Articles tagged with Cancer Treatments
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Researchers developed personalized T cell adoptive immunotherapy for patients with HBV-related HCC, resulting in an objective positive response with volumetric reduction of lung lesions and no new lesions detected. The therapy showed promise with no therapy-related adverse events.
A new assay using droplet digital PCR has been developed to detect closed circular DNA (cccDNA) in serum, single cells, and preserved tissue samples. This allows for the early detection of hepatocellular carcinoma (HCC) and more effective treatment.
A new study reports that consuming high amounts of carbohydrates and sugar prior to treatment for head and neck cancer may increase patients' risks of cancer recurrence and mortality. However, moderate fat and starchy food consumption after treatment appears to have protective benefits, reducing disease recurrence and death rates.
The ALS Association granted Lauren Sciences LLC its third award for developing LAUR-301, a V-Smart Nanomedicine for ALS. LAUR-301 aims to deliver GDNF across the blood-brain barrier and induce neuro-restoration in all ALS patients.
A new study suggests that high-quality cervical cancer screening can be effectively done using automated technology, which could improve coverage in underserved regions. The researchers developed a novel risk score algorithm based on computer-scanned liquid-based slide features to separate HPV-positive women for treatment.
Researchers at Sanford Burnham Prebys Medical Discovery Institute reveal that the loss of p62 in fat cells fuels aggressive prostate cancer by inhibiting energy-consuming processes. This discovery opens new avenues for therapeutic targeting and highlights the importance of considering whole-body metabolism in cancer treatment.
Researchers found that oral sirolimus treatment significantly improved pulmonary function and reduced carcinoid tumor volume in three patients with DIPNECH syndrome. The study provides promising evidence for sirolimus as a viable treatment option for this rare condition.
The American Society for Gastrointestinal Endoscopy has released new guidelines for the use of endoscopic eradication therapy in patients with Barrett's esophagus, a precursor to esophageal adenocarcinoma. The guidelines support evidence-based recommendations and clinical guidelines addressing key issues related to Endoscopic Eradicati...
Researchers developed an index measuring similarity between cancer cells and pluripotent stem cells to predict tumor aggressiveness, treatment resistance, and clinical outcome. The index may help identify novel therapeutic targets against cancer by pinpointing the point at which tumor cells acquire stem cell-like characteristics.
A study published in Journal of the American Academy of Dermatology found an FDA-approved topical solution to be less cytotoxic and damaging to melanocytes than cryosurgery, suggesting a safer option for seborrheic keratosis removal
Patients with alcohol-related liver cancer tend to have poorer overall survival rates compared to those with non-alcohol related liver cancer. The study highlights the need for improved screening and treatment programs for patients at risk of developing cirrhosis or liver cancer, especially those who are still drinking.
A research team at Case Western Reserve University is developing an AI-powered tool to analyze computerized images of tissue samples for patterns that can predict the risk of recurrence in oropharyngeal cancers. This could lead to more personalized treatment approaches for patients with these aggressive tumors.
A new quality improvement initiative, NAPRC, aims to improve US rectal cancer care by adopting a multidisciplinary team approach. The program's proposed quality measures and process indicators were analyzed, revealing varying completion rates among hospitals.
Scientists identified a mechanism of resistance to ibrutinib, a current treatment for non-Hodgkin lymphoma, and discovered a promising therapeutic target in three enzymes. Blocking these enzymes with masitinib completely ablated the B-cell receptor pro-tumorigenic signals.
Researchers have identified two genes, PIAS1 and IRF8, that play a crucial role in regulating the replication of Epstein-Barr virus. By understanding how these genes interact with the virus, scientists may develop new treatments for cancer types associated with EBV infection.
The study found that nearly half of the wives reported that their partner's health problem affected their own health, with many feeling increasingly socially isolated. The women also expressed concerns about the role change in their relationship as their husbands became less able to fulfill their usual roles.
Researchers have identified two new biomarkers, a trio of RNA molecules, to help determine the severity of neuroblastoma in children. This discovery has immediate significance for disease prognosis and will eventually contribute to more effective treatments.
A study found that adults with a history of cancer treatment exhibit higher levels of fatigue and reduced endurance compared to those without a cancer history. The researchers discovered a significant association between a history of cancer treatment and increased fatigability, particularly in older adults.
A major international survey found that around 25% of patients with penile cancer are not receiving recommended treatment. This leads to a significantly lower survival rate, with twice as many patients surviving if treated according to guidelines.
