Research on new and better ways to treat cancer. Covers radiotherapy, targeted microdroplets, nerve-injury protection, drug combinations, and tumor models.
A new study found that patients with low risk of local recurrence can safely undergo surgery alone without receiving chemoradiotherapy. This strategy could reduce the number of patients who receive chemoradiotherapy by half, with minimal risk of undertreatment.
A new tool uses high-throughput DNA sequencing to accurately predict which early-stage Cutaneous T Cell Lymphoma (CTCL) patients are at risk of developing an aggressive form of the disease. The tool, which analyzes specific genes, has shown promise in improving treatment outcomes for these patients.
A new biomarker, CKAP4, has been identified in patients with stage I lung cancer, offering a potential non-invasive diagnostic marker that could improve patient outcomes. The sensitivity of serum CKAP4 was found to be higher than current sero-diagnostic markers.
A new study by Sanford Burnham Prebys Medical Discovery Institute (SBP) researchers describes how nuclear pore component Nup210 is critical for the survival of circulating CD4+ T cells. The findings identify a new node of T cell receptor signaling and could pave the way for the development of future immunotherapies.
A study found that parenting concerns about the impact of illness on minor children have a strong negative association with health-related quality of life among women with metastatic cancer. The researchers recommend interventions to reduce psychological concerns and assess parenting concerns in patient care.
A study published in the British Journal of Cancer found that men with testicular cancer who underwent vigorous exercise improved their energy levels and self-esteem. High-intensity interval training was particularly effective in reducing tiredness and improving overall vitality.
A recent study by Michigan Medicine has found that over one-third of cirrhosis cases are related to alcohol consumption, with women being disproportionately affected. The study reveals that patients with alcohol-related cirrhosis have higher healthcare costs and poorer health outcomes compared to those without the condition.
A systematic review and meta-analysis found that psychological interventions using cognitive behavioral approaches can reduce chronic pain intensity and improve self-efficacy in older adults. However, the study's limitations highlight the need for further research to develop more effective treatments.
A team of melanoma experts at Moffitt's Center of Excellence will investigate the causes and drivers of acral melanoma, a rare form of skin cancer affecting African-Americans. The three-year grant aims to develop better prevention and treatment strategies for this aggressive disease.
New research from UBC Okanagan shows that community-based initiatives and microgrants are effective in increasing physical activity among breast cancer survivors. The program, Project MOVE, supports community-led interventions and fosters social support and confidence
A new web-based support programme offers online cognitive behavioural therapy and peer support to survivors of prostate cancer, aiming to improve their mental health. The programme has shown promising results in reducing distress and improving quality of life among men recovering from the disease.
A recent study published in Cell Reports has revealed that mutant Isocitrate dehydrogenase 1 (IDH1) drives glioma development by cooperating with multiple mutations and events in brain tumor cells. This breakthrough discovery provides substantial evidence for the functional role of mutant IDH1 in tumorigenesis.
Researchers at UTHealth and Ohio State University combined virotherapy with boosting the natural immune system to fight cancer. The study found that increasing the number of externally added NK cells strengthens the ability to fight cancer.
Treating leg ulcers within two weeks improves healing rates by 12% compared to standard treatment, with a success rate of 85.6%. Early intervention helps patients recover quicker and reduces the risk of complications such as amputation.
Researchers at Sanford Burnham Prebys Medical Discovery Institute discovered that PKC zeta deficiency promotes liver metastasis through the inactivation of enzyme ADAR2, leading to increased secretion of miR-200s. Treatment with a compound inhibiting miR-200s reduced liver metastasis in mice with colorectal cancer.
Increasing tumor size relative to testis size is linked to reduced sperm production in men with testicular cancer. The rule of 50s suggests that men with a testis tumor occupying greater than 50% of their testis have less than a 50% chance of sperm production.
Researchers discover urethane, a compound formed during beer and wine fermentation, is more effective at combating seizures caused by organophosphate nerve agents than the current recommended treatment. The study suggests urethane or its derivative may prevent seizures from developing into epilepsy.
The Pancreatic Cancer Collective, funded by the Lustgarten Foundation and Stand Up To Cancer, will accelerate research for pancreatic cancer patients. The initiative aims to improve diagnosis and treatments, as well as support the next generation of pancreatic cancer investigators.
Researchers developed a powerful mouse model using CRISPR-Cas9 and RCAS/TVA system to mimic glioma genetic alterations. The model enables the study of gene fusions and mutations in cancer progression and treatment response.
A real-world study found that patients with chronic hepatitis C virus infection who achieve a sustained virological response (SVR) after direct-acting antiviral agent (DAA) treatment have lower all-cause mortality. Achieving SVR reduced mortality from both liver-related and unrelated causes at all stages of disease.
