Articles tagged with Cancer Treatments
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Researchers discovered novel genetic variants in a hormone receptor-positive male breast cancer patient, which led to a prolonged stable disease. The study provides new insights into the genomic landscape of male breast cancer and suggests potential benefits of combining treatments to block the PI3K/Akt/mTOR pathway.
Research reveals depression alters oxidative stress levels, leading to increased risk of cardiovascular disease and cancer. Treatment can improve malondialdehyde levels, while zinc and uric acid levels normalize.
Men with low-grade prostate cancer are increasingly opting for active surveillance, a management strategy that monitors the cancer's progression without immediate treatment. The study found that about 59% of patients managed by active surveillance remained on this approach after five years.
A pooled analysis of 13 studies covering 33,571 subjects found a significant association between pre-labor cesarean delivery and an increased risk of acute lymphoblastic leukemia in children. The study suggests that the stress response in the fetus caused by labor may be involved in this correlation.
Research breakthrough reveals pancreatic tumours often lose miR-137 expression, triggering uncontrolled cell growth and cancer. Restoring normal miR-137 levels induces senescence and stops cells from spreading.
The Helmholtz Zentrum Munchen has been awarded 14 ERC grants, with three scientists receiving 6 million euros. Dr. Daniel Razansky is investigating non-invasive brain imaging methods, while Dr. Irmela Jeremias focuses on targeted tumor treatment and Dr. Mathias Heikenwaelder explores immune system interactions in liver disease.
The American Cancer Society report reveals progress in reducing cancer death rates among African-Americans, but racial disparities persist in breast and colorectal cancers. The study finds that disparities in access to care and screening contribute to these disparities.
Higher body weight and taller stature during adolescence may increase the risk of developing Non-Hodgkin's Lymphoma later in life. A study of 2,352,988 teens found a 25% increased risk of NHL associated with adolescent overweight and obesity.
Researchers at the University of Minnesota have made a breakthrough in understanding how retrovirus RSV brings together protein molecules to form tiny molecular claws, which can help develop anti-retrovirals to target integrase functions and improve HIV/AIDS therapies.
A recent discovery by FAU researchers reveals a mechanism that promotes metastasis and resistance to treatment in aggressive cancer types. They identified a gene set associated with particularly bad prognosis in breast cancer, enabling the development of biological markers for aggressive tumours.
Researchers at MD Anderson Cancer Center proposed a new staging system for HPV-related oropharyngeal cancer, which better separates patients with different survival rates. The new groupings were proven to have greater predictive power than the current system, particularly in identifying stage III disease with a high risk of death.
Researchers at Trinity College Dublin have made a significant discovery in how our immune system responds to TB, enabling the development of more effective vaccines and personalized therapies. The study highlights the importance of the protein Mal in cell signaling and its impact on responses to Interferon Gamma.
According to a Norwegian study of male cancer patients diagnosed under the age of 25, many male cancer patients have problems reproducing. The researchers found that male cancer survivors are three times as likely to turn to assisted fertilization to have children as males with no cancer diagnosis.
A national patient-powered registry, MyLymeData, has enrolled over 3,000 patients to accelerate research for chronic Lyme disease. Big data tools can help identify treatment responses and subgroup analysis, leading to a better understanding of the disease.
Researchers analyze 500 scientific articles to develop a mathematical model for muscle-invasive bladder cancer. They identify potential biomarkers and clinical parameters to accurately determine cancer stage and develop individual treatment strategies.
Researchers at Tufts University have discovered the bioelectric mechanism behind craniofacial defects in Andersen-Tawil syndrome, a rare genetic disorder. The finding may also shed light on fetal alcohol syndrome and other conditions.
A new analysis found that both phone-based and web-based tobacco cessation programs can help individuals quit smoking. However, certain personal characteristics, such as age, race, ethnicity, education level, and employment status, may influence program effectiveness, with Web-based programs being slightly more successful for some groups.
A Yale study applying evolutionary biology tools sheds light on cancer's genetic origins and tumor progression. The research mapped genetic mutations in normal, primary, and metastatic tumor tissue, revealing that metastases originate from different paths within primary tumors and can diverge early in cancer history.
A new DNA-based digital PCR assay has been developed to detect persistent disease in CML patients who appear to be in remission. The assay was found to be more sensitive than current methods, detecting disease in 81% of samples, and may lead to improved treatment decisions for individual patients.
Scientists discovered that PAD4 works with BRD4 to switch E2F-1 from promoting cell growth to inducing inflammation in cancers. Inhibiting both proteins reduced arthritis symptoms and decreased inflammatory products in mice.
