Researchers from the University of Warwick developed a computational model predicting drug targets for SARS-CoV-2 by understanding host-based metabolic perturbations. The model highlights glycolysis and oxidative phosphorylation pathways as key targets, with potential connections to amino acid biosynthesis.
The Fiji national vaccine program against pneumonia and rotavirus has reduced morbidity and mortality among children in the country. Morbidity rates for rotavirus diarrhoea fell by 87% in under-fives, while hospital admissions decreased, resulting in a 39% drop in mortality for young children.
Researchers developed a microneedle-based technique to extract dermal interstitial fluid, which could provide valuable information for routine clinical monitoring and diagnostic testing. The study found that ISF contains unique compounds not found in blood samples, offering potential insights into skin exposure to products and pesticides.
Jefferson Science Associates has awarded ten graduate fellowships to doctoral students for the 2020-2021 academic year. The fellowships will support students' advanced studies and research at the Thomas Jefferson National Accelerator Facility.
An international team has made a significant step closer to understanding the genetic information of barley by sequencing and decoding its genome. The research identified twenty highly diverse genotypes with unique structural variations in their chromosomes.
Researchers found that small, community-based reserves in Thailand's Salween River Basin serve as critical refuges for fish diversity. These reserves contain on average 27% more fish species and 124% higher fish density compared to adjacent areas.
Researchers at NUST MISIS develop nanocarbon additive from oil waste to improve aluminum 3D printing properties and create high-quality aerospace composites. The new technology reduces material porosity and increases hardness.
The WRF4-LICOM model shows improved summer mean monsoon rainfall, circulations, and sea surface heat fluxes. Regional air-sea coupling enhances the simulated daily SST-rainfall relationship, offering a more accurate representation of the western North Pacific summer monsoon.
The Borexino Collaboration has directly detected CNO cycle neutrinos in the Sun for the first time, providing conclusive proof of this fusion process. The researchers estimated that CNO neutrinos account for about 1% of the energy produced by the Sun.
Research finds that nanosilver disturbs the metabolism of algae, making their membranes more permeable and reducing photosynthesis. This can have significant impacts on the aquatic food chain and oxygen production. The study uses metabolomics to detect early changes induced by nanoparticles.
Researchers tracked brain activity and pupil dilation of basketball fans watching March Madness games to understand how the brain processes surprise. They found that shifts in brain activity only occurred when the outcome contradicted the fan's current beliefs.
Researchers from SMART and TLL discovered a way to detect shade avoidance syndrome (SAS) in plants within hours using Raman spectroscopy, enabling farmers to intervene timely and improve crop yield. The method can be widely applied across various plant species and crops.
A study led by UCSF researchers found that teens with migraines who started school after 8:30 a.m. experienced an average of 4.8 headache days per month, compared to 7.7 days for those who started earlier. The difference remained significant even when adjusting for risk factors.
New global guidelines suggest exceeding weekly recommended physical activity levels can counter early death risk linked to long periods of sedentary time. The World Health Organization recommends 150-300 minutes of moderate intensity physical activity or 75-150 minutes of vigorous-intensity activity per week.
A new study by UCL researchers used quantum sensing abilities of nanodiamonds to improve the sensitivity of paper-based diagnostic tests, enabling earlier detection of diseases such as HIV. The tests can detect lower viral loads and may be adapted for COVID-19 and other diseases.
Entanglement in waste fishing gear poses a significant threat to Ganges River wildlife, including critically endangered species like the three-striped roofed turtle and Ganges river dolphin. The study highlights the need for recycling systems and awareness-raising initiatives to mitigate plastic pollution.
Researchers at Aarhus University have discovered that a part of the CRISPR-Cas system originated from toxin genes in bacteria and archaea, providing new insights into its evolutionary process. The study reveals an ongoing battle between microorganisms and viruses, with the discovery of anti-CRISPR proteins blocking the immune system.
A study found mitochondrial dysfunction to be a common thread driving damage in astronauts' bodies during extended space travel. Researchers used data from various sources and identified alterations affecting biological function as the key issue.
Researchers at Harvard have developed an ionic forcefield coating that allows nanoparticles to bypass the immune system's first line of defense. In mouse experiments, coated nanoparticles survived longer in the body and reached their target location with increased efficiency.
A new study by Crick researchers reveals that stem cells protect their chromosome ends through a unique t-loop structure, distinct from the TRF2-dependent mechanism in somatic cells. This discovery opens up new questions about the evolution of telomere protection and its implications for premature aging and cancer.
