Articles tagged with Cancer Treatments
A team from McGill University Health Centre identified an outbreak of the intestinal parasite Cryptosporidium in Nunavik, Quebec. The strain was found to be Cryptosporidium hominis and had a significant impact on children under five years old, causing growth delays and difficulty at school.
A new study finds HPV vaccination is expected to reduce cancer burden across all racial/ethnic groups, with some disparities persisting despite high vaccine uptake. The study suggests that efforts to improve vaccine uptake must be accompanied by efforts to address access issues for screening and timely diagnoses.
Breast cancer cells challenged with a small-molecule inhibitor targeting specific invasive properties switch to an alternative mode-of-action, rendering them even more aggressive. The results suggest that inhibiting one pathway may not block all aggressiveness in breast cancer cells.
Only 14 mental health apps were examined in a recent literature review, with little efficacy, safety or clinical outcome data found. A framework, ASPECTS, has been proposed to guide psychiatrists and patients in evaluating apps for clinical use.
Researchers found that about 5% of patients experienced unexpected relapses of cancer after laparoscopic radical cystectomy (LRC) despite favorable pathology. The use of pneumoperitoneum during LRC may have played a role in these recurrences, according to the study published in The Journal of Urology.
Researchers at Kazan Federal University and the National Academy of Sciences of Ukraine have identified correlations between superoxide, nitric oxide levels and matrix metalloproteinase activity in gastric cancer patients. This discovery could lead to more accurate diagnostics and personalized treatment plans for stomach cancer.
A leading scientist at Florida Atlantic University has received a $540,250 NIH grant to continue his research on collagen-based diseases. He aims to develop models to study the degradation of collagen in various conditions such as multiple sclerosis, cancer, and sepsis.
A phase II clinical trial showed that watercress extract significantly inhibits the activation of tobacco-derived carcinogens in cigarette smokers, with a stronger effect in those lacking certain genes involved in processing carcinogens. The extract also detoxifies environmental carcinogens and toxicants found in cigarette smoke.
A study published in JAMA found that pembrolizumab, an antibody against PD-1, was associated with a 33% objective response rate and 23-month median overall survival in patients with advanced melanoma. The treatment also showed improved progression-free survival rates of 35% at 12 months and 52% at 12 months
New technology allows for detailed analysis of prostate shape changes after treatment, potentially providing prognostic information and early biomarkers. The study, published in PLOS ONE, involves eight patients and plans to expand to 40 more, tracking long-term outcomes.
The white paper outlines key takeaways, including the importance of proper sunscreen use to reduce melanoma risk by up to 50%, developing more precise diagnosis methods, and overcoming immunotherapy resistance. The research aims to advance treatment and potentially cure melanoma by understanding its unique characteristics.
Researchers at University of California, Irvine, have found a way to reduce the aberrant accumulation of the mutant Huntingtin protein in Huntington's disease. By targeting and modulating levels of PIAS1, they showed improvement in symptoms and neuroinflammation in HD mice.
A new study demonstrates that antiviral therapy for immune tolerant Hepatitis B patients prolongs overall survival and reduces the risk of developing liver cancer (HCC) and scarring of the liver (cirrhosis). Nucleos(t)ide analogue treatment significantly lowers HCC and cirrhosis risks.
A new study found that patients with a prior history of hepatocellular carcinoma and treated with direct-acting antivirals for Hepatitis C have a higher-than-expected early recurrence rate of their liver cancer, with rates exceeding 40% in some subgroups. The recurrences may be due to a weakened immune system following DAA therapy.
Lay health advisors play a crucial role in reducing health disparities among medically underserved groups. Research from Roswell Park and Columbia University found that support from academic institutions is key to their success, with partnerships leading to higher retention rates. The study also highlights the importance of clear role ...
A randomized clinical trial found neratinib plus paclitaxel to delay central nervous system (CNS) metastases and reduce their frequency compared to trastuzumab plus paclitaxel in women with ERBB2-positive breast cancer. However, median progression-free survival was similar between the two groups.
A new study found that only 50% of patients with locally advanced rectal cancer in the US receive the recommended standard therapy, which has increased over the past decade. Socioeconomic factors such as facility volume, race/ethnicity, insurance status, and education level are associated with a lower chance of receiving this treatment.
A new study found that patients with Hepatitis C virus who took direct-acting antiviral treatments had a 'high rate' of re-developing their illness, including liver cancer. The study suggests that these patients require close monitoring due to the high risk of recurrence.
Researchers found increased mutations at gene promoter sites are caused by a compromised nucleotide excision repair system. This highlights the need for further research into gene promoter mutations and their role in cancer development.
