Research on new and better ways to treat cancer. Covers radiotherapy, targeted microdroplets, nerve-injury protection, drug combinations, and tumor models.
Recent studies present contrasting evidence on DAA therapy's association with liver cancer. A study found a higher recurrence rate of hepatocellular carcinoma in patients who received DAAs, while another found no difference in HCC occurrence or recurrence between DAA and interferon-based therapies.
Children and adolescents have a higher risk of dying from second cancers compared to older adults. The study found that survival rates are significantly lower for second cancers in young patients, particularly those under age 40.
The study found that sexual function declined after all treatments, with robotic surgery patients regaining function closest to brachytherapy and radiation levels. Urinary incontinence also decreased most for surgical patients, with robotic surgery showing slight improvement over open surgery.
Scientists at Luxembourg Institute of Health discovered a new molecular mechanism where the human immune system activates T cells to fight off pathogens through the production of glutathione, a substance that stimulates energy metabolism. This discovery offers potential therapeutic strategies for targeting cancer and autoimmune diseases.
Researchers at Cincinnati Children's Hospital Medical Center discovered a small molecular compound, RCM-1, that blocks the transcription factor FOXM1 and its pro-inflammatory activity in asthma. The compound prevented overproduction of mucous-generating goblet cells and reduced lung inflammation.
A new study by University of Illinois researchers describes a method to detect and map tiny additions to DNA called methylations, which can be a warning sign of cancer. The method uses nanopores with an electrical current running through an atomically thin sheet of material.
In a recent editorial, Saint Louis University cardiologist Paul J. Hauptman emphasizes the need for patient-centric symptom relief as a primary goal in treating worsening heart failure. His review of the TRUE-AHF trial suggests that ularitide has limited short-term effects and may not improve longer-term survival.
A recent review suggests that a family history of prostate cancer does not increase the risk of more aggressive cancer progression. Men with a family history should discuss risks and options with their doctor, and further research is needed to confirm these findings, particularly among African American men.
As the US HIV population ages, cancer incidence rates for AIDS-defining cancers are expected to decline due to effective treatment with modern antiretroviral therapies. However, frequencies of other cancers such as lung and prostate cancer are projected to increase.
Osaka University researchers used sharp, ultra-short laser pulses to generate charged particles, achieving beams with higher energy and more precise control. The study challenged conventional models, finding that lower-intensity laser light can produce high-energy charged particles.
A study published in the AACR Annual Meeting found that longer-than-expected telomeres are associated with an increased risk of cancer. The research analyzed blood samples from over 28,000 Chinese people and found a significant link between telomere length and cancer incidence.
A Phase 2 clinical trial found that MLE4901 reduced the number and severity of hot flushes by 73% compared to placebo. The treatment was well-tolerated, with no serious adverse events reported. This study demonstrates the potential for MLE4901 as a non-hormonal treatment option for menopausal hot flushes.
Researchers have developed two new blood tests that can reliably detect previously unidentifiable forms of melanoma, a type of aggressive skin cancer. The tests use DNA fragments in the blood to monitor tumor growth and can detect changes in genes that help cancer cells multiply.
A new study analyzing over 50,000 patients with prostate cancer reveals a significant link between androgen deprivation therapy and dementia risk, suggesting that long-term use of this therapy may impact brain function. The findings also hint at a possible association between the treatment and Alzheimer's disease.
Ludwig researchers present symposiums, plenaries and poster sessions on tumor microenvironment, metabolism and immunotherapy; share insights on predictive biomarkers and early detection technologies like liquid biopsies.
Researchers found similar disease-free survival and overall survival outcomes between laparoscopic and abdominal hysterectomies for stage I endometrial cancer. The study suggests the use of laparoscopic hysterectomy as a viable alternative to traditional abdominal surgery.
A new study reveals that only 30% of men in a national survey reported having a balanced discussion with their doctor about the advantages and disadvantages of prostate-specific antigen (PSA) testing. This trend has become less likely since the U.S. Preventive Services Task Force recommended against PSA testing in 2012.
Researchers found that phototherapy improved behavioral responses and recovered myelin sheaths in rat models of diabetic neuropathy. The treatment also reduced the migration of astrocytes to the site of injury, which release inflammatory mediators.
The patent analysis highlights the importance of saffron bioactives in treating multiple disorders, including neurological and metabolic conditions. Novel derivatives of safranal show promise in treating infectious diseases.
