Research on new and better ways to treat cancer. Covers radiotherapy, targeted microdroplets, nerve-injury protection, drug combinations, and tumor models.
Researchers discovered that a subset of myeloproliferative neoplasms (MPNs) are susceptible to treatment with immune checkpoint inhibitors targeting the PD-1/PD-L1 pathway. MPNs hijack this pathway to prevent T cells from attacking malignant cells, but mutant JAK2 activation can expose a therapeutic vulnerability.
A retrospective study of 1,629 patients with non-Hodgkin lymphoma found no significant differences in 4-year overall survival and disease relapse between those aged 65 and older versus 55-64 years old. The study suggests that age should not be a limiting factor in transplant eligibility.
Researchers at Purdue University found that microRNA miR-223 can help control inflammatory disease by regulating the NF-kB pathway, which is critical in human bronchial epithelial cells. Supplementing this microRNA to epithelial cells may provide a new treatment option for asthma and cancer.
Researchers propose a new conceptualization of cancer based on physical and biophysical symmetry. The study suggests that understanding cancer through the framework of symmetry can help reveal new ways to understand cancer.
A study published in Medical Care found that the Affordable Care Act significantly reduced the uninsured rate among adult cancer survivors, with a 38% relative decrease. Cancer survivors eligible for Medicaid expansion under the ACA had the largest reduction in uninsured rate, with a 16.7 percentage point drop.
Researchers at Imperial College London found that xenon gas can limit blast-induced brain injury by preventing damage from developing. The study suggests that xenon could be a viable treatment option after blasts occur, potentially reducing debilitating symptoms.
A Swedish study revealed that social benefits can mitigate the financial impact on parents of children diagnosed with cancer. However, mothers of children with cancer often experience persistently lower income after these benefits are no longer provided.
Researchers have successfully generated Tasmanian devil stem cells, offering a potential treatment for the deadly transmissible cancer. The development provides hope for saving the species from extinction, which is estimated to occur within 20-30 years.
Discussing patients' bucket lists with their doctors can encourage making medical care fit life plans, providing personalized care and healthy behaviors. Researchers found that 91% of respondents had made a bucket list, with those who valued faith and spirituality more likely to have one.
The proposed immunological model suggests that diseases such as cancers and infectious diseases may be linked to declining T-cell production with age. Therapies targeting improved T-cell production in the aging immune system could hold promise for treatment options.
Researchers have discovered a link between male sex hormone levels and vitamin D metabolism that may be targeted to treat osteoporosis in men undergoing prostate cancer therapy. Progesterone receptor blockers could enhance the effectiveness of vitamin D supplements, reducing bone fracture risks.
The organization raised $2.4 million to fund groundbreaking science at the Salk Institute, Rady Children's Hospital, Moores Cancer Center, and Sanford Burnham Prebys Medical Discovery Institute. This funding supports collaborative, translational research with a focus on clinical trials.
A new study reveals that starvation of sugar can trigger a unique signaling function in cancer cells, leading to cell death. By manipulating this property, researchers propose a potential combination therapy to target cancer metabolism and selectively kill cancer cells while leaving healthy cells intact.
Researchers have identified 52 microRNAs that are decreased in expression as thyroid cancer becomes more aggressive. Restoring these molecules' levels in tumors may be a novel treatment strategy.
3D organoid models derived from patient cells can guide clinical decision-making for individuals with gastrointestinal cancers. Researchers hope these models will predict treatment response and increase response rates by finding the best treatment combination for every patient.
Researchers analyzed over 500 cases of DIPG and related tumors to find that tumors with histone mutations that haven't invaded surrounding brain tissue have better outcomes. Patients with non-invasive tumors had approximately 4-5 times longer survival rates compared to those with invasive tumors.
Researchers used evolutionary dynamics to analyze malignant mutations in colorectal and intestinal cancers, finding that cancer stem cells can produce substantially different daughter cells with potential positive or negative impacts on cancer progression.
Researchers have identified EXD2 as a critical regulator of mitochondrial protein production, which is essential for energy generation and maintaining cellular homeostasis. The study found that EXD2 targets messenger RNA to facilitate the maturation of the mitochondrial ribosome, leading to increased protein production.
The Engineering and Physical Sciences Research Council (EPSRC) has announced support for 28 groundbreaking research projects, ranging from autonomous vehicles to energy storage and healthcare technology. These projects have the potential to make a transformative impact in various fields.
A recent study at Tampere University found that an eNose can identify the most common bacteria causing soft tissue infections without prior sample preparation. The device differentiates between MRSA and MSSA with high accuracy, reducing treatment times and costs.
