Articles tagged with Cancer Treatments
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Research from Brigham and Women's Hospital suggests that breast surgery for low-grade DCIS does not significantly change patient survival rates. For high- and intermediate-grade DCIS, however, surgery improves survival rates compared to non-surgery groups.
Researchers have developed a novel delivery strategy using an aptamer to introduce functional microRNAs into cells, targeting breast cancer and blood vessel cells. The therapy shows anti-cancer and angiogenic activities, inhibiting tumor growth and protecting against atherosclerosis.
The combination of MEDI4736 and tremelimumab has been shown to have manageable toxicity and clinical activity in advanced NSCLC patients, including those with PD-L1 negative tumors. Eight out of 31 evaluable patients achieved a partial response.
A new clinical study published in The Lancet shows that augmentation therapy can preserve lung structure and add years of life for patients with alpha-1 antitrypsin deficiency. The treatment has been found to be effective in slowing the progression of emphysema in severe cases.
A phase I study of ruxolitinib found no dose-limiting toxicities and improved symptoms in 15 evaluable CMML patients. Hematologic improvement and partial responses were observed, particularly in patients with B symptoms.
The American Association for Cancer Research (AACR) has partnered with Bayer HealthCare to expand its Basic Cancer Research Fellowship Program. The partnership aims to support young scientists conducting basic cancer research, addressing the current funding crisis in biomedical research.
A machine learning breakthrough enables fast and accurate measurement of metabolic profiles from biofluid samples, revolutionizing predictive medical screening. This technology accelerates the development of diagnostic tests for various diseases, potentially years before symptoms appear.
A University of Miami researcher has received a $1.9 million grant to investigate the impact of cognitive behavioral therapy (CBT) on smoking cessation in African American, Hispanic and White smokers. The study aims to reduce tobacco-associated health disparities by examining the effects of CBT on stress and depressive symptoms.
A two-year study found that female breast cancer survivors lost an average of 6% of their body weight through lifestyle changes, which may lower the risk of cancer recurrence. The study's results suggest that modest weight loss could become a routine part of oncology care to improve patient outcomes.
Researchers at the University of Minnesota Academic Health Center have developed a new genetic mouse model that reveals genes and pathways driving osteosarcoma. The model identifies SEMA4D and SEMA6D as key proteins to target in osteosarcoma treatment.
A study published in Nature Communications reveals that a specific type of non-coding RNA, known as Eleanors, plays a key role in the development of endocrine therapy resistance in ER-positive breast cancer cells. Resveratrol was found to repress these RNAs, inhibiting the proliferation of resistant cancer cells.
Patients aged 80 and above are significantly less likely to be investigated or aggressively treated after surgery than their younger counterparts. This is despite the fact that the oldest old have higher rates of trauma and multiple underlying conditions on admission.
A study found that 38% of lung cancer survivors developed recurrent or new cancer during a 8.3-year surveillance period. Key risk factors for recurrence included smoking status, prior cancers, and asbestos exposure, highlighting the need for close monitoring and quitting smoking to reduce cancer recurrence.
J. Paul Taylor has been selected as a Howard Hughes Medical Institute (HHMI) investigator, recognizing his expertise in cell and molecular biology, neurological diseases, and genetics. The HHMI initiative will provide Taylor with salary, benefits, and a research budget to accelerate his work on groundbreaking scientific contributions.
A collaborative team of researchers has identified the mechanism behind one of the most common mutations that enable cancer cells to replicate endlessly. The study found that a specific transcription factor selectively binds and activates the mutant TERT promoter in cancer, leading to elevated TERT expression and cell immortality.
A new therapy with high cure rates is available, but the high cost of direct acting antiviral (DAA) treatment limits access for many hepatitis C virus patients. Increasing treatment efficacy and accessibility could avert significant liver-related deaths and end-stage liver disease in Australia.
The Ivy Glioblastoma Atlas Project provides valuable resources for researchers to find cures for aggressive brain cancers, offering detailed information about genes and tumor formation. The atlas aims to advance understanding of glioblastoma biology and lead to novel approaches to improve treatment and survival.
Researchers at The University of Texas MD Anderson Cancer Center found that blocking FGL2 protein could potentially treat brain cancer. By modulating the immune system's checkpoints, FGL2 promotes tumor growth and suppresses the immune response.
Researchers found that hepatitis B patients develop HCC at a younger age with more aggressive disease, while hepatitis C patients have underlying cirrhosis and diabetes. The study highlights the need to consider hepatitis status when developing treatment plans for newly diagnosed patients.
Research found that childhood cancer survivors who received cranial radiation are more likely to be obese, with 47% of those receiving radiation being obese compared to 29.4% of non-radiation survivors. Obesity risk was also linked to glucocorticoids and genetic factors in neurons' growth and repair.
