Articles tagged with Cancer Treatments
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Researchers have identified a key role for the WWOX gene in suppressing cancer development. Lower levels of WWOX are associated with more aggressive and treatment-resistant cancers. The study suggests that targeting the enzyme activity of WWOX could influence cancer cell properties.
A new UCLA study reveals that Alzheimer's disease consists of three distinct subtypes, each requiring targeted research and potential new treatments. The cortical subtype appears to be fundamentally different from the other two, suggesting different causes and optimal treatment approaches.
Researchers discovered that antidepressant amitriptyline increases FGF2 mRNA expression in astrocytes through RTK activation. This signaling cascade could guide the development of novel antidepressants with new mechanisms. The study expands on previous findings, identifying EGR1 as a necessary protein for FGF2 expression.
Researchers at Mayo Clinic's Florida campus have been awarded a $13.3 million grant to conduct a national, phase II clinical trial testing the ability of a folate receptor alpha vaccine to prevent recurrence of triple-negative breast cancer following initial treatment. The vaccine was designed by Dr. Keith Knutson and exploits the need...
Scientists have identified a FOXC1 gene that causes more aggressive cancer in AML patients. When switched on in blood cell tissue, it stunts the development of blood cells and stops them maturing into normal specialized blood cells, leading to faster cancer growth.
Researchers at Nanjing University have discovered new epigenetic markers for colorectal cancer, which may offer a new approach for treatment. The study found that heterochromatin protein HP1γ was critical for CRC cell proliferation and could be specially regulated by miR-30a.
Researchers discovered that Tie1 controls angiogenesis and vascular remodeling by differentially regulating Tie2 in tip and stalk cells, making it a promising therapeutic target for cancer treatment and eye diseases.
Research suggests a treatment that boosts the immune system could improve liver failure treatment outcomes. The therapy uses an immune-boosting molecule called CSF-1 to trigger natural defence mechanisms in the liver.
The International Association for the Study of Lung Cancer has released new data for the TNM classification of lung cancer, which will inform the Eighth Edition of the staging manual. The new database includes 94,708 patients diagnosed worldwide from 1999-2010 and analyzes tumor size, lymph node involvement, and metastatic status.
A new model for preventing and treating obesity in the United States has been proposed, integrating healthcare with community resources. The model centers on individual patients and family engagement, restructuring clinical services to address stigmatization and promoting behavioral changes.
A new study has found that children with coeliac disease react to the same key toxic proteins in gluten as adults, suggesting a potential breakthrough in treatments. The research supports the use of existing treatments and diagnostic tests for adults with coeliac disease for children.
The Mayo Clinic Cancer Center has been awarded a Specialized Program of Research Excellence (SPORE) grant to study the genetic basis of multiple myeloma and develop novel therapies.
Researchers at Johns Hopkins Medicine analyzed survival statistics of 1,298 men with low-risk prostate tumors and found that only two died of prostate cancer after 15 years, while three developed metastatic disease. This suggests that carefully selected patients in active surveillance programs are unlikely to be harmed by their disease.
A 10% increase in wages leads to a 5% drop in smoking rates among male workers with low education levels. Increasing the minimum wage could improve quitting rates for smokers and has significant health benefits.
A study by Helmholtz Munich researchers identified a key role of the protein BMP7 in promoting cell division and migration in pheochromocytoma cells. Targeting this signaling pathway with specific substances may lead to an increase in apoptosis, providing a new approach for treatment.
Daily changes in nuclear positioning of circadian genes regulate their activity with a 24-hour period. Researchers identified two proteins PARP1 and CTCF that bring genes to the periphery, promoting silent state.
The discovery reveals protein structural changes that could inform treatments for inflammatory conditions such as heart disease and colon cancer. The researchers found that two proteins, Tollip and Tom1, work together to regulate the turnover of cell-surface receptor proteins that trigger inflammation.
The study reveals that the mutation disrupts normal cell function by interfering with RNA and protein movement into and out of the nucleus. This leads to neuronal deterioration and death in the brain and spinal cord, causing loss of voluntary muscle movement, paralysis, and respiratory failure.
A study by German Cancer Research Center discovered that citric acid from lemon juice can alter the morphology of norovirus particles, reducing their infectivity. The researchers found that citrate binds to specific proteins on the virus, preventing it from attaching to host cells.
A nine-gene molecular prognostic index (MPI) provides accurate survival stratification for early-stage non-small cell lung cancer (NSCLC) patients. The MPI combines gene expression profiles with clinical data from a large database, enabling robust and clinically applicable predictions.
