Prostate cancer: CRYM protein inhibits tumour growth
Researchers found that CRYM protein binds to hormone T3 and blocks cell membrane formation, inhibiting tumour growth. Lower CRYM levels are associated with poor prognosis.
Cancer Treatments
Articles tagged with Cancer Treatments
Certain CBD oils no better than pure CBD at inhibiting certain cancer cell lines
A recent study published in Medical Cannabis and Cannabinoids found that CBD oils are equally or less effective than pure CBD at inhibiting the growth of certain cancer cells. The researchers tested different types of CBD oil against pure CBD on various cancer cell lines, including brain, skin, and colorectal cancers.
Novel technique 'stuns' arthritis pain in shoulder and hip
A new outpatient procedure has been shown to provide significant pain relief for patients with moderate to severe osteoarthritis in their hip and shoulder joints. Treatment involves the placement of needles where sensory nerves exist, followed by a low-grade current that 'stuns' them, slowing pain transmission to the brain.
A new diagnostic method predicts which cancer patients will respond to immunothe
A new diagnostic tool has been developed to predict which cancer patients are most likely to benefit from immunotherapy treatments. The tool analyzes the interactions between immune cells and tumor cells, as well as the activation state of immune checkpoints.
Plasma treatments quickly kill coronavirus on surfaces
Researchers found that cold atmospheric plasma can kill the novel coronavirus on surfaces such as plastic, metal, and leather within 30 seconds. The treatment uses argon-fed plasma and has been shown to be effective against other viruses like SARS-CoV-2.
Racial/ethnic minorities comprise small portion of patients referred with AL amyloidosis
A recent study found that racial/ethnic minorities comprise only a small percentage of patients with AL amyloidosis, despite being theoretically at higher risk. Younger age and more severe illness were observed among minority patients, who were also less likely to undergo aggressive treatment with stem cell transplantation.
Study examines health literacy and shared decision-making in prostate cancer screening
Researchers found that higher health literacy is associated with higher rates of PSA screening, despite guidelines recommending against it. The study also identified a dynamic interplay between health literacy and shared decision-making.
A better test for the tumor-targeting of CAR-T therapies
Researchers at Ludwig Institute for Cancer Research developed a protocol to overcome difficulties in engineering and expanding mouse T cells for CAR-T cell therapies. The new method showed improved tumor control, proliferation, and persistence of CAR-T cells, as well as enhanced reprogramming of the tumor microenvironment.
Serial screening for COVID-19 in asymptomatic patients receiving anticancer therapy
A screening program for COVID-19 in asymptomatic cancer patients prior to each cycle of anticancer therapy was implemented at a UAE hospital. The study found the program's effectiveness in detecting COVID-19 cases among these patients.
Medicaid expansion linked to lower mortality rates for three major types of cancer
Researchers found that Medicaid expansion is associated with earlier stage of diagnosis, leading to decreased mortality rates for patients with newly diagnosed breast, lung, or colorectal cancer. In states with expanded Medicaid programs, mortality rates were significantly lower than in non-expansion states.
Oncotarget: Predictive biomarkers in Trop-2-expressing triple-negative breast cancer
Researchers found that Trop-2 expression is a predictive biomarker for sacituzumab govitecan efficacy in triple-negative breast cancer. Increasing Trop-2 expression improved SG efficacy in mice with HRR-proficient tumors, suggesting a potential clinical benefit for patients with high Trop-2 levels.
Harnessing the 'wisdom of crowds' can help combat antibiotic over prescription
A new study demonstrates that pooling treatment recommendations from multiple prescribers using the 'wisdom of crowds' concept can improve decisions on antibiotic prescribing and reduce overuse. Using international survey data, researchers found that groups of three or more prescribers showed significant benefits in guideline compliance.
Decision conflict before cancer surgery correlates with lower activity after surgery
A study by Massachusetts General Hospital found that patients with significant decision conflict prior to cancer surgery are less active after surgery. The researchers used a smartphone app and sensor data to measure physical activity levels at 30, 60, and 90 days after surgery.
Study reveals fibulin 5 is required for Schwann cells' myelination
A study published in STEM CELLS revealed that fibulin 5 plays a crucial role in the development of Schwann cells, which produce the myelin sheath surrounding neuronal axons. The research suggests that fibulin 5 may be used to treat Charcot-Marie-Tooth disease and other demyelinating disorders.
Cerebrospinal fluid as liquid biopsy for characterizing & policing of medulloblastoma
A proof-of-concept study shows cerebrospinal fluid as a liquid biopsy for precise characterization and real-time tracking of medulloblastoma. Circulating tumor DNA analysis provides genomic insights into disease evolution, enabling more effective treatment strategies.
