Articles tagged with Cancer Treatments
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A combination of sofosbuvir and ribavirin achieved high sustained virologic response rates in patients with unfavorable treatment characteristics, including advanced liver disease and high baseline HCV RNA levels. The regimen was well-tolerated and safe, with a lower relapse rate compared to traditional interferon-based therapy.
Mayo Clinic researchers found that high-tech imaging technologies are leading to the overdiagnosis and overtreatment of low-risk papillary thyroid cancer. This is exposing patients to unnecessary treatments with potential complications such as nerve injury. The study calls for more research on care for these patients.
A study found wait times for colorectal cancer operations at VA hospitals rose to 32 days, but researchers believe longer waits may be due to improved care and outcomes. The study suggests that more careful care is worth the wait, even if it means delayed treatment.
Researchers have developed a novel treatment for stroke using exosomes containing genetic material from bone marrow stem cells, which significantly improved neurological function in lab rats. The treatment, tested on lab rats with induced stroke, showed gradual and eventually significant improvement over four weeks.
A new study found that poor oral health is associated with an increased risk of oral human papillomavirus (HPV) infection, which can cause oropharyngeal cancers. Good oral hygiene practices can help prevent HPV infection and its related cancers.
Researchers found that a combination of calorie restriction and targeted therapy may increase cancer survival. Calorie restriction decreased Mcl-1 protein activity, sensitizing lymphoma cells to treatment. This study suggests a potential new approach to improve cancer treatment efficacy.
A new biomarker, PROVAR, predicts time to ovarian cancer recurrence and distinguishes between high-risk patients. Analysis of protein biomarkers may help determine treatment plans for ovarian cancer patients.
Researchers evolved hyperswarmable Pseudomonas aeruginosa bacteria, which formed less dense biofilms than their non-hyperswarmable counterparts. This could lead to the development of new anti-biofilm therapies.
The CEO Cancer Gold Standard program, developed by Johnson & Johnson, promotes workplace health promotion and industry practices that support cancer prevention and treatment. Employers can influence healthcare policies and reimbursement through data-driven decision making and the '5 Pillars' framework.
Cervical cancer is a significant burden on women of reproductive age in low- and middle-income countries, with reduced reproductive capacity and associated health risks. Experts argue that cervical cancer screening and treatment should be included in the post-2015 development agenda for improving reproductive health outcomes.
A UCLA study found that women diagnosed with breast cancer who created personal websites experienced reduced depressive symptoms, improved mood, and increased appreciation for life. The project, Project Connect Online, provided a platform for breast cancer patients to share their experiences and connect with friends and family online.
Metabolic fingerprinting looks at metabolite levels in blood, urine, or tissue to analyze tumor development and growth. This technique can improve diagnosis accuracy alongside existing imaging methods.
Using surface-enhanced Raman spectroscopy (SERS), scientists can distinguish between adult stem cells, enabling the use of healthy ones in therapies. This technique holds promise for advancing stem cell and other cell-based therapies to treat diseases like Parkinson's.
Researchers at Ohio State University Comprehensive Cancer Center discovered that the tumor-suppressor gene A20 is silenced due to the loss of microRNA-29, leading to increased levels of NF-kB and tumor progression. This finding could guide the development of more effective therapies for soft-tissue sarcomas.
A new study reveals that certain patient groups feel unmet needs for greater involvement in cancer treatment decisions. Younger patients and those with specific rare types of cancer want more input in the decision-making process. The research emphasizes the importance of shared-decision making policies to address these disparities.
The Louisiana Tumor Registry has been awarded a contract to continue its work as a SEER Program-designated cancer registry, collecting cancer incidence and survival data from 28% of the US population. The funding will support cancer research, including prevention, early detection, treatment, and survivorship studies.
Patricia Resick, PhD, ABPP, received the American Psychological Association's Division of Trauma Psychology Award for Lifetime Achievement in trauma psychology. She has made outstanding contributions to science, practice, advocacy, and education, developing Cognitive Processing Therapy (CPT) for PTSD treatment.
Researchers at the University of Kentucky Markey Cancer Center have made significant discoveries about the Par-4 gene and its role in cancer recurrence. The study found that low levels of Par-4 protein may predict breast cancer relapse, while high levels can eliminate cancer cells through apoptosis.
Researchers at the National Human Genome Research Institute identified biomarkers of kidney damage and demonstrated that antioxidant therapy protected kidney function in mice. These findings offer new tools for monitoring disease progression and may pave the way for clinical trials for patients with methylmalonic acidemia.
