Research on new and better ways to treat cancer. Covers radiotherapy, targeted microdroplets, nerve-injury protection, drug combinations, and tumor models.
Researchers found that humans with genetically long telomeres have an increased risk of dying from cancer, contrary to expectations. The study suggests that targeting the repair process of telomeres could be a promising approach for cancer treatment.
A new study describes the benefits of an active post-discharge intervention program for patients who have undergone thoracic surgery. The program resulted in shorter hospital stays, fewer emergency room visits, cost savings, and no increase in adverse outcomes.
A new special issue of the journal Gastroenterology explores how food affects health and disease, including the gut microbiome, food allergies, and non-celiac wheat sensitivity. The research provides evidence-based summaries to guide clinical recommendations for patients and clinicians.
Researchers at Harvard Medical School have developed an imageable mouse model of brain-metastatic breast cancer and shown the potential of a stem-cell-based therapy to eliminate metastatic cells from the brain and prolong survival. The study also describes a strategy to prevent negative consequences of stem cell therapy.
A new study published in ecancermedicalscience suggests that turmeric's curcumin can quell the activity of human papillomavirus (HPV) in oral cancer cells, potentially providing a means of future control for the virus-related cancers.
Scaling up existing interventions, including infant vaccination and treatment programmes, could prevent 90% of new chronic HBV infections and 65% mortality levels by 2030. Global expansion is necessary to achieve hepatitis B elimination, avoiding 20 million deaths by 2030.
A study found that oophorectomy significantly reduced breast cancer death risk in women with a BRCA1 gene mutation. The procedure also showed promise in reducing all-cause mortality, particularly among estrogen receptor-negative breast cancer patients.
The new guidelines provide a broader scope of therapeutic options for pediatric patients with differentiated thyroid cancer, aiming to limit aggressive therapy when it's unlikely to offer benefit. The guidelines specifically address the differences in biological behavior and management of these entities in children.
The Association for Molecular Pathology compiles current research on liquid biopsy approaches for cancer diagnostics. The review supports the notion that these minimally invasive tests allow for earlier diagnosis, faster and more targeted treatment, reduced costs, and increased quality of life.
A recent study from Huntsman Cancer Institute found that childhood cancer survivors are more than five times as likely to be enrolled in federal social security disability assistance programs compared to individuals without a cancer history. The study identified survivor socio-demographic and treatment characteristics associated with a...
A study led by St. Jude Children's Research Hospital scientists identified a protein called NLRP12 that helps regulate inflammation in T cells. The findings suggest how mutations in the Nlrp12 gene cause disease, paving the way for developing targeted therapies to ease symptoms of autoinflammatory diseases like multiple sclerosis and c...
A novel approach harnessing positron emission tomography (PET) imaging identifies areas of immune cell activity associated with inflammation or tumor development. This method offers a potential breakthrough in diagnostics and monitoring efficacy of cancer therapies.
Smokers diagnosed with cancer were more likely to quit than those without a diagnosis, according to a large study. The study found that a cancer diagnosis acted as a cue-to-action, motivating some smokers to quit in order to lower their future disease risk.
A new study found that cancer-related post-traumatic stress is associated with very limited cognitive impairment before treatment among newly diagnosed breast cancer patients. The study, published in the JNCI Journal of the National Cancer Institute, analyzed data from 166 breast cancer patients and 60 matched controls.
Researchers analyzed data on 325 cancer patients hospitalized with pneumonia and found that severe illness and organ dysfunction are better predictors of outcome than multiresistant bacteria. The study suggests personalized treatment protocols can reduce mortality in these patients.
A research program led by Carlos M. Ferrario aims to unravel the mechanisms of novel peptides in heart disease and atrial fibrillation. The team will conduct studies to evaluate new therapies to halt the progression of heart disease.
Researchers at the University of Missouri have established a model that identifies aging as a key factor in the development of dysphagia. Healthy aging mice exhibit symptoms of swallowing impairment similar to those seen in older adults, with slowed swallowing function and impaired tongue movement.
Cancer Research UK scientists found that mutations in the KRAS gene interfere with protective self-destruct switches, allowing cancer cells to grow and spread. The research may lead to tailored treatments for pancreatic and non-small cell lung cancers.
Physical activity has been shown to reduce symptoms, increase exercise tolerance, and improve quality of life in lung cancer patients. Additionally, increased physical activity may also benefit lung cancer survivors by improving exercise capacity and symptom burden.
The American Cancer Society has awarded $45.6 million in research and training grants to fund investigations into colon cancer, social inequalities in cancer, and other areas of cancer research. The grants will be used to develop vaccines targeting cancer initiation and challenge the mainstream approach to social inequalities in cancer.
