Articles tagged with Cancer Treatments
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Researchers have identified a type I interferon marker that can predict patients with an increased risk of HCV relapse after antiviral therapy. Patients who maintain a strong type I interferon response are more likely to remain HCV-free.
Researchers at UT Southwestern Medical Center suggest that inhibiting the action of enzyme Cdk5 could substantially reduce brain damage after a stroke. The study found that aberrant Cdk5 activity causes nerve cell death during stroke and that blocking this enzyme can help preserve brain tissue.
Researchers have created a device using microchannel technology that can remove endotoxins from blood, preventing sepsis. The technology may offer an alternative to antibiotics and could be used as a prophylactic treatment.
A new microRNA has been identified as a potential therapeutic target for treating osteoporosis by blocking bone destruction. Researchers believe this discovery could lead to innovative treatments for conditions such as osteoporosis and other bone diseases.
A new research approach could improve medical study recruitment by adjusting treatment odds based on early results. In a recent study, patients shown an explanation of the odds were more willing to participate, with 67% volunteering compared to 54% without such explanation.
Activation of estrogen receptor β (ERβ) has been shown to limit tumor cell growth in breast cancer. In mouse models, cancer cells with activated ERβ did not grow well. Conversely, breast cancer patients with activated ERβ in their tissue had increased disease-free survival rates.
New mutations in cohesin proteins are common in various cancers, including bladder cancer and melanoma. Cohesin regulates cell division and DNA repair, making it a potential driver or facilitator for tumours.
Researchers have identified a new therapeutic target for certain myeloproliferative diseases by targeting the microenvironment that sustains hematopoietic stem cells. The treatment involves using clinically approved medications to prevent or reverse damage to this microenvironment.
Researchers at the University of Gothenburg have developed a new combination treatment for cancer using the molecules RVX2135 and HDAC inhibitors. The treatment has been shown to increase survival rates in mice with MYC-driven lymphoma by activating similar genes as existing cancer treatments.
A randomized trial found that telephone-based weight loss advice reduced breast cancer recurrence risk by lowering weight and inflammation. Postmenopausal women with breast cancer who received lifestyle coaching via phone achieved comparable sustained weight loss to in-person consultations.
Seven research projects funded to study genetic changes associated with autism spectrum disorders and improve diagnostics for hereditary cancers. Funding aims to advance understanding and treatment of these conditions, impacting families worldwide.
A team of researchers has found a potential way to enhance the body's ability to sense and inhibit viral infections by boosting a naturally occurring protein called OASL. This discovery could lead to more effective treatments for viruses ranging from hepatitis C to the flu.
A study found that childhood cancer survivors were hospitalized more often and for longer durations than the general population, with conditions like blood disorders and infections leading to hospitalizations. The study highlights the need for regular cancer-focused healthcare to identify health problems throughout their lives.
The study reveals that each glioblastoma tumor contains individual cells from multiple cancer sub-types, and that the distribution of these cells varies from tumor to tumor. This heterogeneity may contribute to drug resistance and disease recurrence, highlighting the need for personalized treatment approaches.
A study of over 2,600 adults with hepatitis B found that antiviral therapy significantly reduced the occurrence of liver cancer (HCC) by 60%. The therapy was more effective than treatment in preventing HCC than untreated patients. Results suggest a potential new approach to preventing a common and deadly form of cancer.
A recent study found that frequent use of permanent dyes and perming treatments may expose hairdressers to banned aromatic amines, linked to increased cancer risk. The researchers recommend protective measures such as wearing gloves to minimize skin exposure.
Researchers discovered a new hormone called Metrnl that activates brown and beige fat, leading to improved metabolic health in obese mice. Interleukin-4 signaling also played a crucial role in stimulating beige fat formation.
Researchers found that intravenous injections of dental pulp stem cells have a protective effect against brain damage from heat stroke in mice. The treatment inhibited neurological deficits and reduced oxidative damage to the brain. However, further studies are needed to determine the precise mechanism of SHED-mediated growth factors.
A University of Houston chemist has received a $600,000 NSF CAREER Award to develop synthetic strategies for increasing the efficiency and yields of chemical reactions. The goal is to improve the treatment of diseases such as cancer and malaria by better understanding molecular reactivity.
Researchers at CNIC and CNIO successfully reproduce chromosomal translocations in human cells, identical to those found in leukemia and sarcoma patients. This breakthrough enables the study of new therapeutic targets and therapies for cancer treatment.
