Research on new and better ways to treat cancer. Covers radiotherapy, targeted microdroplets, nerve-injury protection, drug combinations, and tumor models.
A French prospective study found that nearly one in six premenopausal women with early-stage breast cancer do not adequately adhere to tamoxifen therapy after one year, potentially leading to increased risk of recurrence. The study aimed to identify clinical and social characteristics associated with poor adherence to endocrine therapy.
The European Society for Medical Oncology (ESMO) has launched a global initiative to integrate supportive and palliative care into cancer treatment. Twenty new institutions from Japan, Denmark, Estonia, and Qatar have been recognized as Designated Centres of Integrated Oncology and Palliative Care.
Researchers at CytoReason used machine learning to analyze melanoma biopsies, identifying adipocytes as potential regulators of the tumor microenvironment. The study suggests that these cells may play a previously unreported role in differentiating nivolumab responders from non-responders in ipilimumab-resistant patients.
Day's research develops layer-by-layer assembled nanoshells to deliver tumor suppressor miR-34a into cells, reducing cancer cell growth. Gleghorn discovers TRPV4 regulates airway development in fetal lungs, potentially leading to new therapeutic targets for bronchopulmonary dysplasia.
Researchers at NUS Cancer Science Institute identified a SCC-specific protein complex triggered by TP63 and SOX2, promoting SCC growth through gene cascades. This discovery offers avenues to target SCCs and pave the way for innovative therapies.
Researchers discovered that silencing Farnesoid X Receptor (FXR) repressed HBV replication, while an FXR agonist reduced viral activity in mice. The study also found a link between immature bile salt pathway and chronic infection risk in newborns.
Researchers identified three specific subtypes of myeloma linked to higher risk in African-Americans due to genetic translocations and increased African ancestry. The study provides insight into the mechanisms of health disparity and potential treatment strategies for this population.
Researchers developed a method to make personalized predictions of future disease outcomes for patients with myeloproliferative neoplasms. By combining genetic and clinical information, the study identified eight different genetic subgroups that link to patterns of clinical disease and patient prognosis.
Researchers have discovered that host responses during sepsis progression can vary in important ways based on pathogen type. Boosting anti-inflammatory enzymes or using neuraminidase inhibitors showed therapeutic approaches, indicating a potential direction for drug development.
Researchers discovered that mutations in the ARID1A gene lead to a molecular switch in the SWI/SNF protein complex, causing an increase in BCL2 expression and promoting tumor cell survival. Inhibiting BCL2 using a small molecule inhibitor kills ovarian cancer cells resistant to EZH2 inhibition.
A study published in CANCER found that weight loss in postmenopausal women is associated with a 12% lower risk of invasive breast cancer. Women who lost 5% of their body weight had a lower risk, while those who gained weight had an increased incidence of triple negative breast cancer.
A study found that a simple cleaning procedure using antibacterial shampoo and wipes can prevent therapy dogs from spreading MRSA to children with cancer. The decolonization process reduces MRSA carriage in both patients and dogs, improving patient safety.
A study by Johns Hopkins Bloomberg School of Public Health found that US public and private health insurance policies are inconsistent in covering non-drug treatments for lower back pain. Most plans lacked clear coverage terms for acupuncture, psychological counseling, and physical therapy, with only a few covering these alternatives.
Livia Schiavinato Eberlin has developed the MasSpec Pen, a tool that enables surgeons to rapidly differentiate cancerous tissue from healthy tissue in patients. Her research aims to improve cancer diagnoses and treatment options using mass spectrometry imaging.
Researchers are developing a robot that can detect and treat prostate cancer more accurately, reducing the need for invasive procedures. The robot will guide a steerable flexible needle to target cancer cells, while AI and mathematical modeling ensure precise placement of radioactive material.
New hormone and non-hormone options are available to help women maintain a healthy sex life during menopause. Topical lidocaine, pelvic floor therapy, and vaginal laser therapy show promise in reducing pain and friction.
Researchers at Ann & Robert H. Lurie Children's Hospital of Chicago report successful surgical techniques and outcomes for single ovary removal in girls as young as 5 months old. The procedure causes no complications and can be performed on an outpatient basis without delaying cancer or other therapies.
Researchers at Mayo Clinic developed a new genetics-based prognostic tool for myelodysplastic syndrome, which integrates genetic and clinical information to provide more accurate predictions. The tool identifies favorable gene mutations, such as SF3B1, and unfavorable mutations, like ASXL1 and RUNX1, to guide treatment decisions.
Dr. Robert Gillies, chair of Cancer Physiology and Radiology Research at Moffitt Cancer Center, receives the World Molecular Imaging Society's Gold Medal Award for his lifetime research in molecular imaging. His work focuses on understanding cancers as complex systems, leading to new cancer treatment options.
