Articles tagged with Cancer Treatments
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A recent study published in BMJ Open found that smokers who mainly roll their own cigarettes are less motivated to quit compared to those who mainly smoke factory-made cigarettes. The main reason for this disparity is the relatively cheap cost of RYO products, with users spending around half as much on smoking each week.
New research reveals that financial difficulties are a significant strain on cancer patients, with over 20% reporting financial trouble. The study found that employment status and cancer type significantly impact financial well-being.
The new guidelines from the European Hematology Association and European LeukemiaNet provide standardized approaches to clinical management of Chronic Myelomonocytic Leukemia (CMML). The recommendations are based on expert consensus and include steps to improve evidence supporting clinical guidelines.
The new UK skin cancer database reveals over 45,000 cutaneous squamous cell carcinomas (cSCC) occur every year in England, significantly higher than previously estimated. This data enables researchers to evaluate the effectiveness of prevention initiatives and treatment options for this common form of skin cancer.
Researchers have reported promising preliminary results for cryoablation as a treatment for low-risk breast cancers, with a 99.4% success rate and no serious adverse events. The procedure is being studied as an alternative to surgical lumpectomy.
Healthy blood stem cells exhibit a similar number of DNA mutations as those found in leukemic cells, suggesting that the location of these mutations is more relevant than their quantity. This study's findings have implications for understanding the origins of leukemia and developing targeted treatments.
Researchers use big data from medical studies and large biobanks to develop models predicting biological age, aging rate, and potential targets for future anti-aging therapies. The approach also led to the identification of wearable-based biomarkers of aging and frailty.
The American Society of Hematology has released new clinical practice guidelines for venous thromboembolism, covering evidence-based recommendations for prevention, diagnosis, and treatment. The guidelines aim to improve care for patients with blood clots, addressing current uncertainties and variations in clinical practice.
Researchers used big data from human medical studies and physics approaches to develop novel anti-aging therapeutics and biomarkers of aging. The strategy involves analyzing data from large biobanks and applying concepts from complex dynamic systems to predict biological age, aging rate, and potential targets for therapies.
A randomised controlled trial found that gut-directed hypnotherapy delivered by psychologists was effective in relieving IBS symptoms, with benefits persisting at 9-month follow-up. Group hypnotherapy was as effective as individual sessions, potentially offering a new treatment option for IBS patients.
A research team at Hokkaido University found that lower TRIM29 levels correlate with more mobile and invasive squamous cell carcinoma cells, leading to a worse prognosis. The TRIM-29/keratin interaction plays a crucial role in regulating cell shape and motility.
The OARtrac radiation treatment monitoring system has been awarded a 2018 R&D 100 Award for its innovative application of scintillating fiber material. The system, developed by RadiaDyne and Jefferson Lab, allows clinicians to monitor and adjust radiation delivery to patients.
The Patient-Centered Outcomes Research Institute (PCORI) has approved $54 million to fund 12 new studies comparing different treatments for various conditions, including post-traumatic stress disorder and age-related hearing loss. These studies aim to answer important questions that can inform patient care and outcomes.
A portable device that can screen for cervical cancer using a smartphone has been developed by researchers at the University of Arizona. The device is estimated to be less than $3,000 and can analyze images automatically, recommend treatment, and identify potentially cancerous areas. Its affordability, portability, and ease of use make...
Researchers have developed a technique to isolate circulating tumor cells from blood, allowing for the analysis of protein makeup without biopsies. This could lead to more effective therapies and better patient outcomes by monitoring treatment progress remotely.
Scientists from CNRS and partners have found a promising strategy for protecting neurons after a stroke, involving the extracellular matrix. The new approach, using an agent mimicking structural components of this matrix, has shown effectiveness in rats and may complement existing clot-elimination techniques.
Distinguished Professor Terry Hughes exposed coral reef damage caused by rising water temperatures, while Britt Hermes publicised her research on evidence-based medicine. Both received the 2018 John Maddox Prize for their courage in promoting science.
A new study has shown that genomic profiling can provide meaningful information for more than half of people with rare cancers, influencing diagnosis and treatment. The trial found that 20% of participants received a new treatment plan, and 6% were given a new diagnosis.
Scientists have discovered that excess fat in obese individuals clogs up the molecular machinery of Natural Killer cells, preventing them from killing tumour cells. This research outlines possible paths to re-programming and restoring the cancer-fighting abilities of these cells.
Women who participate in breast screening have a significantly lower risk of dying from breast cancer within 10 and 20 years after diagnosis. The study found that screening detects cancers at an earlier stage, allowing for more effective treatment and a reduced mortality rate.
A study of 1244 patients found a 72% higher risk of heart failure in those receiving androgen deprivation therapy compared to non-users. The researchers recommend counseling patients on modifiable heart failure risk factors and providing cardiovascular examinations.
