Articles tagged with Cancer Treatments
Scientists successfully delivered CRISPR-Cas9 to the eyes of mice with wet AMD, modifying the VEGF gene and reducing choroidal neovascularization (CNV) by 58%. This breakthrough could lead to a new therapeutic modality for non-hereditary degenerative diseases.
A study found that adolescents and young adults (AYAs) with acute leukemia had significantly worse survival rates if not treated at specialized cancer centers. AYAs treated at these centers had outcomes comparable to children, suggesting treatment quality can mitigate poor outcomes.
A 258-page report outlines principles and guidelines for human genome editing, emphasizing caution on germline editing and enhancement. The report also explores clinical applications, risks, and benefits of the technology.
A blood test can detect bladder cancer patients' prognoses by analyzing circulating tumour cells in their blood. The presence of these cells is a predictor of cancer recurrence and death.
After prostate cancer surgery, patients often experience penile shortening due to anatomical changes. The study found that this change is shortest 10 days post-surgery but recovers to normal values within 12 months.
A global research team led by Professor Mike Stratton will study genetic samples from five continents to understand the causes of cancer. The project aims to identify unknown causes, determine environmental factors, and figure out how they lead to cancer.
A new mathematical analysis provides guidance for treating infections and tumors with drug resistance, suggesting that containment may extend effective life and improve patient outcomes in some cases. The study identifies two main factors influencing the choice between containment and aggressive treatment.
Researchers identify factors determining when containment or aggressive treatment is best, providing new guidance for physicians and patients. Containment strategies can prolong treatment life and improve outcomes in certain situations.
Following screening guidelines for HCC in cirrhotic patients significantly increases life expectancy, with a 5-month average gain compared to 'real life' monitoring. Cost-effectiveness analysis reveals that standardized surveillance is cost-effective at $1754/yr per life year gained in French costs and $32,415/yr in US costs.
A recent NIH study identified 40 new genes affected by HIF1α in melanoma, offering potential new targets for treatment. The research also found connections between gene expression and the spread of cancer cells, which could help predict tumor progression.
Researchers studied the impact of antibiotic treatment on gut microbes and metabolites in mice, finding significant changes in bacterial populations and metabolic output. The study highlights the importance of considering both microbiota composition and metabolome in understanding human health.
A new technique separates circulating tumor cells from whole blood at a liquid-liquid interface, capturing 95% of CTCs in one minute. This method enables early detection and monitoring of metastatic disease, improving cancer treatment outcomes.
Research reveals that adult childhood cancer survivors who received neurotoxic treatments are less likely to have had intercourse, be in a relationship, or have children. Despite this, they report similar satisfaction levels with their sex lives and romantic relationships.
Lily and Yuh-Nung Jan receive $100,000 prize for their discoveries on neural development, vision, and hearing; Michaela Gack, Michael Halassa, and Ahmet Yildiz win $50,000 for their innovative work in biomedical science
A study published in JAMA Oncology found that patients with autoimmune diseases taking azathioprine had a higher risk of developing therapy-related myeloid neoplasms. Researchers also identified other medications used by these patients, but only azathioprine showed a statistically significant association.
Researchers predict that melanoma death rates will decrease by 2050 due to the aging of populations, but the number of deaths may increase. Effective treatments could lead to a further decline in mortality rates.
A Yale-led research team found that a melanoma cell and a white blood cell can fuse to form a hybrid with the ability to metastasize, providing insight into how cancer spreads from solid tumors.
A new study reveals that changes in translation play a crucial role in the development of skin cancer. The researchers found that eIF2A, a protein involved in translating genetic instructions, is overexpressed in certain types of cancer and can serve as a potential therapeutic target for treating the disease.
The GSG III Foundation has pledged over $1 million for a new research program at the University of Louisville, aiming to develop better methods for studying lung inflammation and explore potential therapies. The program will focus on chronic obstructive pulmonary disease (COPD), cystic fibrosis, and asthma.
Targeting therapeutic genes to the lungs offers potential for managing serious lung diseases that do not respond to other treatments. Preclinical and human clinical studies have targeted various genetic diseases, including cystic fibrosis, asthma, and lung cancer.
Researchers identified how HIV infects macrophages despite protective protein SAMHD1 being switched off. A treatment to maintain macrophage defences could be crucial for reaching an HIV cure.
Researchers developed a universal CAR T cell therapy that overcomes the obstacle of generating personalized cancer-killing cells from young children. The treatment successfully eradicated leukemia from two infant patients, who remained disease-free for 10 and 16 months.