Researchers uncover crucial gene for growth of Ewing sarcoma
Researchers discovered RING1B is critical for Ewing sarcoma development and hijacks transcriptional program to create cancerous cells. Epigenetic inhibitors may offer new treatment strategies.
Discoveries reshape understanding of gut microbiome
Scientists at the Oklahoma Medical Research Foundation have redefined how the gut microbiome operates and coexists with bacteria. The findings show that the microbiome controls the creation of mucus, which acts as a barrier between bacteria and immune cells in the colon.
Nature Communications publishes Bluestar Genomics' technology for cancer detection study
Researchers developed a novel epigenomic approach to detect pancreatic cancer in its early stages using blood draws, identifying distinctive patterns in thousands of genes that serve as biomarkers. This technology has the potential to lead to more timely treatment and improved patient survival.
Anti-inflammatory therapy shows promise in slowing progression of multiple sclerosis
Researchers at the University of Alberta have discovered that an anti-inflammatory drug, VX-765, can slow disease progression in a preclinical model of multiple sclerosis when delivered intranasally. This new therapy approach has shown promise in preserving myelin and glucose metabolism.
ctDNA may predict outcomes with first-line, but not second-line immunotherapy for melanoma
Baseline ctDNA levels predicted responses to first-line immune checkpoint inhibition in patients with melanoma, but not second-line treatment. Low ctDNA levels associated with longer progression-free survival in both discovery and validation cohorts.
Monash discoveries suggest new breast cancer treatment
Researchers discovered a new combination of treatments that may benefit patients with certain gene mutations. Inhibiting the protein AKT suppressed growth of tumour cells in animal models, while combining dexamethasone with AKT inhibition showed better results.
Inhibition of HDAC and mTOR may improve outcomes for relapsed/refractory Hodgkin lymphoma
In a phase I clinical trial, vorinostat in combination with sirolimus or everolimus demonstrated improved outcomes for patients with heavily pretreated relapsed/refractory Hodgkin lymphoma. The treatment combination achieved an objective response rate of 55% and median progression-free survival of 5.3 months.
Higher average life expectancy after obesity surgery
A University of Gothenburg study finds that individuals who undergo obesity (bariatric) surgery have a higher average life expectancy compared to those given conventional treatment for obesity. The study, published in The New England Journal of Medicine, shows that bariatric surgery prolongs life expectancy by 3 years, but patients sti...
Igniting the synthetic transport of amino acids in living cells
Researchers from ICIQ and IRBBarcelona have developed a synthetic carrier that can transport amino acids, such as Proline, across cell membranes. The study shows a 30-fold increase in L-Proline transport activity, opening up new possibilities for treating diseases related to amino acid metabolism.
Promising breath-test for cancer
Researchers at Flinders University have developed a non-invasive breath test that accurately differentiates between head and neck cancer patients and those with benign diseases. The test uses volatile organic compounds in exhaled breath to detect the presence of cancer, showing high sensitivity and specificity rates.
Study identifies characteristics of infused CAR T cells associated with efficacy and toxicity in in patients with large B-cell lymphoma
A study at MD Anderson Cancer Center found that monitoring early changes in circulating tumor DNA can predict patient outcomes. Infused CAR T cells with certain characteristics are associated with better treatment responses, while those with exhaustion signatures may experience poor outcomes.
Discovery holds potential for reversing vision loss
Researchers identified a compound that disables abnormal blood vessels, potentially reversing vision loss in patients with retinopathy of prematurity and diabetic retinopathy. The treatment targets only the abnormal vessels, sparing healthy ones.
SourceOklahoma Medical Research Foundation·JournalProceedings of the National Academy of Sciences·DateOct 5, 2020
Liquid biopsies timely and effective testing method for NSCLC patients in Canada
Researchers at Princess Margaret Cancer Centre found that over 80% of advanced NSCLC patients had genomic alterations detected in cfDNA. Liquid biopsies were shown to be a timely and effective method for diagnosing and monitoring the disease, with actionable alterations detected in over 56% of treatment-naïve patients.
DNA changes in healthy bladder provide clues on how cancer arises
Researchers found high variability in DNA changes between individuals, suggesting a wide range of factors influence bladder cancer development. A new mutational signature linked to smoking was also identified, shedding light on why tobacco is the single greatest risk factor for bladder cancer.
Timing the life of antimatter particles may lead to better cancer treatment
A Japanese team has developed a simple way to glean more detailed information from standard medical imaging scans by detecting the oxygen concentration of tissues throughout patients' bodies. The upgraded PET scanners may lead to more effective cancer treatment by quickly identifying parts of tumors with aggressive cell growth.