Lauren Greenlee will investigate iron and oxygen atoms using X-ray spectroscopy to improve battery materials and water treatment. The project aims to design catalysts for polymer conversion and recycling, leading to enhanced industrial applications.
A new study examines the 'word-of-machine' effect, where consumer preference for AI recommenders is influenced by the importance of utilitarian versus hedonic attributes. When utilitarian features are emphasized, consumers prefer AI over human assistance, while hedonic features lead to a preference for humans.
The Borexino collaboration has successfully experimentally confirmed the Bethe-Weizsäcker cycle, a crucial component of our Sun's nuclear fusion reactions. This achievement marks a significant breakthrough in understanding solar energy production and neutrino behavior.
Australian researchers discovered a protein that protects kidney cells from 'bystander' damage caused by chemotherapy or radiotherapy. The study found that inhibiting BCL-XL could safely use in laboratory models alone or with other cancer therapies to prevent kidney damage, a common side effect of cancer treatments.
A recent study by researchers at UC Riverside suggests that olfaction may play an important role in motivating mammals to engage in voluntary exercise. The study found genetic differences in the olfactory system between high-runner mice and control lines, which made them perceive smells differently.
Researchers at the University of Gothenburg have discovered a connection between Brachyspira bacteria and IBS, particularly the form causing diarrhea. The study found that Brachyspira was present in 31% of IBS patients, with symptoms often resembling an allergic reaction, sparking hopes for new treatments.
Researchers used high-resolution fossil data to analyze the humerus bone of early tetrapods, finding that they had adaptations indicating some ability to move on land. The study suggests that terrestrial ability coincided with the origin of limbs, providing new insights into the water-to-land transition in vertebrate evolution.
A study found that people who cook with biomass fuels like wood are at risk of suffering considerable damage to their lungs due to breathing in dangerous concentrations of pollutants and bacterial toxins. The researchers also found a smaller subset of biomass users who had very high levels of air trapping and abnormal tissue mechanics.
The study's results provide key insights into the genetic factors behind wheat's adaptability and diversity. The researchers found that chromosome fragments from wild grasses were cross-hybridized with wheat, leading to differences in immune receptors and enabling the crop to adapt to regional climate conditions.
Researchers studied the effects of long-duration space flight on telomere length and DNA damage in a group of 10 astronauts, finding evidence of oxidative stress and individual differences in responses. The study suggests that telomeres may be affected by chronic oxidative stress during spaceflight.
Researchers analyzed soil and sheep feces samples to determine contamination levels of microplastics in Murcia's agricultural soils. They found 100% soil samples contained microplastics, as well as 92% of sheep feces samples, highlighting the ingestion of plastics by livestock.
A study on language aptitude identified key components of language acquisition as cognitive, emotional, and personality-related characteristics. Effective language learning depends on thought process, emotional experience, motivation, and personal traits such as self-esteem and anxiety levels.
Researchers found that space travel can make cellular mitochondria dysfunctional due to changes in gravity, radiation exposure, and other factors. This has significant implications for future space travel and medical science on Earth.
The UC2 system allows users to produce a high-quality microscope at low cost, making it suitable for areas where conventional microscopes are not feasible. The open-source tool also enables researchers to share their knowledge and incorporate it into their work, promoting open science.
A new drug treatment, otilimab, has shown promising results in reducing both inflammation and pain in people with rheumatoid arthritis. In a multicentre trial, patients who received otilimab demonstrated significant improvements in pain scores, while also experiencing reduced tender and swollen joints.
Researchers develop rapid-spray plasma processing technology to produce stable and efficient perovskite solar cells at record-breaking speeds. The new method enables mass production of perovskite modules with high power conversion efficiency and low costs, potentially transforming the solar industry.
A team of scientists found that melting ice sheets in the Northern Hemisphere caused changes in the Antarctic ice sheet, which are thousands of miles away. This study sheds light on how global warming affects ice sheet stability and provides insight into future climate instability.
A new study finds that tiny malfunctioning compartments in neurons, called endosomes, are commonly defective in Alzheimer's patients. Endosomal trafficking disruption is associated with high levels of tau proteins in spinal fluid and blood, making it a promising target for developing therapies.
Researchers found a strong association between diastolic blood pressure before age 50 and brain damage in later life. Controlling diastolic blood pressure in midlife may be crucial for preventing white matter hyperintensities.
Researchers used genome-wide profiling to study the epigenetic landscape of human stem cells, revealing important information about gene regulation. They found differences in chromatin structures between long-term and short-term stem cells, which could improve understanding of cancer cell behavior and stem cell therapy.