Researchers found that powdered cranberry combats colon cancer in mice by reducing tumor size and number. The study suggests that individual components of the fruit could lead to a better understanding of its anti-cancer potential, potentially leading to more effective treatments for colon cancer.
Rice University bioengineers have developed a technique called progeny clustering that clarifies big data clusters, enabling doctors to design personalized treatments. The algorithm increases the size of data sets and reveals distinct patterns, allowing for more accurate cluster grouping.
A recent study published in The Annals of Thoracic Surgery found that patients with suspected lung cancer often wait too long to receive treatment and skip vital diagnostic steps. Only 1 in 10 patients had the recommended combination of three staging tests before surgery, highlighting the need for improved quality care.
A $1.5 million gift will support research in spinal muscular atrophy with respiratory distress (SMARD), a rare condition affecting fewer than 70 reported cases worldwide. The funding will enable the development of effective treatments and therapies for children impacted by this devastating disease.
Researchers discovered that patients with detectable HPV16 DNA in their saliva after cancer treatment are more likely to develop cancer recurrence. The finding could lead to earlier detection and better prognosis for these patients, enabling them to receive timely treatment options.
A study of over 70,000 cancer patients found that those referred late by their GP were more likely to be dissatisfied with their care. Patients who experienced referral delays reported negative experiences across various aspects of their care, including diagnosis and treatment.
The study found that persistent HPV16 DNA detection after treatment was associated with worse disease-free survival and overall survival. This could be a useful tool for long-term tumor surveillance, potentially reducing the need for costly imaging and intensifying visits.
Researchers have identified five distinct types of prostate cancer with unique genetic fingerprints, which could help doctors predict the aggressiveness of tumors and choose the best course of treatment. This breakthrough discovery has important implications for how prostate cancer is diagnosed and treated in the future.
Researchers discovered a small RNA molecule called miR-148a plays a role in lung cancer resistance to TRAIL, and inhibiting NF-κB makes it more effective. This study suggests a way to overcome resistance and develop new treatments for lung cancer.
A new study shows that children with cancer can benefit from adapted physical activities, such as dog sledding, which improves their physical and psychological health. The expedition successfully completed by the children demonstrated statistically significant improvement in both areas.
A metagenome-wide association study uncovered markers in the oral and gut microbiomes that are associated with rheumatoid arthritis (RA). The study found that Haemophilus sp. is depleted in RA patients and Lactobacillus salivarius is over-represented, suggesting potential new targets for diagnosis and treatment.
A new study found that young cancer patients often have limited knowledge about fertility preservation options, which can impact their treatment plans. Males are more likely to discuss fertility preservation with clinicians than females, but both sexes face barriers such as lack of insurance coverage and education.
Researchers at Scripps Research Institute will explore therapeutic potential of proteins regulating human health and associated diseases like Parkinson's and arthritis.
Telomeres, protective caps on chromosome ends, have been linked to numerous illnesses, including many types of cancer. Their shortening is associated with ageing and tissue regeneration issues, but cancer cells can repair them using telomerase.
The Paul G. Allen Family Foundation has awarded $7 million to five research teams to investigate the fundamental causes of Alzheimer's disease. The projects will focus on uncovering the biological roots of the disease, including gene combinations, white matter damage, and pH levels.
Researchers discovered that age affects the interaction between Interleukin-2 and human mesenchymal stem cells. In younger patients, IL-2 and MSCs work together to fight cancer, but older populations see impaired treatment outcomes.
A study found a correlation between abnormal noninvasive prenatal testing (NIPT) results and subsequent maternal cancer diagnoses. Occult malignancies may explain discordant NIPT results, highlighting the need for diagnostic procedures to determine fetal karyotypes.
A large trial shows liquid biopsy (BEAMing technology) detects tumor genotypes not found in tissue biopsies, enabling targeted therapy selection. Regorafenib benefits patients with KRAS and PIK3CA mutations, revolutionizing colorectal cancer treatment.
A new study found that cancer survivors may face limited options for adoption due to agency policies, but a training program for oncology healthcare providers can provide valuable information. Cancer survivors often turn to adoption due to infertility caused by cancer treatments, but the process is long and costly.
The International Society for Sexual Medicine recommends a clinical and biochemical syndrome definition for testosterone deficiency, characterized by low testosterone levels and symptoms. The new guidelines provide evidence-based guidance on testing, lifestyle modifications, and treatment options for men with testosterone deficiency.