A study by American Osteopathic Association finds cervical lesions progressing at different rates among Hispanic, white, Asian, and black women, affecting treatment options and risk assessment. Hispanic women progressed faster to high-grade lesions but recovered faster from them.
A new saliva-based diagnostic test could identify people at risk for throat cancers earlier, enabling early treatment and prevention. The test aims to detect HPV infections in a low-cost, non-invasive manner.
Scientists at Tohoku University found that a protein called TRIM48 labels PRMT1 for destruction, leading to ASK1 hyperactivation and cancer cell death. This study reveals new potential therapeutic targets for treating cancers and neurodegenerative diseases.
Researchers at Monash University have identified a novel molecular 'blueprint' that enables the immune system to fight disease by 'remembering' past infections. This discovery potentially opens new avenues for improving vaccines and therapies, including those targeting cancer and autoimmune diseases.
A new study found that inherited variation in the ADAMTSL1 gene is associated with a poorer survival rate in early-onset breast cancer patients. The research, published in Nature Communications, suggests that this genetic factor may be used to improve prognostic models and inform treatment decisions.
Researchers at the University of Copenhagen have discovered a new mechanism by which cancer-inhibiting proteins regulate signaling molecules. The study found that primary cilia, or cellular antennae, play a crucial role in balancing PDGFRα signaling, preventing excessive receptor activation that can lead to brain and gastrointestinal t...
A new study found that person-to-person genetic differences can impact the efficacy of gene editing technologies like CRISPR-Cas9. The researchers analyzed 7,444 whole-genome sequences and discovered that about 50% of guide RNAs could be affected by variants at their target sites.
Researchers found that socio-demographic factors such as income level, education, and insurance status significantly impact access to stem cell transplants for patients with multiple myeloma. Higher-income Whites and Blacks, and those with private insurance, were more likely to receive the treatment.
Researchers developed a genetic model that predicts outcomes in primary myelofibrosis patients under 70 using gene mutations and clinical variables. The model improves on previous predictive models, which only used clinical variables.
Researchers at Thomas Jefferson University discovered how losing a gene leads to large-scale genetic changes that make cancer more aggressive and resistant to treatment. The study shows promise for personalized therapy using liquid biopsies to track RB status in prostate cancer patients.
Researchers at NUS Cancer Science Institute discovered a molecular pathway in which TIP60 inhibits cancer cell growth by targeting telomerase. This finding offers a new approach to treating various types of cancer triggered by high telomerase levels.
A new gene therapy transplantation technique could improve treatment of neurodegenerative diseases by generating genetically engineered microglia-like cells in the brain. This technique has been tested on an experimental model for a metabolic disease and may have future therapeutic applications for other neurodegenerative diseases.
Scientists have made a breakthrough in treating neurodegenerative disorders and lysosomal storage diseases by transplanting hematopoietic stem cells directly into the brain, achieving therapeutic benefits faster than traditional methods. This innovative technique could pave the way for new treatments for Parkinson's, Alzheimer's, and o...
Large racial disparities were found in the survival of patients with ovarian, colon, and breast cancers in the United States. Black women had consistently worse survival compared to white women, despite similar stage distributions. The five-year net survival for black women was lower than for white women in all three types of cancer.
Researchers at Tufts University have developed a new approach to analyzing complex genomic rearrangements (CGRs), enabling rapid and precise identification of their causes and impact on DNA and cellular formation. This breakthrough could lead to significant advances in diagnosing and treating genetic disorders and certain cancers.
A recent study examined the intubation decision-making process of 73 hospital-based doctors from three academic medical centers. The researchers found that mental models of doctors who deviated from patient preferences focused on reversibility, inferred consent, and comfort levels. This variation highlights the need for well-structured...
D'Angelo will investigate the role of altered nuclear pore complexes in blood cell malignant transformation and cancer. His research may lead to better treatments and potentially cures for leukemia.
Researchers have imaged ATR kinase protein at unprecedented resolution using electron microscopy, revealing regulatory sites poised to activate in response to DNA damage. The high-resolution structural information may aid in developing new therapeutics for cancer treatments and improving cellular health.
A study found that microRNA-31 accelerates intestinal stem cell growth, potentially leading to bowel cancer. The molecule's levels increased after radiation exposure, suggesting a role in regeneration, while also promoting tumor growth.
Researchers investigate pretreatment with etanercept to manage post-treatment inflammation in neurocysticercosis, a major cause of epilepsy worldwide. Etanercept suppresses inflammatory pathways involved in treatment-induced inflammation.