The American Gastroenterological Association (AGA) highlights notable clinical practice data and basic science research presented at Digestive Disease Week (DDW) 2015. Notable abstracts include fecal microbiota transplantation donors, maximizing endoscopy utilization, and bile acid roles in obesity.
A gynecologic oncologist has been awarded $2.7 million in research funding to study the treatment of stress urinary incontinence (SUI) in women undergoing surgery for endometrial cancer. The goal is to improve quality of life and reduce costs by combining two surgeries into one.
A new study by Moffitt researchers found that younger men and those with a lower body mass index are more prone to experiencing hot flashes during androgen deprivation therapy. The study analyzed patient characteristics and DNA to identify genetic factors associated with an increased number of hot flashes.
Myriad Genetics to present three studies supporting the use of Prolaris in predicting outcomes and personalizing treatment plans for men with localized prostate cancer. The tests demonstrate a new active surveillance threshold and validate an active surveillance threshold, showing potential for improved care.
A new study at Ohio State University has identified Foxo1 as a negative regulator of natural killer cell maturation and homing behavior. The findings suggest that reducing Foxo1 expression can enhance NK-cell maturation, providing an opportunity to boost cancer and viral immunity.
Researchers at Case Western Reserve University found that treating gum disease can improve prostate inflammation symptoms and quality of life for men with prostatitis. The study, which treated 27 men with moderate to severe gum disease, showed significant improvements in PSA levels and symptom scores.
A recent study found that the Ga-68-PSMA-ligand PET/CT detected a large number of positive findings in patients with biochemical recurrence after radical prostatectomy, particularly at low PSA-values. The tracer's higher detection rates compared to other imaging methods suggest an early detection advantage for further clinical management.
Researchers found that black men under 65 diagnosed with early-stage breast cancer had a 76% higher risk of death than white men, despite similar treatment. The study suggests that poverty may play an important role in racial disparities in breast cancer mortality.
A meta-analysis found intragastric injection of botulinum toxin A effective for treating obesity, with significant weight loss in treated patients compared to placebo. Additionally, a study concluded that flexible endoscopes can be stored for up to 21 days after reprocessing without microbial colonization
Researchers developed a new algorithm called CONSERTING to identify DNA duplications and deletions in cancer genomes, improving accuracy and sensitivity. The tool helped discover genetic alterations driving various cancers, including pediatric leukemia and brain tumors.
Scientists at The Wistar Institute have identified a way that cells can reprogram their metabolism to overcome senescence, a tumor-suppressing mechanism. This reprogramming allows for the proliferation of cells that should have become senescent and has the potential to lead to tumor formation.
Researchers at the University of Louisville have detailed a crucial connection between silica exposure and rapid lung cancer progression, highlighting the role of inflammatory mediator LTB4 and its receptor BLT1. The study's findings suggest that novel treatment strategies for both silicosis and associated lung cancers may be possible.
Researchers have developed a new therapy using naïve cells to prevent cytomegalovirus, Epstein-Barr virus, and adenovirus infections in cord blood transplant patients. The treatment has shown safety and efficacy in clinical trials.
A new study supports the screening and treatment of depression in brain tumor patients, who are at high risk of depressive symptoms that can impact care outcomes. The authors recommend using reliable screening tools and refer patients with positive results for detailed psychiatric assessment.
A new study reveals that a tumor-secreted protein promotes the activation of Id1, leading to immune suppression and allowing cancer to grow and spread. Targeting Id1 may restore immune function and improve treatment outcomes for patients with melanoma and other advanced-staged cancers.
Researchers found that humans with genetically long telomeres have an increased risk of dying from cancer, contrary to expectations. The study suggests that targeting the repair process of telomeres could be a promising approach for cancer treatment.
A new study describes the benefits of an active post-discharge intervention program for patients who have undergone thoracic surgery. The program resulted in shorter hospital stays, fewer emergency room visits, cost savings, and no increase in adverse outcomes.
A new special issue of the journal Gastroenterology explores how food affects health and disease, including the gut microbiome, food allergies, and non-celiac wheat sensitivity. The research provides evidence-based summaries to guide clinical recommendations for patients and clinicians.
Researchers at Harvard Medical School have developed an imageable mouse model of brain-metastatic breast cancer and shown the potential of a stem-cell-based therapy to eliminate metastatic cells from the brain and prolong survival. The study also describes a strategy to prevent negative consequences of stem cell therapy.
A new study published in ecancermedicalscience suggests that turmeric's curcumin can quell the activity of human papillomavirus (HPV) in oral cancer cells, potentially providing a means of future control for the virus-related cancers.
