Research on new and better ways to treat cancer. Covers radiotherapy, targeted microdroplets, nerve-injury protection, drug combinations, and tumor models.
Two new studies quantify the potential for eliminating cervical cancer in 78 low-income and lower-middle income countries, proposing measures to avert 74 million cases and 62 million deaths over the next century. The proposed triple intervention strategy of HPV vaccination, cervical screening, and treatment could reduce mortality by up...
Magnetic nanostructures show promise in biomedical applications, including cell separation and targeted cancer treatment. High tumor cell death rates were observed with weak magnetic fields, suggesting a strong mechanical force that destroys tumor cells.
Bowel cancer screening tests can miss patients due to NHS staff shortages, particularly in England where lower haemoglobin levels warrant further investigation. Cancer Research UK calls for significant investment to train and recruit more staff to diagnose patients earlier.
A study published in the British Journal of General Practice found an increase in shortness of breath and cough as the first symptoms reported by patients diagnosed with lung cancer. This suggests earlier detection, possibly due to awareness campaigns.
Researchers have discovered a link between a metabolic system in yeast and mammals that regulates cell growth and proliferation. The study found that cancer cells can override sensing systems to maintain uncontrolled proliferation, but disrupting this mechanism can suppress cell growth.
A recent study published in PNAS reveals that extracellular matrix protein-1 (ECM1) plays a crucial role in the pathogenesis of ulcerative colitis, a type of inflammatory bowel disease. The researchers found that ECM1 is highly expressed in macrophages and regulates their polarization through the GM-CSF/STAT5 signaling pathway.
A novel pharmacological chaperone has been shown to restore levels of the sorting molecule VPS35 and prevent the accumulation of abnormal proteins in mice with Alzheimer's disease. This treatment approach has been proven to improve memory and learning, reducing tau tangles and amyloid-beta plaques.
Researchers developed a new technique to predict which primary melanoma patients are at risk for cancer recurrence and spread by analyzing T-cell fraction in skin lesions. Patients with lower T-cell fraction (less than 20%) were found to be 2.5 times more likely to have cancer metastasize.
Researchers have found that an exosome treatment can promote full recovery in swine with severe stroke, even in cases where brain cells are at risk of dying. The treatment works by interrupting the process of cell death and reducing damage signals throughout the brain network.
Rutgers researchers found that online educational videos boost cancer knowledge and awareness among viewers, leading to increased behavioral changes such as self-skin inspections and lung cancer screening. The study highlights the potential of digital health videos to reach disadvantaged populations and improve health outcomes.
Research shows that HPV-negative oropharynx cancer patients are at a significantly higher risk of dying from any cause within two years. In contrast, HPV-positive patients have a lower risk of dying from head and neck cancer and other types of cancer.
Researchers in Dresden aim to develop chemical circuits for the diagnosis and treatment of acute myeloid leukaemia using chemo-fluidic technology. The project seeks to create integrated systems that can analyze hundreds or thousands of individual human cells simultaneously, potentially leading to improved therapy options.
The study found that cerebrospinal fluid from LMM patients contains proteins critical to melanoma cell survival and growth, including TGF-β1. The researchers hope their data will provide insights into potential therapeutic targets for delayed disease progression.
A study at UT Southwestern Medical Center found that patients who received Mohs surgery for melanoma reported a 95% long-term satisfaction rate with their results. The highly precise excision technique resulted in minimal scarring and a nearly 99% cure rate for early melanoma.
In 2020, prostate cancer will claim the most diagnoses among male cancers, with a 21% share of new cases. Early detection is crucial, but screening's benefits are disputed by some, leading to fewer men taking proactive steps towards their health.
A Cornell study identifies a key pathway in gastric SCJ cancers that provides a promising target for future study and therapy. Large pools of immature Lgr5-CD44+ cells, rather than Lgr5+ stem cells, promote cancer in areas where two stomach tissues meet.
Researchers at Uppsala University used a computer algorithm to identify a promising new treatment for neuroblastoma, a form of childhood cancer. The new treatment targets the CNR2 receptor protein, which was discovered using massive amounts of genetic and pharmacological data.
A study from UT Southwestern Medical Center found that individualized physical therapy can effectively reduce urinary incontinence and pain in men after prostate surgery. The approach focuses on relaxing tight pelvic muscles rather than strengthening weak ones, leading to improved outcomes for 87% of patients.
A Hebrew University research team has discovered a potential link between the BCG vaccine and reduced Alzheimer's disease risk in cancer patients. The study found that those who received the BCG vaccine had significantly lower rates of developing Alzheimer's compared to those who did not.