Researchers developed a novel SPECT tracer to image c-Met expression in NSCLC, producing clearer images in less time and reducing radiation exposure. The tracer showed high specificity and rapid clearance from the body, making it potentially suitable for clinical use.
The Bertarelli Foundation has awarded four collaborative research grants to scientists at Harvard Medical School to develop new therapies for debilitating sensory disorders. The grants will focus on addressing hidden hearing loss and developing gene therapy treatments for Usher syndrome.
A research gap means millions of people are living with the lasting side-effects of cancer treatment, affecting their quality of life. The National Cancer Research Institute has identified ten key areas for research to tackle these issues, developed by patients, carers, and experts.
An interactive online LGBT cultural competency training program improved oncologists' knowledge and clinical practices on LGBT patients. The program increased correct answers on LGBT-related knowledge items by 52% and favorable perspectives toward LGBT people by 70%.
Researchers at VIB and KU Leuven uncovered a critical role of the long non-coding RNA SAMMSON in boosting protein synthesis, enabling unrestrained cell growth. The study identifies SAMMSON as an essential step in melanoma initiation.
Researchers at Yale University found that progestin-therapy effectiveness depends on PR status in endometriotic lesions. Women with PR-positive lesions respond better to therapy, while those with PR-negative lesions find little relief. This study suggests a personalized approach to treating endometriosis may be more effective.
A new study found that people tend to overestimate the benefits and underestimate the risks of various medical procedures. In a hypothetical scenario, participants were asked to rate their likelihood of experiencing benefits or side effects of different treatments, revealing an average perception of benefit higher than the midpoint, wh...
Researchers have mapped the chromatin accessibility landscape of 23 primary human cancer types using ATAC-seq, identifying over 500,000 active DNA regulatory elements. This comprehensive dataset may help partition cancer patients for more effective therapies.
Extracellular vesicles, or 'cellular dust', have shown therapeutic properties similar to stem cells without their disadvantages. These gel-like vesicles can be produced by a single donor for several patients and have demonstrated potential in repairing heart, liver, and kidney lesions.
Researchers at St. Jude Children's Research Hospital have developed a new class of compounds called pantazines that may treat the rare neurodegenerative disorder pantothenate kinase-associated neurodegeneration (PKAN). The compounds elevate coenzyme A levels, preventing neuron dysfunction and improving symptoms in mice models.
A study analyzed over 1,000 medical crowdfunding campaigns for five unproven treatments, raising nearly $6.8 million. The campaigns were found on four platforms and included homeopathic cancer treatments and hyperbaric oxygen therapy for brain injury.
Researchers have developed a new tool to study genetic switches in glioblastoma tumors, which drive cancer growth and survival. The new technique uses ChRO-seq data to classify tumors into subtypes based on active switches, with potential applications in predicting patient outcomes and developing new therapies.
Patient-reported outcomes from NRG-RTOG 0232 show that brachytherapy alone is the superior treatment for men with intermediate risk prostate cancer, with less toxicities. The study found significant differences in clinician and patient-reported late toxicity profiles between arms.
A phase 3 clinical trial found that ixekizumab significantly improves AS symptoms, disease activity and quality of life after 16 weeks. The treatment was well-tolerated despite more frequent adverse events compared to placebo.
A French prospective study found that nearly one in six premenopausal women with early-stage breast cancer do not adequately adhere to tamoxifen therapy after one year, potentially leading to increased risk of recurrence. The study aimed to identify clinical and social characteristics associated with poor adherence to endocrine therapy.
The European Society for Medical Oncology (ESMO) has launched a global initiative to integrate supportive and palliative care into cancer treatment. Twenty new institutions from Japan, Denmark, Estonia, and Qatar have been recognized as Designated Centres of Integrated Oncology and Palliative Care.
Researchers at CytoReason used machine learning to analyze melanoma biopsies, identifying adipocytes as potential regulators of the tumor microenvironment. The study suggests that these cells may play a previously unreported role in differentiating nivolumab responders from non-responders in ipilimumab-resistant patients.
Day's research develops layer-by-layer assembled nanoshells to deliver tumor suppressor miR-34a into cells, reducing cancer cell growth. Gleghorn discovers TRPV4 regulates airway development in fetal lungs, potentially leading to new therapeutic targets for bronchopulmonary dysplasia.
Researchers at NUS Cancer Science Institute identified a SCC-specific protein complex triggered by TP63 and SOX2, promoting SCC growth through gene cascades. This discovery offers avenues to target SCCs and pave the way for innovative therapies.
