Research on new and better ways to treat cancer. Covers radiotherapy, targeted microdroplets, nerve-injury protection, drug combinations, and tumor models.
A study found that TERT mRNA levels are highly predictive of aggressive bladder cancers, allowing doctors to recommend targeted treatments and improve patient outcomes. The study also suggests that telomerase reactivation is crucial for the progression of bladder cancers, highlighting a potential target for disease intervention.
Researchers identified super-enhancers in T cells as key to regulating the immune system, which may lead to new treatments for autoimmune disorders such as rheumatoid arthritis. The study found that these enhancers control genes involved in T cell function and activity.
A study of 5,050 patient-clinician encounters found that only 1% were clinically inappropriate, and physicians complied with fewer than 1 in 10 requests. The findings challenge the myth of the 'demanding patient' and suggest a need to redirect attention from unnecessary costs.
A meta-analysis of 52 studies found that short-term hormone replacement therapy (HRT) use is associated with a significantly increased risk of developing the two most common types of ovarian cancer. Women who used HRT for 5 years or more had a 40% higher likelihood of developing ovarian cancer compared to those who never took HRT.
Researchers found that a common oral pathogen can grant tumors an anti-immune defense mechanism, protecting them from destruction by natural killer cells. Blocking this interaction might improve anti-tumor immunity in human patients.
A study found that young adult survivors (18-39) report higher distress levels than older survivors, despite similar time since treatment completion. Fear of cancer recurrence and financial burden were key predictors of elevated distress in these young adults.
A 12-year study by Kaiser Permanente found that common surgical procedures for precancerous cervical lesions do not decrease women's chances of becoming pregnant. In fact, women who had these procedures were more likely to become pregnant than those who did not.
Researchers found that rare EGFR mutations in non-small cell lung cancer (NSCLC) have distinct impacts on disease outcome and therapy response. Classic EGFR mutations were associated with better overall survival and higher TKI therapy response rates compared to rare mutations, which were linked to tobacco smoking and poorer prognosis.
Research published in Annals of the Rheumatic Diseases found that smoking impairs the response to biological drugs used to treat inflammatory back arthritis. Current smokers responded significantly less well to treatment and achieved smaller reductions in disease activity scores compared to non-smokers.
A new Special Issue from ecancermedicalscience tackles fertility-sparing cancer treatments, collecting latest research on preserving fertility in breast, cervical and ovarian cancers. Fertility-sparing treatments balance patient's wishes with oncological outcomes.
A new forecast from Cancer Research UK suggests that 1 in 2 people in the UK will develop cancer at some point in their lives. The increased risk is primarily due to more people living into older age, when cancer is more common.
A study published in the Journal of Immunology found that infusing memory cells can produce and repeatedly replenish all of the T-effector cells needed to fight CMV infection. This approach may improve on current therapeutic options for controlling CMV infection, which affects up to 80% of adults in the US.
A study reveals children with 'biallelic mismatch repair deficiency' (bMMRD) experience a rapid wave of genetic mutations, dubbed the 'great flood', which causes aggressive cancer. The research identifies a previously undiscovered mechanism for cancer progression and potential targets for treatment.
Researchers found that a protein called FADD picks up a phosphate for a specific amino acid when KRAS is active, and that blocking this process can prevent tumors from forming. A CK1-alpha inhibitor is currently being developed as a potential treatment for lung cancer caused by KRAS mutations.
A new analysis found that women with breast cancer have poor knowledge about their illness, with minority patients less likely to know accurate information. The study highlights the need for patient education and provider awareness to improve informed treatment decisions and overall cancer care.
Researchers developed new animal models that faithfully reproduce the evolution and malignancy of different human tumors. This allows for parallel tumor progression, prediction of relapses, and assessment of effective treatments in a controlled laboratory setting.
Researchers have discovered that silver nanoparticles' toxicity can be modulated by carbohydrate coatings, according to a recent study published in the Journal of Nanobiotechnology. The study found that glucose-coated silver nanoparticles are more toxic than those coated with galactose or mannose.
A new study found that high-risk neuroblastoma cells use an efficient but erroneous DNA repair pathway, giving them a survival advantage. This alternative repair mechanism may be the target of new therapies to improve treatment options for children with neuroblastoma.
A comprehensive review published in The Lancet provides guidance on treating multiple myeloma, including established and novel therapies. New approaches to paralyze cancer cells and attack malignant cells are also introduced.
A new analysis has identified over 58,000 long non-coding RNA genes that may play a role in cancer. The study also found that one lncRNA, SChLAP1, is a potential biomarker for aggressive prostate cancer.