Patient navigators are a valuable resource for American Indians and Alaskan Natives with cancer, helping them overcome barriers to diagnosis and care. Researchers found that patients working with a navigator were almost four times more likely to have a definitive diagnosis within a year of an abnormal screening result.
Researchers develop a non-invasive procedure using high-energy carbon ions to treat cardiac arrhythmias, offering a gentler alternative to catheter-based surgery. The method, tested in animal studies, can permanently interrupt the propagation of disruptive impulses with pinpoint accuracy.
A new study reveals significant disparities in US cancer mortality rates among over 3,100 counties, highlighting unacceptable geographic variations and potential explanations for these differences. The analysis of 29 types of cancer shows that areas with high smoking rates and poor prevention programs tend to have higher mortality rates.
A recent study published in the Journal of Oncology Practice found that oncologists often avoid discussing prognosis with their patients due to a cultural norm. By pausing to ask if patients want to talk about test results, oncologists can create an opportunity for more holistic discussions about life and death.
Analysis of US data from 2002 to 2012 reveals significantly higher cervical cancer mortality rates among black women (77% higher) and white women (47% higher), with disparities increasing over time. Black women's corrected mortality rate is 10.1 per 100,000 women, compared to 5.7 for uncorrected rates.
Researchers at Tohoku University identified two new types of microRNA that improved hyperglycemia in a mouse model of diabetes. These miRNAs were shown to promote insulin-producing cell proliferation and regeneration, offering potential for therapeutic beta-cell regenerative therapies.
Researchers found that inhibiting PLSCR1 controls the infected cell's antiviral response, providing long-term protection from immune attack and excessive inflammation. This discovery holds promise for virally delivered treatments, inflammatory conditions, autoimmune disorders, and neurodegenerative diseases.
The study reveals that CPEB4 is essential for driving the liver stress response and preventing fatty liver disease. By understanding the molecular function of CPEB4, researchers can develop predictive markers and treatments to prevent this condition, which affects millions of people worldwide.
The study identified inactivating mutations in the B2M gene, which codes for a protein involved in the immune response. In lung cancer patients, higher levels of B2M expression correlate with improved response to immunotherapy.
A new review of scientific literature on curcumin finds limited evidence to support its therapeutic benefits for cancer and Alzheimer's disease. The compound is unstable under physiological conditions and not readily absorbed by the body, making it a poor therapeutic candidate.
Researchers from UGR and hospitals Virgen de las Nieves and San Cecilio found that telerehabilitation reduces side effects of breast cancer treatment, such as pain and fatigue. The online exercise program showed excellent results for patients, maintaining benefits even after 6 months.
A new study found that the Affordable Care Act (ACA) increased mammography use among all economic subgroups, including those with lower incomes. However, colonoscopy screening rates remained unchanged despite eliminating out-of-pocket expenses under the ACA. The findings suggest that other barriers to colonoscopy access may still exist.
The cancer death rate has decreased by 25% since its peak in 1991, resulting in 2.1 million fewer cancer deaths between 1991 and 2014. The decline is largely driven by reductions in smoking and improvements in early detection and treatment.
The new special issue of Future Oncology explores the field of psycho-oncology, which aims to integrate biomedical and psychosocial aspects of cancer care. The issue highlights the importance of developing a multi-disciplinary approach to cancer care, from both social and biomedical standpoints.
Researchers at Cincinnati Children's Hospital Medical Center found that overexpression of TRAF6 in hematopoietic stem cells drives the onset of myelodysplasia syndromes, a group of pre-malignant disorders leading to blood cancer if untreated. Potential treatment targets for MDS include TRAF6 and related proteins.
Researchers at Scripps Florida have identified a novel signaling circuit driving therapy resistance in advanced prostate cancer. Targeting the components of this circuit, such as the NF-kB pathway and microRNA miR-196b-3p, shows promise in blocking the expression of stem cell transcription factors that fuel aggressive tumor growth.
A University of Florida study found that discrimination interacts with certain genetic variants to alter blood pressure and increase the risk of hypertension. Vicarious unfair treatment, or experiencing discrimination through close friends and family, also had a significant impact on stress levels.
Scientists have developed a temporary tattoo ink that marks the spot for future treatment in skin cancer patients. The new ink glows under specific light conditions and can disappear after a period of time, eliminating the need for laser or surgical removal.
A special issue of Cancer Epidemiology shows that cancer registries in Kenya, Uganda, Colombia, India, and Barbados can provide valuable data for policy-making on cancer prevention, early detection, and treatment. The low cost of registration per person and economies of scale make them a viable option for resource-constrained countries.