A new study finds a significant association between androgen deprivation therapy and depression in patients with localized prostate cancer. Patients treated with hormone therapy experienced higher incidences of depression, with risks increasing with treatment duration.
Researchers found that pericardial window operation, a treatment for malignant pericardial effusion, is less effective in lung cancer cases compared to other types of cancer. The study suggests alternative, less invasive methods such as needle punctures may be more efficient over time.
Researchers identified a novel mutation in the KIT gene that contributes to crizotinib resistance in ROS1+ non-small cell lung cancer patients. Ponatinib, a KIT tyrosine kinase inhibitor, demonstrates potential as a therapeutic option for overcoming this resistance.
Researchers have developed a magnetically controlled material composed of enzymes entrapped within magnetite particles, enabling targeted treatment of cancer and thrombosis. The new material stabilizes itself without additional stabilizers, making it suitable for intravenous injection.
A review found Gamblers Anonymous reduces depression, anxiety, and stress in individuals using it in conjunction with other therapeutic approaches. Combining GA with stress management or cognitive behavioral therapy shows significant improvements in gambling symptoms and overall well-being.
Researchers at University of California, San Diego School of Medicine found that certain groups of gastrointestinal stromal tumors result in a much higher mortality rate than expected. The study analyzed data from 378 patients with malignant GISTs and discovered significant variability in size and malignant behavior.
Women who underwent uterine fibroid embolization reported improved sexual function, including pain, desire, arousal, and satisfaction. About nine in 10 women also experienced a better overall quality of life, with average scores increasing from 45 to 71 one year after treatment.
The Society of Interventional Radiology honored two research papers for their impact on patient care. Dong Il Gwon's study validated a rapid PARTO procedure for treating gastric varices, while Ron C. Gaba's research explored gene expression in hepatocellular carcinoma for improved treatment outcomes.
A recent study published by The Endocrine Society found that radioactive iodine treatment can impair a woman's remaining egg supply, known as ovarian reserve. Women who received high doses of radiation had significantly lower levels of anti-Müllerian hormone (AMH) after treatment.
Scientists at EMBL have increased the efficiency of gene therapy tool Sleeping Beauty, which is being trialed for therapies targeting B-cell leukaemias and lymphomas. The enhancement results in a 30% increase in efficiency and aims to improve patient outcomes.
A study by NIH researchers found that children with Cushing syndrome are at higher risk for depression, anxiety and suicidal thoughts months after successful treatment. The researchers screened the case histories of 149 patients and found 9 children had thoughts of suicide.
A recent U.S. Preventive Services Task Force recommendation suggests pairing smoking cessation with lung cancer screening to maximize benefits and reduce risk. This guideline aims to provide tobacco treatment in conjunction with lung screening to encourage smokers to quit.
Researchers at Beth Israel Deaconess Medical Center have identified a 5-gene classifier that can accurately detect early stages of pancreatic cancer, offering hope for earlier diagnosis and treatment. The classifier achieved high sensitivity and specificity rates in training and validation datasets.
A large study from Japan found that cancer patients who died at home tended to live longer than those who died in hospitals. The study suggests that oncologists should not hesitate to refer patients for home-based palliative care. Home death may have a positive influence on survival, contrary to previous concerns.
Case Western Reserve University scientists develop an optical sensor using nanostructured metamaterials, enabling detection of single lightweight molecules in dilute solutions. The device has been shown to be 1 million times more sensitive than current methods, with potential applications for early cancer diagnosis and treatment.
Researchers at Loyola University Health System have developed a new approach to treating hepatitis C, using mathematical models to predict when patients can safely stop taking direct-acting antiviral medication. This approach could lead to a 50% reduction in treatment cost and improved patient adherence.
Researchers found a compound that prevents scarring in the lungs and liver also shows promise in preventing pancreatic fibrosis. The study used an animal model to demonstrate the effectiveness of the integrin inhibitor in halting fibrosis and potentially preserving pancreatic function.
Researchers found that truckers with OSA who didn't adhere to treatment had a five-fold increase in preventable crashes compared to healthy drivers. Regular screening and treatment can reduce large truck accidents, deaths, and injuries.
A study of 146 veterans with life-threatening illnesses found that exploring their values can help set effective goals for healthcare and treatment plans. The researchers identified five key themes: self-sufficiency, life enjoyment, connectedness and legacy, balancing quality and length of life, and engagement in care.
A new study provides insight into the role of RNA editing in cancer, identifying over 2,000 genes with significant changes in RNA editing levels between tumor and normal tissues. Researchers found that these changes may be linked to different clinical outcomes.
Researchers have developed a CRISPR-Cas9 based method to track the movement of RNA in living cells. This approach enables the study of disease-related RNA processes and may support therapeutic approaches to correct disease-causing RNA behaviors.