Researchers at the Douglas Mental Health University Institute found that glucocorticoid tablets can synchronize peripheral biological clocks in white blood cells, improving synchronization of the body's internal clocks. This breakthrough could lead to innovative therapies for travelers, night-shift workers, and those with sleep disorders.
Research from St. Jude Children's Research Hospital reveals that PTEN tumor suppressor protein is essential for proper regulatory T cell function, helping to prevent autoimmune diseases. The study identified a crucial role of PTEN in controlling Tfh cells and autoantibody production, offering new focus for improving treatment.
Researchers used next-generation sequencing techniques to analyze archived tissue samples of phyllodes tumors, identifying two genes (EGFR and IGF1R) that were amplified in malignant tumors. The study also found the gene MED12 was frequently mutated in all classifications of phyllodes tumors.
Researchers at Columbia University Irving Medical Center have discovered a stem cell capable of regenerating both bone and cartilage. The discovery, published in the journal Cell, suggests that this stem cell could be exploited to treat osteoarthritis and osteoporosis. Further study is needed to determine if this technology can be appl...
Researchers at National University of Singapore have found new interactions between STAT3 and PRL-3, two molecules involved in acute myeloid leukaemia, which may offer a new therapeutic target. The study suggests that disrupting the STAT3-PRL-3 regulatory loop could lead to an attractive anti-leukaemia therapy.
A new study finds that many cancer survivors experience lingering problems affecting their quality of life, including physical issues and anxiety about recurrence. The study suggests that clinicians can develop tailored interventions to address these specific concerns.
A clinical trial conducted by the NIH found that 38 out of 40 volunteers with HCV infections were cured after receiving a combination of three direct-acting oral drugs for six weeks. This short duration therapy may prove relevant for global elimination of hepatitis C, where simple and well-tolerated treatment is required.
A study by University of Central Florida social work professor Mary Ann Burg found that cancer survivors often experience unmet needs, including physical problems like sexual dysfunction and anxiety about recurrence. The study analyzed responses from an American Cancer Society survey of 1,514 cancer survivors.
Researchers developed novel indicators to assess and quantify 'progress' and 'value' in cancer research. The PACE Continuous Innovation Indicators provide a visual representation of progress over time, helping identify gaps and needs.
A long-term follow-up of patients with type 1 diabetes found that intensive treatment was associated with a modestly lower all-cause rate of death compared to conventional therapy. The study's findings suggest that intensive therapy may reduce mortality risk in type 1 diabetes patients.
Scientists have found that the MMP12 enzyme travels to the center of cells, contradicting previous assumptions. This discovery may lead to the development of treatments to turn off this enzyme and others like it when they cause damage.
A Vanderbilt-led team has developed a method for detecting 'cell-free' tumor DNA in the bloodstream, showing promising results in distinguishing prostate cancer from normal controls. The technique, called a 'liquid biopsy,' demonstrated over three times the sensitivity of current PSA screening and accuracy rates of up to 91 percent.
A study found that changes in the H9N2 flu virus in chickens may have contributed to the creation of the H7N9 avian virus, which has caused outbreaks and deaths since 2013. The research suggests tracking genetic diversity of H9N2 on poultry farms could provide an early warning of emerging viruses with pandemic potential.
Researchers at Aarhus University have found that genetic variations in the interferon lambda 4 protein impact treatment effectiveness for hepatitis C. This discovery suggests that personalized medicine targeting specific genetic variants could lead to better treatment outcomes for patients.
Researchers at the University of Louisville have identified mutations that destabilize a DNA structure, turning a gene off in over 75% of glioblastomas and melanomas. This discovery provides a new model for understanding cancer-specific activation of telomerase, an enzyme promoting cell division.
A new review suggests that hormone replacement therapy (HRT) is the most effective treatment for menopausal symptoms in younger women, particularly those experiencing hot flushes and night sweats. The review highlights that HRT provides low doses of estrogen with or without progestogen to alleviate symptoms and minimize risks.
A large study found that laparoscopic radical cystectomy leads to reliable cancer control even years after surgery, with 66% of patients free from recurrence after 5 years. The minimally invasive procedure can be as safe as open surgery for cancer control, supporting its use in bladder cancer management
University of Michigan researchers devise a reliable way to grow cancer cells from patients outside the body for study, increasing success rate to over 73% and opening doors to tailored therapies. The new technique could enable doctors to track cancer progression in real-time, making treatment decisions more informed.
Researchers found that SIRT1 enzyme loss drives early prostate cancer formation in mouse models. The study suggests SIRT1 may be a target for prostate cancer prevention.
Researchers have found that loss of gene PTEN is a common driver event behind high-grade serous ovarian cancer, which is often fatal. Combining image analysis with genetic data helped identify PTEN levels in cancer cells while ignoring normal cells, paving the way for new treatments.
