Research on new and better ways to treat cancer. Covers radiotherapy, targeted microdroplets, nerve-injury protection, drug combinations, and tumor models.
A recent study reveals that blood-based genomic and proteomic testing can rapidly identify genetic mutations in patients with lung cancer, enabling personalized treatment. This approach significantly reduces the wait period between diagnosis and treatment, improving patient outcomes.
The Endocrine Society recommends treating hypopituitarism by replacing hormones at natural patterns, with accurate hormone measurements crucial for diagnosis and treatment monitoring. The guideline also addresses special circumstances like pregnancy care and post-surgical care.
A new study found that androgen deprivation therapy for prostate cancer may be associated with an increased risk of dementia, particularly among older men. The study analyzed electronic medical records data and found a significant association between ADT use and dementia development.
Researchers discovered that pancreatic cancer develops rapidly through a 'big bang' process, where key alterations occur simultaneously. This finding provides new insights into the disease's aggressiveness and may lead to improved diagnostic and therapeutic strategies.
Researchers pinpoint a unique metabolic reprogramming in cancer cells that enables their ability to biosynthesize and replicate, and may provide new treatment opportunities. By blocking specific enzymes involved in this process, tumor growth can be slowed or stopped in preclinical tests.
Patients diagnosed with cancer at emergency presentation have poorer survival rates compared to those diagnosed electively. The review highlights inequalities in socioeconomic groups and ethnicity, emphasizing the need for new screening methods and improved participation in existing screening programs to reduce emergency presentations.
Researchers at the University of Texas at Arlington have developed a novel microwave-induced photodynamic therapy that can target deeply situated tumors. The treatment uses microwaves to activate photosensitive nanoparticles, producing tissue-heating effects that ultimately lead to cell death.
Forty percent of people in Great Britain express concerns about talking through symptoms with GP receptionists, hindering GP visits. Women and those from lower socio-economic backgrounds are more likely to report these barriers. Cancer Research UK emphasizes the need for better training of front desk staff and addressing the GP shortag...
A phase III trial found that MEK inhibition with selumetinib plus docetaxel did not improve progression-free or overall survival in KRAS-mutant non-small-cell lung cancer patients. The study concluded that there is a desperate need for new treatments for this subset of NSCLC patients.
Researchers from UHN describe the genomic landscape of schwannomas, identifying novel mutations and a fusion protein driving tumor development. The study provides insight into personalized medicine approaches for diagnosis and treatment.
Cabozantinib significantly improves progression-free survival and response rate in patients with intermediate or poor-risk clear-cell metastatic renal cell carcinoma compared to sunitinib. The study also found a higher objective response rate in the cabozantinib arm.
University of Groningen scientists discovered that tumor necrosis factor receptor 2 (TNFR2) is essential for preventing neuronal death in neurodegenerative diseases like multiple sclerosis and Alzheimer's. A specific TNFR2 agonist may prevent cell death, offering a new treatment direction.
A research team at UHN has identified new mutations in genes associated with schwannoma development, providing insights into the growth drivers of these tumors. The study's findings have significant implications for personalized medicine and potentially change treatment approaches for some patients with treatment-refractory schwannomas.
A study of over 7,500 patients with invasive breast cancer found that tamoxifen therapy significantly reduced the risk of developing contralateral breast cancer. The risk was highest among those using tamoxifen for four years or more, with a 66% relative reduction in CBC risk.
The University of Warwick is conducting a breakthrough research project to improve the diagnosis and treatment of oral cancers in Pakistan, using digital pathology. The project will generate a repository of information about different types of cancer cells found in oral cancers, enabling pathologists to analyze samples more accurately.
A clinical trial found that ruxolitinib, a JAK inhibitor, significantly restored hair growth in 75% of patients with moderate to severe alopecia areata. The treatment was well-tolerated and showed promise for treating other forms of hair loss.
Researchers develop a portable biological factory platform that can produce pharmaceuticals, specialized therapies, and experimental biomolecules using freeze-dried molecular components. The technology is applied in various fields, including vaccine production and designer antibody development.
A study published in JAMA compared five-year survival rates after endosonography and mediastinoscopy for mediastinal nodal staging of lung cancer. The endosonographic strategy was found to be more sensitive for diagnosing mediastinal nodal metastases.
A set of microRNAs, known as C19MC, was found to be specific to infantile hemangiomas and detectable in patient plasma. These microRNAs may serve as biomarkers for IH diagnosis and treatment monitoring, with levels decreasing before tumor regression but rebounding upon re-growth.