A clinical study found that veterans with subclinical PTSD experience a 29% drop in symptoms after treatment, compared to 14% for those with full PTSD. This discovery highlights the potential benefits of early-stage PTSD treatment and could lead to cost-effectiveness in treating this common disorder.
LDNscience.org offers comprehensive information on low dose naltrexone (LDN) for patients with autoimmune diseases and chronic conditions. The revamped website provides resources, research, and educational materials to support treatment and quality of life.
Researchers review phosphonate-based matrix metalloproteinase inhibitors, which exhibit selective and potent activity on bone resorption. The authors propose these alternatives as a potential therapeutic target for chronic inflammation and cancer.
Scientists have developed a new imaging technique that can detect diseases earlier with enhanced sensitivity, allowing for earlier diagnosis and treatment. The technique uses probes that light up specific targets inside cells, enabling researchers to track changes in molecular make-up of tissues.
Adults aged 55-74 with a history of current or former smoking and 30+ pack-years are advised to undergo annual low-dose CT scans up to three times. This guideline aims to detect lung cancer at an early stage, reducing serious illness and death. Screening should be conducted in healthcare settings with expertise in diagnosing lung cancer.
A study published in the EMBO Journal has identified a gene candidate, GEMC1, associated with a subtype of ciliopathy. GEMC1 regulates key genes involved in this disease, suggesting its potential as a therapeutic target for rare diseases affecting 5 in 10,000 people or fewer.
Researchers discovered novel genetic variants in a hormone receptor-positive male breast cancer patient, which led to a prolonged stable disease. The study provides new insights into the genomic landscape of male breast cancer and suggests potential benefits of combining treatments to block the PI3K/Akt/mTOR pathway.
Research reveals depression alters oxidative stress levels, leading to increased risk of cardiovascular disease and cancer. Treatment can improve malondialdehyde levels, while zinc and uric acid levels normalize.
Men with low-grade prostate cancer are increasingly opting for active surveillance, a management strategy that monitors the cancer's progression without immediate treatment. The study found that about 59% of patients managed by active surveillance remained on this approach after five years.
A pooled analysis of 13 studies covering 33,571 subjects found a significant association between pre-labor cesarean delivery and an increased risk of acute lymphoblastic leukemia in children. The study suggests that the stress response in the fetus caused by labor may be involved in this correlation.
Research breakthrough reveals pancreatic tumours often lose miR-137 expression, triggering uncontrolled cell growth and cancer. Restoring normal miR-137 levels induces senescence and stops cells from spreading.
The Helmholtz Zentrum Munchen has been awarded 14 ERC grants, with three scientists receiving 6 million euros. Dr. Daniel Razansky is investigating non-invasive brain imaging methods, while Dr. Irmela Jeremias focuses on targeted tumor treatment and Dr. Mathias Heikenwaelder explores immune system interactions in liver disease.
The American Cancer Society report reveals progress in reducing cancer death rates among African-Americans, but racial disparities persist in breast and colorectal cancers. The study finds that disparities in access to care and screening contribute to these disparities.
Higher body weight and taller stature during adolescence may increase the risk of developing Non-Hodgkin's Lymphoma later in life. A study of 2,352,988 teens found a 25% increased risk of NHL associated with adolescent overweight and obesity.
Researchers at the University of Minnesota have made a breakthrough in understanding how retrovirus RSV brings together protein molecules to form tiny molecular claws, which can help develop anti-retrovirals to target integrase functions and improve HIV/AIDS therapies.
A recent discovery by FAU researchers reveals a mechanism that promotes metastasis and resistance to treatment in aggressive cancer types. They identified a gene set associated with particularly bad prognosis in breast cancer, enabling the development of biological markers for aggressive tumours.
Researchers at MD Anderson Cancer Center proposed a new staging system for HPV-related oropharyngeal cancer, which better separates patients with different survival rates. The new groupings were proven to have greater predictive power than the current system, particularly in identifying stage III disease with a high risk of death.
Researchers at Trinity College Dublin have made a significant discovery in how our immune system responds to TB, enabling the development of more effective vaccines and personalized therapies. The study highlights the importance of the protein Mal in cell signaling and its impact on responses to Interferon Gamma.
According to a Norwegian study of male cancer patients diagnosed under the age of 25, many male cancer patients have problems reproducing. The researchers found that male cancer survivors are three times as likely to turn to assisted fertilization to have children as males with no cancer diagnosis.
A national patient-powered registry, MyLymeData, has enrolled over 3,000 patients to accelerate research for chronic Lyme disease. Big data tools can help identify treatment responses and subgroup analysis, leading to a better understanding of the disease.