Research on new and better ways to treat cancer. Covers radiotherapy, targeted microdroplets, nerve-injury protection, drug combinations, and tumor models.
Researchers have identified specific cortisol production levels linked to increased mortality risk in patients with benign adrenal tumors. This breakthrough enables healthcare providers to concentrate efforts on high-risk patients and optimize public healthcare resources.
A Ludwig Cancer Research study has discovered how to revive terminally exhausted T lymphocytes, found within tumors, for cancer therapy by using an immune factor called interleukin-10. This revival restores their potent anti-cancer activity, leading to tumor regression and cures in mouse models of melanoma and colon cancer.
Researchers evaluate expression of TAZ and YAP, the p53-MDM2 axis, and RABL6A in sarcomas, finding that elevated YAP and TAZ independently predict worse overall and progression-free survival. Network analysis reveals a possible functional relationship between biomarkers.
Researchers discovered a sub-set of CAR T-cells called 'stem cell memory T-cells' that play a key role in destroying cancer and maintaining immune surveillance. These cells are critical to the long-term success of CAR T-cell therapy, which could improve treatment outcomes for patients with high-risk relapse.
A new study reveals that small uveal melanomas have molecular genetic alterations, making them highly metastatic tumours. Prompt treatment can significantly increase the chances of cure for these patients.
A study by Virginia Commonwealth University researchers found that secondhand smoke exposure during pregnancy is associated with epigenetic changes in babies, which can increase the risk of developmental disorders and cancer. The study analyzed data from over 100 pregnant women and found correlations between low levels of cotinine, a n...
The USPSTF has recommended lowering the age for colorectal cancer screening to 45 years of age, aligning with the American Cancer Society's 2018 guideline. This change aims to catch more early deaths and preventions due to increasing cases in younger individuals. Further research is needed to identify underlying causes and risk factors.
Researchers at The University of Hong Kong have developed synthetic biotherapeutics with anti-tumor, insulin-sensitizing, and hepatoprotective activities, offering potential treatments for obesity-related diseases such as type 2 diabetes, hypertension, and cancer.
The study created a comprehensive catalog of healthy breast tissue cells, enabling scientists to pinpoint the origin of abnormal changes. By tracking gene activity in over 15,000 cells, the team redefined healthy breast tissue and identified subpopulations with different responses to therapies.
Researchers found that obesity-related cancer deaths improved at a slower rate than non-obesity related cancer deaths, with declines of 2.29% and .83%, respectively. Obesity contributes to both cancer risk and heart disease risk, but the study suggests that maintaining a healthy weight can improve overall health.
A machine learning algorithm, FARDEEP, has been developed to assess an individual patient's risk of regenerative outcomes after surgical treatments of peri-implantitis. The study found that immune cell types central to microbial control are strongly correlated with superior clinical outcomes.
A team of Oregon State University scientists discovered a new class of anti-cancer compounds, SMAhRTs, that activate AhR signaling and kill liver and breast cancer cells. These compounds provide exciting new leads for drug development, targeting the AhR pathway to induce anti-cancer effects.
A new form of gene therapy has successfully treated 48 out of 50 children born with a rare and deadly inherited disorder. The treatment, developed by an international team, involves delivering a corrected copy of the ADA gene into stem cells, which are then returned to the child's body to produce healthy immune cells.
A new study by Brigham and Women's Hospital found that Medicaid expansion did not significantly improve receipt of definitive treatment and timeliness of care for cancer patients treated at minority-serving hospitals. Despite increased access to insurance, these hospitals continued to face significant disparities in care.
Researchers identify key protein MavQ that helps Legionella bacteria set up house in human cells, remodeling endoplasmic reticulum to create protective dwellings. This discovery could lead to new treatments for various infections.
Researchers rationally designed a new monoclonal antibody HA98 with improved affinity for CD146, a key adhesion molecule in angiogenesis and cancer metastasis. The study revealed superior inhibitory effects on tumor growth compared to the original AA98 antibody.
Researchers enrolled 50 Black and 50 white men with advanced prostate cancer to test hormone therapy abiraterone acetate plus prednisone. They found that Black men's PSA levels dropped further and more frequently, but disease progression and survival times were similar.
Scientists have discovered nano-scaled apoptotic bodies as a new brain-targeting drug carrier, overcoming the blood-brain barrier challenge. The small apoptotic bodies (sABs) are stable in serum, have a long circulating time, and high drug loading efficiency, making them a promising candidate for drug delivery.
Researchers found that decreased neuronal complexity may be a feature of chronic migraine and propose restoring this complexity as a treatment. HDAC6 inhibition restored cytoskeletal flexibility and relieved migraine-associated pain.