Researchers at Penn Medicine used MRI scans to characterize tumor heterogeneity and predict 10-year breast cancer recurrence. High tumor heterogeneity was found to be a strong predictor of recurrence in patients with primary invasive breast cancer.
Scientists at University of Helsinki and Institut Jacques Monod have identified a molecular machinery that drives rapid depolymerisation of actin filaments and recycles resulting monomers. This discovery provides new avenues for developing therapeutics to inhibit cancer cell migration.
Researchers discovered a key factor, USF1, that inhibits p53 activity, promoting gastric cancer development. USF1 levels can indicate poor prognosis and help identify patients at higher risk of severe forms of gastric cancer.
A new study found that people who presented to California emergency departments with deliberate self-harm had a suicide rate 56.8 times higher than demographically similar Californians. Patients with suicidal ideation had a suicide rate 31.4 times higher, reinforcing the need for universal screening and follow-up care.
The American College of Medical Genetics and Genomics recommends evaluating breast cancer patients for genetic testing based on existing clinical criteria. Genetic testing should include full gene sequencing and be conducted in a lab certified by the College of American Pathologists or Clinical Laboratory Improvement Amendments.
Biomedical engineers at Duke University have created a system that allows real-time observations of individual cells in the colon of a living mouse. This breakthrough enables researchers to study the digestive system's microbiome, inflammatory bowel disease, and colon cancer, as well as explore potential treatments for gastrointestinal...
Researchers developed a photoacoustic (PA) thermometry system for HIFU treatment guidance, enabling real-time monitoring of temperature increase at tumors during treatment. The system allows for simultaneous ultrasound imaging, PA imaging, and PA thermometry, enhancing the accuracy and safety of HIFU treatments.
Researchers integrated genomic and transcriptomic sequencing to classify AML and MDS into distinct biologic subgroups. This new understanding may lead to personalized treatment approaches, improving patient outcomes.
A new study published in British Journal of Cancer has identified the protein stathmin as a crucial player in the spread of neuroblastoma. Stathmin helps regulate PTPN14 expression, affecting migration and invasion of neuroblastoma cells.
Scientists have uncovered key regulatory candidate genes for hypericin biosynthesis in St. John's Wort, a plant with medicinal properties. The study provides unprecedented insight into the development of dark glands and associated biosynthetic pathways.
Researchers have developed a nanopipette pH biosensor that can detect changes in extracellular pH with high sensitivity and spatial resolution. The device uses a zwitterionic membrane to enable faster responses and has been tested on live cancer cells, showing its potential for cancer diagnosis, prognosis, and targeted therapies.
A new study found wide variations in surgery rates for early-stage lung cancer across US counties, with socioeconomic and healthcare delivery factors contributing to the gap. Counties with higher poverty rates, non-Hispanic black populations, and lower surgeon-to-population ratios had lower surgery rates.
A study found that cancer treatments in HIV patients were linked to decreased immune system health (lower CD4 counts) and higher mortality rates. Nearly 200 patients with both conditions were analyzed, providing valuable insights into the effects of cancer treatment on individuals with HIV.
A study found that a specific protein, ARID1A, is linked to aggressive cholangiocarcinoma (ICC) and poor patient outcomes. The researchers identified ARID1A as a potential biomarker for predicting ICC prognosis, which could lead to more effective treatments.
A multi-centre trial led by McMaster researchers found that accelerated partial breast irradiation (APBI) is as effective as whole breast radiation in reducing breast cancer recurrence, with similar recurrence rates after one week of treatment. However, APBI was associated with higher late toxic effects and worse cosmetic outcomes.
The American Cancer Society and Flatiron Health are launching a grant program to support patient-centric research using real-world oncology datasets. Up to $225,000 will be awarded to researchers studying topics such as healthcare disparities, clinical guidelines, and treatment effectiveness.
A new study found that depression affects approximately one-third of newly diagnosed lung cancer patients, leading to severe symptoms such as pain, hopelessness, and impaired day-to-day functioning.
A new study finds that married couples with multiple chronic conditions experience rising depression symptoms, with husbands faring worse when their conditions differ from their wives. The study highlights the importance of recognizing and addressing these dynamics to maintain mental and physical health.
A new study suggests that retelling their story through photography can significantly increase self-esteem and self-efficacy in young cancer survivors. The Framed Portrait Experience intervention integrates therapeutic photography and re-enactment therapy to empower participants to express emotions connected to their illness.
A new home urine test has shown to accurately diagnose aggressive prostate cancer and predict treatment needs up to five years earlier than standard clinical methods. The 'PUR' test looks at gene expression in urine samples and provides vital information about tumor aggressiveness.
A study by University of Seville researchers identified CD44 as a contributor to neuroblastoma's aggressive nature and metastasis. The findings offer a new therapeutic option for eliminating these cells and improving treatment outcomes for patients with high levels of CD44 in their tumors.