The study confirms that long-term OCA treatment leads to reversal or stabilization of fibrosis/cirrhosis in patients with primary biliary cholangitis (PBC) who have had an incomplete response to ursodeoxycholic acid (UDCA). The majority of patients improved or maintained their histological stage, while two patients deteriorated.
Researchers engineered a donor cornea with genes that inhibit vascularization, reducing the risk of tissue rejection in high-risk patients. The study shows promising results for gene therapy in preventing corneal graft rejection.
DAAs therapy in Scotland significantly reduced HCV-related decompensated cirrhosis presentations, with a 29-39% reduction. Early treatment initiation also showed lower lifetime costs and quality-adjusted life years.
Researchers discovered three evolutionarily distinct types of kidney cancer, each with its own evolutionary path. The study sheds light on the fundamental principles of cancer evolution and could lead to future clinical tests for more accurate prognoses and personalized treatment.
Recent studies in the Journal of Lipid Research reveal that dietary lipids can either treat or exacerbate diseases, depending on their type. The ketogenic diet has shown mixed results as a cancer therapy, while polyunsaturated fats like omega-3 and omega-6 have different effects on inflammation and brown fat formation.
Researchers developed personalized T cell adoptive immunotherapy for patients with HBV-related HCC, resulting in an objective positive response with volumetric reduction of lung lesions and no new lesions detected. The therapy showed promise with no therapy-related adverse events.
A new assay using droplet digital PCR has been developed to detect closed circular DNA (cccDNA) in serum, single cells, and preserved tissue samples. This allows for the early detection of hepatocellular carcinoma (HCC) and more effective treatment.
A new study reports that consuming high amounts of carbohydrates and sugar prior to treatment for head and neck cancer may increase patients' risks of cancer recurrence and mortality. However, moderate fat and starchy food consumption after treatment appears to have protective benefits, reducing disease recurrence and death rates.
The ALS Association granted Lauren Sciences LLC its third award for developing LAUR-301, a V-Smart Nanomedicine for ALS. LAUR-301 aims to deliver GDNF across the blood-brain barrier and induce neuro-restoration in all ALS patients.
A new study suggests that high-quality cervical cancer screening can be effectively done using automated technology, which could improve coverage in underserved regions. The researchers developed a novel risk score algorithm based on computer-scanned liquid-based slide features to separate HPV-positive women for treatment.
Researchers at Sanford Burnham Prebys Medical Discovery Institute reveal that the loss of p62 in fat cells fuels aggressive prostate cancer by inhibiting energy-consuming processes. This discovery opens new avenues for therapeutic targeting and highlights the importance of considering whole-body metabolism in cancer treatment.
Researchers found that oral sirolimus treatment significantly improved pulmonary function and reduced carcinoid tumor volume in three patients with DIPNECH syndrome. The study provides promising evidence for sirolimus as a viable treatment option for this rare condition.
The American Society for Gastrointestinal Endoscopy has released new guidelines for the use of endoscopic eradication therapy in patients with Barrett's esophagus, a precursor to esophageal adenocarcinoma. The guidelines support evidence-based recommendations and clinical guidelines addressing key issues related to Endoscopic Eradicati...
Researchers developed an index measuring similarity between cancer cells and pluripotent stem cells to predict tumor aggressiveness, treatment resistance, and clinical outcome. The index may help identify novel therapeutic targets against cancer by pinpointing the point at which tumor cells acquire stem cell-like characteristics.
A study published in Journal of the American Academy of Dermatology found an FDA-approved topical solution to be less cytotoxic and damaging to melanocytes than cryosurgery, suggesting a safer option for seborrheic keratosis removal
Patients with alcohol-related liver cancer tend to have poorer overall survival rates compared to those with non-alcohol related liver cancer. The study highlights the need for improved screening and treatment programs for patients at risk of developing cirrhosis or liver cancer, especially those who are still drinking.
A research team at Case Western Reserve University is developing an AI-powered tool to analyze computerized images of tissue samples for patterns that can predict the risk of recurrence in oropharyngeal cancers. This could lead to more personalized treatment approaches for patients with these aggressive tumors.
A new quality improvement initiative, NAPRC, aims to improve US rectal cancer care by adopting a multidisciplinary team approach. The program's proposed quality measures and process indicators were analyzed, revealing varying completion rates among hospitals.
Scientists identified a mechanism of resistance to ibrutinib, a current treatment for non-Hodgkin lymphoma, and discovered a promising therapeutic target in three enzymes. Blocking these enzymes with masitinib completely ablated the B-cell receptor pro-tumorigenic signals.
