Researchers have identified a potential universal therapeutic target for treating multiple infections, including Ebola, by targeting the GRP78 protein. The OSU-03012 (AR-12) and FDA-approved Phosphodiesterase 5 Inhibitors combination has shown promise in preventing viral replication, killing cancer cells, and reducing antibiotic-resist...
Corals expel damaged symbiotic zooxanthellae under moderate thermal stress to avoid accumulation and maintain stable carbon concentration. However, prolonged exposure can lead to increased expulsion of photosynthetically damaged cells, which may not be enough to prevent coral deterioration.
Research suggests yoga can positively impact cardio-metabolic health by reducing CVD risk factors and improving metabolic syndrome outcomes. A systematic review and meta-analysis of randomized controlled trials found significant evidence supporting the effectiveness of yoga as a therapy for these conditions.
Medical ethicists offer guidance on life-sustaining therapies for Ebola patients in developed countries, balancing risks and benefits. Former Surgeon General David Satcher discusses the importance of credibility and influence in the role, emphasizing scientific evidence-based reports.
A team of researchers at Harvard, UC Santa Barbara, and the University of Chicago has developed a technique to precisely place nitrogen vacancy centers within nano-sized diamond structures, enhancing their fluorescence. This achievement is crucial for using NV centers as qubits in future quantum computers.
A new study published in PNAS reveals that atomic steps on metal surfaces can slow down oxidation by forcing them to bunch closer together and eventually stopping their growth. This discovery could have significant implications for understanding and controlling oxidation in a wide range of materials.
Researchers at the University of Missouri School of Medicine have developed a credible tool to assess medical students' ability to deliver patient-centered care. The Patient-centered Care - Objective Structured Clinical Exam (PCC-OSCE) evaluates behaviors such as effective communication, empathy, and active listening.
Researchers found that estrogen enhances an enzyme driving life-threatening allergic reactions in female mice, leading to more severe and longer-lasting reactions. Blocking estrogen or reducing eNOS activity eliminated the gender disparity, suggesting a potential role for estrogen in allergic reactions.
Researchers discovered that aluminum atoms involved in forming oxide stripes come exclusively from the steps, not the terraces. The growing oxide stripes are confined to the flat terraces and must push the steps away as oxygen continues to grab aluminum atoms from the edges.
A study by ASPS members analyzed medial thigh lift in 106 patients with massive weight loss, finding that 68% experienced some complication. Most complications were minor wound-healing issues that resolved without surgery, while swelling was common but usually resolved over time.
Researchers at NYU Langone Medical Center stress the importance of blink assessment in facial transplant procedures, as well as during and after surgery. Careful evaluation can help preserve vision and prevent complications such as corneal exposure and eyelid retraction.
Researchers at EPFL have created a highly sensitive motion detector that can detect the movement of microorganisms, including bacteria and yeast, without prior knowledge of their chemistry. The system uses a nano-sized cantilever to capture vibrations caused by living cells, making it suitable for detecting life on other planets.
A study published in Plastic and Reconstructive Surgery found that breast reconstruction using the patient's own tissues provides higher satisfaction scores compared to implant-based reconstruction. However, the findings may be influenced by differences in patient characteristics, such as age and genetic risk of breast cancer.
Archaeologists discovered intestinal parasites' eggs from the Celtic period in Switzerland, indicating poor sanitation and mixed living environments. The parasite eggs suggest a lack of proper waste management and possible livestock introduction, highlighting the challenges faced by ancient communities.
A study reveals that Mycoplasma pneumoniae CARDS toxin triggers excessive inflammation by activating NALP3, leading to tissue injury and airway narrowing. The discovery could lead to the development of therapeutic strategies to improve health in individuals with airway diseases.
Researchers at the University of California, San Diego School of Medicine have found that feeding mice Neu5Gc promotes spontaneous cancers and systemic inflammation. The study suggests a potential link between red meat consumption and cancer risk, and may also explain connections to other diseases exacerbated by chronic inflammation.
A study published in Plastic and Reconstructive Surgery reveals that careful surgical planning and technique are essential for restoring blinking function after facial transplantation. The research highlights the importance of monitoring restoration of reflex blinking to protect long-term visual outcomes.
