Articles tagged with Cancer Treatments
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Researchers created a deformable nanolipogel-based delivery system for CRISPR knockout of oncogene Lcn2, reducing tumor growth by 77% in human and mouse models. The delivery method shows promise as a precise therapeutic tool for treating triple-negative breast cancer.
Women with breast cancer who experience depression, anxiety, or mental health conditions are more likely to use opioids and have lower survival rates. Researchers recommend alternative pain management options like physical therapy, massage, and acupuncture to improve treatment outcomes.
A clinical trial demonstrates the safety and feasibility of gold-silica nanoshells for treating localized prostate cancer, showing no serious side effects during treatment. The vast majority of treated lesions showed no evidence of tumor after 12 months.
Researchers analyzed the reaction mechanism of PUVA therapy using time-resolved laser spectroscopy. The process involves two stages: initial binding and cyclobutane ring formation, which triggers programmed cell death and destroys diseased cells.
A study published in Acta Neuropathologica Communications found that interregional differences in the somatic genetic landscape of glioblastoma affect prognosis. The research analyzed Japanese patients with IDH-wildtype GBM and discovered a biomarker, triple CNA, associated with survival duration.
A study by Massachusetts General Hospital researchers has found a mutation in the RABL3 gene linked to hereditary forms of pancreatic cancer. The discovery may lead to earlier diagnoses and improved treatments for patients with strong family histories.
Researchers from Bern, Switzerland have been awarded major grants by the US Department of Defense to study new treatments for prostate cancer and develop methods to preserve severed limbs. The projects aim to identify factors driving metastasis and improve survival rates in prostate cancer patients.
A two-step gene therapy treatment has shown promise in treating recurrent glioblastoma by boosting IL-12 production and enhancing antitumor immune cell infiltration. The treatment has also been found to be safe, with serious side effects easily reversible after discontinuing treatment.
Researchers found that DNA methylation patterns can affect the impact of aspirin on mortality in women with breast cancer. Women with certain DNA characteristics who take aspirin before a breast cancer diagnosis may live longer, according to the study published in Cancer journal.
A new AI system developed at UCLA has shown promising results in accurately reading biopsies and diagnosing breast cancer. The system outperformed human pathologists in distinguishing between ductal carcinoma in situ (DCIS) and atypia, a type of abnormal cell associated with higher breast cancer risk.
A study found that chaperone protein Hsp70 inhibits toxic protein aggregates in the androgen receptor, which causes Kennedy's disease and prostate cancer. Hsp70 may be useful as a therapeutic target to treat these conditions.
Adults aged 85 years and older account for the fastest-growing age group in the US, with higher cancer incidence rates but lower screening and treatment rates. The most common cancers among this population are lung, breast, prostate, and colorectum, but late-stage diagnosis and poorer survival outcomes are also reported.
A University of Technology Sydney study found that a micronized mineral compound reduced asbestos-induced cellular damage in cell lines and significantly slowed MM development in mouse models. The discovery offers new hope for treating MM and asbestosis, two incurable diseases.
Scientists at Oregon State University have discovered a protein modification that enables tumor cells to proliferate without harming healthy cells. This finding opens up new avenues for cancer therapies with minimal side effects.
Researchers have described a new treatment that could cope with Heterotopic Ossification and Fibrodysplasia Ossificans Progressiva using a PI3-kinase inhibitor. The study shows promising results in preclinical models, potentially leading to improved treatment options for patients.
A new study has found that elderly cancer patients who are HIV-positive have poorer outcomes compared to those without the virus. The research found higher mortality rates from breast and prostate cancers among HIV-infected patients.
Researchers compared outcomes in patients with and without HIV who received stage-appropriate cancer treatment after a cancer diagnosis at age 65. The study found no significant difference in overall survival between the two groups, suggesting that age alone may not be a determining factor in cancer treatment outcomes.
Scientists have discovered a crucial protective role of Polo-like kinase (PLK1) in guarding against severe DNA damage during cell division. PLK1 is essential for maintaining chromosome rigidity and preventing chromosome rearrangements that can lead to cancers.
A new DNA methylation test has been shown to accurately predict which cases of precancerous cervical disease will become more serious, helping women decide on treatment options. Most women with moderate dysplasia can be safely followed without surgery until their disease resolves.
A team of researchers at Ruhr-Universität Bochum has shown that the supposed disorder in the HMGA1a protein is not disorder after all. The protein adopts dynamic, more compact structures that depend on its phosphorylation state. This discovery could lead to new therapeutic strategies for cancers caused by HMGA1a.
