Articles tagged with Cancer Treatments
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A new study reveals that patients with prostate, bladder, or kidney cancers who have had psychiatric care prior to treatment are at a greater risk of dying. The research also found an increased suicide risk among these patients, even after adjusting for previous mental health treatment.
Researchers have found that testosterone replacement therapy reduces prostate cancer recurrence in low-risk patients by nearly three-fold over three years. This study challenges the long-held notion that testosterone promotes prostate cancer and suggests a potential new treatment approach for these patients.
A new diagnostic tool has been developed to detect ovarian cancer earlier, with high sensitivity and specificity rates. The test uses liquid biopsy proteomics to identify unique protein signatures in uterine fluid, promising improved detection rates for young women at high risk of developing the disease.
Research links early menopause to increased bladder cancer risk, particularly in smokers. The study found that women who went into menopause before the age of 45 were 45% more likely to develop bladder cancer than those who had later menopause.
A new study reveals that the development of progenitor cells depends on protein quantity and interaction with other cells. Cells with high P120ctn expression remain in the central part of the pancreas, while those with low expression migrate to the peripheral area, where they acquire their final fate.
Researchers have identified a major mutation pattern in human cancer that occurs in bursts, with the cause of these mutational bursts remaining mysterious. The study, published in Cell, provides a vast resource for investigating the biological mechanisms behind cancer mutations.
A VA study evaluated quality indicators for hormone therapy in menopausal women and found that nearly 40% of prescriptions were inconsistent with evidence-based guidelines. The study suggests that point-of-care information and decision support are needed to ensure patients receive guideline-adherent care.
A diet rich in green tea and carrot compounds reversed Alzheimer's-like symptoms in mice, supporting the idea that plant-based supplements might offer protection against dementia. Combination therapy is suggested as a potential approach to treating the disease.
Researchers at University of Utah Health have developed a novel treatment that delays the onset of type 1 diabetes in mice and halts the progression of paralysis in multiple sclerosis models. The treatment targets misfunctioning immune cells, leaving normal immune cells intact.
The article highlights the challenges in predicting and stratifying cardiovascular risk in women due to sex-specific factors, traditional risk models' flaws, and inadequate representation of women in CVD research. This has led to a persistent gap in awareness, diagnosis, and treatment of ischemic heart disease in women.
Peripartum cardiomyopathy (PPCM) is a disorder where heart failure develops during or after pregnancy. Recent studies suggest angiogenic imbalance plays a key role, with soluble fms-like tyrosine kinase-1 (sFlt1) and prolactin being important factors. The latest IPAC study recommendations are also referenced.
A global modelling study estimates nearly 400,000 new cases of childhood cancer annually, while current records count only around 200,000. Undiagnosed cases could account for more than half of the total in Africa, South Central Asia and the Pacific Islands.
A recent study reports radiation contamination at an Arizona crematorium following treatment of a patient with a radioactive drug. The contamination was detected on equipment and in the operator's urine, raising concerns about potential health effects.
Patients living with HIV have equal access to optimal cancer therapy, according to a recent study in the journal CANCER. The findings challenge traditional beliefs that HIV infection is a contraindication for intensive cancer treatment.
A new sequencing method, TET-assisted pyridine borane sequencing (TAPS), detects chemical modifications to DNA that contribute to cancer progression and resistance to therapy. The method is less damaging and more efficient than bisulfite sequencing, enabling the detection of mutations and structural variations.
A new report emphasizes the importance of transforming healthcare delivery in the US to reduce cancer burden. The study identifies goals for a high-performing healthcare system, including access to primary care, timely evidence-based treatment, and patient-centered care.
Researchers have developed a new compound that shows promise in treating multiple sclerosis by reducing inflammation and promoting neuroprotection and remyelination. The compound, based on chloroindazole, has been found to be effective in improving primary symptoms in a mouse model of the disease.
The UVA Health System is launching a program that uses telehealth to connect primary care providers in Appalachia with specialists to improve lung disease prevention, diagnosis, and treatment. Residents in the region have higher-than-average rates of lung cancer and COPD, and limited access to subspecialty physicians.
A Mayo Clinic study found that patients with a poor immune response to follicular lymphoma exhibited reduced costimulatory receptors on their T-cells, leading to shorter survival rates. The research may lead to the development of new therapies for some patients with follicular lymphoma.
A novel mobile application called MyPath uses AI to provide personalized guidance and support to breast cancer patients in rural Georgia. The app adapts to each stage of a patient's journey, offering relevant resources and suggestions based on their medical data and changing needs.
The report highlights the expanding role of interventional inflammatory bowel disease (IBD) endoscopy in managing complex conditions, such as strictures, fistulas, and colitis-associated neoplasia. This approach can help reduce or postpone surgical resection and treat postoperative adverse events.