The Lancet review highlights the importance of statin therapy in preventing cardiovascular disease. Lowering cholesterol by 2 mmol/L with a low-cost statin can prevent major cardiovascular events in patients with pre-existing vascular disease or those at increased risk.
The new technique, called 'Chirped-Standing-Wave Acceleration', could enable compact and inexpensive ion treatment facilities, increasing access to advanced cancer therapy. Researchers have developed a novel method to accelerate ions using lasers, promising a paradigm shift in the field.
The European Society for Medical Oncology (ESMO) has awarded four distinguished recipients for their outstanding contributions to cancer treatment and research. Alberto Sobrero received the ESMO Award for his world-renowned research on gastrointestinal cancer, while Sir Richard Peto was recognized for his important contributions to bre...
A new study from Uppsala University found that biobank storage time is a crucial factor in medical research, rivalling the importance of blood donor age. The researchers analyzed 380 samples from 106 women, isolating the impact of storage time to show its significant influence on test results.
Researchers present cutting-edge studies on healthcare economics, sleep apnea, and 3-D printed tissue engineering, showcasing potential breakthroughs for obstructive sleep apnea and head and neck cancer treatments. The findings have significant implications for the future of otolaryngology.
A large single-center study found that EUS-FNA is beneficial for diagnosing malignant BD-IPMNs, particularly those with suspicious features missed by CT/MRI. The procedure also improved long-term outcomes for patients with malignant lesions, reducing recurrence risk.
Researchers found that a 40% reduction in sepsis deaths was achieved through simple steps, including increased training and a special observation chart. Standardized treatment plans can increase survival rates and reduce mortality from serious infections.
Researchers have developed a method to utilize CRISPR/Cas9 technology to diagnose and inactivate cancer mutations. The study found that over 80% of reported cancer mutations can be targeted with the CRISPR/Cas9 system, enabling the rapid separation of driver from passenger mutations.
Researchers at Sanford Burnham Prebys Medical Discovery Institute have discovered a previously unknown protein, SETDB2, that helps the liver adapt to fasting states. This protein is increased during times of fasting and alters the genome to turn on genes needed for energy storage.
Researchers created novel scaffolds with aligned ceramic nanofibers to control stem cell development and cancer cell behavior. The unique hybrid nano-network selectively guides stem cells towards specific lineages while suppressing inflammatory factors in cancer cells.
A new study reveals that socioeconomic differences between white and ethnic minority patients are the main factor affecting their chances of survival. Patients with higher income, insurance status, and marital status tend to have better outcomes.
Researchers have developed a gene therapy approach using ultrasound energy and microbubbles to selectively open cells, allowing delivery of therapeutic agents. The study's findings will help refine this technique as a clinical tool and translate it into an effective gene or drug delivery tool for patients.
A study published in the American Journal of Roentgenology suggests that nephron-sparing treatment for small renal masses can improve life expectancy in patients with mild or moderate chronic kidney disease. The study developed a framework for incorporating tumor imaging features and renal function into treatment selection, providing a...
A new regenerative bandage heals diabetic foot ulcers faster and promotes healing without cancer risk, according to Northwestern University researchers. The bandage delivers a protein that recruits stem cells and creates new blood vessels, improving wound repair.
A new study reveals that chromosomal changes in breast cancer occur in short, punctuated 'bursts' at the earliest stages of tumor growth, contradicting the traditional gradual acquisition model. This finding has significant implications for diagnosis and treatment, suggesting a potential new approach to clinical management.
Researchers found that angiogenin promotes hematopoietic regeneration by dichotomously regulating quiescence of stem and progenitor cells. ANG simultaneously reduces proliferation of stem cells and promotes proliferation of myeloid progenitor cells, which give rise to mature myeloid cells.
A study from Michigan Medicine found that women who engaged on social media after a breast cancer diagnosis expressed more deliberation about their treatment decision and more satisfaction with the path they chose. However, the researchers also identified significant barriers to social media use among certain groups of patients.
Drexel researchers create chains of microscopic magnetic bead-based robots that can swim at impressive speeds through a microfluidic environment. The team demonstrates their ability to link and unlink the beads using a rotating magnetic field, paving the way for targeted medicine delivery and minimally invasive surgery.
The UK Lung Cancer Screening randomized controlled trial found that CT screening did not cause unnecessary anxiety, despite fear and stigma being barriers to participation. The trial recruited over 4,000 participants aged 50-75 at high risk of lung cancer, with a significant reduction in deaths for those who received screening.
Scientists at Newcastle University have identified a group of molecules that can be targeted to slow tumor growth in prostate cancer patients. The research found that testosterone changes these molecules, making cancer cells more likely to survive and spread.