Researchers have identified two genes, PIAS1 and IRF8, that play a crucial role in regulating the replication of Epstein-Barr virus. By understanding how these genes interact with the virus, scientists may develop new treatments for cancer types associated with EBV infection.
The study found that nearly half of the wives reported that their partner's health problem affected their own health, with many feeling increasingly socially isolated. The women also expressed concerns about the role change in their relationship as their husbands became less able to fulfill their usual roles.
Researchers have identified two new biomarkers, a trio of RNA molecules, to help determine the severity of neuroblastoma in children. This discovery has immediate significance for disease prognosis and will eventually contribute to more effective treatments.
A study found that adults with a history of cancer treatment exhibit higher levels of fatigue and reduced endurance compared to those without a cancer history. The researchers discovered a significant association between a history of cancer treatment and increased fatigability, particularly in older adults.
A major international survey found that around 25% of patients with penile cancer are not receiving recommended treatment. This leads to a significantly lower survival rate, with twice as many patients surviving if treated according to guidelines.
For male anti-NMDA receptor encephalitis patients without tumors, plasmapheresis has been found to be an effective treatment strategy. Studies comparing treatments such as intravenous immunoglobulin and rituximab with plasmapheresis have shown that the latter is not inferior in efficacy.
Researchers from the University of Pennsylvania School of Nursing used implementation science to evaluate cervical cancer prevention programs in sub-Saharan Africa. They identified a need for additional organizational and structural support to sustain implementation and improve cervical cancer prevention.
A new imaging technology has been developed to grade tumour biopsies, eliminating human subjectivity and variability. The Digistain method uses mid-infrared light to map out chemical changes that signal cancer onset, providing a reliable indicator of disease progression.
Researchers at Washington University School of Medicine have discovered a new way to fight sepsis by boosting the immune system with a drug that increases key immune cells. The approach has shown significant and lasting improvements in patients, offering hope for improved survival rates.
A recent study published in JAMA Ophthalmology found that high levels of ICAM-1 are associated with better response to current treatments for diabetic macular edema. The discovery could lead to more personalized and tailored medicine, alleviating treatment burdens on patients and the healthcare system.
The Physicians Committee's new app provides comprehensive nutrition information for nearly 100 medical conditions, addressing key issues like diabetes, heart disease, and obesity. Developed in partnership with Unbound Medicine, the app is designed to support clinicians in their daily practice.
Researchers developed a novel small molecule PET tracer to noninvasively detect EGFR mutation status in NSCLC patients. The approach showed high accuracy and potential for predicting treatment response and monitoring dynamic changes during therapy.
A recent study found that patients are willing to travel up to 75 minutes longer and 5 hours longer to receive specialized cancer care with improved outcomes. Centralization of cancer surgery services can reduce variations in quality of care and improve patient health outcomes.
The Neuroendocrine Tumor Research Foundation (NETRF) has awarded six new research grants totaling $1.85 million to leading academic institutions worldwide. The funding aims to improve current treatments for neuroendocrine tumors, a rare and poorly understood cancer affecting hormone-producing cells.
Early clinical studies with BET inhibitors and EZH2 inhibitors have shown remarkable activity in patients with lymphoma, including diffuse large B-cell lymphoma and NUT carcinoma. Tolerability has been generally good, but side effects such as thrombocytopaenia and fatigue have emerged.
The University of Plymouth will continue its neuro-tumour research with a £100,000 grant from Great Ormond Street Hospital Children's Charity and Sparks. The project aims to investigate the causes of Neurofibromatosis 2, a hereditary condition that leads to tumours in the nervous system.
Researchers found that in vitro testing is no help in predicting which nanoparticles successfully enter cells in living animals. A new DNA barcoding technique allows testing of over 100 nanoparticles simultaneously in a single animal, accelerating the development of gene therapies.
Researchers found that viruses use epigenetic regulation to mute the immune system, causing cancer cells to proliferate. By demethylating specific gene promoter regions, it may be possible to revive an immune system muted by cancer-causing viruses and increase the effectiveness of immune-based therapies.
A new special issue of the Journal of Cancer Policy highlights the need for long-term research and better support for cancer survivors' non-medical issues. The issue aims to increase awareness of socio-economic challenges faced by survivors and engage stakeholders in research and practice.
Mutated Cyclin E and Myc genes induce premature DNA replication, leading to molecular collisions and new mutations. The study identified a method to map replication origins on all chromosomes, revealing that aberrant sites can cause genomic instability in cancers.
Researchers developed an AI-based computational tool to screen patients for common retinal diseases, achieving over 95% accuracy in diagnosis. The tool also showed promise in diagnosing childhood pneumonia with over 90% accuracy, highlighting its potential applications in healthcare.