For male anti-NMDA receptor encephalitis patients without tumors, plasmapheresis has been found to be an effective treatment strategy. Studies comparing treatments such as intravenous immunoglobulin and rituximab with plasmapheresis have shown that the latter is not inferior in efficacy.
Researchers from the University of Pennsylvania School of Nursing used implementation science to evaluate cervical cancer prevention programs in sub-Saharan Africa. They identified a need for additional organizational and structural support to sustain implementation and improve cervical cancer prevention.
A new imaging technology has been developed to grade tumour biopsies, eliminating human subjectivity and variability. The Digistain method uses mid-infrared light to map out chemical changes that signal cancer onset, providing a reliable indicator of disease progression.
Researchers at Washington University School of Medicine have discovered a new way to fight sepsis by boosting the immune system with a drug that increases key immune cells. The approach has shown significant and lasting improvements in patients, offering hope for improved survival rates.
A recent study published in JAMA Ophthalmology found that high levels of ICAM-1 are associated with better response to current treatments for diabetic macular edema. The discovery could lead to more personalized and tailored medicine, alleviating treatment burdens on patients and the healthcare system.
The Physicians Committee's new app provides comprehensive nutrition information for nearly 100 medical conditions, addressing key issues like diabetes, heart disease, and obesity. Developed in partnership with Unbound Medicine, the app is designed to support clinicians in their daily practice.
Researchers developed a novel small molecule PET tracer to noninvasively detect EGFR mutation status in NSCLC patients. The approach showed high accuracy and potential for predicting treatment response and monitoring dynamic changes during therapy.
A recent study found that patients are willing to travel up to 75 minutes longer and 5 hours longer to receive specialized cancer care with improved outcomes. Centralization of cancer surgery services can reduce variations in quality of care and improve patient health outcomes.
The Neuroendocrine Tumor Research Foundation (NETRF) has awarded six new research grants totaling $1.85 million to leading academic institutions worldwide. The funding aims to improve current treatments for neuroendocrine tumors, a rare and poorly understood cancer affecting hormone-producing cells.
Early clinical studies with BET inhibitors and EZH2 inhibitors have shown remarkable activity in patients with lymphoma, including diffuse large B-cell lymphoma and NUT carcinoma. Tolerability has been generally good, but side effects such as thrombocytopaenia and fatigue have emerged.
The University of Plymouth will continue its neuro-tumour research with a £100,000 grant from Great Ormond Street Hospital Children's Charity and Sparks. The project aims to investigate the causes of Neurofibromatosis 2, a hereditary condition that leads to tumours in the nervous system.
Researchers found that in vitro testing is no help in predicting which nanoparticles successfully enter cells in living animals. A new DNA barcoding technique allows testing of over 100 nanoparticles simultaneously in a single animal, accelerating the development of gene therapies.
Researchers found that viruses use epigenetic regulation to mute the immune system, causing cancer cells to proliferate. By demethylating specific gene promoter regions, it may be possible to revive an immune system muted by cancer-causing viruses and increase the effectiveness of immune-based therapies.
A new special issue of the Journal of Cancer Policy highlights the need for long-term research and better support for cancer survivors' non-medical issues. The issue aims to increase awareness of socio-economic challenges faced by survivors and engage stakeholders in research and practice.
Mutated Cyclin E and Myc genes induce premature DNA replication, leading to molecular collisions and new mutations. The study identified a method to map replication origins on all chromosomes, revealing that aberrant sites can cause genomic instability in cancers.
Researchers developed an AI-based computational tool to screen patients for common retinal diseases, achieving over 95% accuracy in diagnosis. The tool also showed promise in diagnosing childhood pneumonia with over 90% accuracy, highlighting its potential applications in healthcare.
Researchers discovered that a subset of myeloproliferative neoplasms (MPNs) are susceptible to treatment with immune checkpoint inhibitors targeting the PD-1/PD-L1 pathway. MPNs hijack this pathway to prevent T cells from attacking malignant cells, but mutant JAK2 activation can expose a therapeutic vulnerability.
A retrospective study of 1,629 patients with non-Hodgkin lymphoma found no significant differences in 4-year overall survival and disease relapse between those aged 65 and older versus 55-64 years old. The study suggests that age should not be a limiting factor in transplant eligibility.
Researchers at Purdue University found that microRNA miR-223 can help control inflammatory disease by regulating the NF-kB pathway, which is critical in human bronchial epithelial cells. Supplementing this microRNA to epithelial cells may provide a new treatment option for asthma and cancer.
Researchers propose a new conceptualization of cancer based on physical and biophysical symmetry. The study suggests that understanding cancer through the framework of symmetry can help reveal new ways to understand cancer.
