Research on new and better ways to treat cancer. Covers radiotherapy, targeted microdroplets, nerve-injury protection, drug combinations, and tumor models.
Researchers found that people with depression have impaired mood homeostasis, which can be improved through targeted interventions. The study suggests that training individuals to regulate their mood through daily activities could prevent or better treat depression.
A study found that using family history-based guidelines to identify individuals for early screening could help detect young-onset colorectal cancer. Researchers analyzed data from adults with and without colorectal cancer and estimated the potential impact of these guidelines on early detection and prevention.
A new grant aims to gather evidence on the safest pulse rate for pediatric swallow studies, ensuring both safety and diagnostic accuracy. Research shows that developing cells in children are more susceptible to radiation than mature ones.
Researchers developed a new method to separate extracellular vesicles from urine with high purity, revealing protein signatures specific to urological cancers. This breakthrough brings us closer to developing promising new urine tests for faster diagnosis and timely treatment of urological cancers.
Caspase-6 plays a critical role in regulating the ZBP1-NLRP3 inflammasome, facilitating PANoptosis during viral infection. Modulation of caspase-6 could be beneficial for treating viral diseases like influenza and other inflammatory diseases including cancer.
Researchers have discovered a way to trigger heart cell regeneration using the overactive Myc gene, offering a potential first curative treatment for heart disease. The breakthrough involves targeting a specific protein, Cyclin T1, which enables the cells to replicate and regenerate.
A new study has identified a potent Nrf2 inhibitor, triptolide, as a promising therapeutic approach for IDH1-mutated glioma. The research reveals that disrupting the glutathione synthesis pathway establishes synergistic lethality with a neomorphic IDH1 mutation.
Pulsed electromagnetic field therapy significantly decreases prostate volume and improves lower urinary tract symptoms in men with benign prostatic hyperplasia. Men without metabolic syndrome benefit most from the treatment.
A new prognostic tool called IPS-E predicts how long CLL patients can wait before starting treatment, helping alleviate frustration and improve decision making. The tool is based on three widely available tests and categorizes patients into low, intermediate, or high risk of needing treatment within five years.
A new therapy targeting Gaucher disease has been discovered using nanovesicles, which can selectively target brain tissue and deliver enzyme replacement therapy without harming healthy cells. This approach shows promise in treating other neurologic conditions like Parkinson's disease.
A systematic review and meta-analysis of prospective studies found that consuming a diet high in fiber was associated with a reduced incidence of breast cancer. The findings suggest that soluble fiber and higher total fiber intake are linked to lower risks of breast cancer, particularly in premenopausal and postmenopausal women.
Researchers create a radiotracer labelled with the fluorine isotope 18F, enabling visualization of special transport proteins often found in cancer cells. The new compound has a relatively short half-life of 110 minutes and can be produced automatically.
A case study suggests that tocilizumab may effectively address severe COVID-19 symptoms in patients with multiple myeloma and other blood cancers. The patient's IL-6 levels decreased aftertocilizumab treatment, and his symptoms resolved.
Researchers at UCI found that depriving colon cancer cells of glutamine causes them to adapt and become more invasive, but a modified version of the metabolite alpha-ketoglutarate inhibits key signaling pathways and curbs tumor growth
Researchers at Nagoya University's ITbM discovered two new compounds that target specific components of the circadian clock. KL101 and TH301 lengthen the period of the circadian clock and are expected to provide a promising foundation for treating obesity.
Researchers at St. Jude Children's Research Hospital discovered a novel predisposition gene, ELP1, in the SHH subgroup of pediatric medulloblastoma, affecting 40% of cases. The study found that patients with this mutation tend to do well on therapy and may benefit from tailored treatment in the future.
Scientists at St. Jude Children's Research Hospital have identified the ABCC4 transporter as critical to the SHH signaling pathway in medulloblastoma. Targeting this transporter shows promise for treating this disease, with increased expression correlating to poor overall survival.
A phase 3 clinical trial found that oral octreotide capsules effectively control symptoms of acromegaly in adults without pain or lost workdays. The treatment has the potential to expand options for patients beyond injectables.
Researchers at Moffitt Cancer Center identified potential therapeutic targets for cutaneous squamous cell carcinoma by studying the activity of protein TAp63 and microRNAs. The study found that miR-30c-2* and miR-497, which are normally expressed in normal skin, are underexpressed in cuSCC tumors and inhibit growth when reintroduced.
Cervical cancer screening rates dropped by over 3% in four areas of Miyagi Prefecture after the 2011 Great East Japan Earthquake, with rates still lower five years later. Long-term monitoring is needed to restore screening rates in affected areas.