A recent study by Sanford Health identified gene mutations that could impact treatment for adult cancer patients. The study found nearly 90% of patients had genes that matched treatment options, with 40% able to receive personalized therapy.
Researchers have identified BRCA1 mutations that predict treatment resistance in breast and ovarian cancers. Studies found that tumors with these mutations express a RING-deficient BRCA1 protein, leading to poor treatment responses.
Researchers at Washington State University have developed a technique to visualize DNA damage caused by ultraviolet radiation, shedding light on its impact on skin cancer. The study provides clues on how sunlight triggers mutations and cancer, with implications for future therapies.
The Scripps Research Institute has received a grant to support safety and quality tests of a potential stem cell therapy for Parkinson's disease. The two-year project will investigate induced pluripotent stem cells derived from adult subjects, which can differentiate into dopamine-producing neurons.
Researchers have successfully programmed a virus to transport genetic material to affected tissue and nerve cells, opening up new options for treating various diseases. The approach uses attenuated viruses to selectively target diseased cells, reducing damage to healthy ones.
A recent study by Northwestern University found that metastatic prostate cancer cases have increased by 72% between 2004 and 2013, with men aged 55-69 being disproportionately affected. The study suggests that both more aggressive disease and lax screening may be contributing factors.
A significant increase in metastatic prostate cancer cases has been observed, particularly among men aged 55-69. This rise is attributed to changes in screening practices and highlights the need for refining prostate cancer screening and treatment in the US.
A new pilot study evaluates an online decision-support tool called the Decision Counseling Program, which increases rates of active surveillance among men with localized, low-risk prostate cancer. Patients who used the tool reported feeling less conflicted about their treatment decisions.
Researchers have captured new images of a calcium-shuttling molecule that has been linked to aggressive cancers. This discovery could lead to the development of novel therapies and diagnostic tools for diseases caused by malfunctioning calcium adsorption.
Researchers from OVC at the University of Guelph discovered a new way to boost immune responses against cancer by injecting oncolytic viruses into the spleen, bypassing traditional vaccine limitations. This breakthrough could lead to safer and more targeted cancer treatments for various types of cancer.
A new study has found a way to starve tumors of their blood supply by inhibiting the replenishment of an intracellular substrate needed for vascular endothelial cells to respond to pro-angiogenic signals. This approach limits the growth of new blood vessels and enhances the effectiveness of therapy.
A new study found that individuals with diabetes may have a higher risk of developing cancer before and immediately after a diabetes diagnosis. The study suggests that type 2 diabetes may increase the risk of several types of cancer, particularly shortly after diagnosis.
A study published in GIE: Gastrointestinal Endoscopy found that patients with pancreatic cysts are at a significantly increased risk of developing pancreatic cancer, with an estimated 19.64 times higher risk compared to those without cysts.
Researchers at The Wistar Institute have discovered a specific network of proteins present in the mitochondria of cancer cells that enables their ability to proliferate, migrate, and spread. By targeting this pathway, they believe it may be possible to develop new treatments for various types of tumors
A molecule believed to indicate good cancer prognosis has been shown to cause genomic instability and promote tumor growth. The study, published in Nature Cell Biology, suggests that targeting p21 could lead to new cancer treatments.
A recent special issue of Future Oncology examines the field of oncofertility, highlighting its importance in cancer survivors' well-being. The focus on preserving fertility in cancer patients has revolutionized reproductive medicine and biology, with direct impact on oncology.
Researchers at Eindhoven University of Technology have developed a new computer analysis method to detect early stages of esophageal cancer in people with Barrett's esophagus, which can be as accurate as top specialists. The method aims to improve the detection and treatment of esophageal cancer, reducing the need for invasive surgery.
A study by University of Minnesota researchers has identified distinct structural features among seven types of retroviruses, including HIV and HTLV-1. The findings could inform the development of new antiviral treatments and vaccines for various diseases caused by these viruses.
A new study from Imperial College London reveals that patient complaints can have a profound impact on doctors' psychological wellbeing. The research found that many doctors experience feelings of worthlessness, helplessness, and even suicidal thoughts after receiving complaints.
The study projects that by 2040, there will be 26.1 million cancer survivors in the US, with 73% aged 65 or older. Increasing age increases the chance of comorbid conditions, and gaps exist between men and women in older age groups.
Researchers developed a novel method to identify likely cancer drivers among hundreds of genomic alterations. The technique uses tumor gene alterations to report on cancer progression, pinpointing GON4L as a potential driver and therapeutic target.