A German survey found that overall awareness of heart failure has not increased over the past decade, with many adults lacking knowledge on its causes, presentation, prognosis, and treatment. The study emphasizes the importance of raising awareness about heart failure to improve early recognition and treatment.
A Vanderbilt University study found that active surveillance is a viable option for low-risk prostate cancer patients, preserving quality of life without significant side effects. The treatment was associated with excellent three-year survival rates and comparable outcomes to traditional treatments.
A new study found that adolescent and young adult cancer survivors often experience prolonged social difficulties, persisting even after treatment. Despite initial improvements in social functioning during the first year post-diagnosis, these patients tend to remain socially impaired relative to their cancer-free peers.
Scientists identify a molecular pathway that enables prostate cancer cells to escape the primary tumor and form secondary tumors. This discovery holds promise for developing new therapeutic strategies to stop cancer cells from spreading, offering hope for improved treatment options for patients with metastatic prostate cancer.
Researchers have identified pre-metastatic niches that prepare the ground for tumor cells to survive before invading other organs. Understanding this phenomenon could lead to new diagnostic and therapeutic tools to prevent cancer-related death.
A genetic connection to aggressive prostate cancer has been discovered, increasing the risk by threefold for men with a specific gene variant. The study's findings may lead to the development of a blood test to predict disease severity and aid in targeted treatment.
Scientists at IDIBAPS and IRB Barcelona developed a novel strategy to genetically modify viruses that selectively target tumor cells while sparing healthy tissue. The study's results show promising effectiveness in controlling tumor growth and destroying cancer cells, offering hope for new cancer therapies.
A Finnish-Swiss research team analyzed half of the human protein phosphatome, identifying molecular functions and pathways connecting protein phosphatases. The study reveals phosphatase-based regulation of human cancer and promises therapeutic intervention.
A recent study found that only a small percentage of baby boomers have been tested for hepatitis C virus (HCV) infection, despite the availability of treatments. The study suggests that increased awareness and innovative strategies, such as state-mandated testing, are needed to improve HCV testing rates among this demographic.
A recent study suggests that hormone replacement therapy may help improve heart health and overall survival in women, with lower levels of atherosclerosis and plaque buildup detected. The research found significant age-related benefits from the therapy, with women using it being 30% less likely to die than those not on hormone therapy.
A Cedars-Sinai study suggests that hormone replacement therapy is linked with lower levels of plaque buildup in the heart's arteries and improved survival rates among women. Women using HRT were found to be 30% less likely to die than those not on the therapy.
A study published in the Journal of Clinical Oncology finds that childhood cancer deaths within a month of diagnosis are significantly higher than previously reported, affecting young children and minority groups disproportionately. The study used a large national database to find that early deaths from some pediatric cancer subtypes w...
A Japanese research group has identified a newly-identified autoimmune endocrine disease caused by thymomas, which leads to hypopituitarism. The study found that abnormal expression of PIT-1 in thymoma cells triggers immune tolerance breakdown, resulting in autoimmunity.
A new study by Michigan Medicine researchers found that cells from lung transplant patients with bronchiolitis obliterans syndrome (BOS) can become activated and promote scarring. The team identified a chain of upstream signals starting with autotaxin, an enzyme that generates lysophosphatidic acid, which stimulates collagen production.
Researchers have made a major step forward in understanding the molecular mechanisms of Diffuse Intrinsic Pontine Glioma (DIPG), a rare and aggressive brain tumor in children. They identified a possible method for treating this type of tumour using an EZH2 inhibitor, which has shown efficacy in mouse models and human cell lines.
The editorial warns of significant consequences for cancer care and research in a post-Brexit world. The authors highlight uncertainties regarding research funding, patient data handling, and regulatory frameworks, which could disadvantage UK cancer patients and research if not addressed.
Researchers found that the activated S6 ribosomal protein P-S6S240 was present in 32% of high-grade tumors and associated with shorter progression-free survival. PI3K/mTOR inhibitors showed promising results in two patient-derived xenograft models, suggesting a potential treatment option for patients with this type of uterine sarcoma.
Researchers discovered PERK protein's role in coordinating cell communication between the endoplasmic reticulum and plasma membrane. This finding opens up promising therapeutic avenues for diseases such as Alzheimer's, cancer, and diabetes.
A novel mutation in the DNA repair protein ALKBH7 has been associated with an increased risk of prostate cancer in African American men. The study's findings suggest that this mutation may interfere with the protein's normal activity, leading to reduced ability to repair DNA damage.
