Articles tagged with Cancer Treatments
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Researchers have uncovered the intricate details of interleukin-2's interactions with receptor molecules, providing a blueprint for more targeted therapies. The study shows how IL-2 can act as either a throttle or a brake on the immune response in different contexts.
Researchers at Princeton University identified key factors essential for chronic hepatitis B infection. The study found that five human proteins are necessary for the repair process of HBV DNA, and targeting these factors could potentially prevent the infection.
Researchers at UCL have developed a new test to identify the earliest genetic changes of prostate cancer in blood plasma. The process, known as DNA methylation, uses Next Generation Sequencing (NGS) to establish if prostate cancer DNA is present in blood plasma.
A study published in Cancer Epidemiology, Biomarkers & Prevention found that young women with breast cancer experience substantial financial difficulties after diagnosis, even if they have stable jobs and insurance coverage. The study highlights the need for better financial planning and awareness of the costs associated with cancer care.
Establishing an inducible BCL6 knock-out model allows studying the phenotype of BCL6 loss in DLBCL xenografts in vivo. The study demonstrates significant tumor growth inhibition and initial tumor stasis followed by slow tumor growth kinetics upon treatment with BCL6 degraders.
A novel cause of fatty liver disease has been discovered in lean individuals undergoing immune checkpoint blockade therapy. Researchers report a case of a woman who experienced severe inflammation of her subcutaneous fat and developed nonalcoholic fatty liver disease after treatment with the PD-1 inhibitor Nivolumab.
A new study found improvements in five-year survival rates for all cancers in young adults, with some cancer types showing little to no improvement since the 1970s. Treatment advances have led to steady improvements in estimated survival rates among adolescents and young adults.
A recent study has found that the five-year survival rate for adolescents and young adults with certain types of cancer has improved substantially over the past three decades. Leukemia and non-Hodgkin lymphoma have seen significant declines in mortality rates, with improvements ranging from 20-30 percentage points between 1975 and 2005.
A systematic evidence review by OHSU researchers found that new direct-acting antiviral therapies are highly effective in eliminating the Hepatitis C virus infection. The review informed a new recommendation for universal screening of Hepatitis C, with the therapy being more than 95% effective even in young people.
A recent study published in BMC Cancer found that nearly two-thirds of women diagnosed with breast cancer experience significant weight gain, with the majority gaining over 20 kilograms. The study highlights the importance of early intervention and management strategies to prevent weight-related issues after a breast cancer diagnosis.
African American cancer survivors who engage in regular physical activity report higher health-related quality of life and lower depression. The study found that increases in physical activity correlated with improvements in quality of life.
A new study from the University of Gothenburg shows that bariatric surgery is as effective for individuals who developed obesity early in life as it is for those who developed it later. The study found no difference in weight loss or obesity-related complications between the two groups.
A study of over 925,000 adults with new cancer diagnoses found that Medicaid expansion improved insurance status, led to earlier cancer stage detection, and resulted in timely treatment. The findings suggest a positive association between Medicaid expansion and cancer care outcomes.
Researchers compared treatment and survival rates between African American and white women with mammography-detected triple-negative breast cancer. African American women have a higher rate of death from breast cancer, likely due to the aggressive nature of this type of breast cancer.
Researchers found that white patients received earlier treatment and had better survival rates than black patients, with hospitals having a significant impact on outcomes. The study suggests structural issues at the hospital level influence differences in cancer outcomes across racial groups.
Researchers at Stanford University have developed a CRISPR-Cas tool that can detect and debug faulty genetic circuits, facilitating more precise treatments for diseases like cancer. The technology allows for greater precision in identifying and eliminating diseased cells, with potential applications beyond cancer treatment.
Researchers found a genetic variant associated with aggressive disease and shorter survival in men with metastatic prostate cancer. Genetic testing for the HSD3B1(1245C) variant may help identify patients most likely to benefit from additional treatment.
Researchers at ORNL developed a multitask convolutional neural network to extract key information from cancer pathology reports. The AI tool can complete multiple tasks simultaneously, reducing processing time by an average of five times compared to single-task models.
Researchers at Huntsman Cancer Institute have identified a critical protein called ETV4 that promotes estrogen signaling in endometrial cancer cells. By removing ETV4, tumor growth can be significantly reduced, offering new avenues for treatment development.
A novel vaccine called Triplex reduced CMV complications by half and induced immunity in patients undergoing allogeneic hematopoietic stem cell transplant. No vaccine-associated safety concerns were identified in the phase 2 randomized clinical trial.
The MSTARS consortium aims to further develop mass spectrometry technology for clinical application and detection of treatment resistance in various diseases. By combining expertise in mass spectrometry, patient care, and data analysis, the team hopes to improve precision medicine and tailor treatments to individual patients.