A study published in Medical Care found that the Affordable Care Act significantly reduced the uninsured rate among adult cancer survivors, with a 38% relative decrease. Cancer survivors eligible for Medicaid expansion under the ACA had the largest reduction in uninsured rate, with a 16.7 percentage point drop.
Researchers at Imperial College London found that xenon gas can limit blast-induced brain injury by preventing damage from developing. The study suggests that xenon could be a viable treatment option after blasts occur, potentially reducing debilitating symptoms.
A Swedish study revealed that social benefits can mitigate the financial impact on parents of children diagnosed with cancer. However, mothers of children with cancer often experience persistently lower income after these benefits are no longer provided.
Researchers have successfully generated Tasmanian devil stem cells, offering a potential treatment for the deadly transmissible cancer. The development provides hope for saving the species from extinction, which is estimated to occur within 20-30 years.
Discussing patients' bucket lists with their doctors can encourage making medical care fit life plans, providing personalized care and healthy behaviors. Researchers found that 91% of respondents had made a bucket list, with those who valued faith and spirituality more likely to have one.
The proposed immunological model suggests that diseases such as cancers and infectious diseases may be linked to declining T-cell production with age. Therapies targeting improved T-cell production in the aging immune system could hold promise for treatment options.
Researchers have discovered a link between male sex hormone levels and vitamin D metabolism that may be targeted to treat osteoporosis in men undergoing prostate cancer therapy. Progesterone receptor blockers could enhance the effectiveness of vitamin D supplements, reducing bone fracture risks.
The organization raised $2.4 million to fund groundbreaking science at the Salk Institute, Rady Children's Hospital, Moores Cancer Center, and Sanford Burnham Prebys Medical Discovery Institute. This funding supports collaborative, translational research with a focus on clinical trials.
A new study reveals that starvation of sugar can trigger a unique signaling function in cancer cells, leading to cell death. By manipulating this property, researchers propose a potential combination therapy to target cancer metabolism and selectively kill cancer cells while leaving healthy cells intact.
Researchers have identified 52 microRNAs that are decreased in expression as thyroid cancer becomes more aggressive. Restoring these molecules' levels in tumors may be a novel treatment strategy.
3D organoid models derived from patient cells can guide clinical decision-making for individuals with gastrointestinal cancers. Researchers hope these models will predict treatment response and increase response rates by finding the best treatment combination for every patient.
Researchers analyzed over 500 cases of DIPG and related tumors to find that tumors with histone mutations that haven't invaded surrounding brain tissue have better outcomes. Patients with non-invasive tumors had approximately 4-5 times longer survival rates compared to those with invasive tumors.
Researchers used evolutionary dynamics to analyze malignant mutations in colorectal and intestinal cancers, finding that cancer stem cells can produce substantially different daughter cells with potential positive or negative impacts on cancer progression.
Researchers have identified EXD2 as a critical regulator of mitochondrial protein production, which is essential for energy generation and maintaining cellular homeostasis. The study found that EXD2 targets messenger RNA to facilitate the maturation of the mitochondrial ribosome, leading to increased protein production.
The Engineering and Physical Sciences Research Council (EPSRC) has announced support for 28 groundbreaking research projects, ranging from autonomous vehicles to energy storage and healthcare technology. These projects have the potential to make a transformative impact in various fields.
A recent study at Tampere University found that an eNose can identify the most common bacteria causing soft tissue infections without prior sample preparation. The device differentiates between MRSA and MSSA with high accuracy, reducing treatment times and costs.
A study by American Osteopathic Association finds cervical lesions progressing at different rates among Hispanic, white, Asian, and black women, affecting treatment options and risk assessment. Hispanic women progressed faster to high-grade lesions but recovered faster from them.
A new saliva-based diagnostic test could identify people at risk for throat cancers earlier, enabling early treatment and prevention. The test aims to detect HPV infections in a low-cost, non-invasive manner.
Scientists at Tohoku University found that a protein called TRIM48 labels PRMT1 for destruction, leading to ASK1 hyperactivation and cancer cell death. This study reveals new potential therapeutic targets for treating cancers and neurodegenerative diseases.
Researchers at Monash University have identified a novel molecular 'blueprint' that enables the immune system to fight disease by 'remembering' past infections. This discovery potentially opens new avenues for improving vaccines and therapies, including those targeting cancer and autoimmune diseases.
A new study found that inherited variation in the ADAMTSL1 gene is associated with a poorer survival rate in early-onset breast cancer patients. The research, published in Nature Communications, suggests that this genetic factor may be used to improve prognostic models and inform treatment decisions.