A new study presents a minimally invasive procedure using focused ultrasound to reduce tremors and improve quality of life in patients with Parkinson's disease. The treatment, known as MRgFUS thalamotomy, shows substantial improvement in 95% of patients, with significant reductions in tremor severity and quality of life.
A recent study found significantly lower rates of death from any cause and all cancers combined in Adventist populations, with even lower rates among Black Adventists. The findings suggest that health benefits may be available to all Americans who choose similar diets, such as plant-based eating and regular physical activity.
Researchers at Duke University have developed DNA-based biomolecular reaction networks that can identify cancer cells by analyzing molecular signatures on their surface. The technology distinguishes cell types with higher specificity than previous methods, making it a promising step toward more accurate cancer screenings and therapies.
A US-led study found that anticoagulants for atrial fibrillation lose their effectiveness in older patients due to increased mortality from non-stroke causes. The study of nearly 15,000 AF patients aged 75+ found warfarin and apixaban were not beneficial after age 87 and 92, respectively.
Researchers have discovered that autophagy activity is essential to maintain high mTORC1 activity in cells with mutated genes, and blocking this process can mimic human TSC symptoms. This finding holds promise for developing new therapeutic concepts for treating patients with this devastating disease.
A new study by RAND Corporation outlines the challenges Australia faces in preparing for a possible breakthrough treatment for Alzheimer's disease. The Australian healthcare system lacks sufficient medical specialists, diagnostic scanners, and infusion centers to handle the influx of patients, leading to long wait times and potential u...
Researchers have gained insights into how nanoparticles can be used to identify invasive microbes and deliver targeted treatments, potentially preventing deadly diseases contracted on medical equipment. The study, conducted by Monash University researchers, found that nanoparticles bound to fungal cells but were non-toxic to them.
Researchers found that patients with cardiogenic shock developed malignant arrhythmias, and intense cooling may increase MA incidence. Risk factors included faster temperature decline and lower serum potassium levels during the cooling period.
Acute myeloid leukemia (AML)-M7 is the most aggressive subtype of leukemia affecting children, with a poor prognosis. Research reveals that this disease develops specifically in young patients due to differences in fetal cells, and that targeting surrounding proteins may improve treatments.
A study has developed a method to determine activity in bone marrow, enabling personalized dosimetry. This approach can predict the effectiveness of treatment and prevent bone marrow toxicity.
Researchers developed implantable scaffolds that attract and analyze cancer cells, providing unique information on disease progression. The technology has potential to improve early detection and monitoring of cancer treatments.
Researchers at Michigan State University have developed a new approach to detect and attack cancer cells using light-activated fluorescent dyes. The breakthrough utilizes technology traditionally reserved for solar power, offering promising results in breast, lung, and skin cancer cell lines and mouse models.
Scientists at Newcastle University have made a breakthrough in understanding CYLD cutaneous syndrome, a rare genetic skin disease. Changes in the DNA of tumour cells were identified, which may provide a target for new treatments to inhibit their growth.
A Vanderbilt University study found men with breast cancer have a 19% higher five-year mortality rate than women, attributed to clinical characteristics and undertreatments. The disparity persists even when considering cancer types, access to care, and lifestyle factors like smoking and obesity.
The American Cancer Society has awarded Dr. Dmitry Gabrilovich a $400,000 research professorship to explore the roles of myeloid immune cells in cancer and develop new approaches to target tumor immunity.
Screening for ever-smokers with high lung cancer risk and long life-expectancy can prevent more deaths than current guidelines. A new study suggests using gains in life expectancy as a criterion to select candidates for screening, which could improve the balance of benefits and harms.
Researchers tracked the disruption of gut microbes after antibiotics, finding that some individuals experienced long-term changes to their microbiome. The study used bioinformatic tools to analyze fecal samples from 30 young adults who received single or triple antibiotic treatments.
Bioinformatician Serena Nik-Zainal is awarded the Dr. Josef Steiner Cancer Research Award for her development of new methods to classify tumors using bioinformatics. Her research aims to improve cancer diagnosis and prognosis by making comprehensive computational infrastructure accessible to clinicians.
A new American Cancer Society study links health insurance literacy with medical and non-medical financial hardships among adult cancer survivors. The study found that those with health insurance literacy problems were more likely to report material and psychological hardships, as well as make non-medical financial sacrifices.
A plant-based compound closely related to resveratrol has been found to enhance gene delivery to hematopoietic stem cells, reducing antiviral restriction at endosomes. This breakthrough enables faster and more efficient treatments for diseases such as sickle cell anemia and leukemia.