Researchers discovered that silencing Farnesoid X Receptor (FXR) repressed HBV replication, while an FXR agonist reduced viral activity in mice. The study also found a link between immature bile salt pathway and chronic infection risk in newborns.
Researchers identified three specific subtypes of myeloma linked to higher risk in African-Americans due to genetic translocations and increased African ancestry. The study provides insight into the mechanisms of health disparity and potential treatment strategies for this population.
Researchers developed a method to make personalized predictions of future disease outcomes for patients with myeloproliferative neoplasms. By combining genetic and clinical information, the study identified eight different genetic subgroups that link to patterns of clinical disease and patient prognosis.
Researchers have discovered that host responses during sepsis progression can vary in important ways based on pathogen type. Boosting anti-inflammatory enzymes or using neuraminidase inhibitors showed therapeutic approaches, indicating a potential direction for drug development.
Researchers discovered that mutations in the ARID1A gene lead to a molecular switch in the SWI/SNF protein complex, causing an increase in BCL2 expression and promoting tumor cell survival. Inhibiting BCL2 using a small molecule inhibitor kills ovarian cancer cells resistant to EZH2 inhibition.
A study published in CANCER found that weight loss in postmenopausal women is associated with a 12% lower risk of invasive breast cancer. Women who lost 5% of their body weight had a lower risk, while those who gained weight had an increased incidence of triple negative breast cancer.
A study found that a simple cleaning procedure using antibacterial shampoo and wipes can prevent therapy dogs from spreading MRSA to children with cancer. The decolonization process reduces MRSA carriage in both patients and dogs, improving patient safety.
A study by Johns Hopkins Bloomberg School of Public Health found that US public and private health insurance policies are inconsistent in covering non-drug treatments for lower back pain. Most plans lacked clear coverage terms for acupuncture, psychological counseling, and physical therapy, with only a few covering these alternatives.
Livia Schiavinato Eberlin has developed the MasSpec Pen, a tool that enables surgeons to rapidly differentiate cancerous tissue from healthy tissue in patients. Her research aims to improve cancer diagnoses and treatment options using mass spectrometry imaging.
Researchers are developing a robot that can detect and treat prostate cancer more accurately, reducing the need for invasive procedures. The robot will guide a steerable flexible needle to target cancer cells, while AI and mathematical modeling ensure precise placement of radioactive material.
New hormone and non-hormone options are available to help women maintain a healthy sex life during menopause. Topical lidocaine, pelvic floor therapy, and vaginal laser therapy show promise in reducing pain and friction.
Researchers at Ann & Robert H. Lurie Children's Hospital of Chicago report successful surgical techniques and outcomes for single ovary removal in girls as young as 5 months old. The procedure causes no complications and can be performed on an outpatient basis without delaying cancer or other therapies.
Researchers at Mayo Clinic developed a new genetics-based prognostic tool for myelodysplastic syndrome, which integrates genetic and clinical information to provide more accurate predictions. The tool identifies favorable gene mutations, such as SF3B1, and unfavorable mutations, like ASXL1 and RUNX1, to guide treatment decisions.
Dr. Robert Gillies, chair of Cancer Physiology and Radiology Research at Moffitt Cancer Center, receives the World Molecular Imaging Society's Gold Medal Award for his lifetime research in molecular imaging. His work focuses on understanding cancers as complex systems, leading to new cancer treatment options.
Researchers found that autologous fecal microbiota transplantation (auto-FMT) restored beneficial gut bacteria to near baseline levels within days, mitigating the effects of intense antibiotic treatment. This approach may prove a simple way to quickly restore a healthy microbiome following intensive antimicrobial therapy.
A study published in the American Cancer Society journal found that black women and women living in poverty are less likely to report barriers to breast cancer screening due to medical distrust and social norms. Patient navigators can reduce disparities, but require training to address diverse needs.
A $929,475 project aims to understand genetic variation and its role in optimizing smoking cessation treatment choice using data from nine existing clinical trials. The research will provide unparalleled precision medicine to improve the prediction of who is more likely to quit smoking based on their genetics.
The European Academy of Cancer Sciences (EACS) has issued a position paper to improve cancer research and care in Europe. The paper emphasizes the need for coordinated efforts between researchers, healthcare systems, and policymakers to decrease cancer incidence and increase cure rates.
Human skeletal stem cells have been isolated from fetal and adult bones, providing a breakthrough in understanding the molecular diagnosis and treatment of skeletal diseases. The discovery enables researchers to create a detailed lineage map of stem-cell-mediated formation of skeletal tissues in humans.
Researchers have identified a link between inflammation and cancer growth in HER2-negative breast cancers, revealing anakinra as a potential treatment target. Anakinra, an existing anti-inflammatory drug, reduces gene expression of IL1b and other cytokines, improving symptoms and quality of life for some patients.