UM171 saves another life
A young man suffering from severe aplastic anemia has been given a life-saving blood transplant using the UM171 molecule, which increases stem cell production and reduces immunological complications. The procedure was performed by a medical team at the Institute of Hemato-oncology and Cellular Therapy.
NIH awards $35.5 million to use bioengineered organ models to improve clinical trials
The National Institutes of Health has awarded grants to support researchers' efforts in using tiny, bioengineered models of human tissues and organ systems to study diseases and test drugs. The goal is to develop ways to predict which patients are most likely to benefit from an investigational therapy prior to initiating clinical trials.
Women could conceive after ovarian tumors
A study from Karolinska Institutet in Sweden found that women receiving fertility-sparing surgery for treatment of borderline ovarian tumours were able to have children, with most preserving natural fertility. The study also showed similar survival rates as those who underwent radical surgical cancer treatment.
New insights into colorectal cancer: Growth factor R-spondin suppresses tumor growth
Researchers discovered that R-spondin treatment reduces intestinal tumor growth and promotes healthy epithelial cell function. The study suggests a new rationale for treating familial adenomatous polyposis patients with APC mutations.
Higher risk of death in cancer patients with COVID-19 may be due to advanced age and more pre-existing conditions, rather than cancer itself
Research suggests that cancer patients with COVID-19 have a higher mortality rate due to their age and comorbidities, rather than the cancer. The study found that survival at 30 days was worse in cancer patients compared to non-cancer patients.
Targeting the treatment of autoimmune diseases
Researchers at Charité - Universitätsmedizin Berlin and the Deutsches Rheuma-Forschungszentrum (DRFZ) successfully treat two patients with systemic lupus erythematosus using daratumumab, a monoclonal antibody targeting plasma cells. The treatment resulted in sustainable clinical responses and reduced systemic inflammation.
Black women may be less likely to receive timely treatment for breast cancer
A new study published in Cancer found that Black women experience longer waits for treatment initiation and prolonged duration of treatment after a breast cancer diagnosis. The research, which analyzed data from over 2,800 participants, identified financial and transportation issues as key contributors to these delays.
Study: Black women with breast cancer experience delayed, longer treatment than whites
A recent study published in the journal Cancer found that Black women with breast cancer experience delays in starting treatment and have extended durations of treatment compared to white women. The study, led by UNC Lineberger Comprehensive Cancer Center researchers, also identified socioeconomic status as a significant factor influen...
Changes in lung cancer treatment during COVID-19 pandemic
The study evaluated changes in lung cancer treatment during the COVID-19 pandemic, highlighting shifts in treatment options and patient outcomes. The research found that the pandemic led to reduced access to certain treatments, resulting in decreased survival rates for some patients.
Morris Animal Foundation awards nearly $1M in grants for new studies for equine health
The Morris Animal Foundation has awarded nearly $1 million in grants to support 14 large animal health research projects focused on improving the well-being of horses. These studies will investigate genetic tests for heart arrhythmias, guidelines for air-transported horses, and the impact of gut microbiome variation on horse health.
New smart drug delivery system may help treatment for neurological disorders
A Rutgers-led team has created a smart drug delivery system to reduce inflammation and promote tissue repair in damaged nervous tissues. The system, which uses ultrathin biomaterials, aims to improve the treatment of spinal cord injuries and other neurological disorders.
Physical diseases can negatively affect a depression
Patients with a first-time depression diagnosis have an increased risk of worsening and requiring hospitalisation if they have previously been treated for a physical disease at a hospital. The risk is also influenced by age and the number of physical diseases, with more diseases under 65 increasing the risk.
Researchers discovered a novel gene involved in primary lymphedema
Researchers identified mutations in the novel gene ANGPT2, responsible for primary lymphedema. The discovery provides insights into the disease's underlying mechanisms, potentially leading to improved treatments.
Polycythaemia vera: Determination of individual DNA variants allows for more effective treatment
Researchers have found that specific DNA variants can affect the response to interferon-alpha-based treatments, leading to personalized therapy options. The discovery may improve treatment outcomes for patients with polycythaemia vera, a rare chronic malignant blood disease.
CNIO researchers develop an effective strategy against KRAS mutant lung tumors in mice
Researchers from CNIO achieved complete remission in 25% of lung tumors induced by KRAS oncogene in mice following genetic inactivation of CDK4 and RAF1. This strategy also prevented cancer cell growth in healthy mice and identified molecular mechanisms that triggered resistance, such as PI3K pathway activation.
SourceCentro Nacional de Investigaciones Oncológicas (CNIO)·JournalProceedings of the National Academy of Sciences·DateSep 8, 2020
Novel insights of how prostate cancer causes secondary tumors
A new study by Umeå University researchers sheds light on the molecular mechanisms of prostate cancer cell mobilization. They found that an amino acid in TGF-β signalling molecule Smad7 enables cancer cells to spread and form life-threatening metastases.