Researchers found that inflammatory cells from the bloodstream play a key role in neurodegeneration in Parkinson's disease. CD95L-bearing immune cells cause damage to neurons, and blocking this molecule can prevent neurodegeneration in mice. This suggests that early treatment with drugs targeting CD95L might mitigate Parkinson's symptoms.
The 14th St. Gallen International Breast Cancer Consensus Conference highlighted the need to refine breast cancer classification and predict treatment responses. The conference recommendations will set the standard for breast cancer care for two years, taking into account variable resource limitations worldwide.
Researchers at the University of Michigan Medical School found that patients with chronic myelomonocytic leukemia (CMML) who responded to decitabine treatment had a distinct DNA methylation pattern. This signature can be used to predict patient response to treatment, enabling more effective treatment planning.
Moffitt scientists are using a new theory called the Big Bang model of cancer heterogeneity, which suggests that mutations occur early during tumor development. This approach has significant implications for treatments, as it recognizes that tumors can change during treatment and that current therapeutic approaches ignore this fact.
A committee of lymphoma experts identified key priority areas in infrastructure and research to advance treatments. The Roadmap for Discovery and Translation in Lymphoma outlines priorities to improve understanding of lymphoma biology across diverse subtypes.
The updated guidelines offer a state-of-the-art basis for clinical care of patients with MTC, highlighting areas in need of further investigation. The revised recommendations aim to improve overall survival for these patients by developing more effective drugs or combinations of drugs.
Dr. Vakoc's work reveals an essential connection between epigenetic regulation and oncogenesis, leading to potential new therapeutic approaches for leukemias and other cancers. He will present his lecture at the AACR Annual Meeting 2015.
Dr. Sara A. Courtneidge is being recognized by the American Association for Cancer Research (AACR) for her groundbreaking research on Src-family kinases and their role in cancer development. Her work has also focused on promoting women in science, leadership, and mentorship.
A recent study is comparing the direct and indirect costs of three minimally invasive fibroid treatments: global fibroid ablation, myomectomy, and uterine artery embolization. The TRUST Study aims to determine which treatment offers the best balance between cost and benefits for women seeking to preserve their uterus.
Researchers at Mayo Clinic have discovered that it is possible to detect endometrial cancer using tumor DNA picked up by ordinary tampons. The study found higher methylation levels in vaginal secretions from women with endometrial cancer, suggesting a potential tool for early detection.
Scientists at St. Jude Children's Research Hospital have identified key receptors that trigger the immune system to attack tularemia-causing bacteria, potentially leading to new protective treatments and vaccines. The discovery could also shed light on autoimmune diseases and cancers.
A new study finds that providing women with stress management skills during breast cancer treatment can lead to improved mood and quality of life many years later. Women who received the intervention had persistently less depressive symptoms and better quality of life up to 15 years post-treatment.
A new study by the University of Miami found that women who received stress management training during breast cancer treatment experienced improved mood and quality of life for up to 15 years. The study suggests that early stress management can have long-term benefits for psychosocial health.
A study of 500 women in California found that black and Hispanic patients were less likely to choose their surgeon based on reputation compared to white women. Health plans played a significant role in hospital selection for all groups. These findings suggest minority patients have less involvement in choosing their healthcare providers.
Recent studies show that breast milk contains beneficial bacteria to protect infants from diseases, while probiotics may restore balance in the gut and improve psychiatric symptoms in autism. Research also highlights the connection between gut microbiota and cancer prevention and treatment, as well as diet and intestinal health.
A new study published in Journal of Vascular Surgery found that minimally invasive aortic aneurysm repair can extend lives even in patients with advanced age and kidney disease. However, not all high-risk patients benefit from the procedure, particularly those undergoing cancer treatment.
Researchers developed a nanotechnology-based method to assess prostate cancer risk, enabling doctors to identify aggressive forms of the disease and tailor treatment recommendations. The study's findings suggest that this approach may improve patient outcomes by minimizing side effects.
A Swiss Institute of Bioinformatics-led trial demonstrates the potential of mathematical modelisation and experimentation in treating breast cancer. By combining clinical and experimental oncology with modelisation, researchers identified mechanisms that enable tumour cells to shape monocyte activities for their advantage.
Researchers at Salk Institute have developed a new method to convert cells from x-linked SCID patients into stem cell-like state, fix the genetic mutation and prompt corrected cells to successfully generate NK cells in the laboratory. This technique could lead to a more effective and less invasive treatment for this devastating disease.