Researchers at University of Tsukuba found that tumor cells produce a protein called soluble CD155 to disable the immune system in mice. Soluble CD155 prevents NK cells from releasing toxic proteins to cancer cells by binding to DNAM-1, allowing tumors to grow and spread.
A new method for detecting circulating tumour cells (CTCs) has been developed to improve the monitoring of cancer patients. This approach increases detection rates from 40-87% to 72%, offering a new avenue for cancer diagnosis and therapies.
A new synthetic biology toolkit called COMET allows researchers to design and tune gene expression programs in mammalian cells with unprecedented precision. This breakthrough could lead to the development of novel cell-based therapies for cancer and other challenging diseases.
Researchers at St. Jude Children's Research Hospital are exploring genetically engineered immune cells to attack pediatric sarcoma using a new ACGT grant. The approach aims to target not only cancer cells but also blood vessels supporting tumor growth, offering a promising new treatment for children with solid tumors.
A team of researchers has begun a doctor-initiated clinical trial for a new cell spray treatment method targeting heart failure. The product, ADR-002K, uses a spraying technique to administer mesenchymal stem cells onto the heart, aiming to improve prognosis and cardiac function in patients with ischemic cardiomyopathy.
A new method to monitor residual disease after treatment in high-risk neuroblastoma patients has been developed using droplet digital PCR. This method enables precise monitoring of minimal residual disease and early diagnosis of tumor relapse/regrowth, leading to improved patient prognoses.
A new study suggests that targeting Hsp47 could block cancer cell-platelet interaction and inhibit metastasis in triple-negative breast cancer patients. The protein is often amplified in the genes of metastatic breast cancer tissue, potentially serving as a biomarker for metastasis.
Researchers used the Pan-Cancer dataset to classify structural variations in cancer genomes and link them to mechanisms of formation. They identified complex processes that can lead to cancer genes becoming active, and developed methods to identify these variations.
This study reveals that chromothripsis is common across multiple types of cancer, with frequencies greater than 50% in some tumours. The research demonstrates how chromothripsis shapes the tumour genome, leading to oncogene amplification and loss of tumour suppressor genes.
A study of over 2,500 tumor genomes reveals that most cancer cells use alternative mechanisms to lengthen their telomeres, increasing their lifespan. The researchers discovered unique variations in these telomere sequences and their integration into the genome, which may hold clues for developing targeted treatments.
The European Society of Human Reproduction and Embryology has found substantial variations in the legal and funding framework of 43 European countries regarding assisted reproduction. Access to treatment, third-party donation, fertility preservation, and public funding vary significantly among countries.
Researchers at Michigan State University developed a new method to detect protein density in blood plasma using magnetic levitation. This technique could lead to improved disease diagnosis and treatment by identifying distinct patterns of proteins associated with various health conditions, such as opioid abuse and multiple sclerosis.
A study published in Clinical Cancer Research found that circulating tumor cells were associated with a decrease in relapse-free survival at six months, and this association persisted at a 54-month longer-term follow-up. This suggests that CTC assessment may be useful in identifying patients at risk for relapse who could benefit from m...
Two studies published in The Lancet conclude that cervical cancer could be eliminated worldwide by the next century, with North America expected to see almost complete eradication by 2040. High vaccination coverage and high uptake of screening and treatment are key to achieving this goal.
Two new studies quantify the potential for eliminating cervical cancer in 78 low-income and lower-middle income countries, proposing measures to avert 74 million cases and 62 million deaths over the next century. The proposed triple intervention strategy of HPV vaccination, cervical screening, and treatment could reduce mortality by up...
Magnetic nanostructures show promise in biomedical applications, including cell separation and targeted cancer treatment. High tumor cell death rates were observed with weak magnetic fields, suggesting a strong mechanical force that destroys tumor cells.
Bowel cancer screening tests can miss patients due to NHS staff shortages, particularly in England where lower haemoglobin levels warrant further investigation. Cancer Research UK calls for significant investment to train and recruit more staff to diagnose patients earlier.
A study published in the British Journal of General Practice found an increase in shortness of breath and cough as the first symptoms reported by patients diagnosed with lung cancer. This suggests earlier detection, possibly due to awareness campaigns.
Researchers have discovered a link between a metabolic system in yeast and mammals that regulates cell growth and proliferation. The study found that cancer cells can override sensing systems to maintain uncontrolled proliferation, but disrupting this mechanism can suppress cell growth.