A new study found increasing global rates of liver cancer, particularly in people aged 30-59 years and 60 years and older, as well as a notable increase in men. The research, published in the journal Cancer, also revealed that hepatitis B vaccinations and obesity are associated with decreased rates of liver cancer in younger adults.
The study discovered a link between the amount of DESNT subtype cells in a tumor sample and disease progression. The findings also identified three new subtypes of prostate cancer that could be used to stratify patients for different treatments.
Researchers found that plasma monitoring by RT-PCR-based EGFR mutation test can rapidly identify NSCLC patients resistant to osimertinib treatment due to different types of mutations. The study suggests that fluctuating levels of EGFR sensitizing mutations in plasma reflect tumor burden.
A recent study reveals that the loss of protein MCL1 can drive cancer formation in the intestine, even without bacterial-driven inflammation. The research found that mice lacking MCL1 developed tumors and intestinal damage, similar to human cases with chronic intestinal inflammation.
Researchers redefine Non-Alcoholic Fatty Liver Disease (NAFLD) as Metabolic Associated Fatty Liver Disease (MAFLD), a condition characterized by liver fat build-up affecting over 1 billion people. The new definition aims to improve treatment pathways, trial design, and drug development for this disease.
Researchers have uncovered the intricate details of interleukin-2's interactions with receptor molecules, providing a blueprint for more targeted therapies. The study shows how IL-2 can act as either a throttle or a brake on the immune response in different contexts.
Researchers at Princeton University identified key factors essential for chronic hepatitis B infection. The study found that five human proteins are necessary for the repair process of HBV DNA, and targeting these factors could potentially prevent the infection.
Researchers at UCL have developed a new test to identify the earliest genetic changes of prostate cancer in blood plasma. The process, known as DNA methylation, uses Next Generation Sequencing (NGS) to establish if prostate cancer DNA is present in blood plasma.
A study published in Cancer Epidemiology, Biomarkers & Prevention found that young women with breast cancer experience substantial financial difficulties after diagnosis, even if they have stable jobs and insurance coverage. The study highlights the need for better financial planning and awareness of the costs associated with cancer care.
Establishing an inducible BCL6 knock-out model allows studying the phenotype of BCL6 loss in DLBCL xenografts in vivo. The study demonstrates significant tumor growth inhibition and initial tumor stasis followed by slow tumor growth kinetics upon treatment with BCL6 degraders.
A novel cause of fatty liver disease has been discovered in lean individuals undergoing immune checkpoint blockade therapy. Researchers report a case of a woman who experienced severe inflammation of her subcutaneous fat and developed nonalcoholic fatty liver disease after treatment with the PD-1 inhibitor Nivolumab.
A new study found improvements in five-year survival rates for all cancers in young adults, with some cancer types showing little to no improvement since the 1970s. Treatment advances have led to steady improvements in estimated survival rates among adolescents and young adults.
A recent study has found that the five-year survival rate for adolescents and young adults with certain types of cancer has improved substantially over the past three decades. Leukemia and non-Hodgkin lymphoma have seen significant declines in mortality rates, with improvements ranging from 20-30 percentage points between 1975 and 2005.
A systematic evidence review by OHSU researchers found that new direct-acting antiviral therapies are highly effective in eliminating the Hepatitis C virus infection. The review informed a new recommendation for universal screening of Hepatitis C, with the therapy being more than 95% effective even in young people.
A recent study published in BMC Cancer found that nearly two-thirds of women diagnosed with breast cancer experience significant weight gain, with the majority gaining over 20 kilograms. The study highlights the importance of early intervention and management strategies to prevent weight-related issues after a breast cancer diagnosis.
African American cancer survivors who engage in regular physical activity report higher health-related quality of life and lower depression. The study found that increases in physical activity correlated with improvements in quality of life.
A new study from the University of Gothenburg shows that bariatric surgery is as effective for individuals who developed obesity early in life as it is for those who developed it later. The study found no difference in weight loss or obesity-related complications between the two groups.
A study of over 925,000 adults with new cancer diagnoses found that Medicaid expansion improved insurance status, led to earlier cancer stage detection, and resulted in timely treatment. The findings suggest a positive association between Medicaid expansion and cancer care outcomes.
Researchers compared treatment and survival rates between African American and white women with mammography-detected triple-negative breast cancer. African American women have a higher rate of death from breast cancer, likely due to the aggressive nature of this type of breast cancer.
Researchers found that white patients received earlier treatment and had better survival rates than black patients, with hospitals having a significant impact on outcomes. The study suggests structural issues at the hospital level influence differences in cancer outcomes across racial groups.
