Articles tagged with Cancer Treatments
A recent study by Sanford Health identified gene mutations that could impact treatment for adult cancer patients. The study found nearly 90% of patients had genes that matched treatment options, with 40% able to receive personalized therapy.
Researchers have identified BRCA1 mutations that predict treatment resistance in breast and ovarian cancers. Studies found that tumors with these mutations express a RING-deficient BRCA1 protein, leading to poor treatment responses.
Researchers at Washington State University have developed a technique to visualize DNA damage caused by ultraviolet radiation, shedding light on its impact on skin cancer. The study provides clues on how sunlight triggers mutations and cancer, with implications for future therapies.
The Scripps Research Institute has received a grant to support safety and quality tests of a potential stem cell therapy for Parkinson's disease. The two-year project will investigate induced pluripotent stem cells derived from adult subjects, which can differentiate into dopamine-producing neurons.
Researchers have successfully programmed a virus to transport genetic material to affected tissue and nerve cells, opening up new options for treating various diseases. The approach uses attenuated viruses to selectively target diseased cells, reducing damage to healthy ones.
A recent study by Northwestern University found that metastatic prostate cancer cases have increased by 72% between 2004 and 2013, with men aged 55-69 being disproportionately affected. The study suggests that both more aggressive disease and lax screening may be contributing factors.
A significant increase in metastatic prostate cancer cases has been observed, particularly among men aged 55-69. This rise is attributed to changes in screening practices and highlights the need for refining prostate cancer screening and treatment in the US.
A new pilot study evaluates an online decision-support tool called the Decision Counseling Program, which increases rates of active surveillance among men with localized, low-risk prostate cancer. Patients who used the tool reported feeling less conflicted about their treatment decisions.
Researchers have captured new images of a calcium-shuttling molecule that has been linked to aggressive cancers. This discovery could lead to the development of novel therapies and diagnostic tools for diseases caused by malfunctioning calcium adsorption.
Researchers from OVC at the University of Guelph discovered a new way to boost immune responses against cancer by injecting oncolytic viruses into the spleen, bypassing traditional vaccine limitations. This breakthrough could lead to safer and more targeted cancer treatments for various types of cancer.
A new study has found a way to starve tumors of their blood supply by inhibiting the replenishment of an intracellular substrate needed for vascular endothelial cells to respond to pro-angiogenic signals. This approach limits the growth of new blood vessels and enhances the effectiveness of therapy.
A new study found that individuals with diabetes may have a higher risk of developing cancer before and immediately after a diabetes diagnosis. The study suggests that type 2 diabetes may increase the risk of several types of cancer, particularly shortly after diagnosis.
A study published in GIE: Gastrointestinal Endoscopy found that patients with pancreatic cysts are at a significantly increased risk of developing pancreatic cancer, with an estimated 19.64 times higher risk compared to those without cysts.
Researchers at The Wistar Institute have discovered a specific network of proteins present in the mitochondria of cancer cells that enables their ability to proliferate, migrate, and spread. By targeting this pathway, they believe it may be possible to develop new treatments for various types of tumors
A molecule believed to indicate good cancer prognosis has been shown to cause genomic instability and promote tumor growth. The study, published in Nature Cell Biology, suggests that targeting p21 could lead to new cancer treatments.
A recent special issue of Future Oncology examines the field of oncofertility, highlighting its importance in cancer survivors' well-being. The focus on preserving fertility in cancer patients has revolutionized reproductive medicine and biology, with direct impact on oncology.
Researchers at Eindhoven University of Technology have developed a new computer analysis method to detect early stages of esophageal cancer in people with Barrett's esophagus, which can be as accurate as top specialists. The method aims to improve the detection and treatment of esophageal cancer, reducing the need for invasive surgery.
A study by University of Minnesota researchers has identified distinct structural features among seven types of retroviruses, including HIV and HTLV-1. The findings could inform the development of new antiviral treatments and vaccines for various diseases caused by these viruses.
A new study from Imperial College London reveals that patient complaints can have a profound impact on doctors' psychological wellbeing. The research found that many doctors experience feelings of worthlessness, helplessness, and even suicidal thoughts after receiving complaints.
The study projects that by 2040, there will be 26.1 million cancer survivors in the US, with 73% aged 65 or older. Increasing age increases the chance of comorbid conditions, and gaps exist between men and women in older age groups.
