Articles tagged with Cancer Treatments
A study by University of Seville researchers identified CD44 as a contributor to neuroblastoma's aggressive nature and metastasis. The findings offer a new therapeutic option for eliminating these cells and improving treatment outcomes for patients with high levels of CD44 in their tumors.
A new study presents a minimally invasive procedure using focused ultrasound to reduce tremors and improve quality of life in patients with Parkinson's disease. The treatment, known as MRgFUS thalamotomy, shows substantial improvement in 95% of patients, with significant reductions in tremor severity and quality of life.
A recent study found significantly lower rates of death from any cause and all cancers combined in Adventist populations, with even lower rates among Black Adventists. The findings suggest that health benefits may be available to all Americans who choose similar diets, such as plant-based eating and regular physical activity.
Researchers at Duke University have developed DNA-based biomolecular reaction networks that can identify cancer cells by analyzing molecular signatures on their surface. The technology distinguishes cell types with higher specificity than previous methods, making it a promising step toward more accurate cancer screenings and therapies.
A US-led study found that anticoagulants for atrial fibrillation lose their effectiveness in older patients due to increased mortality from non-stroke causes. The study of nearly 15,000 AF patients aged 75+ found warfarin and apixaban were not beneficial after age 87 and 92, respectively.
Researchers have discovered that autophagy activity is essential to maintain high mTORC1 activity in cells with mutated genes, and blocking this process can mimic human TSC symptoms. This finding holds promise for developing new therapeutic concepts for treating patients with this devastating disease.
A new study by RAND Corporation outlines the challenges Australia faces in preparing for a possible breakthrough treatment for Alzheimer's disease. The Australian healthcare system lacks sufficient medical specialists, diagnostic scanners, and infusion centers to handle the influx of patients, leading to long wait times and potential u...
Researchers have gained insights into how nanoparticles can be used to identify invasive microbes and deliver targeted treatments, potentially preventing deadly diseases contracted on medical equipment. The study, conducted by Monash University researchers, found that nanoparticles bound to fungal cells but were non-toxic to them.
Researchers found that patients with cardiogenic shock developed malignant arrhythmias, and intense cooling may increase MA incidence. Risk factors included faster temperature decline and lower serum potassium levels during the cooling period.
Acute myeloid leukemia (AML)-M7 is the most aggressive subtype of leukemia affecting children, with a poor prognosis. Research reveals that this disease develops specifically in young patients due to differences in fetal cells, and that targeting surrounding proteins may improve treatments.
A study has developed a method to determine activity in bone marrow, enabling personalized dosimetry. This approach can predict the effectiveness of treatment and prevent bone marrow toxicity.
Researchers developed implantable scaffolds that attract and analyze cancer cells, providing unique information on disease progression. The technology has potential to improve early detection and monitoring of cancer treatments.
Researchers at Michigan State University have developed a new approach to detect and attack cancer cells using light-activated fluorescent dyes. The breakthrough utilizes technology traditionally reserved for solar power, offering promising results in breast, lung, and skin cancer cell lines and mouse models.
Scientists at Newcastle University have made a breakthrough in understanding CYLD cutaneous syndrome, a rare genetic skin disease. Changes in the DNA of tumour cells were identified, which may provide a target for new treatments to inhibit their growth.
A Vanderbilt University study found men with breast cancer have a 19% higher five-year mortality rate than women, attributed to clinical characteristics and undertreatments. The disparity persists even when considering cancer types, access to care, and lifestyle factors like smoking and obesity.
The American Cancer Society has awarded Dr. Dmitry Gabrilovich a $400,000 research professorship to explore the roles of myeloid immune cells in cancer and develop new approaches to target tumor immunity.
Screening for ever-smokers with high lung cancer risk and long life-expectancy can prevent more deaths than current guidelines. A new study suggests using gains in life expectancy as a criterion to select candidates for screening, which could improve the balance of benefits and harms.
Researchers tracked the disruption of gut microbes after antibiotics, finding that some individuals experienced long-term changes to their microbiome. The study used bioinformatic tools to analyze fecal samples from 30 young adults who received single or triple antibiotic treatments.
Bioinformatician Serena Nik-Zainal is awarded the Dr. Josef Steiner Cancer Research Award for her development of new methods to classify tumors using bioinformatics. Her research aims to improve cancer diagnosis and prognosis by making comprehensive computational infrastructure accessible to clinicians.
A new American Cancer Society study links health insurance literacy with medical and non-medical financial hardships among adult cancer survivors. The study found that those with health insurance literacy problems were more likely to report material and psychological hardships, as well as make non-medical financial sacrifices.