Research from St. Jude Children's Research Hospital found a link between inherited BRCA2 mutations and an increased risk of childhood non-Hodgkin lymphoma. The study analyzed data from 1,380 lymphoma survivors and found that members with BRCA2 mutations were more likely to develop the disease.
Researchers found that antibiotics can reduce the number of cancer cells and diminish cancer in patients with CTCL, a rare type of lymphoma. The study suggests that aggressive antibiotic treatment may inhibit not only the bacteria but also the cancer cells.
Researchers at Kazan Federal University and Fox Chase Cancer Center have developed a safer alternative to existing drainage methods for malignant pleural effusion. The new hydrogel-based approach improved patient outcomes by stalling health deterioration and increasing survival rates by 55% compared to standard therapy.
A new benchmarking study has determined the best analysis tools for identifying errors in a patient's DNA that are responsible for driving disease. GRIDSS was found to be one of the most accurate options, detecting DNA rearrangements with high precision.
PCORI is funding two projects to expand use of PCORI-funded research findings in real-world practice. A $1.4 million project aims to increase lung cancer screening rates, while an $860,000 project seeks to improve care for adolescents with TBI through a self-guided online therapy program.
A global report found that one in three cancer patients struggle to access psychological support, with 34% saying it was not available despite needing it. The survey also identified key areas for improvement, including swift diagnosis, information-sharing, and integrated multidisciplinary care.
Researchers have discovered a potent KRAS inhibitor, BI-2852, that can target both active and inactive forms of the enzyme. The compound has shown promising results in lab assays, paving the way for the development of specific RAS inhibitors for cancer therapy.
A recent study published in CANCER found that the incidence of colorectal cancer in adults under 50 years old has increased in the United States since 1970. Younger adults are diagnosed with more advanced disease, and African American and Hispanic populations have a higher proportion of young onset disease.
A CUNY Graduate School of Public Health and Health Policy professor has received a $2.1 million NIH grant to investigate the connection between the human microbiome and cancer, with the goal of developing more effective treatments.
Researchers at St. Jude Children's Research Hospital have discovered an association between a mutation in the NEU1 gene and fibrotic conditions, including idiopathic pulmonary fibrosis. The study found that mice lacking the Neu1 gene developed muscle atrophy due to excessive connective tissue production.
St. Jude Children's Research Hospital scientists have determined the structure of the minichromosome maintenance complex, a ring-shaped enzyme that plays a central role in DNA replication. The research proposes a rotary mechanism to initiate DNA replication and may help solve one of biology's greatest mysteries.
A researcher at Oregon State University has received a $2.3 million grant to develop an effective treatment for cachexia, a muscle-wasting syndrome that kills up to 30% of cancer patients. The new research aims to preserve muscle mass and reduce death and suffering among patients with various cancers.
Dr. Carlo C. DiClemente, an internationally renowned scientist, will deliver the 11th Annual Jack Mendelson Honorary Lecture at the NIH. His presentation focuses on the necessity of relapse and recycling in recovery from alcohol use disorder using the Transtheoretical Model of behavior change.
A team at Brigham Young University studied how the mechanistic target of rapamycin (mTOR) complex is assembled, revealing its importance in regulating cell growth and survival. The researchers believe that understanding mTOR's assembly process could lead to new cancer therapies and treatments for diabetes.
A study led by Dr. Alliric Willis found that over 25% of low-risk thyroid cancer patients receive unnecessary radioactive iodine ablation treatment, carrying potential long-term risks and financial burdens. Younger patients, men, Hispanic, and Asian individuals are more at risk of overtreatment.
A new study published in the Journal of Cancer reveals significant disparities in triple-negative breast cancer diagnoses among women of color and younger women. The research found that non-Hispanic black women had a 2.3-times higher odds of being diagnosed with triple-negative breast cancer compared to non-Hispanic white women.
A new probe has been developed to help surgeons detect cancer cells during surgery, with the potential to improve surgical outcomes for patients. The probe uses fluorescence imaging and has been published in Chemical Science, a study led by RCSI researchers.
A recent study by Waseda University reveals a decline in federally funded inventions and their technological impact, suggesting a need for a more effective grant review system. Strengthening translational science through targeted initiatives can help bridge the gap between bench-to-bedside research.
A Penn study of over 150,000 men with prostate cancer found that hormone therapy increased the likelihood of developing Alzheimer's disease or dementia. The treatment was associated with a 14% increased risk of Alzheimer's and a 20% increased risk of dementia compared to patients who did not receive hormone therapy.