A new study has identified 16 quality measures for end-of-life care in children with cancer, covering topics such as avoiding medically intensive care and assessing sibling needs. The measures aim to standardize care and identify disparities in quality of care received by different groups of children.
Researchers developed an AI system, TOAD, that accurately predicts the origin of tumors in cancer cases with unknown primary sites. The model, trained on gigapixel pathology images, correctly identified cancer types and listed diagnoses as top predictions 96% of the time.
Research has expanded hyaluronic acid's uses beyond cosmetics, exploring its potential in wound healing, nerve and muscle pain treatments, and cancer therapy. The ingredient is being combined with other proven ingredients to create optimized products with tangible results.
A new neuroimaging technique using diffuse optical tomography studied brain stimulation for depression, finding reduced brain activation in response to rTMS. The study suggests that treatment parameters may need adjusting for patients with severe depression.
Petco Love and Blue Buffalo have partnered with Morris Animal Foundation to support pet cancer research, investing over $16 million in the fight against pet cancer. The $100,000 grant will be used to match donor gifts and raise awareness for animal cancer research.
A team of researchers, including Saket Navlakha and Dr. Sejal Morjaria, developed a computational tool to predict COVID-19 severity in cancer patients. The tool has an accuracy rate of 70-85% and prevents unnecessary expensive testing, improving patient care.
A Phase II trial found that BKV-specific T cells from healthy donors are safe and effective in treating debilitating complications after stem cell transplants. Patients experienced rapid responses, with 81.6% showing improvement after 28 days, and no cases of severe GVHD or toxicities.
A new treatment has shown promising results in reducing the severity of acute respiratory distress syndrome caused by the flu in mice. The therapy, based on natural molecules, improves lung function and prevents progression of disease in infected animals.
Researchers discovered that distinct Notch family members are modified differently by phosphorylation, leading to opposite effects on transcriptional activity and oncogenic behavior. The study suggests that targeting PIM or Notch proteins may provide new treatment options for hormone-dependent breast cancer with poor prognosis.
Researchers developed a predictive model to estimate the age of natural menopause in middle-aged women based on hormone levels, menstrual cycle irregularities, and lifestyle factors. The study demonstrated adequate prediction accuracy, suggesting potential benefits for health promotion and family planning decisions.
A new study by Massachusetts General Hospital researchers finds that a proposed law to regulate high-risk diagnostic tests could increase US healthcare costs by $565 million to $1.1 billion over a three-year period, depending on stringency of enforcement.
A new mathematical model developed by Chalmers University of Technology can predict how different bacteria interact and affect the intestinal microbiome. The model was tested on two clinical studies, one involving Swedish infants and another adults in Finland, showing high accuracy in predicting multiple variables.
A new study from the University of Bergen reveals that targeted therapy using PARP inhibitors can be effective in treating early-stage triple negative breast cancers. The study found a significant response rate among patients not harboring germline mutations, highlighting a potential for improved personalized treatment.
This issue of APSB features studies on protecting against doxorubicin-induced cardiotoxicity via increasing YAP1 expression, as well as investigating alternative strategies to downregulate PD-L1 in gastric cancer cells. The journal also publishes research on a novel injectable micelle-hydrogel hybrid for localized drug delivery and tar...
A recent study found that banning tanning beds among U.S. minors would significantly reduce the number of melanoma cases in adolescents, with estimates suggesting up to 15,101 cases prevented over the lifetime of 17.1 million minors. The study also estimated that such a ban would save millions of dollars in healthcare costs.
A recent study by Yale Cancer Center reveals that young patients with early-onset colorectal cancer (under age 50) have a better survival rate than those diagnosed at older ages. After adjusting for stage at diagnosis, these patients had a 5% lower risk of death compared to those diagnosed between 51-55 years old.
Tumor gene profiling decreases patient acceptance of active surveillance among men with clinically similar prostate cancers and low health literacy, a new study found. The study suggests that education on prostate cancer treatment options is needed for this population.
Researchers designed and synthesized acrylamide-based DHODH inhibitors for treating rheumatoid arthritis. The lead compound showed encouraging in vivo anti-arthritic effects in a dose-dependent manner.
A newly released position paper from ESMO and SIOPE defines a common vision for improving outcomes for AYAs with cancer in Europe. The paper highlights the key challenges of AYA care, including limited awareness of cancer biology, availability of specialist centres, and access to clinical trials.
The Vilcek Foundation has launched a digital celebration to recognize the 2021 Vilcek Foundation Prizewinners. Four scientists from diverse backgrounds are being honored for their groundbreaking contributions to biomedical science and creative promise in filmmaking.
A new study published in JCI Insights found that COVID-19 convalescent plasma treatment with high levels of antibodies is safe and significantly improves clinical outcomes. The treatment was effective in non-mechanically ventilated patients, with a survival rate of 88.9% at the 30-day mark.