A plant-based compound closely related to resveratrol has been found to enhance gene delivery to hematopoietic stem cells, reducing antiviral restriction at endosomes. This breakthrough enables faster and more efficient treatments for diseases such as sickle cell anemia and leukemia.
Researchers at UNIGE identified a protein called S100A9 that regulates blood glucose and lipids, improving glucose management and reducing harmful side effects in diabetic mice. A clinical trial is underway to test the safety and efficacy of this new therapy in humans.
The RESILIENT trial found disease control in 114 out of 126 patients evaluable per protocol and progression-free survival. The study suggests that label-agnostic therapy regimens guided by Encyclopedic Tumor Analysis can offer meaningful clinical benefits for patients with relapsed refractory metastatic malignancies.
A new study published by The Menopause Society finds that fractional CO2 laser therapy is as effective and safe as vaginal estrogen in improving sexual and urinary functionality in postmenopausal women. After 6 months of follow-up, researchers reported similar improvements in symptoms such as vaginal dryness, itching, and burning.
Zachary Schug receives $2,679,000 NIH award to study link between high sugar/fat diet, alcohol use and cancer. He aims to uncover molecular mechanisms underlying this connection and develop novel therapies.
A new analysis of two international clinical trials predicts that benralizumab may be effective for a subpopulation of patients with moderate to very severe COPD who have elevated blood eosinophil counts and a history of frequent exacerbations. The study found no significant efficacy in reducing annual COPD exacerbation rates for patie...
A new study presents promising results from the CheckMate 358 trial, a phase I/II investigational immune-therapy trial combining nivolumab and ipilimumab for recurrent and metastatic cervical cancer. The combination showed higher clinical benefit rates compared to single-agent treatments.
The Blood and Immune Deficiency-Cellular Therapy Program (BID-CTP) integrates expertise from multiple medical specialties to treat rare blood and immune system diseases. Patients with hundreds of different primary immune deficiency diseases can now receive unified care through a single, multi-specialty team.
Researchers found PML dysfunction due to altered protein modification, specifically sumoylation, enables pancreatic tumor resistance to chemotherapeutic treatment. High PML expression and sumoylation are associated with better survival rates in patients.
Researchers created CAR T cells targeting BAFF-R, a surface marker found on B cells and cancerous B cells. This approach showed promise in killing cancer cells that lack CD19, reducing the risk of relapse in patients with lymphoma.
A single-session sleep education program has been shown to cure insomnia in many cancer survivors, according to a new study. Those who don't benefit from this approach are often helped by a more extensive three-session program. The findings suggest a 'stepped care' model can be effective for improving insomnia in cancer survivors.
Researchers propose targeting cancer patients' mindsets to improve their health, functioning, and well-being. They identify specific mindsets that can impact cancer patients' health, such as viewing cancer as manageable or seeing the body as capable and resilient.
Researchers at RMIT University have developed a non-viral gene delivery method that has proven effective in laboratory tests, opening the door to treatment of various genetic diseases. The method uses Metal Organic Frameworks (MOFs) and could significantly reduce the time and expense involved in bringing new treatments to market.
Scientists have made a breakthrough in understanding the construction of mitochondrial ribosomes, also known as mitoribosomes, which are crucial for protein synthesis. The study reveals that these structures undergo multiple assembly steps involving various proteins and machinery.
Researchers found that mitochondrial fission factor is a key regulator of cancer cell survival and proliferation. The protein's interaction with VDAC1 is critical for tumor cell growth, but disrupting this complex can activate mechanisms of mitochondrial cell death.
Markey researchers identify nuclear glycogen's role in cancer progression and find epigenetic connections between glycogen metabolism and gene expression. The study reveals new therapeutic targets to treat non-small cell lung cancers.
Cancer survival in the UK has improved since 1995, with significant increases in one-year and five-year survival rates for various cancers. Despite this progress, the UK still lags behind other high-income countries in cancer survival.
A Brazilian multicenter study found that older hospitalized patients with cancer have a high prevalence of malnutrition, affecting nearly half of the patient population. The study highlights the need for nutritional assessments soon after hospitalization to prevent malnutrition and weight loss.
The American Society for Gastrointestinal Endoscopy has released an updated guideline on screening and surveillance of Barrett's esophagus, aiming to improve patient outcomes. The guideline addresses various endoscopic procedures and technologies used in screening and surveillance, including advanced imaging and sampling modalities.
Scientists created a 3D map of a mouse genome using ultra-deep chromosome conformation capture technology, revealing surprising changes in genomic organization during development. The study used machine learning to gauge how easily accessible genes are for transcription, shedding light on gene regulation and its role in disease.