A special issue of Pediatric Blood & Cancer establishes evidence-based standards for pediatric psychosocial care, addressing topics like monitoring psychosocial health and supporting siblings. The standards aim to improve quality of life outcomes for children with cancer and their family members.
Researchers at Michigan Medicine have identified a strong interaction between KRAS and AGO2 that could contribute to its role in cancer development. The study suggests that targeting this interaction may be a potential therapy for KRAS-related cancers.
A 28-year-old transgender woman experienced a delay in testicular cancer diagnosis due to inadequate access to insurance coverage and transportation challenges. The case study emphasizes the importance of addressing biopsychosocial needs and creating venues for medical providers to learn appropriate care for transgender patients.
Researchers at CNIO have identified two biomarkers, p21 and mTOR activation, that predict a less aggressive head and neck cancer progression. The study's findings could lead to personalized treatment options for patients.
Researchers discovered a new way to classify gliomas by analyzing their molecular characteristics, specifically DNA methylation levels. This approach predicts which tumors are more likely to grow rapidly and can guide treatment decisions.
A collection of articles explores fertility issues in patients with cancer, including the legal framework and potential solutions for disputes involving donated genetic material. The articles also highlight the importance of oncologists providing fertility care to their patients.
Researchers discovered a new biomarker, pro-NPY, which correlates with increased risk of prostate cancer death. The study suggests that high pro-NPY levels can predict prostate cancer-related death among diagnosed patients who haven't received surgical treatment.
A study by Mayo Clinic researchers found that people who quit smoking for over 15 years are still at a higher risk of developing lung cancer. Expanding lung cancer screening to include this group could detect more cases and further reduce mortality.
Researchers at Scripps Research Institute and UC Berkeley have made a breakthrough in understanding the proteasome, a molecular machine responsible for breaking down toxic proteins. The new study reveals how a crucial enzyme, Rpn11, is activated to remove harmful proteins from cells, providing potential new therapies for diseases such ...
A recent study published in Nature Genetics has identified 10 new genes linked to lupus, an autoimmune disease affecting millions worldwide. The research analyzed over 17,000 DNA samples from Asian populations and found that these genes play a significant role in the development of lupus.
New figures show that screening picks up the majority of bowel cancer cases at an early stage. Screening detected more than a third of bowel cancers at stage one and fewer than one in ten advanced to stage four. Patients whose cancers are picked up at an earlier stage have better chances of survival due to effective treatment.
Researchers at the University of Colorado Boulder have developed light-activated therapeutic nanoparticles that successfully killed 92% of drug-resistant bacterial cells in a lab-grown culture. The quantum dots, which can be tailored to specific infections, offer a new hope for combating antibiotic-resistant superbugs.
A large-scale study by the University of Melbourne found that both real and sham acupuncture showed a 40% improvement in hot flush severity and frequency after eight weeks. The benefits were sustained at six months. Women with breast cancer or ovarian removal were not included.
The UK's first national tissue bank aims to develop new treatments and improve patient outcomes for pancreatic cancer. The Tissue Bank will store high-quality samples from consenting patients, enabling researchers to test ideas and validate their research more effectively.
Researchers at Cornell University have discovered potent cancer-killing proteins that can travel by white blood cells to kill tumors in the bloodstream of mice with metastatic prostate cancer. The therapy has shown several advantages, including no toxicity and good results with low dosages.
Liver cancer experts say following international guidelines is costing lives in Peru due to a lack of tailored treatment. The study suggests that using local knowledge and data can lead to better management of the disease in developing countries.
Research published in Journal of Thoracic Oncology found that non-small cell lung cancer patients with early-stage tumors had a higher rate of nodal upstaging and longer hospital stays when undergoing open chest surgery compared to video-assisted thoracic surgery (VATS). This study suggests that VATS may not be equivalent to open surge...
A novel PET/CT imaging method has been shown to accurately measure HER2 expression in metastatic breast cancer, potentially leading to more optimal individualized treatments. This non-invasive technique may one day substitute traditional tissue sampling.
Clinical research experts discuss various topics, including the impact of personalized genomic data on healthcare systems, strategies to combat multidrug-resistant tuberculosis, and population approaches to reduce diabetes incidence. They also highlight the need for improved cancer diagnosis and treatment for neurodegenerative diseases.
A study published in JAMA found that nearly half of working individuals with stage III colorectal cancer lost their jobs due to their diagnosis. However, those with access to paid sick leave were more likely to retain their jobs and experience reduced personal financial burdens. The study highlights the importance of providing paid sic...
Even before the Affordable Care Act (ACA), cancer survivors in non-expansion states had limited access to healthcare. The study analyzed data from the 2012 and 2013 Behavioral Risk Factor Surveillance System and found that these survivors were less likely to have a personal doctor, receive an annual checkup, or see a doctor due to cost.