A recent study published in PNAS reveals that extracellular matrix protein-1 (ECM1) plays a crucial role in the pathogenesis of ulcerative colitis, a type of inflammatory bowel disease. The researchers found that ECM1 is highly expressed in macrophages and regulates their polarization through the GM-CSF/STAT5 signaling pathway.
A novel pharmacological chaperone has been shown to restore levels of the sorting molecule VPS35 and prevent the accumulation of abnormal proteins in mice with Alzheimer's disease. This treatment approach has been proven to improve memory and learning, reducing tau tangles and amyloid-beta plaques.
Researchers developed a new technique to predict which primary melanoma patients are at risk for cancer recurrence and spread by analyzing T-cell fraction in skin lesions. Patients with lower T-cell fraction (less than 20%) were found to be 2.5 times more likely to have cancer metastasize.
Researchers have found that an exosome treatment can promote full recovery in swine with severe stroke, even in cases where brain cells are at risk of dying. The treatment works by interrupting the process of cell death and reducing damage signals throughout the brain network.
Rutgers researchers found that online educational videos boost cancer knowledge and awareness among viewers, leading to increased behavioral changes such as self-skin inspections and lung cancer screening. The study highlights the potential of digital health videos to reach disadvantaged populations and improve health outcomes.
Research shows that HPV-negative oropharynx cancer patients are at a significantly higher risk of dying from any cause within two years. In contrast, HPV-positive patients have a lower risk of dying from head and neck cancer and other types of cancer.
Researchers in Dresden aim to develop chemical circuits for the diagnosis and treatment of acute myeloid leukaemia using chemo-fluidic technology. The project seeks to create integrated systems that can analyze hundreds or thousands of individual human cells simultaneously, potentially leading to improved therapy options.
The study found that cerebrospinal fluid from LMM patients contains proteins critical to melanoma cell survival and growth, including TGF-β1. The researchers hope their data will provide insights into potential therapeutic targets for delayed disease progression.
A study at UT Southwestern Medical Center found that patients who received Mohs surgery for melanoma reported a 95% long-term satisfaction rate with their results. The highly precise excision technique resulted in minimal scarring and a nearly 99% cure rate for early melanoma.
In 2020, prostate cancer will claim the most diagnoses among male cancers, with a 21% share of new cases. Early detection is crucial, but screening's benefits are disputed by some, leading to fewer men taking proactive steps towards their health.
A Cornell study identifies a key pathway in gastric SCJ cancers that provides a promising target for future study and therapy. Large pools of immature Lgr5-CD44+ cells, rather than Lgr5+ stem cells, promote cancer in areas where two stomach tissues meet.
Researchers at Uppsala University used a computer algorithm to identify a promising new treatment for neuroblastoma, a form of childhood cancer. The new treatment targets the CNR2 receptor protein, which was discovered using massive amounts of genetic and pharmacological data.
A study from UT Southwestern Medical Center found that individualized physical therapy can effectively reduce urinary incontinence and pain in men after prostate surgery. The approach focuses on relaxing tight pelvic muscles rather than strengthening weak ones, leading to improved outcomes for 87% of patients.
A Hebrew University research team has discovered a potential link between the BCG vaccine and reduced Alzheimer's disease risk in cancer patients. The study found that those who received the BCG vaccine had significantly lower rates of developing Alzheimer's compared to those who did not.
Researchers at Penn Medicine used MRI scans to characterize tumor heterogeneity and predict 10-year breast cancer recurrence. High tumor heterogeneity was found to be a strong predictor of recurrence in patients with primary invasive breast cancer.
Scientists at University of Helsinki and Institut Jacques Monod have identified a molecular machinery that drives rapid depolymerisation of actin filaments and recycles resulting monomers. This discovery provides new avenues for developing therapeutics to inhibit cancer cell migration.
Researchers discovered a key factor, USF1, that inhibits p53 activity, promoting gastric cancer development. USF1 levels can indicate poor prognosis and help identify patients at higher risk of severe forms of gastric cancer.
A new study found that people who presented to California emergency departments with deliberate self-harm had a suicide rate 56.8 times higher than demographically similar Californians. Patients with suicidal ideation had a suicide rate 31.4 times higher, reinforcing the need for universal screening and follow-up care.
The American College of Medical Genetics and Genomics recommends evaluating breast cancer patients for genetic testing based on existing clinical criteria. Genetic testing should include full gene sequencing and be conducted in a lab certified by the College of American Pathologists or Clinical Laboratory Improvement Amendments.
Biomedical engineers at Duke University have created a system that allows real-time observations of individual cells in the colon of a living mouse. This breakthrough enables researchers to study the digestive system's microbiome, inflammatory bowel disease, and colon cancer, as well as explore potential treatments for gastrointestinal...