Research on new and better ways to treat cancer. Covers radiotherapy, targeted microdroplets, nerve-injury protection, drug combinations, and tumor models.
A new study published in the Journal of Cancer reveals significant disparities in triple-negative breast cancer diagnoses among women of color and younger women. The research found that non-Hispanic black women had a 2.3-times higher odds of being diagnosed with triple-negative breast cancer compared to non-Hispanic white women.
A new probe has been developed to help surgeons detect cancer cells during surgery, with the potential to improve surgical outcomes for patients. The probe uses fluorescence imaging and has been published in Chemical Science, a study led by RCSI researchers.
A recent study by Waseda University reveals a decline in federally funded inventions and their technological impact, suggesting a need for a more effective grant review system. Strengthening translational science through targeted initiatives can help bridge the gap between bench-to-bedside research.
A Penn study of over 150,000 men with prostate cancer found that hormone therapy increased the likelihood of developing Alzheimer's disease or dementia. The treatment was associated with a 14% increased risk of Alzheimer's and a 20% increased risk of dementia compared to patients who did not receive hormone therapy.
A study of 154,089 older men diagnosed with prostate cancer found that androgen deprivation therapy increased the likelihood of being diagnosed with Alzheimer disease or dementia. The therapy was associated with a higher risk over an average follow-up period of eight years.
A new report by American Cancer Society researchers calculates that cancer took 8.7 million years of life and $94.4 billion in lost earnings among US residents aged 16 to 84 in 2015. Lung cancer was the leading cause of lost earnings, followed by colorectal, breast, and pancreatic cancers.
A study of 18,805 patients treated with radioactive iodine found a modest association between higher doses and increased risk of solid cancer death, including breast cancer. The analysis has limitations due to uncertainties in organ dose estimates and small sample sizes.
A follow-up study reaffirms the effectiveness of low-dose computed tomography (LDCT) in reducing lung cancer mortality. The research found that LDCT can prevent lung cancer deaths or at least delay them for more than a decade, with only 303 patients needed to be screened to prevent one death.
A 65-year follow-up study of nearly 7,000 Norwegian patients with multiple sclerosis found an overall risk of developing cancer 14% higher than the general population. Respiratory cancer risk was particularly high at 66%, while urinary and central nervous system cancer risks were also significantly increased.
Researchers at Lund University discovered a link between protein DDX3X and MITF gene, which plays a crucial role in melanoma cell aggressiveness. The study's findings suggest that DDX3X levels can predict disease prognosis.
Researchers have discovered that tungsten trioxide can replace barium in X-ray exams and cancer treatments, offering a more effective and safer alternative. The compound's high absorptive capacity makes it suitable for creating a new class of contrast agents.
Researchers used advanced imaging techniques to visualize macrophages in living mice with brain tumors, finding clear morphological and behavioral differences between blood-derived and brain-resident macrophages. Blocking macrophage infiltration improved survival in treated mice.
Researchers developed a urine test called 'PUR' that can diagnose aggressive prostate cancer and predict treatment needs up to five years earlier than standard methods. The test identified men who are up to eight times less likely to require treatment within five years of diagnosis.
A new study found that veterans with PTSD are twice as likely to die from suicide, accidental injury, and viral hepatitis than the general population. The study also identified age-specific mortality risks for veterans with PTSD.
Researchers developed a wearable vest to collect data for personalized therapy in patients with metastatic NETs. The device provides organ-specific measurement recordings within the patient's comfort, allowing for more effective treatment and improved progression-free survival.
Researchers discovered that CA19-9, a complex sugar molecule, causes pancreatitis by recruiting the immune system and inducing deleterious biochemical reactions. Targeting CA19-9 with antibodies may prevent or treat pancreatitis and its progression to pancreatic cancer.
A new report reveals that nearly 5.4 million cancer survivors in the US experience chronic pain, with one in six reporting high-impact pain. The prevalence of chronic pain is significantly higher among certain groups, including those with lower education levels and household income.
A widely recognized biomarker, CA19-9, is found to promote the development of pancreatic diseases and cancer in genetically engineered mice models. This discovery suggests new treatment strategies for pancreatic cancer and other cancer biomarkers.
A new study reveals significant global disparities in cervical cancer rates among women living with HIV, particularly in South Africa and Latin America. The analysis shows that ICC rates are more than double in Latin America and 11 times higher in South Africa compared to European women.
The program, iQuit Mindfully, combines mobile health technology with mindfulness training to provide round-the-clock support for quitting smoking. A 2019 pilot study showed the technology is effective for diverse, underserved adult populations of low socioeconomic status.