Researchers at Stanford University have developed a CRISPR-Cas tool that can detect and debug faulty genetic circuits, facilitating more precise treatments for diseases like cancer. The technology allows for greater precision in identifying and eliminating diseased cells, with potential applications beyond cancer treatment.
Researchers found a genetic variant associated with aggressive disease and shorter survival in men with metastatic prostate cancer. Genetic testing for the HSD3B1(1245C) variant may help identify patients most likely to benefit from additional treatment.
Researchers at ORNL developed a multitask convolutional neural network to extract key information from cancer pathology reports. The AI tool can complete multiple tasks simultaneously, reducing processing time by an average of five times compared to single-task models.
Researchers at Huntsman Cancer Institute have identified a critical protein called ETV4 that promotes estrogen signaling in endometrial cancer cells. By removing ETV4, tumor growth can be significantly reduced, offering new avenues for treatment development.
A novel vaccine called Triplex reduced CMV complications by half and induced immunity in patients undergoing allogeneic hematopoietic stem cell transplant. No vaccine-associated safety concerns were identified in the phase 2 randomized clinical trial.
The MSTARS consortium aims to further develop mass spectrometry technology for clinical application and detection of treatment resistance in various diseases. By combining expertise in mass spectrometry, patient care, and data analysis, the team hopes to improve precision medicine and tailor treatments to individual patients.
Researchers at University of Tsukuba found that tumor cells produce a protein called soluble CD155 to disable the immune system in mice. Soluble CD155 prevents NK cells from releasing toxic proteins to cancer cells by binding to DNAM-1, allowing tumors to grow and spread.
A new method for detecting circulating tumour cells (CTCs) has been developed to improve the monitoring of cancer patients. This approach increases detection rates from 40-87% to 72%, offering a new avenue for cancer diagnosis and therapies.
A new synthetic biology toolkit called COMET allows researchers to design and tune gene expression programs in mammalian cells with unprecedented precision. This breakthrough could lead to the development of novel cell-based therapies for cancer and other challenging diseases.
Researchers at St. Jude Children's Research Hospital are exploring genetically engineered immune cells to attack pediatric sarcoma using a new ACGT grant. The approach aims to target not only cancer cells but also blood vessels supporting tumor growth, offering a promising new treatment for children with solid tumors.
A team of researchers has begun a doctor-initiated clinical trial for a new cell spray treatment method targeting heart failure. The product, ADR-002K, uses a spraying technique to administer mesenchymal stem cells onto the heart, aiming to improve prognosis and cardiac function in patients with ischemic cardiomyopathy.
A new method to monitor residual disease after treatment in high-risk neuroblastoma patients has been developed using droplet digital PCR. This method enables precise monitoring of minimal residual disease and early diagnosis of tumor relapse/regrowth, leading to improved patient prognoses.
A new study suggests that targeting Hsp47 could block cancer cell-platelet interaction and inhibit metastasis in triple-negative breast cancer patients. The protein is often amplified in the genes of metastatic breast cancer tissue, potentially serving as a biomarker for metastasis.
Researchers used the Pan-Cancer dataset to classify structural variations in cancer genomes and link them to mechanisms of formation. They identified complex processes that can lead to cancer genes becoming active, and developed methods to identify these variations.
This study reveals that chromothripsis is common across multiple types of cancer, with frequencies greater than 50% in some tumours. The research demonstrates how chromothripsis shapes the tumour genome, leading to oncogene amplification and loss of tumour suppressor genes.
A study of over 2,500 tumor genomes reveals that most cancer cells use alternative mechanisms to lengthen their telomeres, increasing their lifespan. The researchers discovered unique variations in these telomere sequences and their integration into the genome, which may hold clues for developing targeted treatments.
The European Society of Human Reproduction and Embryology has found substantial variations in the legal and funding framework of 43 European countries regarding assisted reproduction. Access to treatment, third-party donation, fertility preservation, and public funding vary significantly among countries.
Researchers at Michigan State University developed a new method to detect protein density in blood plasma using magnetic levitation. This technique could lead to improved disease diagnosis and treatment by identifying distinct patterns of proteins associated with various health conditions, such as opioid abuse and multiple sclerosis.
A study published in Clinical Cancer Research found that circulating tumor cells were associated with a decrease in relapse-free survival at six months, and this association persisted at a 54-month longer-term follow-up. This suggests that CTC assessment may be useful in identifying patients at risk for relapse who could benefit from m...
Two studies published in The Lancet conclude that cervical cancer could be eliminated worldwide by the next century, with North America expected to see almost complete eradication by 2040. High vaccination coverage and high uptake of screening and treatment are key to achieving this goal.