Research on new and better ways to treat cancer. Covers radiotherapy, targeted microdroplets, nerve-injury protection, drug combinations, and tumor models.
Scientists identified a molecular driver of glioblastoma, a highly aggressive and treatment-resistant brain cancer, by analyzing cell-by-cell genetic data. Researchers found that reprogramming primitive oligodendrocyte progenitors into stem-like cells plays a key role in glioma initiation and progression.
A new study investigates the Auger effect in aromatic hydrocarbons, revealing that molecules with pi electrons have a lower double ionization threshold. This finding favors Auger decay over saturated hydrocarbons, with potential applications in cancer treatment and atomic identification.
Research shows that branched actin transmits information to cells about their environment and regulates growth, a mechanism that can be targeted to fight certain types of cancer. Inhibiting branched actin formation prevents the growth of melanoma cells, offering new therapeutic options.
Researchers have developed a gene editing approach that corrects over 80% of patient cells, targeting the COL7A1 gene mutation responsible for recessive dystrophic epidermolysis bullosa. The technique shows promise for treating this rare disease with high efficiency and safety.
A new study has revealed a previously unknown interaction between proteins that causes certain types of cancer called sarcoma. The research, led by Pierre Åman, found that tumor-altered FET proteins bind to the SWI/SNF complex, leading to misregulation and disruptions in genetic programming.
Scientists at the Institut Pasteur have identified a cellular protein that can degrade hepatitis B virus DNA, potentially leading to a 'Trojan horse' approach to target infected liver cells. This discovery offers new hope for developing curative treatments for chronic HBV infection.
Rising liver cancer death rates in the US are largely confined to individuals with lower educational attainment, particularly men. The study highlights the need for targeted efforts to address the growing burden of liver cancer in lower socioeconomic groups.
Scientists developed a new imaging technology to visualize what cells eat, such as glucose, which could aid in the diagnosis and treatment of diseases like cancer. The technique uses chemical probes that light up when they attach to specific molecules consumed by cells.
A new study found that continued smoking by patients with cancer adds significant costs to subsequent cancer treatment. The analysis conservatively suggests a total of nearly $11,000 in increased treatment costs for each smoking patient after their initial cancer treatment fails.
A study published in JAMA Network Open found that continued smoking after a cancer diagnosis increases the risk of cancer treatment failure and adds $11,000 to treatment costs per patient. The research estimates $3.4 billion in national additional cancer treatment costs if patients continue to smoke.
A recent commentary suggests that treatment guidelines recommended by medical specialist organizations are more likely to lead to overdiagnosis, overtreatment, and increased healthcare costs. The authors argue that specialty bias and fee-for-service compensation models contribute to this issue.
Researchers have unraveled the three-dimensional structure of ATP citrate lyase (ACLY), a central metabolic enzyme crucial for fatty acid and cholesterol production. The study's findings provide new insights into ACLY's role in metabolism, evolution, and potential therapeutic targeting of cancer and metabolic diseases.
Researchers found that chronic morphine treatment decreased survival in control mice, but not in sickle mice with sickle cell disease. Chronic opioid therapy also caused hyperalgesia, a condition of increased pain sensitivity, in sickle mice. The study suggests that opioids may still be effective for managing pain in SCD patients despi...
Lauren Sciences LLC has received an AU$1 million grant from FightMND to advance its development of LAUR-301, a novel V-Smart Nanomedicine for ALS. The therapy aims to protect motor neurons and induce neuro-restoration, slowing or reversing the disease.
A study of almost 276,000 children found a small association between IVF conception and an increased risk of childhood cancer, mostly rare tumor types. The link was limited to the first decade of life and was found in only a subset of cancers.
The Cancer Control and Survivorship Program at St. Jude Children's Research Hospital has been awarded the 13th annual AACR Team Science Award for its innovative research advancing childhood cancer treatment and long-term survival outcomes. The program's work has significantly contributed to our understanding of pediatric cancer epidemi...
Scientists found that current WHO guidelines for chronic hepatitis B fail to detect 50% of patients in need of treatment in Ethiopia. The guidelines are based on European and American data, highlighting the need for regionalized approaches to identify patients with significant liver disease.
Researchers at the Garvan Institute of Medical Research have developed a new diagnostic method that screens cancer samples for 'fusion genes', which are linked to one in five cancers. The test identifies 20% more fusion genes than current methods, potentially leading to personalized treatments.
A preclinical study found that combining CAR T-cell therapy with photothermal ablation suppressed melanoma tumor growth for up to 20 days in mice. Among the treated mice, 33% remained tumor-free after 20 days.