The European Society for Medical Oncology (ESMO) has announced the winners of its annual awards, recognizing Prof. Eric Van Cutsem's pioneering work in gastrointestinal oncology and Dr. Angelo Di Leo's lifetime achievements in cancer research and education. The ESMO Women for Oncology Award was also presented to Prof. Cristiana Sessa, ...
Scientists have discovered a key protein structure that could lead to the development of treatments for Epstein-Barr virus infections. The portal protein plays a crucial role in the virus's DNA entry and exit mechanisms, and understanding its structure may enable the design of virus-specific inhibitors.
The University of Texas at Arlington has been awarded over $2 million in Cancer Prevention & Research Institute of Texas (CPRIT) grants to support its thriving cancer research initiatives. Dr. Piya Ghose received a $2 million grant for her work on programmed cell death, while Dr. Yaowu Hao received $200,000 to investigate radioactive n...
Research funded by Cancer Research UK found that average monthly cigarette consumption fell by 24.4% based on survey data and 24.1% based on sales data between 2011 and 2018. The decline suggests that stricter tobacco laws and quitting smoking initiatives are working, with current smoking rates at 16% of English adults.
A national survey found that about one-third of middle- and high-school students were exposed to vaping aerosols in 2018, a 30% increase from previous years. The Centers for Disease Control and Prevention reported an alarming rise in second-hand e-cigarette exposure among young people.
The BC2 Basel Computational Biology Conference aims to bridge the gap between Big Data and clinical applications, featuring renowned experts from precision oncology to infectious diseases. Key takeaways include the importance of single-cell data in cancer research and biological big data analysis methods.
Researchers created a deformable nanolipogel-based delivery system for CRISPR knockout of oncogene Lcn2, reducing tumor growth by 77% in human and mouse models. The delivery method shows promise as a precise therapeutic tool for treating triple-negative breast cancer.
Women with breast cancer who experience depression, anxiety, or mental health conditions are more likely to use opioids and have lower survival rates. Researchers recommend alternative pain management options like physical therapy, massage, and acupuncture to improve treatment outcomes.
A clinical trial demonstrates the safety and feasibility of gold-silica nanoshells for treating localized prostate cancer, showing no serious side effects during treatment. The vast majority of treated lesions showed no evidence of tumor after 12 months.
Researchers analyzed the reaction mechanism of PUVA therapy using time-resolved laser spectroscopy. The process involves two stages: initial binding and cyclobutane ring formation, which triggers programmed cell death and destroys diseased cells.
A study published in Acta Neuropathologica Communications found that interregional differences in the somatic genetic landscape of glioblastoma affect prognosis. The research analyzed Japanese patients with IDH-wildtype GBM and discovered a biomarker, triple CNA, associated with survival duration.
A study by Massachusetts General Hospital researchers has found a mutation in the RABL3 gene linked to hereditary forms of pancreatic cancer. The discovery may lead to earlier diagnoses and improved treatments for patients with strong family histories.
Researchers from Bern, Switzerland have been awarded major grants by the US Department of Defense to study new treatments for prostate cancer and develop methods to preserve severed limbs. The projects aim to identify factors driving metastasis and improve survival rates in prostate cancer patients.
A two-step gene therapy treatment has shown promise in treating recurrent glioblastoma by boosting IL-12 production and enhancing antitumor immune cell infiltration. The treatment has also been found to be safe, with serious side effects easily reversible after discontinuing treatment.
Researchers found that DNA methylation patterns can affect the impact of aspirin on mortality in women with breast cancer. Women with certain DNA characteristics who take aspirin before a breast cancer diagnosis may live longer, according to the study published in Cancer journal.
A new AI system developed at UCLA has shown promising results in accurately reading biopsies and diagnosing breast cancer. The system outperformed human pathologists in distinguishing between ductal carcinoma in situ (DCIS) and atypia, a type of abnormal cell associated with higher breast cancer risk.
A study found that chaperone protein Hsp70 inhibits toxic protein aggregates in the androgen receptor, which causes Kennedy's disease and prostate cancer. Hsp70 may be useful as a therapeutic target to treat these conditions.
Adults aged 85 years and older account for the fastest-growing age group in the US, with higher cancer incidence rates but lower screening and treatment rates. The most common cancers among this population are lung, breast, prostate, and colorectum, but late-stage diagnosis and poorer survival outcomes are also reported.
A University of Technology Sydney study found that a micronized mineral compound reduced asbestos-induced cellular damage in cell lines and significantly slowed MM development in mouse models. The discovery offers new hope for treating MM and asbestosis, two incurable diseases.
Scientists at Oregon State University have discovered a protein modification that enables tumor cells to proliferate without harming healthy cells. This finding opens up new avenues for cancer therapies with minimal side effects.