Researchers identified T-bet as the key control point regulating genetic risk in specific diseases like IBD and Celiac disease. This discovery provides a specific target for treatment development, potentially leading to more effective therapies for life-changing auto-immune conditions.
Scientists successfully delivered CRISPR-Cas9 to the eyes of mice with wet AMD, modifying the VEGF gene and reducing choroidal neovascularization (CNV) by 58%. This breakthrough could lead to a new therapeutic modality for non-hereditary degenerative diseases.
A study found that adolescents and young adults (AYAs) with acute leukemia had significantly worse survival rates if not treated at specialized cancer centers. AYAs treated at these centers had outcomes comparable to children, suggesting treatment quality can mitigate poor outcomes.
A 258-page report outlines principles and guidelines for human genome editing, emphasizing caution on germline editing and enhancement. The report also explores clinical applications, risks, and benefits of the technology.
A blood test can detect bladder cancer patients' prognoses by analyzing circulating tumour cells in their blood. The presence of these cells is a predictor of cancer recurrence and death.
After prostate cancer surgery, patients often experience penile shortening due to anatomical changes. The study found that this change is shortest 10 days post-surgery but recovers to normal values within 12 months.
A global research team led by Professor Mike Stratton will study genetic samples from five continents to understand the causes of cancer. The project aims to identify unknown causes, determine environmental factors, and figure out how they lead to cancer.
A new mathematical analysis provides guidance for treating infections and tumors with drug resistance, suggesting that containment may extend effective life and improve patient outcomes in some cases. The study identifies two main factors influencing the choice between containment and aggressive treatment.
Researchers identify factors determining when containment or aggressive treatment is best, providing new guidance for physicians and patients. Containment strategies can prolong treatment life and improve outcomes in certain situations.
Following screening guidelines for HCC in cirrhotic patients significantly increases life expectancy, with a 5-month average gain compared to 'real life' monitoring. Cost-effectiveness analysis reveals that standardized surveillance is cost-effective at $1754/yr per life year gained in French costs and $32,415/yr in US costs.
A recent NIH study identified 40 new genes affected by HIF1α in melanoma, offering potential new targets for treatment. The research also found connections between gene expression and the spread of cancer cells, which could help predict tumor progression.
Researchers studied the impact of antibiotic treatment on gut microbes and metabolites in mice, finding significant changes in bacterial populations and metabolic output. The study highlights the importance of considering both microbiota composition and metabolome in understanding human health.
A new technique separates circulating tumor cells from whole blood at a liquid-liquid interface, capturing 95% of CTCs in one minute. This method enables early detection and monitoring of metastatic disease, improving cancer treatment outcomes.
Research reveals that adult childhood cancer survivors who received neurotoxic treatments are less likely to have had intercourse, be in a relationship, or have children. Despite this, they report similar satisfaction levels with their sex lives and romantic relationships.
Lily and Yuh-Nung Jan receive $100,000 prize for their discoveries on neural development, vision, and hearing; Michaela Gack, Michael Halassa, and Ahmet Yildiz win $50,000 for their innovative work in biomedical science
A study published in JAMA Oncology found that patients with autoimmune diseases taking azathioprine had a higher risk of developing therapy-related myeloid neoplasms. Researchers also identified other medications used by these patients, but only azathioprine showed a statistically significant association.
Researchers predict that melanoma death rates will decrease by 2050 due to the aging of populations, but the number of deaths may increase. Effective treatments could lead to a further decline in mortality rates.
A Yale-led research team found that a melanoma cell and a white blood cell can fuse to form a hybrid with the ability to metastasize, providing insight into how cancer spreads from solid tumors.
A new study reveals that changes in translation play a crucial role in the development of skin cancer. The researchers found that eIF2A, a protein involved in translating genetic instructions, is overexpressed in certain types of cancer and can serve as a potential therapeutic target for treating the disease.
The GSG III Foundation has pledged over $1 million for a new research program at the University of Louisville, aiming to develop better methods for studying lung inflammation and explore potential therapies. The program will focus on chronic obstructive pulmonary disease (COPD), cystic fibrosis, and asthma.
Targeting therapeutic genes to the lungs offers potential for managing serious lung diseases that do not respond to other treatments. Preclinical and human clinical studies have targeted various genetic diseases, including cystic fibrosis, asthma, and lung cancer.
Researchers identified how HIV infects macrophages despite protective protein SAMHD1 being switched off. A treatment to maintain macrophage defences could be crucial for reaching an HIV cure.