The study found that urban American-Indian and Alaskan Native individuals had a higher risk of mortality from prostate and breast cancer, with AIANs facing an 87% increased risk for prostate cancer-specific mortality. The community's unique history of social and environmental injustices may be contributing to these disparities.
A recent study published in Cancer journal shows that communities with strong smoke-free workplace laws have lower rates of new lung cancer diagnoses. The study found an eight percent reduction in lung cancer incidence in communities with strong smoke-free laws compared to those without such laws.
Researchers have discovered a molecular commonality between two progeroid syndromes and introduced a method for disease recognition that could lead to breakthroughs in therapy. By characterizing disruptions in DNA replication timing, the team identified a shared abnormality in the gene TP63.
A team of scientists led by Johns Hopkins University biologist Vincent Hilser has cracked the mystery of proteins that emerged as a distinct type less than 30 years ago. They discovered how these 'intrinsically disordered proteins' regulate their activities and interact with other proteins, constituting the majority of proteins involve...
Researchers at UVA Cancer Center are developing a tool to assist patients in making treatment decisions based on their tumor's genomic information. The tool aims to provide personalized comparisons of treatment options, incorporating factors like age, personal priorities, and health conditions.
Researchers developed tiny robots measuring a few millionths of a metre long that can diagnose and treat illness in hard-to-reach areas. The robots could track chemical changes linked to illness onset and deliver targeted drugs with high precision, potentially paving the way for new diagnostic and therapeutic approaches.
Researchers at NIST developed a novel method for measuring tumor growth using disposable diapers as 'phantoms' with water. Volumetric measurement proved more accurate than the traditional RECIST approach, potentially enabling earlier and more effective cancer screenings.
A recent study found that approximately one-fifth of cancer patients develop PTSD several months after diagnosis. Researchers emphasize the need for early identification and treatment to improve psychological well-being and quality of life.
A subset analysis of the FLAURA trial found that osimertinib improved progression-free survival by 16.5 months compared to 11.0 months with standard therapy in Asian patients with EGFR-mutated non-small-cell lung cancer, resulting in a hazard ratio of 0.54.
A new project led by Queen Mary University of London aims to develop and test a talking-based therapy for cancer survivors, addressing issues such as fatigue, fear of recurrence, and concerns about returning to work. The therapy, Acceptance and Commitment Therapy (ACT), will be assessed in a full trial involving 344 participants.
Ludwig Cancer Research researchers will present findings on cancer cell metabolism, tumor microenvironment, and potential therapeutic targets. They will also discuss the use of immunotherapy to treat brain cancer, including results from a Phase 2 clinical trial.
A high dose of hydroxyurea significantly increased fetal hemoglobin levels and reduced hospitalizations among young sickle cell anemia patients. The study found that maximizing the dose resulted in a substantial reduction in hospitalizations, with nearly all patients experiencing improved health outcomes.
The summit brought together experts to define endoscopic therapies in obesity management and reframe the debate around obesity as a chronic disease. Key findings include the need for public health measures, reduced stigma, and increased collaboration among medical specialties.
Cristina Lo Celso, a rising star in biomedical research, has been awarded the Foulkes Foundation Medal for her groundbreaking work on leukemia. Her research focuses on understanding how leukaemia cells develop and relapse, with the ultimate goal of improving treatments and preventing disease recurrence.
A new study found significant disparities in survival rates for patients with different types of human papillomavirus (HPV)-associated cancers. The findings highlight the need for improved HPV vaccination, cancer screening, and treatment access to address these disparities.
A new study found that antidepressants are ineffective in treating depressed patients with chronic kidney disease, prompting experts to reconsider treatment approaches. Alternative therapies such as ketamine, electroconvulsive therapy, and psychotherapy may be more effective for these patients.
The European Society for Medical Oncology advocates for a unified and comprehensive cancer research program across Europe. Key findings include the urgent need for integrated cancer research, diagnosis, and treatment targets.
Chronic hepatitis B and C cause life-threatening liver damage, cancer, and premature death, with 300 million infected worldwide. Donors are essential to deliver results in the next 13 years, as domestic funding is unlikely to meet the challenge.
A new article proposes a virtual European Cancer Institute to combine innovative prevention and treatment strategies, achieving high survival rates in countries with well-developed healthcare systems. The initiative aims to address economic and social inequalities in less developed systems
A recent study by UNC Lineberger Comprehensive Cancer Center researchers found that more than half of men with prostate cancer prefer preserving sexual function, but this preference was not strongly linked to the choice of treatment strategy. Active surveillance is widely recognized as the best option for preserving sexual function, ye...