebrospinal fluid as a liquid biopsy for precise characterization and real-time tracking of medulloblastoma. Circulating tumor DNA analysis provides genomic insights into disease evolution, enabling more effective treatment strategies.
Researchers discovered RING1B is critical for Ewing sarcoma development and hijacks transcriptional program to create cancerous cells. Epigenetic inhibitors may offer new treatment strategies.
Scientists at the Oklahoma Medical Research Foundation have redefined how the gut microbiome operates and coexists with bacteria. The findings show that the microbiome controls the creation of mucus, which acts as a barrier between bacteria and immune cells in the colon.
Researchers developed a novel epigenomic approach to detect pancreatic cancer in its early stages using blood draws, identifying distinctive patterns in thousands of genes that serve as biomarkers. This technology has the potential to lead to more timely treatment and improved patient survival.
Researchers at the University of Alberta have discovered that an anti-inflammatory drug, VX-765, can slow disease progression in a preclinical model of multiple sclerosis when delivered intranasally. This new therapy approach has shown promise in preserving myelin and glucose metabolism.
Baseline ctDNA levels predicted responses to first-line immune checkpoint inhibition in patients with melanoma, but not second-line treatment. Low ctDNA levels associated with longer progression-free survival in both discovery and validation cohorts.
Researchers discovered a new combination of treatments that may benefit patients with certain gene mutations. Inhibiting the protein AKT suppressed growth of tumour cells in animal models, while combining dexamethasone with AKT inhibition showed better results.
In a phase I clinical trial, vorinostat in combination with sirolimus or everolimus demonstrated improved outcomes for patients with heavily pretreated relapsed/refractory Hodgkin lymphoma. The treatment combination achieved an objective response rate of 55% and median progression-free survival of 5.3 months.
A University of Gothenburg study finds that individuals who undergo obesity (bariatric) surgery have a higher average life expectancy compared to those given conventional treatment for obesity. The study, published in The New England Journal of Medicine, shows that bariatric surgery prolongs life expectancy by 3 years, but patients sti...
Researchers from ICIQ and IRBBarcelona have developed a synthetic carrier that can transport amino acids, such as Proline, across cell membranes. The study shows a 30-fold increase in L-Proline transport activity, opening up new possibilities for treating diseases related to amino acid metabolism.
Researchers at Flinders University have developed a non-invasive breath test that accurately differentiates between head and neck cancer patients and those with benign diseases. The test uses volatile organic compounds in exhaled breath to detect the presence of cancer, showing high sensitivity and specificity rates.
A study at MD Anderson Cancer Center found that monitoring early changes in circulating tumor DNA can predict patient outcomes. Infused CAR T cells with certain characteristics are associated with better treatment responses, while those with exhaustion signatures may experience poor outcomes.
Researchers identified a compound that disables abnormal blood vessels, potentially reversing vision loss in patients with retinopathy of prematurity and diabetic retinopathy. The treatment targets only the abnormal vessels, sparing healthy ones.
Researchers at Princess Margaret Cancer Centre found that over 80% of advanced NSCLC patients had genomic alterations detected in cfDNA. Liquid biopsies were shown to be a timely and effective method for diagnosing and monitoring the disease, with actionable alterations detected in over 56% of treatment-naïve patients.
Researchers found high variability in DNA changes between individuals, suggesting a wide range of factors influence bladder cancer development. A new mutational signature linked to smoking was also identified, shedding light on why tobacco is the single greatest risk factor for bladder cancer.
A Japanese team has developed a simple way to glean more detailed information from standard medical imaging scans by detecting the oxygen concentration of tissues throughout patients' bodies. The upgraded PET scanners may lead to more effective cancer treatment by quickly identifying parts of tumors with aggressive cell growth.
A young man suffering from severe aplastic anemia has been given a life-saving blood transplant using the UM171 molecule, which increases stem cell production and reduces immunological complications. The procedure was performed by a medical team at the Institute of Hemato-oncology and Cellular Therapy.
The National Institutes of Health has awarded grants to support researchers' efforts in using tiny, bioengineered models of human tissues and organ systems to study diseases and test drugs. The goal is to develop ways to predict which patients are most likely to benefit from an investigational therapy prior to initiating clinical trials.
A study from Karolinska Institutet in Sweden found that women receiving fertility-sparing surgery for treatment of borderline ovarian tumours were able to have children, with most preserving natural fertility. The study also showed similar survival rates as those who underwent radical surgical cancer treatment.
Researchers discovered that R-spondin treatment reduces intestinal tumor growth and promotes healthy epithelial cell function. The study suggests a new rationale for treating familial adenomatous polyposis patients with APC mutations.
Research suggests that cancer patients with COVID-19 have a higher mortality rate due to their age and comorbidities, rather than the cancer. The study found that survival at 30 days was worse in cancer patients compared to non-cancer patients.
Researchers at Charité - Universitätsmedizin Berlin and the Deutsches Rheuma-Forschungszentrum (DRFZ) successfully treat two patients with systemic lupus erythematosus using daratumumab, a monoclonal antibody targeting plasma cells. The treatment resulted in sustainable clinical responses and reduced systemic inflammation.
A new study published in Cancer found that Black women experience longer waits for treatment initiation and prolonged duration of treatment after a breast cancer diagnosis. The research, which analyzed data from over 2,800 participants, identified financial and transportation issues as key contributors to these delays.
A recent study published in the journal Cancer found that Black women with breast cancer experience delays in starting treatment and have extended durations of treatment compared to white women. The study, led by UNC Lineberger Comprehensive Cancer Center researchers, also identified socioeconomic status as a significant factor influen...
The study evaluated changes in lung cancer treatment during the COVID-19 pandemic, highlighting shifts in treatment options and patient outcomes. The research found that the pandemic led to reduced access to certain treatments, resulting in decreased survival rates for some patients.
The Morris Animal Foundation has awarded nearly $1 million in grants to support 14 large animal health research projects focused on improving the well-being of horses. These studies will investigate genetic tests for heart arrhythmias, guidelines for air-transported horses, and the impact of gut microbiome variation on horse health.
A Rutgers-led team has created a smart drug delivery system to reduce inflammation and promote tissue repair in damaged nervous tissues. The system, which uses ultrathin biomaterials, aims to improve the treatment of spinal cord injuries and other neurological disorders.
Patients with a first-time depression diagnosis have an increased risk of worsening and requiring hospitalisation if they have previously been treated for a physical disease at a hospital. The risk is also influenced by age and the number of physical diseases, with more diseases under 65 increasing the risk.
Researchers identified mutations in the novel gene ANGPT2, responsible for primary lymphedema. The discovery provides insights into the disease's underlying mechanisms, potentially leading to improved treatments.
Researchers have found that specific DNA variants can affect the response to interferon-alpha-based treatments, leading to personalized therapy options. The discovery may improve treatment outcomes for patients with polycythaemia vera, a rare chronic malignant blood disease.
Researchers from CNIO achieved complete remission in 25% of lung tumors induced by KRAS oncogene in mice following genetic inactivation of CDK4 and RAF1. This strategy also prevented cancer cell growth in healthy mice and identified molecular mechanisms that triggered resistance, such as PI3K pathway activation.