Researchers have found a way to separate cannabis' medical benefits from its negative effects by blocking a specific pathway. This breakthrough could lead to safe cannabis-based therapies that preserve pain relief and memory function.
The foundation named four young scientists to tackle cancers in children and young adults. The fellowship award will provide nearly $875,000 to support their research over four years.
The Lymphoma Epidemiology of Outcomes Cohort Study will enroll 12,000 NHL patients and follow them for long-term prognosis and survivorship. The grant aims to improve the length and quality of life for NHL survivors.
A joint study by IRB Barcelona researchers reveals CEP63's crucial role in brain cell division and sperm production, providing new insights into Seckel Syndrome and microcephaly. The protein's inhibition may lead to therapeutic approaches for treating these conditions.
Rates of active surveillance for low-risk prostate cancer increased sharply from 2010 to 2013, while high-risk disease was treated more appropriately with local treatments. Treatment patterns varied across individual practices, but suggest a genuine change in prostate cancer management in the US.
A UCLA review of common practices in prostate cancer has found that monitoring men with very low- and low-risk prostate cancers using watchful waiting or active surveillance is an effective approach for many patients. This approach could spare them the debilitating side effects of aggressive treatments, which are often used unnecessari...
A meta-analysis found that cognitive behavioral therapy for insomnia was associated with reduced insomnia symptoms and sleep disturbances in individuals with coexisting psychiatric and medical conditions. Patients who received cognitive behavioral therapy had twice the percentage of remission from insomnia compared to control groups.
A new study by the American Cancer Society found that cancer survivors who currently smoke report fewer negative opinions about smoking and have more barriers to quitting. They are also more likely to be exposed to other smokers, which may contribute to continued smoking.
Researchers have identified specific genetic mutations in patients with aplastic anemia that can help doctors optimize treatment. The study, which analyzed over 400 patient genomes, found that certain mutations are associated with poorer long-term outcomes and increased risk of blood cancers.
A new detection method has been developed to rapidly and accurately detect drug-resistant HCV mutants, including the Y93H mutation. The system achieved a high success rate of 98.9% in detecting this mutation in Japanese HCV genotype 1b patients.
A small molecule agent PSMA-617 specifically attaches to prostate-specific membrane antigen on cancer cells, allowing for early detection of secondary tumors and monitoring response to therapy. This agent has shown promising results in PET scans and holds potential as a therapeutic option for hormone-resistant prostate carcinoma.
The American College of Cardiology seeks to expand cardio-oncology services to address the growing need for specialized care in cardiovascular health for cancer patients. Currently, many hospital training programs lack formal training or services in this area, and a nationwide survey reveals gaps in resources and best practices.
Researchers at St. Jude Children's Research Hospital have found a way to prevent or slow progression of colorectal cancer by boosting the activity of a protective gene called AIM2 and giving patients healthy donor bacteria.
A Vanderbilt-led study found a 28% decline in new prostate cancer diagnoses in the U.S. following the USPSTF's recommendation to discontinue routine PSA screenings. This decrease was observed mainly among low-risk cancers and men over age 70.
Leading researchers from Canada and Israel are working together to uncover the molecular landscape of pancreatic cancer and develop new biomarkers for detection and diagnostics. The collaboration aims to improve patient outcomes by discovering targeted therapies.
Researchers at Helmholtz Zentrum München have found that the viral protein LMP2A helps EBV-infected cells evade immune detection. This may contribute to the development of cancer, particularly in nasopharyngeal carcinoma and Hodgkin's lymphoma.
A dose reduction strategy for TNF inhibitors can maintain good clinical response in RA patients even when the dose is reduced by one-third. Reducing the dose by two-thirds results in more flares, but these subsided when the higher dose was restarted.
Fatigue remains a debilitating problem for RA patients, with healthcare professionals often failing to measure it. New guidelines recommend validated fatigue measurements to improve patient outcomes. In contrast, treatment aimed at achieving disease remission is unlikely to be effective in addressing fatigue.
A new study by Cancer Research UK found that breast cancer patients are disproportionately affected, with only 20% having surgery after an emergency diagnosis in hospital. In contrast, those diagnosed via urgent GP referrals have a much higher likelihood of receiving lifesaving surgery.
Abelardo Colon and Jennifer Gill from the University of Puerto Rico won the top honors with their video explaining a new method for disinfecting drinking water using a nanodiamond powder. The process has promising results, reducing fecal E. coli colonies and increasing density.