Researchers found that autologous fecal microbiota transplantation (auto-FMT) restored beneficial gut bacteria to near baseline levels within days, mitigating the effects of intense antibiotic treatment. This approach may prove a simple way to quickly restore a healthy microbiome following intensive antimicrobial therapy.
A study published in the American Cancer Society journal found that black women and women living in poverty are less likely to report barriers to breast cancer screening due to medical distrust and social norms. Patient navigators can reduce disparities, but require training to address diverse needs.
A $929,475 project aims to understand genetic variation and its role in optimizing smoking cessation treatment choice using data from nine existing clinical trials. The research will provide unparalleled precision medicine to improve the prediction of who is more likely to quit smoking based on their genetics.
The European Academy of Cancer Sciences (EACS) has issued a position paper to improve cancer research and care in Europe. The paper emphasizes the need for coordinated efforts between researchers, healthcare systems, and policymakers to decrease cancer incidence and increase cure rates.
Human skeletal stem cells have been isolated from fetal and adult bones, providing a breakthrough in understanding the molecular diagnosis and treatment of skeletal diseases. The discovery enables researchers to create a detailed lineage map of stem-cell-mediated formation of skeletal tissues in humans.
Researchers have identified a link between inflammation and cancer growth in HER2-negative breast cancers, revealing anakinra as a potential treatment target. Anakinra, an existing anti-inflammatory drug, reduces gene expression of IL1b and other cytokines, improving symptoms and quality of life for some patients.
Researchers found that a program designed to reduce stress in cancer patients can be taught to therapists across the country and effectively improves mood. The study involved 15 sites and 158 patients with various types of cancer, showing significant improvement on measures of mood and physical activity.
Physicists from the Helmholtz-Zentrum Dresden-Rossendorf have developed a new type of diagnostics to investigate the complex acceleration process of electrons and ions in hot plasma created by ultra-powerful lasers. The results, published in Physical Review X, confirm the spatial and temporal resolution of the diagnostic method.
A novel cosmetic product has shown promise in covering facial scars, with patients reporting improved satisfaction with their appearance. The treatment's effectiveness varies depending on the location and degree of scarring, but the results suggest a potential long-term solution for those affected.
Prescription drug shortages lead to estimated $230 million in annual costs due to rising prices and substitution drugs. Researchers found price increases reflect manufacturers' opportunistic behavior during shortages.
A new study reveals how KSHV protein LANA drives chromosomal instability, promoting cell proliferation and aneuploidy. The findings identify NNLS as a promising target for antiviral therapies.
Researchers at University of Helsinki have identified a key regulator of kidney development, revealing how MAPK activity influences nephron number in mature kidneys. This discovery holds promise for developing stem cell-based regenerative therapies as novel treatments for renal diseases.
Researchers have identified mutations defining two common subtypes of MPAL, B/myeloid and T/myeloid, and shown that some patients may benefit from targeted therapies. The study provides a genetically based framework for designing clinical trials to develop more effective treatments.
Researchers developed a new framework combining three methods to find large DNA mutations in cancer cells. The approach reveals how these mutations contribute to cancer development and can help predict effective treatment plans.
A new study published in CANCER journal reveals that social support is the most decisive factor associated with life satisfaction among young patients with cancer. The research found that young adults with cancer who have strong social connections experience higher life satisfaction, regardless of other factors.
Scientists developed a bioadhesive, wirelessly-powered implant emitting light to kill cancer cells, promising effective treatment for internal organ cancers. The device overcomes limitations of conventional photodynamic therapy by providing continuous, local light delivery.
Researchers created a new diagnostic tool using advanced analyses to identify tumors with unknown origins. The tool helped diagnose a metastasis of melanoma residing in the lung, leading to effective treatment with BRAF inhibitors.
A new four-year study aims to decrease psychological distress in cancer patients and their family caregivers during treatment using a sequential multiple assignment randomized trial. The study will employ two interventions: a printed symptom management handbook and a telephone counseling intervention.
Researchers developed a predictive model using liquid biopsies and serial blood samples from patients with advanced colorectal cancer treated with anti-EGFR therapies. The model accurately predicted personalized waiting times for disease progression, outperforming traditional tumor genotyping methods.
A new study finds that clinical quality registries for surgery often exclude treatment-related adverse events, leading to misleading conclusions. The study analyzed data from Finland and compared it with US and UK quality registers.
Osaka University researchers successfully delivered microRNAs to immune response cells in inflamed intestinal tracts using a super carbonate apatite (sCA), reducing inflammatory cytokines. The study showed that sCA could be used to treat a wide range of immunity and allergic disorders caused by immune responses.