A new study shows that uterine fibroid embolization (UFE) is as effective as surgical treatment in treating uterine fibroids, with fewer post-procedure complications. UFE preserves the uterus and allows women to return to their normal lives sooner.
The study found that the percentage of younger women initiating bisphosphonate treatment decreased over the 12-year period, while older women and those with osteopenia or osteoporosis increased. The overall percentage of osteoporosis among white and Asian women also rose.
Researchers have developed a more precise gene-editing technique to reduce DNA breaks and prevent cancer in stem cells. This breakthrough could improve the safety of CRISPR treatments for inherited blood disorders.
A recent study by Cancer Research UK reveals that African-American cancer patients with inherited red blood cell conditions are 20% more likely to experience serious adverse events. This disparity may be attributed to the rigors of therapy and the disproportionately higher incidence of these disorders in the African-American population.
A new study found that keeping blood pressure around 130 mm Hg for three years significantly reduced the accumulation of harmful brain lesions compared to maintaining a higher systolic blood pressure. This reduction also led to fewer major cardiovascular events, such as heart attacks and strokes.
Guidelines issued by North American specialty societies recommend health services linked to their specialties, differing from European guidelines. This phenomenon, known as 'specialty bias,' may exacerbate healthcare costs and worsen patient outcomes.
A new study reveals that patients with prostate, bladder, or kidney cancers who have had psychiatric care prior to treatment are at a greater risk of dying. The research also found an increased suicide risk among these patients, even after adjusting for previous mental health treatment.
Researchers have found that testosterone replacement therapy reduces prostate cancer recurrence in low-risk patients by nearly three-fold over three years. This study challenges the long-held notion that testosterone promotes prostate cancer and suggests a potential new treatment approach for these patients.
A new diagnostic tool has been developed to detect ovarian cancer earlier, with high sensitivity and specificity rates. The test uses liquid biopsy proteomics to identify unique protein signatures in uterine fluid, promising improved detection rates for young women at high risk of developing the disease.
Research links early menopause to increased bladder cancer risk, particularly in smokers. The study found that women who went into menopause before the age of 45 were 45% more likely to develop bladder cancer than those who had later menopause.
A new study reveals that the development of progenitor cells depends on protein quantity and interaction with other cells. Cells with high P120ctn expression remain in the central part of the pancreas, while those with low expression migrate to the peripheral area, where they acquire their final fate.
Researchers have identified a major mutation pattern in human cancer that occurs in bursts, with the cause of these mutational bursts remaining mysterious. The study, published in Cell, provides a vast resource for investigating the biological mechanisms behind cancer mutations.
A VA study evaluated quality indicators for hormone therapy in menopausal women and found that nearly 40% of prescriptions were inconsistent with evidence-based guidelines. The study suggests that point-of-care information and decision support are needed to ensure patients receive guideline-adherent care.
A diet rich in green tea and carrot compounds reversed Alzheimer's-like symptoms in mice, supporting the idea that plant-based supplements might offer protection against dementia. Combination therapy is suggested as a potential approach to treating the disease.
Researchers at University of Utah Health have developed a novel treatment that delays the onset of type 1 diabetes in mice and halts the progression of paralysis in multiple sclerosis models. The treatment targets misfunctioning immune cells, leaving normal immune cells intact.
The article highlights the challenges in predicting and stratifying cardiovascular risk in women due to sex-specific factors, traditional risk models' flaws, and inadequate representation of women in CVD research. This has led to a persistent gap in awareness, diagnosis, and treatment of ischemic heart disease in women.
Peripartum cardiomyopathy (PPCM) is a disorder where heart failure develops during or after pregnancy. Recent studies suggest angiogenic imbalance plays a key role, with soluble fms-like tyrosine kinase-1 (sFlt1) and prolactin being important factors. The latest IPAC study recommendations are also referenced.
A global modelling study estimates nearly 400,000 new cases of childhood cancer annually, while current records count only around 200,000. Undiagnosed cases could account for more than half of the total in Africa, South Central Asia and the Pacific Islands.
A recent study reports radiation contamination at an Arizona crematorium following treatment of a patient with a radioactive drug. The contamination was detected on equipment and in the operator's urine, raising concerns about potential health effects.
Patients living with HIV have equal access to optimal cancer therapy, according to a recent study in the journal CANCER. The findings challenge traditional beliefs that HIV infection is a contraindication for intensive cancer treatment.
A new sequencing method, TET-assisted pyridine borane sequencing (TAPS), detects chemical modifications to DNA that contribute to cancer progression and resistance to therapy. The method is less damaging and more efficient than bisulfite sequencing, enabling the detection of mutations and structural variations.