Researchers developed a novel method to identify likely cancer drivers among hundreds of genomic alterations. The technique uses tumor gene alterations to report on cancer progression, pinpointing GON4L as a potential driver and therapeutic target.
A study of older women with newly diagnosed stage I to III breast cancer found that approximately one in five experienced functional decline within a year of treatment initiation. The Vulnerable Elders Survey was used to identify those at risk, showing promise for early identification and prevention of functional decline.
A team of scientists has developed a computational method to map cancer progression, which offers new insights into the factors that spur this affliction. The researchers used gene sequencing data to create a model that predicts how a tumor's genomes will change over time.
A new study found that simple activities such as playing cards or throwing a foam ball can help patients regain strength and coordination after a stroke. The study showed improvements in motor performance of up to 40% with these activities compared to virtual reality games.
A team of researchers at St. Jude Children's Research Hospital discovered that the loss of essential protein Alix leads to hydrocephalus in mice by compromising the epithelial barrier and disrupting tight junctions. This study provides new insights into the molecular mechanisms underlying brain homeostasis.
Researchers outline recent progress in clinical applications of retinal gene replacement therapy and preclinical advances in gene-specific therapy for photoreceptor diseases. Gene therapy strategies are being developed to treat a broader range of disorders affecting vision, providing new hope for individuals with eye diseases.
A review of 60 studies found that plant-based therapies like phytoestrogens and herbal remedies may improve menopausal symptoms, such as hot flashes and vaginal dryness. However, the evidence is limited by quality and more rigorous studies are needed to confirm these findings.
A study found that surgeons who admit to bias towards their specialty increase patient trust and lead to more surgical treatments. Patients who hear this admission are nearly three times more likely to choose surgery, indicating a significant influence on patient decision-making.
Researchers found that inhibiting the p110α PI3K isoform is sufficient to block tumor growth and metastasis in a mice model of pancreatic neuroendocrine tumors. The study demonstrates promise for a new targeted therapy, with potential benefits including reduced toxicity compared to generic inhibitors.
A study analyzing over 34,000 lung cancer patients in England found that those aged 50-64 are more likely to be diagnosed at a late stage compared to older age groups. Younger patients in their 70s are more likely to be diagnosed with early-stage disease.
Researchers at The University of Texas Medical Branch found that adolescent and young adult cancer survivors are more likely to be current cigarette smokers. The study highlights the importance of addressing smoking during medical visits to encourage survivors to quit.
Paul A. Northcott, a researcher at St. Jude Children's Research Hospital, has been selected as a Pew-Stewart Scholar to tackle medulloblastoma, the most common malignant pediatric brain tumor. The award includes four years of funding and aims to develop much-needed therapies for patients who relapse.
A study found that patients with rheumatoid arthritis (RA) who are positive for the anti-CCP antibody respond better to abatacept, a T cell co-stimulation blocker. In contrast, patients without this antibody do not show significant differences in treatment response to TNF inhibitors.
ROSC provides coordinated, patient-centered services for substance abuse and psychiatric disorders, supported by primary care providers. The special issue highlights the critical role of ROSC in overcoming obstacles and sustaining recovery.
A new hybridization-induced aggregation technology detects KRAS mutations in lung and colorectal cancers, enabling targeted therapies. The technique is simple, rapid, and inexpensive, with 100% agreement with sequencing results.
A new pre-surgery technique using an expandable tube may make colostomy bags redundant for emergency bowel cancer patients. The study found that less than half of those who had their bowel unblocked needed a colostomy bag, while more than two-thirds required one after emergency surgery.
Researchers report that two topical creams are effective in most primary, low-risk superficial BCC patients, with favorable comparison to photodynamic therapy. The study found high clearance rates for imiquimod and fluorouracil treatments, but noted a higher recurrence rate for fluorouracil.
Researchers developed a new contrast agent to monitor stem cell treatments inside the body using MRI scans. The agent addresses technical challenges such as toxicity and accumulation in cells, offering improved resolution and sensitivity.
A commentary suggests that gene therapy treatments for rare diseases should be valued based on long-term cost savings. The authors propose tying costs to efficacy and creating a federal initiative to support new therapies.
Recent evidence suggests that AAV vectors used for gene therapy can trigger liver cancer in rare patients. A new article challenges re-interpreted data, reaffirming the link between insertional mutagenesis and hepatocellular carcinoma.
Many young adult female cancer survivors experience unmet informational needs and reproductive concerns, leading to decisional conflict about post-treatment fertility preservation. The study highlights the need for better resources to support survivors in making informed decisions about their reproductive options.
