Articles tagged with Cancer Treatments
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Researchers at National University of Singapore have found new interactions between STAT3 and PRL-3, two molecules involved in acute myeloid leukaemia, which may offer a new therapeutic target. The study suggests that disrupting the STAT3-PRL-3 regulatory loop could lead to an attractive anti-leukaemia therapy.
A new study finds that many cancer survivors experience lingering problems affecting their quality of life, including physical issues and anxiety about recurrence. The study suggests that clinicians can develop tailored interventions to address these specific concerns.
A clinical trial conducted by the NIH found that 38 out of 40 volunteers with HCV infections were cured after receiving a combination of three direct-acting oral drugs for six weeks. This short duration therapy may prove relevant for global elimination of hepatitis C, where simple and well-tolerated treatment is required.
A study by University of Central Florida social work professor Mary Ann Burg found that cancer survivors often experience unmet needs, including physical problems like sexual dysfunction and anxiety about recurrence. The study analyzed responses from an American Cancer Society survey of 1,514 cancer survivors.
Researchers developed novel indicators to assess and quantify 'progress' and 'value' in cancer research. The PACE Continuous Innovation Indicators provide a visual representation of progress over time, helping identify gaps and needs.
A long-term follow-up of patients with type 1 diabetes found that intensive treatment was associated with a modestly lower all-cause rate of death compared to conventional therapy. The study's findings suggest that intensive therapy may reduce mortality risk in type 1 diabetes patients.
Scientists have found that the MMP12 enzyme travels to the center of cells, contradicting previous assumptions. This discovery may lead to the development of treatments to turn off this enzyme and others like it when they cause damage.
A Vanderbilt-led team has developed a method for detecting 'cell-free' tumor DNA in the bloodstream, showing promising results in distinguishing prostate cancer from normal controls. The technique, called a 'liquid biopsy,' demonstrated over three times the sensitivity of current PSA screening and accuracy rates of up to 91 percent.
A study found that changes in the H9N2 flu virus in chickens may have contributed to the creation of the H7N9 avian virus, which has caused outbreaks and deaths since 2013. The research suggests tracking genetic diversity of H9N2 on poultry farms could provide an early warning of emerging viruses with pandemic potential.
Researchers at Aarhus University have found that genetic variations in the interferon lambda 4 protein impact treatment effectiveness for hepatitis C. This discovery suggests that personalized medicine targeting specific genetic variants could lead to better treatment outcomes for patients.
Researchers at the University of Louisville have identified mutations that destabilize a DNA structure, turning a gene off in over 75% of glioblastomas and melanomas. This discovery provides a new model for understanding cancer-specific activation of telomerase, an enzyme promoting cell division.
A new review suggests that hormone replacement therapy (HRT) is the most effective treatment for menopausal symptoms in younger women, particularly those experiencing hot flushes and night sweats. The review highlights that HRT provides low doses of estrogen with or without progestogen to alleviate symptoms and minimize risks.
A large study found that laparoscopic radical cystectomy leads to reliable cancer control even years after surgery, with 66% of patients free from recurrence after 5 years. The minimally invasive procedure can be as safe as open surgery for cancer control, supporting its use in bladder cancer management
University of Michigan researchers devise a reliable way to grow cancer cells from patients outside the body for study, increasing success rate to over 73% and opening doors to tailored therapies. The new technique could enable doctors to track cancer progression in real-time, making treatment decisions more informed.
Researchers found that SIRT1 enzyme loss drives early prostate cancer formation in mouse models. The study suggests SIRT1 may be a target for prostate cancer prevention.
Researchers have found that loss of gene PTEN is a common driver event behind high-grade serous ovarian cancer, which is often fatal. Combining image analysis with genetic data helped identify PTEN levels in cancer cells while ignoring normal cells, paving the way for new treatments.
Araim Pharmaceuticals' ARA 290 peptide shows clinically significant pain reduction and improved metabolic control in type 2 diabetics. The novel agent is engineered to activate the innate repair receptor, which turns off inflammation and turns on the body's natural repair system.
A randomized clinical trial found that a telephone-based motivational counseling intervention with tobacco treatment specialists increased quit rates among low-SES adult smokers compared to usual care. The program also showed promise in addressing social context factors related to smoking, with women, blacks, and those living in low-in...
A new study by University of Michigan researchers suggests that using war metaphors to describe cancer can have a negative impact on prevention behaviors. Participants who were exposed to such language were less likely to consider limiting unhealthy habits like smoking and excessive alcohol consumption.
Researchers at Walter and Eliza Hall Institute have developed a potential cure for chronic hepatitis B virus (HBV) infection. The new treatment, birinapant, triggers the breakdown of proteins that prevent infected cells from self-destructing, allowing infected cells to die.