Researchers have found that inflammation plays a role in the development of epilepsy in TSC patients and that targeting this process could be a potential therapy. Studies using a mouse model of TSC found increased levels of inflammatory molecules in brain tissue before seizure onset, which were reversed by anti-inflammatory compounds.
A Malaysian study found that four in five cancer survivors suffer from anxiety and depression a year after diagnosis. The study also highlighted the importance of addressing quality of life for cancer patients beyond clinical outcomes.
DBA's molecular mechanisms involve ribosomal protein deficiency, leading to p53 pathway activation and microRNA34A-mediated decreased red blood cell formation. Exogenous nucleosides may alleviate symptoms by reducing DNA damage response and increasing energy metabolism.
A special issue of Cancer Epidemiology highlights the importance of cancer registration in resource-constrained settings, demonstrating cost savings through economies of scale. The study reviews cancer registries in Kenya, Uganda, Colombia, India, and Barbados, offering lessons for other countries with similar constraints.
A new study published in Journal of Investigative Dermatology reports initial success with imiquimod, a topical skin cream for low-risk basal cell carcinoma lesions. The 5-year follow-up results show sustained efficacy and low recurrence rates for patients treated with imiquimod.
A new study found that socially isolated breast cancer survivors had a 40% higher risk of recurrence, a 60% higher risk of dying from breast cancer, and a 70% higher risk of dying from any cause. Women with larger social networks experienced better outcomes.
Researchers at Imperial College London have discovered a gene network of 320 genes associated with epilepsy. The M30 network is thought to be involved in how brain cells communicate with each other and its malfunction triggers seizures. Finding medications that restore this network could provide new treatments for the condition.
Researchers have developed biocompatible nanocapsules that transport glucose oxidase and L-arginine into tumor cells, starving them of nutrients while releasing toxic nitrogen monoxide. This synergistic treatment concept successfully inhibits cell growth, initiates cell death, and shrinks tumors in mice.
Researchers developed a model system to study ARID1A's tumor-suppressing effects on colon cancer. They found that ARID1A functions as a principal tumor suppressor by regulating active enhancers.
Recent evidence suggests a link between the gut microbiome and colorectal cancer development, with specific types of intestinal bacteria contributing to disease progression. Dietary-based therapeutic interventions, such as probiotics and prebiotics, may help modify the gut microbiome to reduce CRC risk.
Scientists discovered truncated p53 proteins that can promote cancer growth and metastasis. The mutant proteins interact with mitochondria and alter its functions, leading to tumor progression and poor outcomes.
Researchers found that administering amlodipine alongside chelation therapy effectively reduces cardiac iron in patients with thalassemia major, potentially combating heart failure and fatal arrhythmias. The treatment is considered safe and inexpensive, with no significant side effects.
The phase 3 ECOG-ACRIN E2905 Intergroup Study found that lenalidomide plus epoetin alpha resulted in improved major erythroid response rates and a similar toxicity profile compared to lenalidomide alone. This combination therapy showed significant benefits for patients with lower-risk, erythropoietin-refractory MDS.
A metabolite called D-2-hydroxyglutarate (D-2HG) has been identified as a promising target for future cancer therapies due to its ability to promote cancer cell transformation and increase the likelihood of tumor spread in colorectal cancer patients.
IDIBELL researchers describe the Ewing's sarcoma methylation profile for the first time, unveiling the potential of the PTRF gene as a prognostic marker and possible future therapeutic target. The study found that PTRF expression is associated with better survival rates in patients.
Fertility preservation for girls and young women with cancer is hindered by lack of awareness and funding. Despite guidelines, access to treatment is restricted due to variable oncologist awareness and conflicting funding policies.
A study found a sixfold increase in thyroid cancer incidence in South Korea between 1999 and 2008, mainly due to overdetection by screening. The researchers call for reduced ultrasound examinations in the general population to mitigate the economic burden of unnecessary treatments.
The Journal of X-Ray Science and Technology has added embedded 3D image videos to its articles, enhancing the value of five papers on kidney injuries, tumor diagnoses, and dental medicine. The videos allow readers to examine rotating 3D images in detail, gaining a deeper understanding of diagnoses, prognoses, and treatments.
Researchers at NUS have found that controlling TIP60 protein levels could prevent breast cancer cell spread. TIP60 interacts with DNMT1 and SNAIL2 to inhibit metastasis, suggesting a potential new strategy for treating various cancers.