Immune cells build a molecular memory of their first meal after eating a dying neighboring cell, shaping their inflammatory behavior. This discovery may lead to novel therapies for inflammatory disorders such as atherosclerosis, cancer, and arthritis.
Researchers identify mutation in ATP4a gene responsible for aggressive form of inherited gastric NET. Restoring normal gastric acid balance with hydrogen chloride solution prevents tumour development in genetically engineered mice.
Researchers found that men with localized prostate cancer often underestimate their life expectancy without treatment and overestimate the benefits of surgery or radiation. This can lead to overtreatment, decisional regret, and decreased post-treatment quality of life. A recent study published in the Annals of Family Medicine suggests ...
Researchers from Memorial Sloan Kettering Cancer Center share results of experience with over 500 patients with pulmonary metastases from STS, identifying prognostic factors associated with improved survival. The study found that leiomyosarcoma histologic subtype, primary tumor size, and minimally invasive resections were significantly...
Breast cancer tumor-initiating cells use mTOR signaling to recruit myeloid-derived suppressor cells (MDSCs), which are involved in suppressing the body's response against tumors. This interaction helps researchers understand the events leading to tumor growth and metastasis, identifying potential therapeutic targets.
Ana Sofia Silva received the Best Ph.D. Thesis Award for her research on multifunctional nano-in-micro formulations for lung cancer theragnosis, proposing a new therapeutic approach to combat the disease.
Research shows that 1 in 5 colorectal cancer patients are depressed at diagnosis, and this can significantly impact their quality of life. The study highlights the importance of considering psychological factors in patient care and support.
The Society of Surgical Oncology and European Society of Surgical Oncology propose a global curriculum to address training variations and inadequacies. The curriculum aims to create a robust workforce of well-trained surgical oncologists to meet the growing need resulting from the rising global cancer burden.
The report, based on over 3,000 patient surveys, sheds light on the physical, emotional, financial, practical, and informational needs of cancer patients during and after treatment. It aims to inform program development and address patient needs throughout their continuum of care.
Researchers have discovered biomarkers in the brain that could help scientists develop effective treatments for single-sided deafness. The study used multi-modal imaging techniques to analyze changes in brain structure and function in response to the condition.
A UK study published in Nature reveals neurotensin as a potential biological marker for the development of obesity. Neurotensin, produced mainly in the gastrointestinal tract and central nervous system, is released with fat ingestion and stimulates fatty acid absorption in the intestine.
A study published in PLOS ONE found that gamma-retroviruses preferentially insert near cancer-associated genes, suggesting a new tool for identifying genes driving specific cancers. This discovery could lead to the identification of potential therapeutic targets.
Researchers from 39 institutions worldwide analyzed 91 samples of adrenocortical carcinoma, uncovering double the number of genetic drivers known to fuel adrenal cancer. The study also identified three distinct subtypes of adrenal cancer linked to different outcomes, suggesting a way to use molecular biomarkers for targeted therapy.
A new study found that cancer increases the risk for certain health issues beyond normal aging, including declines in activities of daily living and physical function. However, having a cancer diagnosis did not increase the likelihood of developing arthritis or vision/hearing problems, and did not exacerbate existing conditions.
A new study by Cardiff University found that combining insulin with metformin reduces mortality and heart attacks in people with type 2 diabetes. The researchers tracked 12,020 patients for three and a half years on average, finding no difference in cancer risk between single-insulin therapy and combination treatment.
A new study published in Cell Reports identifies microRNA molecule miR551b as a promising candidate biomarker and therapeutic target for treating ovarian cancers. The research found that targeting miR551b expression could block STAT3 activity, offering potential for treating the most common and deadly form of ovarian cancer.
The study uncovered five new genes associated with breast cancer and 13 new mutational signatures that influence tumour development. The analysis revealed the genetic variations in breast cancers and their distribution across the genome.
Researchers have developed a method to identify HPV infections using self-collected vaginal swabs, which provides accurate results similar to clinician-collected cervical specimens. This technology enables same-day screening and treatment, critical for preventing premature deaths from HPV-associated cancers in low-income countries.
Researchers at the Universities of York and Leiden have created fluorescent chemical probes to measure acid alpha-glucosidase enzyme levels in human cells. This technology enables rapid detection of enzyme deficiencies, informing more effective treatments for Pompe disease and potentially other inherited conditions.