The study analyzed images of biopsy samples from patients with neuroblastoma and used Graph Theory to describe the organization of vitronectin fibrils. The results suggest that the degree of organisation correlates with tumour aggressiveness, potentially allowing for patient classification before treatment.
A new study by University of Surrey researchers found that community pharmacy interventions significantly improved physical activity levels and reduced weight, BMI, and cholesterol in men with prostate cancer. These lifestyle changes also led to increased grip strength and better overall fitness.
Despite improvements in cancer treatment for HIV/AIDS-related cancers, adolescents and young adults continue to face disparities in survival rates by race, ethnicity, and socioeconomic status. The study highlights the need for continued research to improve survival rates in this vulnerable age group.
Researchers have developed a comprehensive database of synonymous mutations found in cancer, revealing their influence on cellular functions and disease processes. The SynMIC database contains information on 659,194 entries across 88 types of cancer, providing a valuable resource for cancer researchers.
Researchers discovered that fibrinogen inhibits MMP2, an enzyme important for normal organ development and repair. High levels of fibrinogen may excessively inhibit MMP2, leading to arthritic and cardiac disorders.
Researchers found HPV16 antibodies develop in body between 6-40 years prior to throat cancer diagnosis, increasing risk significantly. The presence of these antibodies indicates a strong increased risk of disease, particularly among white people, with an estimated 100-fold increase compared to black people.
The number of cancer survivors in the US is projected to increase to over 22 million by 2030 due to a growing and aging population. The American Cancer Society reports that 68% of cancer survivors were diagnosed five or more years ago, highlighting the need for proactive assessment and management of their unique medical needs.
A prospective study found that higher levels of abdominal and thigh fat are associated with an increased risk of aggressive prostate cancer. Men with a lower BMI showed a stronger association between visceral fat and advanced prostate cancer. Lifestyle interventions, such as diet and exercise, may also reduce the risk of prostate cancer.
The use of mini-organs from tumors and healthy tissue in cancer research has been explored, revealing their potential in studying tumor development and testing existing and new therapies. This innovative approach holds promise for improving cancer treatment outcomes and advancing personalized medicine.
A study published in Blood found that slower walking pace is strongly associated with poorer outcomes in older adults with blood cancers. Gait speed was found to be an independent predictor of death even after adjusting for other factors, highlighting its potential as a tool to tailor care.
Berkeley Lab scientists develop faster technique to purify elements, opening door to faster discovery of new elements and easier nuclear fuel reprocessing. The method achieves separation factors many orders of magnitude higher than current state-of-the-art methods, reducing contaminants and increasing efficiency.
A molecule called LL-37 has been found to boost the function of dendritic cells, which are used in cancer therapy. This improvement could lead to more effective treatments by increasing the success rate of dendritic cell-based therapies.
SORLA promotes HER2 receptor recycling and cancer cell proliferation. Removing SORLA from HER2 positive cancer cells inhibits tumor growth and formation.
A new laser-based method can double the energy of a proton beam produced by particle accelerators, enabling more compact and affordable equipment for cancer treatment. The technique involves colliding two less intense laser pulses to create highly charged protons with higher energy levels.
A study published in JNCI has identified hnRNP K as an oncogene that may cause B-cell lymphomas. The overexpression of this tumour suppressor gene was found to promote the development of cancer, leading to poor recovery and low survival rates for patients.
York University researchers have identified novel genes that play a crucial role in regulating muscle cell differentiation and growth. The study found that Smad7 and β-catenin proteins work together to control the pathway for normal gene expression, resulting in normal skeletal muscle cells.
A study found that female mice replace their entire set of hormone-producing cells within 3 months, while it takes male mice 9 months. This sex-specific difference could lead to sex-specific treatments for diseases like adrenal cancer.
A study published in CANCER journal found that sexual minority cancer survivors, especially female survivors, experience poor access to medical care and lower quality of life. This disparity is linked to poorer physical and mental well-being, as well as decreased survival rates compared to heterosexual counterparts.
A new clinical trial has shown that partial breast irradiation produces similar long-term survival rates and risk for recurrence compared to whole breast irradiation for many women with low-risk, early stage breast cancer. The study found a 4.6% recurrence rate for partial breast irradiation and a 3.9% rate for whole breast irradiation.
Graduates can expect to earn nearly £670,000 more over their working life due to SES education. SES research is vital to tackling global health challenges like obesity, diabetes, and cancer.
Researchers have developed a novel compound that specifically targets the endoplasmic reticulum stress response in cancer cells, promoting apoptosis and inhibiting tumor growth. The compound can be precisely activated by UV irradiation and emits fluorescence, allowing real-time tracking of its activity.