Researchers at St. Jude Children's Research Hospital developed a method to customize and reduce drug interaction alerts in electronic health records. The study made 26 changes that affected 47% of alerts, resulting in a 40% decrease in alert overrides.
Researchers at University of Toledo have developed a mouse model that spontaneously develops type I diabetes and its complications, allowing for study of disease progression. The breakthrough has the potential to reshape how type I diabetes is studied and may lead to new treatments or a cure.
Researchers found that obstructive sleep apnea promotes a persistent low-intensity inflammatory state, damaging organs. This link could lead to more precise treatments, such as vitamin C or plant-derived antioxidants, to reverse inflammation and protect the body from future damage.
A large study found that direct-acting antiviral treatment is associated with reduced risk of mortality and hepatocellular cancer, but not decompensation of cirrhosis. Patients treated with direct-acting antivirals were 52% less likely to die prematurely than those who were untreated.
New DNA-based nanomachines can selectively target malignant cells, breaking down vital genes and inducing apoptotic death. The design allows for better interaction with folded RNA molecules, but further experiments are needed to improve specificity.
Researchers found that prostate cancer cells absorb fatty acids, increasing tumor growth, and blocking this process slows cancer development. The study suggests a possible therapeutic target for treating prostate cancer, particularly for men with aggressive disease.
Researchers discovered a novel metabolic pathway in cancer cells that produces an unusual fatty acid, sapienate, allowing them to bypass fatty acid metabolism inhibition. This finding can explain the resistance of certain cancer types to therapy and opens new avenues for targeted treatment.
A research team at Tokyo Medical and Dental University classified hepatocellular carcinoma into three distinct subgroups based on mutation patterns, gene expression, and immune system characterization. The findings suggest that each subgroup has a unique clinical profile, enabling targeted treatment approaches.
Researchers created a lab model of a blood vessel to study angiogenesis, revealing how the molecule EGFL7 influences blood vessel sprouting and integrity. The study suggests EGFL7 as a potential therapeutic target for diseases like retinopathy and cancer.
Researchers discovered 27 new molecules with significant therapeutic potential for treating fatty liver disease and obesity by activating the PPAR-delta protein. These molecules are currently undergoing pharmaceutical evaluations and show promise in improving physical endurance and reducing waistlines.
A new 3D imaging technique has revealed that pancreatic cancers can develop in two distinct types - 'endophytic' and 'exophytic' - depending on the size of the duct. This breakthrough may lead to improved treatments for pancreatic cancers by better understanding how cancer grows.
A new assay accurately measures TNF concentrations during adalimumab treatment, revealing that circulating TNF levels increase 50-fold before stabilizing. Lower TNF concentrations after the fourth week are associated with more antibodies against the drug and a lower chance of remission.
Researchers found that stroke risk factors increased by tripling the likelihood of a stroke within 10 years, with hormonal treatment and racial differences also playing a role. The study calls for targeted interventions to reduce stroke risk among post-menopausal breast cancer survivors.
Researchers engineered a virus that selectively targets and kills cancer cells, surpassing another viral treatment currently in use. The modified adenovirus, dl355, replicates more efficiently in cancer cells than normal cells, resulting in higher cancer cell kill rates.
A recent study published in Nicotine & Tobacco Research found that female smokers experience more stress and craving after viewing cellphone-delivered stress-inducing images than male smokers. This suggests that improving quit outcomes in women may require gender-specific cessation strategies. Researchers hope to use the data from this...
The National University of Singapore engineers have developed a novel bottom-up synthesis strategy to consistently construct TMD QDs of specific size, offering a cheaper and more scalable method. The synthesized MoS2 QDs demonstrate potential biomedical applications, including photodynamic therapy for cancer treatment.
The debate centers on renaming ultra-low risk cancers to avoid unnecessary investigations and treatments. Experts recommend recalibrating thresholds for cancer diagnosis to categorize very low risk cancers as benign, reducing anxiety and improving patient outcomes.
A new study reveals that cancer survivors experience greater financial burdens compared to non-cancer individuals, with younger survivors facing the most hardship. Privately insured cancer survivors with high deductible health plans without health savings accounts were particularly vulnerable to medical financial hardship.
Charité is leading three new EU-funded projects: ReSHAPE, VirtualBrainCloud, and ENDOSCAPE. The ReSHAPE project aims to develop a treatment for transplant rejection using regulatory T cells, while VirtualBrainCloud creates personalized brain simulations for neurodegenerative diseases. ENDOSCOPE develops non-viral gene delivery technolo...