New study reveals stable survival rates for HIV-associated lymphoma patients during the antiretroviral therapy era. Despite increased incidence and changing demographics, recent diagnosis years are not associated with decreased mortality. The study highlights an ongoing need to improve treatments for this challenging population.
Undergraduate students at University of Houston are conducting research on Alzheimer's diagnostics, breast cancer treatment, and fruit fly courtship patterns. Their projects aim to develop new diagnostic methods and treatments, while exploring adaptations to environmental changes.
Researchers have characterised the binding of IFNβ proteins to cells, providing a breakthrough in understanding immune response mechanisms. This study offers new avenues for developing treatments with reduced side effects and improved effectiveness.
Women who survive cancer have more frequent, severe, and troubling hot flashes than other women with menopausal symptoms. However, the study also found that the cancer survivors reported better psychological and social well-being, similar levels of sexual activity and function compared to women without cancer.
A study of over 10,000 men with nonmetastatic prostate cancer found that use of androgen deprivation therapy (ADT) was associated with a significantly increased risk of acute kidney injury. The association remained consistently elevated across different types of ADTs, particularly in the first year of treatment.
Gay men are more than 15 times as likely to develop genital cancer as straight men due to HPV infection. Targeted vaccination is recommended for those aged up to 26 years, with sexual health clinics ideal for offering the vaccine.
Older African-American and Hispanic male cancer survivors are more likely to miss specialist visits and preventive care, such as vaccinations, compared to their white counterparts. The study found that disparities persist despite access to Medicare and adjustments for factors like education and insurance.
Chemists from North Carolina State University have successfully performed a DNA-based logic-gate operation within a human cell. The researchers used a DNA-based Boolean logic gate that was activated only when two specific microRNAs were present in cells, generating an output by releasing a fluorescent molecule.
A large UK cohort study found that children born through assisted reproduction have no higher cancer risk than naturally conceived children. However, rare cancer types were associated with low birth weight and small absolute excess risks.
A study found that biological tumor necrosis factor inhibitors did not significantly reduce work loss compared to conventional treatment in patients with early rheumatoid arthritis. Early and aggressive treatment can help reverse increasing work loss days, but the cost of infliximab outweighs its benefits.
Research published in the Journal of Leukocyte Biology found that excessive mast cells lead to delayed wound healing due to overproduction of IL-10. The study provides a potential therapeutic target for future drug development.
Researchers have developed two new methodologies to determine ALK status in non–small-cell lung cancer (NSCLC) patients. The first method improves IHC assay sensitivity using a novel hapten and tyramide amplification, detecting low levels of ALK protein expression. The second method combines brightfield IHC with in situ hybridization f...
Researchers will study pediatric sarcomas, a rare and aggressive form of cancer affecting 11% of all childhood cancers, with the goal of developing new therapies. The project aims to improve outcomes for children with advanced or metastatic disease, who have limited success with current treatments.
Researchers evaluate immunohistochemistry for detecting ALK rearrangement in lung adenocarcinoma, finding it a reliable and cost-effective method. The study suggests that IHC can effectively detect ALK rearrangement and identify suitable candidates for targeted therapy.
A recent study published in the Journal of the American College of Cardiology found that heart failure patients are more likely to develop cancer, with a significant increase in mortality rates. The study suggests that side effects of cardiovascular treatments and inflammation may be contributing factors.
A study finds a link between prenatal ICP and postnatal obesity in offspring, while another investigation reveals genetic changes in preeclampsia and brain inflammation caused by chronic cannabis use. These findings may have implications for understanding and treating metabolic diseases and pregnancy complications.
Researchers at Max Planck Institute discover Chlamydia promotes gene mutations, impairing DNA damage response and leading to uncontrolled cell growth. The infection can cause chronic damage, increasing risk of cervical and ovarian cancer.
Naked mole rats have a unique protein richly present in their tissues that protects them from cancer, according to recent research. The researchers identified high molecular weight hyaluronan (HMW-HA) as the chemical responsible for this resistance.
A multicenter European study found that short-term hormonal therapy for transsexualism is effective and safe, with few side effects. The treatment, which involves large doses of male or female sex hormones, was shown to be effective in changing the external characteristics of trans individuals.
Researchers found gastrointestinal and liver-related GVHD increases risk of death in patients with chronic GVHD. Elevated bilirubin levels, higher gastrointestinal scores, and lower gastrointestinal involvement are associated with increased mortality rates.
A study analyzing US data reveals that up to one-third of rheumatoid arthritis patients discontinue therapy within the first year, with loss of efficacy being the leading reason. The findings highlight the need for early intervention and improved adherence to treatment to enable patients to lead active lives.