Childhood adrenocortical tumors have been analyzed on a genomic scale for the first time, revealing key molecular events in pediatric cancer. The study identified TP53 and IGF2 genetic mutations that trigger tumor development and poor prognosis.
A recent study has explored the effect of mutations in PKC on tumour growth, revealing that most 'loss of function' mutations stop PKC from working. The study found that correcting these mutations in bowel cancer cells resulted in a reduction in tumour growth.
Researchers at CWRU found that African-American cancer patients with depression often experience different symptoms than white patients, including irritability and social isolation. These findings suggest that culturally sensitive depression measures are needed to accurately diagnose and treat black cancer patients.
A survey of 1200 Canadians found that most valued news of incidental findings, but personal utility depended on the type of findings. Individuals preferred hearing about diseases with lifestyle modifications or treatment available, while those without treatment options saw less value in receiving such information.
Researchers have discovered a nanobody called Nano-85 that can bind to intact norovirus-like particles, detecting virus in one-third of stool samples. This finding could lead to the development of an antiviral therapy for norovirus infections, particularly beneficial for immunosuppressed individuals.
Researchers have discovered a magnetic material that can heat cancer cells to high temperatures without harming healthy tissue. This breakthrough material uses a unique Curie temperature-dependent heating effect that stops quickly and cannot get hotter.
Researchers have found that IL-33 is a critical messenger triggering changes in the stomach's inflammatory response to H. pylori infection, potentially leading to new therapies targeting gastric damage. Elevated IL-33 levels may be associated with chronic infection and metaplasia.
A new study identified older white males with advanced bladder cancer as a high-risk group for suicide. Researchers found that these patients have a higher suicide risk compared to those with other genitourinary cancers.
A new study found that 20% of men with normal testosterone levels received a prescription for testosterone therapy. The study also found that nearly half of new testosterone users did not receive prostate cancer screening during treatment.
A study of 992 patients with asymptomatic benign thyroid nodules found that most exhibited no significant growth over a 5-year period, and diagnoses of thyroid cancer were rare. The study suggests that current guidelines for follow-up may be overly aggressive and that individualized surveillance strategies could be more efficient.
New research shows that non-cancerous prostate cells with genetic mutations can develop into cancer, potentially explaining why prostate cancer often has multiple genetically different tumours. This discovery could lead to a rethink of treatment strategies and improve outcomes for men with the disease.
The Society of Interventional Radiology has selected 23 new Fellows, recognizing their achievements in research, teaching, and leadership in the field. The SIR Fellowship is a prestigious honor conferred to members who have demonstrated excellence in advancing medical practice through image-guided treatments.
A study of 308 patients with CLL found that 10% discontinued ibrutinib therapy due to disease progression and Richter's transformation, while others stopped for other reasons. Patients who discontinued therapy had poor prognosis, highlighting the need for new research targets.
Researchers have identified two urinary biomarkers that can predict bladder cancer-specific survival and guide treatment. The study validated the biomarkers in over 400 clinical samples, showing they are independent predictors of cancer prognosis.
Research at Mayo Clinic found that a decline in smoking rates may lead to fewer people qualifying for early detection of lung cancer through low-dose CT scans. As smokers quit earlier, more patients are diagnosed at a later stage, increasing mortality.
An analysis of 80,000 health web pages reveals that nine out of ten visits result in personal health information being leaked to third parties. This can lead to identity theft and discrimination due to predictive algorithms grouping individuals into categories.
A new study found that cancer patients' preferences for involving family members in treatment decisions differ significantly by ethnic background, marital status, sex, age, and insurance status. Non-English speaking Asian patients and Spanish-speaking Hispanic patients were more likely to share decision-making with their families.
Fox Chase Cancer Center has received a one-year grant from the National Breast Cancer Foundation to provide mammography screening and navigation services to underserved women. The program aims to increase access to care by bringing cancer screening into community settings via its mobile unit.
Men with favorable intermediate-risk prostate cancer may be candidates for active surveillance, with no significantly increased risk of death compared to those with low-risk PC. The study found that the absolute estimates of PC-specific mortality were less than one percent in men with both low-risk and favorable intermediate-risk PC.
Researchers at St. Jude Children's Research Hospital have identified a potential strategy to combat the parasitic tropical disease leishmaniasis. Neutralizing the activity of interleukin 18 (IL-18) protected mice from infection, suggesting this approach may aid in fighting the disease.
Scientists at UC San Diego School of Medicine discovered that autism mutations are connected to a pathway regulating brain development. The study found that specific genes were expressed in different developmental periods, influencing brain growth and behavior.