A recent study found that American cities emit several times more light per capita than comparably sized German cities. The difference grew with city size, highlighting the need for further research on urban light emissions to uncover the reasons behind these disparities.
A study of 411 patients found that economic insecurity is associated with poor diabetes control and increased healthcare use. Material need insecurities, such as food insecurity and cost-related medication underuse, were significant predictors of poor diabetes control.
Researchers used geolocalized tweets to identify land use patterns in Manhattan, Madrid, and London. They found that nighttime tweet activity is concentrated on weekends in Madrid and weekdays in Manhattan, while daytime leisure areas are prominent in London. This study shows the potential of social media data for urban planning.
Researchers develop a novel evolvable Internet architecture framework with design constraints and models analysis to meet future Internet demands. The framework balances the advantages of both clean-slate and dirty-slate approaches, promoting flexibility and stability.
A new study from Indiana University finds that a patient self-reporting version of the Healthy Aging Brain Care Monitor is reliable and valid. The tool measures 27 items on a four-point scale to assess cognitive, functional and psychological symptoms, providing valuable information for busy physicians.
A University of Colorado Cancer Center study reveals that reprogramming damaged stem cells can prevent cancer after full-body radiation. The research suggests that genetic inhibition of the C/EBPA gene allows healthy stem cells to dominate the blood cell production system, reducing the risk of leukemia.
Tropical Cyclone Kate peaked in strength on Dec. 28 with maximum sustained winds near 70 knots, but weakened to 65 knots by Dec. 29 as it moved away from Cocos Island. The satellite imagery showed bands of thunderstorms spiraling into the center of the storm.
Researchers at City College of New York have discovered a new type of quantum particle that combines light and matter properties. This breakthrough could lead to the development of devices that utilize both light and matter, potentially revolutionizing computing and communication technologies.
Research finds mice infected with Lyme disease pathogen facilitate spread of babesiosis, a lesser-known emerging disease. Lyme disease and babesiosis share symptoms, but babesiosis is potentially fatal in immunocompromised patients and poses additional public health threat.
Tropical Storm Jangmi is expected to bring strong winds and heavy rainfall to the Philippines as it moves westward through the Sulu Sea. NASA's Aqua satellite detected the storm on December 29, revealing a tightly wrapped low-level circulation centered near 10.0 north latitude and 124.2 east longitude.
A recent article describes clinical trials targeting TRK fusions in various cancer types, including lung, breast, and melanoma. The TRK family of genes can cause cancer when improperly fused with other nearby genes.
Researchers discover enzyme SPPL3 activates T cells without cutting proteins, providing new insight into immune system control. The findings could also shed more light on presenilin functions and related Alzheimer's disease.
A Harvard study found that members of an East African herding tribe who engaged in violent raids had more wives and thus more opportunities to increase their reproductive success. The study, which analyzed the data of 120 men, found a clear correlation between raid participation and higher reproductive capacity.
Researchers found that sending text message reminders increased receipt of the second dose of the vaccine by the end of the season and brought children in sooner to be vaccinated. When educational information was embedded into the text messages, the effect was even greater compared to conventional text messages or written reminders only.
A new clinical trial has shown that using available heart failure drugs can slow the progressive decline in heart function in boys with Duchenne muscular dystrophy. The combination of eplerenone and either an ACE inhibitor or angiotensin receptor blocker significantly reduces left ventricular function decline.
A study found that changes in the H9N2 flu virus in chickens may have contributed to the creation of the H7N9 avian virus, which has caused outbreaks and deaths since 2013. The research suggests tracking genetic diversity of H9N2 on poultry farms could provide an early warning of emerging viruses with pandemic potential.
Researchers found a significant impact of the FTO gene variant on body mass index (BMI) that largely depends on birth year, with stronger correlations in later years. The study suggests that broad environmental changes may alter the effect of the gene variant, highlighting the importance of considering time of birth in genetic studies.
After a small number of MS patients received high-dose immunosuppressive therapy and then transplanted with their own hematopoietic stem cells, most sustained remission of active relapsing-remitting MS. Improvements in neurological function, quality-of-life, and functional scores were also noted.