Moffitt researchers identify metastasis driver in BRAF inhibitor resistant melanoma
Researchers identified EphA2 as a key driver of metastasis and BRAF-MEK inhibitor resistance in melanoma. The study found that the noncanonical pathway of EphA2 induces an amoeboid phenotype that enhances metastatic potential.
SourceH. Lee Moffitt Cancer Center & Research Institute·JournalJournal of Investigative Dermatology·DateSep 2, 2020
New EU-funded research project 'HCA|Organoid'
The HCA|Organoid project will establish an open access Organoid Cell Atlas, enabling future discovery-driven and translational research on rare genetic diseases, complex multifactorial diseases, and cancer. The project will derive and comprehensively characterize human brain and colon organoids from 100 individuals each.
SourceCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences·DateAug 31, 2020
Trial clarifies which patients with acute pulmonary embolism can be managed at home
The HOME-PE trial found that home management is safe and effective for selected patients with acute pulmonary embolism. Using the Hestia criteria or sPESI score, over 30% of patients can be treated at home with a low rate of complications.
FEFU scientists are developing genetic methods to understand malignant tumors
Researchers at FEFU are working on genetically modified models of brain tumors to understand the role of IDH1 and TP53 gene mutations. They plan to create laboratory models of these mutations to develop new diagnostic markers and test antitumor compounds, potentially leading to personalized therapy for glioma patients.
Cellular energy audit reveals energy producers and consumers
Scientists at Gladstone Institutes have performed a massive cellular energy audit to understand how cells regulate ATP levels. They identified genes and proteins that can be targeted to manipulate cellular energy and treat disease, including neurodegenerative disorders and cancer. The study reveals new pathways for boosting cellular en...
Hip fracture risk linked to nanoscale bone inflexibility
Researchers found that donors without fractures had more flexible collagen and mineral nanostructure than those with fractures. The study suggests that flexibility at the nanoscale could be an important predictor of future bone fractures, highlighting the need for new treatments targeting nanoscale bone health.
New models help predict liver cancer after successful hepatitis C virus (HCV) treatment
Researchers developed new predictive models to identify patients at highest risk of developing hepatocellular carcinoma (HCC) after successful hepatitis C virus (HCV) treatment. The models used clinical parameters and identified specific clusters of patients with elevated or impaired liver function, suggesting more personalized HCC sur...
NUS researchers develop new system for accurate telomere profiling in less than 3 hours
Researchers have developed a novel STAR assay to measure absolute telomere length, enabling rapid diagnosis of cancer and age-related diseases. The method can process up to 48 samples from low DNA amounts, providing critical information for precision therapy.
Protein structural insights chart the way to improved treatments for heart disease
Researchers used cryo-electron microscopy to capture detailed conformational changes involving the β1-adrenergic receptor and its activation mechanism. The findings provide new details for improved therapeutic treatments for cardiac disease, a leading cause of death worldwide.
Current lung cancer public health screening guidelines under count African Americans
A study found that current USPSTF and CMS guidelines for lung cancer screening undercount African Americans due to their age, smoking history, and quitting time. The PLCOm2012 model improved sensitivity in both Whites and African American ever-smokers, eliminating the eligibility disparity.
SourceInternational Association for the Study of Lung Cancer·JournalJournal of Thoracic Oncology·DateAug 18, 2020
Research finds daily cranberry intake associated with reduced with reduced H. pylori infection rates
A clinical trial found that consuming 44mg of proanthocyanidins (PACs) per day in cranberry juice resulted in a 20% reduction in H. pylori infection rates in Chinese adults. The study suggests that twice-daily consumption of this specific amount of PACs may be an effective natural management strategy for adults infected with H. pylori.
Targeting the LANDO pathway holds a potential clue to treating Alzheimer's disease
Researchers identified the LANDO pathway as a key factor in neuroinflammation, which is a major hallmark of Alzheimer's disease. By disrupting this pathway, scientists found that they could reduce neuroinflammation and even improve cognition and memory in a mouse model.
Molecules in urine allow doctors to monitor skin cancer
Scientists have discovered a rapid, inexpensive, and non-invasive method to track malignant melanoma using fluorescent molecules in urine samples. The technique allows doctors to diagnose and monitor the disease without requiring invasive biopsies.
Researchers propose strategy to evaluate tumor photothermal therapy in real-time
A new strategy using organic nanoparticles evaluates PTT efficiency on tumors in real time, enabling doctors to adjust treatment plans promptly. The approach is based on the correlation between PTT efficiency, Casp3 activity, and near-infrared fluorescence intensity.