Researchers from CNIO and CNIC successfully reproduced chromosomal translocations in human stem cells, identical to those found in patients with acute myeloid leukemia and Ewing's sarcoma. This breakthrough allows for the study of new therapeutic targets and experimental recapitulation of tumour development.
The number of cancer survivors in the US is expected to grow from 14.5 million to almost 19 million by 2024 due to an aging population and improved treatment outcomes. The majority of cancer survivors were diagnosed five or more years prior, with nearly half aged 70 or older.
A study found that smokers are more likely to quit after receiving a serious lung cancer screening result. The effect appeared to be durable, lasting up to 5 years after the last screening.
Ronald M. Evans, director of the Gene Expression Laboratory at Salk Institute, is one of three scientists chosen for The Lustgarten Foundation's Distinguished Scholars program to focus on finding a cure for pancreatic cancer. He will expand his research on Vitamin D therapies using clinical trials in patients.
A new Vanderbilt University study found that women with blood in their urine were less likely to be referred to a urologist for further tests than men with the same issue. The disparity may contribute to delayed diagnoses and worse mortality rates among women with bladder cancer.
Researchers at UT Southwestern Medical Center discovered a critical role for microRNA cluster miR-143 and miR-145 in regulating wound healing in the intestine, which may lead to potential treatments for chronic digestive diseases like ulcerative colitis and Crohn's disease.
Researchers will analyze fat stem cells from obese patients to understand the mechanism underlying excess fat storage and insulin response. The study aims to identify potential therapeutic strategies for treating different groups of obese individuals at varying risk of developing diabetes and other health issues.
A systematic review compared the efficacy and safety of radiofrequency ablation (RFA) and complete endoscopic resection (EMR) for dysplastic Barrett's esophagus. Both treatments were found to be effective in short-term treatment, but RFA had lower short-term adverse event rates. Long-term esophageal strictures were more common with EMR.
The Prolaris test accurately predicted 10-year death rates from prostate cancer and outperformed antiquated upgrading practice. In conservatively managed patients, the test differentiated high-risk disease from lower-risk disease.
Researchers have developed a lab-on-a-chip platform capable of detecting protein cancer markers in blood at extremely low concentrations, enabling early diagnoses and treatment monitoring. The device's high sensitivity and portability make it an attractive tool for future cancer treatments.
Researchers developed herpes-loaded stem cells that significantly improved survival rates in mice with glioblastoma multiforme when applied to tumors. The treatment used mesenchymal stem cells as drug delivery vehicles, allowing oncolytic viruses to replicate and kill residual cancer cells.
Beaumont Children's Hospital has been awarded a $20,000 grant from CureSearch to support therapeutic clinical trials for children with cancer. The hospital believes that clinical trials are essential in helping children with cancer, and this funding will enable them to open additional studies and reach more patients.
Rice University researchers have developed a tunable virus that can target and destroy cancer cells by unlocking only in the presence of two selected proteases. The virus uses peptides to lock its capsid, which is then unlocked by specific enzymes, allowing it to bind to diseased cells.
A recent study used hip bone mineral density (BMD) measurements to predict fracture risk in postmenopausal women who stopped taking bisphosphonate therapy. The findings suggest that older age and lower hip BMD at the time of discontinuation were associated with higher rates of clinical fractures.
Men with low-risk prostate cancer who have low testosterone levels may be at increased risk of developing more aggressive disease. Low levels of free testosterone were significantly linked to an increased risk, suggesting a contradictory role for testosterone in prostate cancer progression.
Scientists have discovered that endogenous dendritic cell-derived interleukin-27 promotes tumor growth by recruiting regulatory T-cells. This finding suggests that targeting IL-27 could lead to more effective cancer immunotherapies.
Researchers at Dana-Farber Cancer Institute identified natural human antibodies against MERS, a severe respiratory disease with a mortality rate of over 40 percent. These 'neutralizing' antibodies prevented the virus from attaching to host cells, offering a possible development of antibody-based immunotherapy.
A recent study led by the University of Waterloo found that parents of children with life-limiting illnesses often report positive outcomes as well, known as posttraumatic growth. This phenomenon is characterized by growth in areas such as personal strength, appreciation for life, and spiritual change.
A study has found that genetic loss of Ron receptor and its growth factor HGFL leads to aggressive inflammation and damage to the colon in models with IBD. The research suggests these genes may reduce their function due to SNPs, leading to chronic intestinal inflammation.
Researchers at Northwestern University developed a new technology to modify human cells for programmable therapeutics that can target cancer and disease sites. The Modular Extracellular Sensor Architecture (MESA) enables cells to sense specific factors and respond with customized gene expression programs.