The April issue of SLAS Technology explores the therapeutic potential of reactive oxygen species (ROS) in applications ranging from wound healing and hair growth enhancement to cancer treatment and stem cell differentiation. However, limitations in controlling the temporal pattern of ROS release hinder their clinical translation.
The study analyzed 412 high-risk NMIBC patients treated with BCG therapy and found significant differences in outcomes according to specific features of the disease. Total median costs at one, two, and five years from start of BCG induction were $29,459, $55,267, and $117,361, respectively.
A recent review article published in Chinese Medical Journal explores the associations between psoriasis treatments and risks of cardiovascular diseases. The study finds that some treatments, such as TNF-α inhibitors and methotrexate, may reduce long-term cardiovascular risk, while others, like IL-12/23 inhibitors, may increase it.
Researchers created a novel platelet-based delivery system to target and penetrate tumors, combining photothermal therapy and immunotherapy. The biomimetic formulation demonstrated potent therapeutic effects against multiple types of cancer in murine models.
Researchers found that early intensive training improved motor and memory skills in a mouse model of Rett syndrome, delaying symptom onset. The study proposes newborn genetic testing followed by training to help girls retain milestones and improve quality of life.
Researchers at Kumamoto University found that aging cells in abdominal fluid contribute to peritoneal dissemination of gastric cancer by promoting cellular senescence and inflammation. This understanding could lead to new treatments targeting cancer cells and associated fibroblasts.
A phase III clinical trial showed that reducing steroid use in intermediate-fit older patients with newly diagnosed multiple myeloma yields similar outcomes to standard treatment. The adapted Rd treatment schedule spares steroid use after nine months, resulting in fewer adverse effects and improved event-free survival.
Scientists have discovered that large numbers of inherited genetic mutations collectively increase cancer risk, particularly for late-onset types. This breakthrough could lead to more effective early detection strategies and personalized cancer treatments tailored to an individual's genetics.
Research from Michigan State University highlights the racial disparity gap in cervical cancer information and follow-up, citing poor provider-patient communication as a key factor. The study suggests that improving education and using digital channels like text messages can help bridge this gap.
A minimally invasive treatment known as radiofrequency ablation (RFA) provides quick and sustained pain relief, improving quality of life for cancer patients with bone tumors. The benefits last more than 12 months, significantly outperforming radiation treatment.
Researchers at UIC have found that HPSE drives antiviral immunity, proliferative signals and cell death, with potential applications in treating dysregulation of the protein in various diseases. This discovery has broad implications for diseases such as cancer, atherosclerosis and autoimmune disorders.
A comprehensive analysis of biomarker testing reveals substantial variation in test utilization and treatment outcomes for stage IV NSCLC patients. Whole-genome sequencing may streamline diagnostic workflows and reduce complexity, but its cost-effectiveness remains uncertain.
A new study by Uppsala University found that unmarried patients and those with low educational attainment are less likely to be treated with a stem-cell transplantation for mantle cell lymphoma. The study suggests that this may result in poorer survival rates.
Researchers at Imperial College London have developed a new type of nanoprobe that uses second harmonic generation (SHG) to detect tumors more brightly and precisely than existing fluorescent nanoprobes. The biodegradable bioharmonophores attach specifically to tumor cells, reducing misrepresentation and improving detection sensitivity.
The CNIO team found that telomeres respond to external signals inducing cell proliferation and that blocking these signals can interfere with cancer cells becoming immortal. The study identifies telomeres as a key target of the AKT pathway, which plays a crucial role in tumorigenesis.
UC researchers found that cooperation between HER2 and MED1 genes promotes breast tumor growth, spread, and treatment resistance. Targeting MED1 alone or in combination with current therapies may be an effective treatment strategy for nearly 90% of breast cancer patients.
Researchers conducted a randomized intervention that improved continuity of care and interprofessional collaboration between lung cancer patients and their family physicians. The bidirectional exchange of patient information and care summaries led to enhanced patient and family physician perceptions of care, resulting in better outcomes.
Researchers have developed a novel stem-cell-based therapy targeting key targets in solid tumors, successfully prolonging the lifespan of mouse models with brain metastatic breast cancer. The engineered molecule EvDRL was delivered via allogeneic stem cells, which crossed the blood-brain barrier to home in on tumors.
A new study found that cancer patients who died by suicide were generally older and less likely to have histories of physical and psychiatric problems. These patients were also more likely to communicate about their suicidal intent before death.
A recent study published in Oncotarget identified elevated platelet counts as a prognostic factor for poor outcomes in patients with metastatic clear-cell renal cell carcinoma, particularly those classified as intermediate-risk. These findings highlight the importance of stratification models in guiding treatment decisions and design c...