A new analysis found that nearly 60% of metastatic cancer patients experience some change in employment due to illness. Controlling symptoms is key for many patients to remain employed, with better performance status and non-Hispanic White ethnicity/race being associated with continued work.
A new method allows researchers to create 3D images of oxygen and CO2 transport in the lungs, providing hope for improved treatment of COPD and lung cancer. The technique enables doctors to better predict patient outcomes and develop personalized treatments.
A study found that patients younger than 50 diagnosed with non-small-cell lung cancer have a higher likelihood of having a targetable genomic alteration for which therapies exist. However, they also have an unexpectedly poor prognosis, with median survival rates ranging from 13.6 months for those over 70 to 18.2 months for those under 40.
The Journal of Comparative Effectiveness Research discusses new recommendations from the Center for Medical Technology Policy's Green Park Collaborative for evaluating oncology treatment sequences. The framework developed by GPC-USA aims to fill evidence gaps and identify patient-important outcomes, ultimately improving cancer patient ...
Researchers discovered a compound that targets gut microbes to prevent heart disease by preventing the formation of toxic metabolic byproducts. This new approach may provide a whole new strategy for treating cardiovascular and metabolic diseases.
A study published in The Journal of Urology found that patients with low mental health self-assessments before radical cystectomy had higher rates of high-grade complications, highlighting the importance of preoperative assessment.
The American Gastroenterological Association has released six clinical practice guidelines for common gastrointestinal conditions. The guidelines recommend budesonide for microscopic colitis treatment and suggest selectively using antibiotics in acute diverticulitis management. AGA also advises against upper GI biopsies in immunocompro...
A new study by University of Guelph researchers found that adding estrogen to female mouse brains boosts short-term learning, likely through a 'use-it-or-lose-it' process. The team discovered that brain cells grow more synapses on branches of neurons when exposed to estrogen.
A study published in JNCI Journal of the National Cancer Institute found that continuous joint use of estrogen and progestin reduces the risk of endometrial cancer by 35% in postmenopausal women. The study analyzed data from 16,608 women aged 50-79 with normal uteri, who were randomly assigned to daily estrogen plus progestin or placebo.
Researchers have identified 335 genes that regulate the formation and function of extracellular vesicles (EVs), tiny bubbles released by cells. EVs can promote tissue repair or carry disease signals for cancer and neurodegenerative diseases like Alzheimer's. Understanding EV biology could lead to new therapeutic treatments.
A study published in Gastroenterology reveals that the inhibition of CPEB4 protein can prevent the development of abnormal blood vessels associated with cirrhosis. This finding has significant implications for the treatment of this disease, which is responsible for a high rate of hospital admissions and use of health resources.
Researchers investigated the reasons behind tamoxifen's varying efficacy in women. Genetic variants on the CYP2D6 gene were initially linked to worse survival rates, but subsequent studies found no association. Advanced statistical modeling suggests that genotyping errors may have contributed to these findings.
A recent study suggests that elevated levels of the enzyme APOBEC3B drive tamoxifen resistance in estrogen receptor-positive breast cancer. Higher APOBEC3B levels were associated with shorter progression-free survival times.
Researchers at UT Health Science Center discover how poxviruses outsmart the body's immune system by targeting a key restriction factor called SAMD9. This finding has significant implications for cancer treatment and therapy, as SAMD9 also suppresses tumors.
The ABCSG-18 clinical trial found that adding denosumab to adjuvant aromatase inhibitor therapy improved disease-free survival in postmenopausal patients with HR+ breast cancer. After a median follow-up of four years, patients assigned denosumab had an 18 percent reduced risk of disease recurring compared with those assigned placebo.
The newly established Collaborative Research Centre on selective autophagy aims to improve therapy for diverse diseases by targeting autophagy at the molecular and cellular level. Researchers will study autophagy in complex organisms, including humans, to understand its role in pathophysiology and develop new therapies.
A study published in PLOS ONE found that treating ear mites in Santa Catalina Island foxes reduced ear tumor prevalence by 99% and inflammation by 90%. The success story highlights the impact of preventative treatments on wildlife populations, with improved conditions for foxes' ear canals and a notable decline in tumors.
A Stanford University study has found that men treated with androgen deprivation therapy for prostate cancer are nearly twice as likely to be diagnosed with Alzheimer's disease. The researchers analyzed electronic medical records of thousands of patients, revealing a significant increase in cognitive decline among those receiving ADT.
A new $4.4 million research project aims to improve diagnosis and therapies for obesity-related health problems, including coronary heart disease, endometrial cancer, type-2 diabetes, and degenerative joint disease. The project will utilize big data analytics and genomics to gain insights into the causes of obesity.