This review discusses four key physiologic processes in bone/tooth formation affected by rare bone diseases. The authors highlight causative mutations, etiopathology, and treatments for conditions like fibrous dysplasia, osteogenesis imperfecta, and hypophosphatasia.
Researchers discovered that microRNA-135b (miR-135b) is overexpressed in both mouse and human colorectal tumors, associated with poor clinical outcomes. The study suggests that miR-135b could be a valuable target for colorectal cancer treatment and a biomarker of tumor progression.
Researchers found that nearly one-third of pediatric kidney cancer cases are linked to the Lin28 gene, which holds promise for regenerating damaged kidneys. The study's findings suggest that controlled expression of Lin28 can promote kidney development and may lead to new therapeutic targets for treating Wilms tumors.
A new oral combination therapy has been shown to cure hepatitis C infection in over 90% of patients with liver cirrhosis, providing a significant improvement over the current treatment options. The study found that the treatment was well-tolerated and resulted in no long-term relapses.
Studies predict improved HCC patient outcomes with new diagnostic approaches. Gadoxetic acid-enhanced MRI shows higher detection sensitivity for early-stage HCC, potentially improving treatment outcomes by ensuring optimum care.
Young adult cancer survivors are at higher risk of mortality due to lifestyle factors such as exercise, alcohol consumption, and physical activity. Additionally, poor self-reported health status, worries about future health and insurance, and frequent medical visits can also impact life expectancy.
Dr. Michael Barrett of TGen received a $200,000 grant to investigate the molecular drivers of pancreatic cancer spread. The grant supports research into high-priority areas to double pancreatic cancer survival by 2020.
A study found that chronic cigarette smoking impairs postural stability in individuals with alcohol use disorders, even during sobriety. Non-smoking AD individuals improved on a measure of postural stability over eight months, while smoking AD individuals showed no significant improvement.
Researchers found that green tea extract increases brain connectivity and improves working memory performance. The study suggests potential clinical applications for treating cognitive impairments in neuropsychiatric disorders like dementia.
Researchers from Fox Chase Cancer Center found that NEDD9 protein activates oncogenic signaling pathways in cancer cells, encouraging metastases. The study suggests the protein plays an important role in initial development and dissemination of ovarian cancer.
The Deutsche Forschungsgemeinschaft (DFG) is establishing five new Research Units to explore innovative research directions in various fields. The new groups will focus on composite structures, personnel decisions, and metastatic cancer progression, with the goal of improving our understanding of these complex topics.
Researchers at Karolinska Institutet have identified a new way of treating cancer by inhibiting the MTH1 enzyme, which cancer cells require for survival. This approach differs from previous treatments that target specific genetic defects and offers a potential breakthrough in fighting the disease.
The new center aims to develop computational methods to understand how human cognition works and how it becomes disrupted in psychiatric disorders. The centre will combine advanced brain imaging with computational approaches to identify causes of mental health problems and develop personalized treatments.
A study published in Neural Regeneration Research found that early rehabilitation significantly improved sensory function, motor function, and activity of daily living in pediatric children with spinal tumors. The research suggests that rehabilitation programs initiated earlier are effective in achieving functional independency levels ...
A multicenter study found colchicine significantly reduced the rate of disease recurrence, improved symptoms, and hospitalization rates in patients with recurrent pericarditis. The medication was also associated with higher remission rates compared to placebo.
Dr. Tu's research identified a unique nutritional pathway in mammalian cells crucial to cancer cell growth, which he hopes will lead to new treatments for human disease. He received the award for his work expanding our understanding of metabolism's role in cellular processes.
A study found that radiofrequency ablation significantly reduced the risk of progression to high-grade dysplasia and cancer in patients with Barrett esophagus and low-grade dysplasia. Treatment resulted in a 25% lower absolute risk of progression.
Researchers at Columbia University Irving Medical Center have devised a new system for classifying periodontal disease based on the genetic signature of affected tissue. The new classification system may allow for earlier detection and more individualized treatment of severe periodontitis.
Researchers found that fat cells expand with disuse, causing accelerated growth of lipid droplets and altering the environment of surrounding cells. This discovery offers new insights into the development of obesity and potential solutions to prevent or reverse fat gain.
A new study from the University of Southern California Keck School of Medicine found that long-term survivors of esophagectomy with gastric pull-up can enjoy a satisfying meal and good quality of life. The study concluded that pessimism about the long-term quality of life after esophagectomy is unwarranted.