A study of 154,089 older men diagnosed with prostate cancer found that androgen deprivation therapy increased the likelihood of being diagnosed with Alzheimer disease or dementia. The therapy was associated with a higher risk over an average follow-up period of eight years.
A new report by American Cancer Society researchers calculates that cancer took 8.7 million years of life and $94.4 billion in lost earnings among US residents aged 16 to 84 in 2015. Lung cancer was the leading cause of lost earnings, followed by colorectal, breast, and pancreatic cancers.
A study of 18,805 patients treated with radioactive iodine found a modest association between higher doses and increased risk of solid cancer death, including breast cancer. The analysis has limitations due to uncertainties in organ dose estimates and small sample sizes.
A follow-up study reaffirms the effectiveness of low-dose computed tomography (LDCT) in reducing lung cancer mortality. The research found that LDCT can prevent lung cancer deaths or at least delay them for more than a decade, with only 303 patients needed to be screened to prevent one death.
A 65-year follow-up study of nearly 7,000 Norwegian patients with multiple sclerosis found an overall risk of developing cancer 14% higher than the general population. Respiratory cancer risk was particularly high at 66%, while urinary and central nervous system cancer risks were also significantly increased.
Researchers at Lund University discovered a link between protein DDX3X and MITF gene, which plays a crucial role in melanoma cell aggressiveness. The study's findings suggest that DDX3X levels can predict disease prognosis.
Researchers have discovered that tungsten trioxide can replace barium in X-ray exams and cancer treatments, offering a more effective and safer alternative. The compound's high absorptive capacity makes it suitable for creating a new class of contrast agents.
Researchers used advanced imaging techniques to visualize macrophages in living mice with brain tumors, finding clear morphological and behavioral differences between blood-derived and brain-resident macrophages. Blocking macrophage infiltration improved survival in treated mice.
Researchers developed a urine test called 'PUR' that can diagnose aggressive prostate cancer and predict treatment needs up to five years earlier than standard methods. The test identified men who are up to eight times less likely to require treatment within five years of diagnosis.
A new study found that veterans with PTSD are twice as likely to die from suicide, accidental injury, and viral hepatitis than the general population. The study also identified age-specific mortality risks for veterans with PTSD.
Researchers developed a wearable vest to collect data for personalized therapy in patients with metastatic NETs. The device provides organ-specific measurement recordings within the patient's comfort, allowing for more effective treatment and improved progression-free survival.
Researchers discovered that CA19-9, a complex sugar molecule, causes pancreatitis by recruiting the immune system and inducing deleterious biochemical reactions. Targeting CA19-9 with antibodies may prevent or treat pancreatitis and its progression to pancreatic cancer.
A new report reveals that nearly 5.4 million cancer survivors in the US experience chronic pain, with one in six reporting high-impact pain. The prevalence of chronic pain is significantly higher among certain groups, including those with lower education levels and household income.
A widely recognized biomarker, CA19-9, is found to promote the development of pancreatic diseases and cancer in genetically engineered mice models. This discovery suggests new treatment strategies for pancreatic cancer and other cancer biomarkers.
A new study reveals significant global disparities in cervical cancer rates among women living with HIV, particularly in South Africa and Latin America. The analysis shows that ICC rates are more than double in Latin America and 11 times higher in South Africa compared to European women.
The program, iQuit Mindfully, combines mobile health technology with mindfulness training to provide round-the-clock support for quitting smoking. A 2019 pilot study showed the technology is effective for diverse, underserved adult populations of low socioeconomic status.
The study analyzed images of biopsy samples from patients with neuroblastoma and used Graph Theory to describe the organization of vitronectin fibrils. The results suggest that the degree of organisation correlates with tumour aggressiveness, potentially allowing for patient classification before treatment.
A new study by University of Surrey researchers found that community pharmacy interventions significantly improved physical activity levels and reduced weight, BMI, and cholesterol in men with prostate cancer. These lifestyle changes also led to increased grip strength and better overall fitness.
Despite improvements in cancer treatment for HIV/AIDS-related cancers, adolescents and young adults continue to face disparities in survival rates by race, ethnicity, and socioeconomic status. The study highlights the need for continued research to improve survival rates in this vulnerable age group.
Researchers have developed a comprehensive database of synonymous mutations found in cancer, revealing their influence on cellular functions and disease processes. The SynMIC database contains information on 659,194 entries across 88 types of cancer, providing a valuable resource for cancer researchers.
Researchers discovered that fibrinogen inhibits MMP2, an enzyme important for normal organ development and repair. High levels of fibrinogen may excessively inhibit MMP2, leading to arthritic and cardiac disorders.