A new report emphasizes the importance of transforming healthcare delivery in the US to reduce cancer burden. The study identifies goals for a high-performing healthcare system, including access to primary care, timely evidence-based treatment, and patient-centered care.
Researchers have developed a new compound that shows promise in treating multiple sclerosis by reducing inflammation and promoting neuroprotection and remyelination. The compound, based on chloroindazole, has been found to be effective in improving primary symptoms in a mouse model of the disease.
The UVA Health System is launching a program that uses telehealth to connect primary care providers in Appalachia with specialists to improve lung disease prevention, diagnosis, and treatment. Residents in the region have higher-than-average rates of lung cancer and COPD, and limited access to subspecialty physicians.
A Mayo Clinic study found that patients with a poor immune response to follicular lymphoma exhibited reduced costimulatory receptors on their T-cells, leading to shorter survival rates. The research may lead to the development of new therapies for some patients with follicular lymphoma.
A novel mobile application called MyPath uses AI to provide personalized guidance and support to breast cancer patients in rural Georgia. The app adapts to each stage of a patient's journey, offering relevant resources and suggestions based on their medical data and changing needs.
The report highlights the expanding role of interventional inflammatory bowel disease (IBD) endoscopy in managing complex conditions, such as strictures, fistulas, and colitis-associated neoplasia. This approach can help reduce or postpone surgical resection and treat postoperative adverse events.
Researchers at St. Jude Children's Research Hospital developed a method to customize and reduce drug interaction alerts in electronic health records. The study made 26 changes that affected 47% of alerts, resulting in a 40% decrease in alert overrides.
Researchers at University of Toledo have developed a mouse model that spontaneously develops type I diabetes and its complications, allowing for study of disease progression. The breakthrough has the potential to reshape how type I diabetes is studied and may lead to new treatments or a cure.
Researchers found that obstructive sleep apnea promotes a persistent low-intensity inflammatory state, damaging organs. This link could lead to more precise treatments, such as vitamin C or plant-derived antioxidants, to reverse inflammation and protect the body from future damage.
A large study found that direct-acting antiviral treatment is associated with reduced risk of mortality and hepatocellular cancer, but not decompensation of cirrhosis. Patients treated with direct-acting antivirals were 52% less likely to die prematurely than those who were untreated.
New DNA-based nanomachines can selectively target malignant cells, breaking down vital genes and inducing apoptotic death. The design allows for better interaction with folded RNA molecules, but further experiments are needed to improve specificity.
Researchers found that prostate cancer cells absorb fatty acids, increasing tumor growth, and blocking this process slows cancer development. The study suggests a possible therapeutic target for treating prostate cancer, particularly for men with aggressive disease.
Researchers discovered a novel metabolic pathway in cancer cells that produces an unusual fatty acid, sapienate, allowing them to bypass fatty acid metabolism inhibition. This finding can explain the resistance of certain cancer types to therapy and opens new avenues for targeted treatment.
A research team at Tokyo Medical and Dental University classified hepatocellular carcinoma into three distinct subgroups based on mutation patterns, gene expression, and immune system characterization. The findings suggest that each subgroup has a unique clinical profile, enabling targeted treatment approaches.
Researchers created a lab model of a blood vessel to study angiogenesis, revealing how the molecule EGFL7 influences blood vessel sprouting and integrity. The study suggests EGFL7 as a potential therapeutic target for diseases like retinopathy and cancer.
Researchers discovered 27 new molecules with significant therapeutic potential for treating fatty liver disease and obesity by activating the PPAR-delta protein. These molecules are currently undergoing pharmaceutical evaluations and show promise in improving physical endurance and reducing waistlines.
A new 3D imaging technique has revealed that pancreatic cancers can develop in two distinct types - 'endophytic' and 'exophytic' - depending on the size of the duct. This breakthrough may lead to improved treatments for pancreatic cancers by better understanding how cancer grows.
A new assay accurately measures TNF concentrations during adalimumab treatment, revealing that circulating TNF levels increase 50-fold before stabilizing. Lower TNF concentrations after the fourth week are associated with more antibodies against the drug and a lower chance of remission.
Researchers found that stroke risk factors increased by tripling the likelihood of a stroke within 10 years, with hormonal treatment and racial differences also playing a role. The study calls for targeted interventions to reduce stroke risk among post-menopausal breast cancer survivors.
Researchers engineered a virus that selectively targets and kills cancer cells, surpassing another viral treatment currently in use. The modified adenovirus, dl355, replicates more efficiently in cancer cells than normal cells, resulting in higher cancer cell kill rates.