Researchers found genetic variation related to placental biology is partly responsible for miscarriage etiopathogenesis. Miscarriage has been linked to health outcomes such as asthma, depression, and irritable bowel syndrome.
Researchers at Vienna University of Technology have developed stable catalysts for water splitting and CO2 reduction by studying atomic surface structures. The team found that specific surface angles can create microscopically small triangular holes that stabilize the material and enhance its effectiveness.
Researchers identified new molecular mechanisms driving late-onset Alzheimer's Disease and a promising therapeutic candidate, ATP6V1A, which improved neuronal function when normalized. The study also found potential broad neuroprotective effects for ATP6V1A.
A study found that narcissists who feel a sense of grandiose superiority share more about their work on social media, feeling more important and admired. This exposure triggers increased narcissistic feelings, especially among communal narcissists who value being helpful.
A new lung-on-chip model has provided insight into the body's response to early tuberculosis infection. The study revealed that alveolar epithelial cells play a crucial role in controlling bacterial growth by producing surfactant, which reduces surface tension and prevents uncontrolled bacterial growth.
Researchers found that the COVID-19 virus can survive on surfaces for hours due to a nanometer-thick liquid film clinging to the surface. This survival time is orders of magnitude longer than typical respiratory droplet drying times, emphasizing the need for frequent disinfection and heating surfaces.
A new study found that young people's anxiety levels increased significantly during the first COVID-19 lockdown, doubling from 13% to 24%, and remained high even after restrictions were eased. The study highlights the need for mental health support and interventions to address emerging inequalities.
Several patients using germicidal lamps developed painful inflammation of the cornea after exposure, prompting warnings from ophthalmologists. Manufacturer recommendations must be closely followed to prevent injury.
A Cornell University project aims to develop worm-like, soil-swimming robots to sense and record soil properties, water, and root growth. The goal is to improve breeding efforts and soil management to increase food productivity and security.
The UC Santa Cruz Genomics Institute is teaming up with No Stomach For Cancer to release a web portal that combines vast amounts of gene variant data with corresponding clinical data. This collaboration aims to advance science and patient survival by identifying individuals at risk of hereditary stomach cancers.
A Canadian team has developed an inexpensive molecule to fight antibiotic-resistant strains of Neisseria gonorrhoeae and N. meningitidis, two bacteria responsible for gonorrhea and meningococcal meningitis. The molecule's specificity allows it to target pathogenic Neisseria while leaving other types unaffected.
A new study finds that Medicaid expansion increases health insurance coverage, ability to see a physician, and foot examinations among patients with diabetes. However, it does not improve follow-up examinations, care, or treatment for diabetes, highlighting the need for additional structural changes.
Scientists create miniscule robots with plastic chassis and magnetic metal wheels, powered by rotating magnetic fields, opening up applications for delivering medications and treating aneurysms.
The Association of Cannabis Specialists (ACS) has named Cannabis and Cannabinoid Research their Official Journal, providing evidence-based education and standards for cannabis medicine. The journal aims to enhance clinical best practices, safeguard patient care, and advance cannabinoid research.
Researchers have observed ideal type-II Weyl points in classical circuits, which exhibit strongly tilted band structures and linear degenerate points. These findings provide a new platform for studying Weyl physics and topological phenomena.
A new study found that consuming dried fruit is linked to better diet quality and health markers, including lower body mass index and waist circumference. However, it's essential to choose unsweetened versions and monitor portion sizes due to the higher calorie content.
A study published by the American Heart Association found that older women who spend more waking hours in sedentary behaviors have an increased risk of heart failure serious enough to require hospitalization. Breaking free from prolonged sitting or lying down can help prevent this serious condition.
An interdisciplinary team analyzed over 600 fossils from 82 archaeological sites in the Iberian Peninsula, revealing common presence at major sites and changes throughout prehistory. The study confirms the need for an interdisciplinary approach to analyze zooarchaeological records and sheds new light on fossil collection practices.
A Cleveland Clinic study shows that bariatric surgery prior to contracting COVID-19 is associated with a lower risk of hospital and ICU admission. Patients who underwent weight-loss surgery had a significantly lower rate of severe illness compared to those without a history of bariatric surgery.
A new poll reveals that while most adults over 50 say they'll get vaccinated against COVID-19, many are hesitant due to concerns about vaccine safety and cost. The poll found that people of color, those with lower incomes or education levels, and older adults are less likely to take the vaccine.