Araim Pharmaceuticals' ARA 290 peptide shows clinically significant pain reduction and improved metabolic control in type 2 diabetics. The novel agent is engineered to activate the innate repair receptor, which turns off inflammation and turns on the body's natural repair system.
A randomized clinical trial found that a telephone-based motivational counseling intervention with tobacco treatment specialists increased quit rates among low-SES adult smokers compared to usual care. The program also showed promise in addressing social context factors related to smoking, with women, blacks, and those living in low-in...
A new study by University of Michigan researchers suggests that using war metaphors to describe cancer can have a negative impact on prevention behaviors. Participants who were exposed to such language were less likely to consider limiting unhealthy habits like smoking and excessive alcohol consumption.
Researchers at Walter and Eliza Hall Institute have developed a potential cure for chronic hepatitis B virus (HBV) infection. The new treatment, birinapant, triggers the breakdown of proteins that prevent infected cells from self-destructing, allowing infected cells to die.
Research from St. Jude Children's Research Hospital identifies a high-risk group of young patients who may experience intellectual decline after bone marrow transplantation. The study found that those aged 3 or younger at the time of transplantation with total body irradiation were at higher risk, leading to lower IQ scores and potenti...
Researchers identified a critical pathway that enables cancer cells to survive despite DNA errors, relying on the PKCƐ signal pathway. Disrupting this pathway could trigger cancer cells to self-destruct, offering a new strategy to beat the disease.
Researchers discovered a protein called BAZ2A that influences epigenetic patterns in prostate cancer cells, leading to increased malignancy and tumor growth. High levels of BAZ2A expression were linked to more advanced tumors, metastases, and poor patient outcomes.
A study by Dana-Farber Cancer Institute researchers found that levels of two microRNAs, let-7e and 106b/25, can predict progression-free survival in multiple myeloma patients. The study suggests that these microRNAs may also help doctors determine which patients are likely to have the best responses to different types of therapy.
Researchers found a significant benefit in adding carfilzomib to standard lenalidomide and dexamethasone treatment, extending disease-free periods by nearly 50%. The three-drug combination resulted in improved remission rates and overall survival, with patients reporting better quality of life.
The Multiple Myeloma Research Foundation has made landmark genomic and clinical data from the CoMMpass Study available to researchers via the MMRF's Researcher Gateway. This data includes patient-level biomarker and clinical data, genomic information, and treatment responses, offering new avenues for research into multiple myeloma.
Scientists at VCU Massey Cancer Center use computer modeling to predict which patients are at greatest risk for developing GVHD after stem cell transplantation. The researchers found that minor histocompatibility antigens play a crucial role in shaping the development of T-cell clonal families.
The Prolaris test could save the healthcare system $6 billion over 10 years by reducing costs and improving health outcomes. The test improves health outcomes, reduces healthcare costs, and aids physicians in providing clinical care for their patients.
A study by Cancer Research UK found that people often dismiss cancer symptoms as less serious and attribute them to other causes. Only two per cent thought cancer was a possible cause, despite experiencing red-flag symptoms such as unexplained coughs or persistent changes in bowel habits.
High levels of miR-21 in tumor stroma and epithelia are associated with poorer clinical outcomes in triple-negative breast cancer. The study found that changes in the tumor microenvironment play a crucial role in determining disease progression.
Researchers discovered lactate plays a key role in ASPS tumor cells' behavior, fueling their growth and aggressiveness. The study also confirms the fusion gene ASPSCR1-TFE3 as the driver of this rare cancer.
Scientists have made a breakthrough in treating epidermolysis bullosa by using induced pluripotent stem cells to grow back healthy skin cells. The new technique, called therapeutic reprogramming, was tested on mice and showed promising results.
A new hybrid vehicle has been developed to deliver DNA vaccines that can fight HIV, cancer, influenza, and other diseases. The technology improves the delivery of genes to the immune system, increasing its effectiveness in treating major illnesses.
A new study published in The Journal of Urology analyzed data from three independent registries and found no increase in prostate cancer incidence among men treated with long-term testosterone therapy. The study followed over 1,000 men for up to 17 years, with a median follow-up of approximately 5 years.
A study published in CANCER found that adult survivors of retinoblastoma have few cognitive or social problems decades after diagnosis and treatment. The research suggests the brain may adapt to early insults, with some survivors performing better on verbal memory tasks.
Researchers developed a new approach to breast cancer follow-up that considers individual risk factors. For postmenopausal women with moderate prognosis early breast cancer, less frequent surveillance may be more cost-effective, especially for those older than 70 years.