Researchers at NUST MISIS have developed a system that improves cancer diagnosis accuracy and provides opportunities for targeted therapy. The magnetoferritin compound, introduced into the body before diagnosis, enhances contrast signals in imaging and targets tumor cells for destruction.
A new study identifies HIF1A, a gene that regulates metabolic changes and oxygen levels in cells, as a potential therapeutic target for treating myelodysplastic syndromes (MDS). The researchers found that inhibiting HIF1A reversed a broad spectrum of MDS symptoms in genetic mouse models.
ReMix uses wireless signals to pinpoint the location of ingestible implants inside the body with centimeter-level accuracy. This technology has the potential to improve proton therapy cancer treatment by allowing doctors to track tumors in real-time and deliver targeted radiation.
Research found that STAT3 is constitutively activated in CAEBV-infected T- or NK-cells, promoting cell survival and inflammation. Ruxolitinib inhibition blocks survival and reduces pro-inflammatory cytokine production, suggesting a potential therapeutic target for this fatal disorder.
Researchers at the University of Copenhagen have developed a new method to diagnose cancer at its early stages using a malaria protein. The method retrieves individual cancer cells from blood samples, catching them in greater numbers than existing methods, allowing for earlier detection and improved treatment outcomes.
Researchers at H. Lee Moffitt Cancer Center suggest that lowering pH inside cancer cells can slow down the growth and spread of the disease. By analyzing how variations in pH affect metabolic enzymes, they identified potential therapeutic targets for breast cancer treatment.
Researchers have identified 85 genes essential for fission yeast cells to maintain their ability to divide after being starved of nitrogen. The study sheds light on the genetic network required for resting cells like cancer stem cells to reactivate and has potential applications in developing new therapies to treat cancer. This discove...
Researchers discovered a molecular switch, PI3KC2A, that regulates signaling cascades in cells. Activating or inhibiting this enzyme may lead to new therapies for cancer and diabetes. The study's findings provide unprecedented insight into cellular processes and offer potential targets for treatment.
Researchers have identified a blood biomarker called KIM-1 that can predict the risk of developing kidney cancer over the next 5 years. Measuring levels of KIM-1 in the blood may help detect kidney cancer earlier, potentially improving survival rates.
Research suggests that psychedelic drugs can help treat disorders such as social anxiety, depression, and PTSD when used in combination with psychotherapy. Studies have shown promising results for MDMA, psilocybin, and ayahuasca in reducing symptoms of anxiety, depression, and disordered eating.
Researchers at the University of Exeter discovered new compounds that can reverse key aspects of human cell aging by targeting mitochondria. The findings, published in the journal Aging, show a significant reduction in senescent cells and potential therapeutic applications for anti-aging treatments.
A study found that reducing NOVA1 gene activity inhibits telomerase, leading to shorter telomeres and reduced tumor growth in non-small cell lung cancer. The research provides a new approach to targeting cancer cells and may lead to more effective treatments for this prevalent form of age-related cancer.
Research suggests that early childhood trauma may be a risk factor for anxiety and depression in adults diagnosed with head/neck cancer. The study found that patients who experienced emotional neglect were more likely to have advanced cancer stages, while physical child abuse was linked to increased anxiety levels.
Researchers identify a new mechanism used by Henipaviruses to hijack the DNA-damage response machinery, allowing them to prosper in cells. This discovery may lead to the development of new anti-viral therapies.
Jackson Laboratory Assistant Professor Mingyang Lu has developed a computational approach called RACIPE to capture genetic events in cellular decision-making. The algorithm could have broad impact on basic research and designing new therapeutic interventions in genomic medicine.
Medical nutrition therapy (MNT) is crucial for slowing chronic kidney disease progression and reducing healthcare costs. Despite its importance, only 10% of non-dialysis kidney patients receive MNT, which includes individualized nutrition assessment and personalized dietary education.
A computational study has shown that cancer cells proliferate less and are more vulnerable to acidic conditions than initially thought. The researchers have identified potential therapeutic targets by analyzing how variations in pH affect metabolic enzyme activity, providing opportunities for new treatments.
A large-scale retrospective study has shown that nearly doubling the number of lymph nodes removed during operations for right-sided colon cancers improves the survival rate for these patients. The study found improved outcomes when at least 22 lymph nodes were harvested, with a 20% increase in five-year survival rates.
Researchers explore two approaches to stem cell therapy for Parkinson's disease, one using patient-specific induced pluripotent stem cells and the other utilizing parthenogenetic-derived neural stem cells. The latter approach offers advantages in terms of reduced immunogenicity and evasion of ethical issues surrounding embryos.
A new study published in the American Cancer Society journal reveals that many patients with cancer face significant financial difficulties due to treatment costs. Despite medical oncologists, surgeons, and radiation oncologists reporting some engagement with patients about financial concerns, unmet patient needs persist.