Research from St. Jude Children's Research Hospital identifies a high-risk group of young patients who may experience intellectual decline after bone marrow transplantation. The study found that those aged 3 or younger at the time of transplantation with total body irradiation were at higher risk, leading to lower IQ scores and potenti...
Researchers identified a critical pathway that enables cancer cells to survive despite DNA errors, relying on the PKCƐ signal pathway. Disrupting this pathway could trigger cancer cells to self-destruct, offering a new strategy to beat the disease.
Researchers discovered a protein called BAZ2A that influences epigenetic patterns in prostate cancer cells, leading to increased malignancy and tumor growth. High levels of BAZ2A expression were linked to more advanced tumors, metastases, and poor patient outcomes.
A study by Dana-Farber Cancer Institute researchers found that levels of two microRNAs, let-7e and 106b/25, can predict progression-free survival in multiple myeloma patients. The study suggests that these microRNAs may also help doctors determine which patients are likely to have the best responses to different types of therapy.
Researchers found a significant benefit in adding carfilzomib to standard lenalidomide and dexamethasone treatment, extending disease-free periods by nearly 50%. The three-drug combination resulted in improved remission rates and overall survival, with patients reporting better quality of life.
The Multiple Myeloma Research Foundation has made landmark genomic and clinical data from the CoMMpass Study available to researchers via the MMRF's Researcher Gateway. This data includes patient-level biomarker and clinical data, genomic information, and treatment responses, offering new avenues for research into multiple myeloma.
Scientists at VCU Massey Cancer Center use computer modeling to predict which patients are at greatest risk for developing GVHD after stem cell transplantation. The researchers found that minor histocompatibility antigens play a crucial role in shaping the development of T-cell clonal families.
The Prolaris test could save the healthcare system $6 billion over 10 years by reducing costs and improving health outcomes. The test improves health outcomes, reduces healthcare costs, and aids physicians in providing clinical care for their patients.
A study by Cancer Research UK found that people often dismiss cancer symptoms as less serious and attribute them to other causes. Only two per cent thought cancer was a possible cause, despite experiencing red-flag symptoms such as unexplained coughs or persistent changes in bowel habits.
High levels of miR-21 in tumor stroma and epithelia are associated with poorer clinical outcomes in triple-negative breast cancer. The study found that changes in the tumor microenvironment play a crucial role in determining disease progression.
Researchers discovered lactate plays a key role in ASPS tumor cells' behavior, fueling their growth and aggressiveness. The study also confirms the fusion gene ASPSCR1-TFE3 as the driver of this rare cancer.
Scientists have made a breakthrough in treating epidermolysis bullosa by using induced pluripotent stem cells to grow back healthy skin cells. The new technique, called therapeutic reprogramming, was tested on mice and showed promising results.
A new hybrid vehicle has been developed to deliver DNA vaccines that can fight HIV, cancer, influenza, and other diseases. The technology improves the delivery of genes to the immune system, increasing its effectiveness in treating major illnesses.
A new study published in The Journal of Urology analyzed data from three independent registries and found no increase in prostate cancer incidence among men treated with long-term testosterone therapy. The study followed over 1,000 men for up to 17 years, with a median follow-up of approximately 5 years.
A study published in CANCER found that adult survivors of retinoblastoma have few cognitive or social problems decades after diagnosis and treatment. The research suggests the brain may adapt to early insults, with some survivors performing better on verbal memory tasks.
Researchers developed a new approach to breast cancer follow-up that considers individual risk factors. For postmenopausal women with moderate prognosis early breast cancer, less frequent surveillance may be more cost-effective, especially for those older than 70 years.
Researchers used computational modeling to examine the role of genetic mutations in cancer growth, finding that genes never observed in cancers may be the best targets for therapy. Targeting these 'never mutations' in combination with therapies targeting driver genes was found to be highly effective.
Researchers from CNIO discovered that a derivative of vitamin B3, nicotinamide riboside, prevents the development of liver tumors and induces tumor regression in mice. The study suggests that boosting NAD+ levels may have beneficial effects on cancer.
Researchers discovered that WNT signaling molecules are crucial for cellular reprogramming, a process similar to regenerative processes in organisms. This finding has significant implications for stem cell-based regenerative medicine, wound repair therapies and potential cancer treatments.
Researchers developed a gene therapy that boosts Factor IX levels in men with severe hemophilia B, resulting in significant reductions of 90-94% in spontaneous bleeding episodes. The treatment has enabled patients to adopt more active lifestyles without needing frequent clotting factor injections.