Researchers developed cell membrane-coated nanocarriers to overcome immune clearance and biotoxicity issues. These biomimetic hybrids achieve improved biocompatibility, circulation time, and therapeutic efficiency.
Abnormal chromosome number abnormalities are linked to increased risk of lethal disease in prostate cancer patients. Patients with five or more predicted aneuploidy alterations had a 5.3 times higher odds of lethal cancer during follow-up.
A new study found that children with inflammatory bowel disease, including ulcerative colitis and Crohn's disease, have a higher risk of developing cancer and dying early compared to the general population. The study suggests that cancer surveillance and mental health assessment are crucial for young patients with these conditions.
Researchers at Uppsala University found that inhibiting ribosome biogenesis can revert aggressive tumors to a non-invasive state, potentially regaining sensitivity to hormonal therapy. The study also showed a marked reduction in lung metastases.
A large study found that HER2 expression can predict DCIS recurrence and progression, enabling targeted treatments for high-risk patients. By screening DCIS patients for HER2, doctors can minimize the chance of recurrence or spread in lower-risk patients.
A study of 429 men with metastatic castration-resistant prostate cancer found correlations between specific genetic alterations and clinical outcomes. The loss of the RB1 tumor suppressor gene was significantly correlated with poor survival in patients treated with androgen receptor signaling inhibitors.
A new nomogram developed by researchers can accurately predict the likelihood of occult lymph node metastases in esophageal cancer. This tool may help clinicians identify high-risk patients who would benefit from neoadjuvant therapy, leading to more informed treatment discussions and potentially improved patient outcomes.
A study by Johns Hopkins Medicine and partners found that a simple performance evaluation letter can reduce unnecessary tissue removal in Mohs micrographic surgery for skin cancer. The intervention led to an improvement in surgical behavior, sustained for one year, with 83% of notified physicians reducing their practice.
Researchers found a truncated variant of the p53 protein, Δ40p53, forming amyloid aggregates in endometrial cancer cells. This finding promises new perspectives for treating Type 2 endometrial cancer, the most aggressive form of the disease.
Researchers have identified four hallmarks of cancer metastasis: motility, modulation of the microenvironment, plasticity, and ability to colonize. This understanding could lead to the development of new therapeutic interventions for this complex process, which is responsible for up to 90% of cancer deaths.
Researchers found that repeated detection of HPV DNA in oral rinses after cancer treatment was associated with a higher risk of cancer recurrence and death. The study suggests HPV DNA may be a promising biomarker for understanding cancer treatment response and future risk of progression.
Researchers at CNIO describe the RUVBL1-RUVBL2 ATPases as the 'energy engine' in the co-chaperone R2TP, regulating access to ATP for energy production. The study found a gate-like structure in RUVBL2 that controls energy exchange, coupled to the assembly of mTOR complexes.
The number of cardiologists trained in cardio-oncology is not meeting the growing needs of cancer survivors, who are aging and developing co-morbid cardiovascular disease. Limited training programs and resources are emerging to address this need, highlighting the importance of collaboration between cardiologists and oncologists.
A pilot program investigates human-animal interactions (HAIs) in reducing suffering of children with cancer undergoing debilitating treatments. Children are randomly assigned to a group receiving usual care or a group receiving HAI plus therapy dog visits.
Researchers at H. Lee Moffitt Cancer Center discovered a signaling pathway between cytokines and BRAF that promotes tumor growth. Blocking ITCH activity or BRAF ubiquitination may be an effective treatment approach to slow tumor growth in melanoma.
A deep-learning model developed using serial image scans of tumors from patients with non-small cell lung cancer (NSCLC) predicted treatment response and survival outcomes better than standard clinical parameters. The model's performance improved with the addition of each follow-up scan, predicting two-year survival with an accuracy of...
The article discusses the potential of liquid biopsy in cancer diagnosis, focusing on targeted disease diagnosis and detection of cancer biomarkers. Researchers have successfully detected specific genetic mutations using digital PCR, identifying promising biomarkers for various cancers, including melanoma and lung squamous cell carcinoma.
Researchers identified UNC45A as a key player in cancer cell proliferation and tumor growth. Inhibiting UNC45A was found to decrease cancer cell proliferation and cause mitotic catastrophe, leading to cell death.
Researchers have discovered that amplifying the amount of VGLL3 in skin cells pushes the immune system into overdrive, leading to autoimmune responses. This finding may help explain why women are more likely to develop autoimmune diseases like lupus and could lead to new treatments.