Scaling up existing interventions, including infant vaccination and treatment programmes, could prevent 90% of new chronic HBV infections and 65% mortality levels by 2030. Global expansion is necessary to achieve hepatitis B elimination, avoiding 20 million deaths by 2030.
A study found that oophorectomy significantly reduced breast cancer death risk in women with a BRCA1 gene mutation. The procedure also showed promise in reducing all-cause mortality, particularly among estrogen receptor-negative breast cancer patients.
The new guidelines provide a broader scope of therapeutic options for pediatric patients with differentiated thyroid cancer, aiming to limit aggressive therapy when it's unlikely to offer benefit. The guidelines specifically address the differences in biological behavior and management of these entities in children.
The Association for Molecular Pathology compiles current research on liquid biopsy approaches for cancer diagnostics. The review supports the notion that these minimally invasive tests allow for earlier diagnosis, faster and more targeted treatment, reduced costs, and increased quality of life.
A recent study from Huntsman Cancer Institute found that childhood cancer survivors are more than five times as likely to be enrolled in federal social security disability assistance programs compared to individuals without a cancer history. The study identified survivor socio-demographic and treatment characteristics associated with a...
A study led by St. Jude Children's Research Hospital scientists identified a protein called NLRP12 that helps regulate inflammation in T cells. The findings suggest how mutations in the Nlrp12 gene cause disease, paving the way for developing targeted therapies to ease symptoms of autoinflammatory diseases like multiple sclerosis and c...
A novel approach harnessing positron emission tomography (PET) imaging identifies areas of immune cell activity associated with inflammation or tumor development. This method offers a potential breakthrough in diagnostics and monitoring efficacy of cancer therapies.
Smokers diagnosed with cancer were more likely to quit than those without a diagnosis, according to a large study. The study found that a cancer diagnosis acted as a cue-to-action, motivating some smokers to quit in order to lower their future disease risk.
A new study found that cancer-related post-traumatic stress is associated with very limited cognitive impairment before treatment among newly diagnosed breast cancer patients. The study, published in the JNCI Journal of the National Cancer Institute, analyzed data from 166 breast cancer patients and 60 matched controls.
Researchers analyzed data on 325 cancer patients hospitalized with pneumonia and found that severe illness and organ dysfunction are better predictors of outcome than multiresistant bacteria. The study suggests personalized treatment protocols can reduce mortality in these patients.
A research program led by Carlos M. Ferrario aims to unravel the mechanisms of novel peptides in heart disease and atrial fibrillation. The team will conduct studies to evaluate new therapies to halt the progression of heart disease.
Researchers at the University of Missouri have established a model that identifies aging as a key factor in the development of dysphagia. Healthy aging mice exhibit symptoms of swallowing impairment similar to those seen in older adults, with slowed swallowing function and impaired tongue movement.
Cancer Research UK scientists found that mutations in the KRAS gene interfere with protective self-destruct switches, allowing cancer cells to grow and spread. The research may lead to tailored treatments for pancreatic and non-small cell lung cancers.
Physical activity has been shown to reduce symptoms, increase exercise tolerance, and improve quality of life in lung cancer patients. Additionally, increased physical activity may also benefit lung cancer survivors by improving exercise capacity and symptom burden.
The American Cancer Society has awarded $45.6 million in research and training grants to fund investigations into colon cancer, social inequalities in cancer, and other areas of cancer research. The grants will be used to develop vaccines targeting cancer initiation and challenge the mainstream approach to social inequalities in cancer.
Researchers found that inflammatory cells from the bloodstream play a key role in neurodegeneration in Parkinson's disease. CD95L-bearing immune cells cause damage to neurons, and blocking this molecule can prevent neurodegeneration in mice. This suggests that early treatment with drugs targeting CD95L might mitigate Parkinson's symptoms.
The 14th St. Gallen International Breast Cancer Consensus Conference highlighted the need to refine breast cancer classification and predict treatment responses. The conference recommendations will set the standard for breast cancer care for two years, taking into account variable resource limitations worldwide.
Researchers at the University of Michigan Medical School found that patients with chronic myelomonocytic leukemia (CMML) who responded to decitabine treatment had a distinct DNA methylation pattern. This signature can be used to predict patient response to treatment, enabling more effective treatment planning.
Moffitt scientists are using a new theory called the Big Bang model of cancer heterogeneity, which suggests that mutations occur early during tumor development. This approach has significant implications for treatments, as it recognizes that tumors can change during treatment and that current therapeutic approaches ignore this fact.
A committee of lymphoma experts identified key priority areas in infrastructure and research to advance treatments. The Roadmap for Discovery and Translation in Lymphoma outlines priorities to improve understanding of lymphoma biology across diverse subtypes.