A promising anti-cancer approach targeting Malt1 protein's protease function in lymphoma cells may also cause destructive autoimmune inflammation when its other functions are preserved. Researchers discovered this unexpected side effect using an animal model, emphasizing the need for new alternatives to treat lymphomas.
Researchers found that small financial incentives doubled smoking cessation rates among socioeconomically disadvantaged smokers. The study, published in the American Journal of Public Health, suggests that such programs could be a cost-effective solution to reduce smoking-related illnesses.
Researchers at UT Southwestern Medical Center found a novel looping mechanism involving DNA end caps that determines gene regulation, contributing to aging and disease. The study reveals how telomere length affects gene expression patterns, potentially influencing the onset of disease and optimizing fitness with age.
Researchers at Cancer Research UK have identified over 400 areas of hidden faults in the human genome, which could conceal cancer-causing gene mutations. These 'blind spots' are difficult to detect using current gene-reading technology, highlighting opportunities for new diagnostic tests and treatments.
A majority of obese people in Britain deny being obese, describing themselves as 'just right' or 'very overweight' instead. The study suggests that media coverage and public health campaigns may be contributing to this phenomenon, as people become less likely to recognize the health risks associated with their weight.
The $2.5 million grant will support the establishment of the ACRF Breakthrough Technologies Laboratory, enabling research into common and deadly cancers. The laboratory will utilize CRISPR-Cas9 technology to modify specific genes in cancer cells, providing insights into cancer development and treatment resistance.
A new study by Penn and Dresden researchers has identified the protein Del-1 as a key player in blocking multiple sclerosis relapses in mice. The protein, also found to prevent inflammation and bone loss in gum disease, shows promise as a potential therapeutic target for treating neurodegenerative diseases.
The American College of Physicians recommends a systematic approach to discussing end-of-life care goals with patients, aiming for better quality of life and longer survival rates. The guidelines also highlight the importance of training clinicians, identifying at-risk patients, and using structured communication formats.
A new therapy to eradicate liver cells infected with hepatitis B virus has shown promising results in pre-clinical research. The treatment aims to clear patients of the disease, offering hope for those with chronic HBV infection. Dr Greg Ebert's work could lead to significant improvements in health outcomes for Australians and worldwide.
The Myriad myPath Melanoma test has been shown to improve patient care through more definitive diagnoses of skin lesions, particularly in difficult-to-call cases. This resulted in a 49% change in physicians' treatment recommendations for patients with melanoma subtypes.
Researchers at City College of New York led by Dr. Debra Auguste have discovered a potential molecular target and biomarker for treating triple negative breast cancers, which have a high mortality rate due to aggressive proliferation and metastasis.
A 47-year-old woman with intrahepatic cholangiocarcinoma received a uniquely personalized treatment based on her genetic profile, achieving significant tumour shrinkage and symptom improvement. The use of next-generation sequencing revealed a rare BRAF mutation, which was targeted by dabrafenib and trametinib therapies.
A risk stratification model based on lymph node characteristics confirms the true lack of lung cancer in sampled nodes. The model categorizes low-risk nodes with a high chance of being truly negative, while high-risk nodes have a significant false-negative rate.
Researchers at CNIO have developed a mouse model that expresses the most common K-Ras mutation found in Noonan patients, reproducing its most representative features. The study aims to advance knowledge of the syndrome and develop specific treatments for each mutation.
Researchers discovered a new correlation between specific molecular features and CLL subgroups with different prognosis. The study identified subsets of patients with distinct clinical courses, allowing for better adjustment of therapeutic strategies and follow-up.
Researchers found that autophagy plays a central role in mediating the non-specific immune effects of BCG, leading to trained immunity. Monocytes from individuals with specific variants of the ATG2B gene respond with trained immunity, supporting the hypothesis that autophagy is clinically relevant.
A recent study published in Psycho-Oncology highlights the need for well-designed trials to determine the effectiveness of phone counseling interventions for cancer survivors. The research found that while some studies showed significant improvement, the results were not robust across multiple end points or studies.
Rare cancer patients face scarce clinical evidence due to conventional trial methodologies requiring large patient numbers. The European Organisation for Research and Treatment of Cancer recommends alternative study designs and collaborative networking.
The Canadian Task Force on Preventive Health Care recommends against using the PSA test to screen for prostate cancer in most men, citing an increased risk of false positives and overdiagnosis. The guideline aims to balance potential benefits with substantial harms.
The Rutgers technology uses rare earth nanocrystals and infrared light to reveal small cancerous tumors and cardiovascular lesions, allowing for earlier detection and potentially reducing treatment costs.