Researchers conducted a randomized study involving 73 adults with mild to moderate active ulcerative colitis, finding that pooled donor FMT induced remission in 32% of patients, compared to 9% with placebo. The study used anaerobically processed stool to preserve bacteria, which survived and administered to patients.
Researchers at Sanford Burnham Prebys Medical Discovery Institute have found that muscle stem cells can give rise to cancer in DMD patients. The study identified two genes linked to the tumor's growth and suggests that treatments targeting muscle stem cells should consider potential cancer risk.
A recent study analyzed over 8,000 human tumors and discovered common molecular hallmarks of low oxygen levels, which can predict cancer aggressiveness and inform treatment decisions. The findings provide new insights into the complex relationship between hypoxia, genetic changes, and tumor evolution.
Scientists have identified a novel step in gene expression that controls the expression of genes crucial for breast cancer cell growth and tumour progression. The discovery highlights a specific modification allowing RNA polymerase II to overcome a pausing barrier, enabling the transcription of proliferation genes.
A study published in Cancer Cell found that Tinagl1, a protein-based therapy, reduced the spread of triple-negative breast cancer in mice by blocking two main pathways. The treatment is based on a naturally occurring protein and has been shown to be effective even after tumors have begun to metastasize.
Researchers developed two machine learning models to predict cancer patients' symptoms like depression, anxiety, and sleep disturbance. The models accurately predicted the severity of these symptoms throughout treatment, suggesting a potential improvement in quality of life for cancer patients.
Connexin43 is a widely distributed gap junction protein involved in myocardium disease and tumor migration. Understanding its role in these processes can provide insight into new therapeutic options for cancer and myocardial disease diagnosis and therapy.
A recent study suggests that black men diagnosed with low-risk prostate cancer (Gleason score 6) may have a more aggressive form of the disease, leading to higher mortality rates compared to non-black men. The research found a significant disparity in prostate cancer death rates between black and non-black patients with Gleason 6 cancers.
Researchers at CNIO and Hospital 12 de Octubre have discovered a potential new combination therapy for myelofibrosis, a severe haematological disease. The three-drug combination of nilotinib, prednisone, and ruxolitinib enhances the treatment's effectiveness by potentiating each other's benefits.
Researchers developed a computer model predicting prostate cancer progression using tumor genomes from nearly 300 patients. This enables clinicians to develop tailor-made treatments, potentially improving patient outcomes.
Researchers have revealed the brain mechanism behind the uncontrollable itch-scratching cycle. A small subset of neurons in the periaqueductal gray region tracks itch-evoked scratching behavior. The study provides a starting point to decipher how itch is processed and modulated in the brain.
A 29-year study found that only 12% of men with advanced prostate cancer were saved from dying by surgery, while 80% had died after 29 years. Surgery did extend life expectancy by 2.9 years, but also came with significant side effects.
A phase I/II trial found that combining nab-paclitaxel with gemcitabine significantly improved survival rates even among patients with reduced health status. The study's results suggest alternative treatment options for patients typically underrepresented in clinical trials.
A new study by University of Plymouth researchers has identified Prominin-1, a protein that plays a crucial role in stem cell activation and differentiation. The discovery highlights Prominin-1 as a potential therapeutic target for treating cancer and regenerating damaged tissues.
PSMA-targeted PET/MRI performs equally well as clinical nomograms to determine risk for advanced disease in high-risk prostate cancer patients, providing valuable information for treatment planning. The study results show whole-body imaging with 68Ga-PSMA-11 PET/MRI offers a one-stop shop for staging and guiding treatment options.
A new study found that young women with hormone receptor-positive luminal A breast cancer have a lower five-year disease-free survival rate compared to older patients. The study's authors hope their findings can inform better treatment options for this age group.
Researchers have discovered a higher risk of cervical cancer in women whose cervical cells test positive for certain high-risk human papillomavirus types but do not show any signs of cellular abnormalities. A total of 96 cases were found to develop pre-cancerous changes and 4 cervical cancers during the 9-year follow-up period.
Researchers from Charité - Universitätsmedizin Berlin studied genetic factors behind different tumor subtypes and their prognoses. They found that telomere maintenance mechanisms play a crucial role in the development of malignant tumors, enabling precise predictions of disease prognosis.
Advanced breast cancer patients with detectable PIK3CA mutations in their blood show improved progression-free survival when treated with alpelisib added to fulvestrant. Liquid biopsy analysis reveals a 45% risk reduction compared to tissue biopsy.
A new study identifies key molecular features that predict clinical outcomes in neuroblastoma patients. The research suggests a molecular classification scheme to select the best treatment for each patient, with tumors lacking telomere maintenance mechanisms considered low-risk and those with these features deemed higher-risk.