Fei Li, an assistant professor at NYU, has been selected as a Pew Scholar in the Biomedical Sciences. He will continue his research on centromeres and chromosome structure to understand how changes lead to cancer.
Researchers from Spain and the US have identified nine molecular hallmarks of aging, including genomic instability, telomere shortening, and epigenetic alterations. By understanding these hallmarks, they hope to develop treatments that can combat cancer and other diseases linked to aging.
Researchers at the University of Minnesota have discovered a way to correct genetic defects in skin cells of patients with epidermolysis bullosa. They used engineered transcription activator-like effector nucleases to target and fix mutation-causing genes, resulting in the production of missing proteins in living skin models.
A new mathematical method simplifies cancer-cell genome data, identifying recurrent events and revealing tumor evolution. The CORE technique improves prognosis and treatment decision-making by distinguishing subpopulations of cancer cells.
A phase 1 clinical trial shows a new treatment safely reduces immune system reactivity to myelin in multiple sclerosis patients by 50-75%. The therapy, which uses specially processed white blood cells, preserves the function of the normal immune system. Researchers hope to launch a phase 2 trial to prevent MS progression.
Scientists have created a model to study breast cancer biology, confirming that primary tissue from patients behaves similarly to those derived from long-term cultured cell lines. This breakthrough advances the development of targeted therapies for advanced cancer treatments.
A study by Ben-Gurion University found that oncologists face difficulties in communicating about end-of-life issues, despite high patient needs. Common barriers include physician factors, patient reluctance, and institutional stigmas.
Researchers at Karolinska Institutet have discovered a promising strategy for defeating neuroblastoma by targeting the MYCN protein. The approach involves inhibiting the MYC gene, which leads to the accumulation of fat droplets in cancer cells and ultimately causes cell death or development into harmless neurons.
Researchers found that cytomegalovirus (CMV) can speed the progression of glioblastoma, a deadly form of brain cancer, when particular genes are shut off. CMV was found to stimulate tumor-cell proliferation by activating a biochemical cell pathway called STAT3.
A three-year study published in The Journal of Urology finds that tibial nerve stimulation significantly improves symptoms of overactive bladder. Participants experienced a nearly 30% decrease in daytime trips to the bathroom and almost 40% fewer nighttime trips.
Scientists at the University of Leeds have discovered a molecule that targets and destroys a key protein associated with the development of cervical and other cancers. The RNA aptamer latches onto the carcinogenic protein, significantly reducing its presence in cells in laboratory-derived cervical cancer cells.
A recent study published in Cancer found that African American men with prostate cancer face longer treatment delays than their Caucasian counterparts. The analysis of SEER-Medicare registry data revealed an average delay of 7 days for African American patients, compared to 4 days for Caucasians. Additionally, African Americans were mo...
Researchers at Rockefeller University have developed a multicolor fluorescence labeling method to visualize miRNAs in tissue sections, enabling the identification of tumor-specific miRNAs and distinguishing between different tumor types. This technology shows promise as a molecular diagnostic tool for clinical settings.
A modified poliovirus is infecting and killing glioblastoma brain tumor cells with encouraging results in an ongoing phase 1 study, researchers report. The virus-based therapy, known as PVSRIPO, triggers the immune system to attack infected tumor cells.
Researchers at Mayo Clinic have developed a promising method to distinguish between pancreatic cancer and chronic pancreatitis. A molecular marker obtained from pancreatic 'juices' can identify almost all cases of pancreatic cancer, with a detection rate of 75%.
Depressive symptoms observed in cancer survivors between one and ten years after diagnosis increase the risk of premature death. Cancer survivors with depression are twice as likely to have died early compared to those without depression.
Drs. Yueming Li and Lennart Mucke have made significant contributions to understanding Alzheimer's disease mechanisms, identifying underlying processes that impair cognitive functions. Their work has led to promising new directions for treatment, including targeting gamma-secretase activity and modulating protein interactions.
A study published in Neurology found that individuals with skin cancer had a nearly 80% lower risk of developing Alzheimer's disease. The researchers suggest physical activity and biological factors as possible explanations for this link.
A new analysis found a significant link between Agent Orange exposure and high-grade prostate cancer among US Veterans. Exposure to the herbicide was associated with a 52% increase in overall risk of prostate cancer detection by biopsy, as well as a 75% increase in risk of high-grade prostate cancer.
A study published in JAMA Network found that creative arts therapies significantly improved anxiety, depression, and pain symptoms, as well as quality of life among cancer patients during treatment. However, the effects were reduced during follow-up.