Articles tagged with Cancer Treatments
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A large study of nearly 60,000 patients found that stage at diagnosis only partly explains the wide variation in lung cancer survival rates among different developed countries. Treatment differences also played a key role, with some countries experiencing lower survival rates due to delays in diagnosis or suboptimal staging.
Experts recommend physicians engage in gun policy dialogue, leveraging their skills in managing fears and providing mental health treatment. They can influence Congress through collective advocacy and lead by example.
Researchers from University of Copenhagen identify Fbxl10 as crucial for embryonic stem cell differentiation and suggest it as a potential target for cancer therapy. The protein recruits Polycomb complexes to silence genes, maintaining cellular identity.
Researchers have designed a guideline for physicians and patients with Androgen Insensitivity Syndrome (AIS), a rare condition that prevents tissues from responding to male hormones. The guideline includes follow-up protocols from birth to adulthood, therapy options such as hormone replacement therapy, and more.
The discovery of the Mcl-1 gene's critical role in keeping antibody-producing cells alive could lead to better treatments for diseases like myeloma and chronic immune disorders. Without this gene, plasma cells die within two days.
Researchers found that breast cancer tissue has a mix of stiff and soft zones, whereas healthy tissue has uniform stiffness. This discovery may help improve breast cancer diagnosis and therapy by identifying potential for cancer spread. The study used advanced microscopy techniques to analyze tissue properties at the nanoscale.
A new study suggests that early diagnosis and treatment of Hepatitis C in intravenous drug users can prevent many transmissions by identifying 'super-spreaders' who are highly infectious. By understanding how the virus spreads in these individuals, researchers hope to develop targeted interventions to stop its spread.
A genetically reprogrammed Herpes simplex virus has been engineered to target and kill cancer cells expressing the HER-2 oncogene, specifically breast and ovarian cancer metastases. This breakthrough oncolytic herpesvirus has shown promising results in treating experimental metastasis, holding promise for a novel type of cancer treatment.
Researchers have identified how two genes, Ipl1 and Mps1, work together to correct mistakes in chromosome distribution during cell division. This understanding could lead to targeted cancer treatments by controlling these master regulator genes.
A pioneering study published in The Lancet Oncology found that local volunteers increased early breast cancer detection rates in a low-income rural area. The study showed that 70% of women screened were diagnosed with benign lesions or successfully treated for breast cancer, significantly improving long-term survival chances.
Researchers discovered XPD protein's role in locating damaged DNA, which aids cancer treatment development. The protein works like a scanner that glides along the DNA double helix, marking damaged spots for repair.
A meta-analysis of large randomised trials found no significant increase in cancer risk among those taking daily folic acid for 5 years or less. The study provides reassurance about the safety of folic acid intake, particularly in countries where fortification is mandatory.
Researchers discovered a novel class of early replicating fragile sites contributing to genome instability in B cell lymphomas. These sites, uncovered through genome-wide sequencing, overlap with mutations associated with the disease and suggest a major feature of its mutational landscape.
The new book, Navigating Life with a Brain Tumor, offers comprehensive guidance on managing brain tumors, including treatment options, side effects, and coping strategies. Written by neuro-oncologists from Mayo Clinic and Tufts Medical Center, the book aims to empower patients to be active participants in their care.
Researchers developed a new method to predict individual patient's brain tumor growth, enabling physicians to rapidly identify effective therapies. The approach accounts for tumor features such as shape, density, and growth rate, allowing clinicians to distinguish between patients with different tumor characteristics.
A new multiple gene expression profile test can predict the presence of harmful BRCA1 or BRCA2 mutations in otherwise healthy women. The test showed a sensitivity of 95% and specificity of 88%, and has the potential to replace expensive sequencing tests, making it an affordable option for high-risk carriers.
The new age of proteomics brings a comprehensive understanding of cellular proteins, shedding light on their role in illnesses. The next-generation proteomics technology enables improved biomarker search, personalized therapies, and enhanced cancer diagnosis.
Researchers at UNC developed a method to visualize aging and tumor growth in mice using gene-activated luminescent cells. They found that old mice were brighter than young mice, with sites of cancer formation becoming extremely bright, allowing for early identification of developing cancers.
A recent study by IASLC found that EGFR mutations do not serve as a prognostic factor in NSCLC patients. Instead, smoking status appears to be the most significant predictor of overall survival. The researchers also discovered that administering EGFR TKI can prolong survival after disease recurrence.
A Kaiser Permanente study found that annual percent changes in prostate-specific antigen (PSA) levels are more accurate for detecting aggressive prostate cancer than single measurements. The study analyzed nearly 220,000 men and found a moderate increase in PSA levels with age.
Researchers at CSHL have discovered how Chd5 exerts its beneficial effects by binding to histone H3, preventing cancer initiation and promoting tumor suppression. This finding has important implications for treating diverse human cancers.
Exposure to environmental toxins can cause chronic health problems like respiratory, endocrine, reproductive, and neuropsychiatric disorders in children. Unique risk factors include their small size, developmental stage, and habit of putting things in their mouths.
A recent study found that a third of trials with no statistically significant benefit reported on secondary outcomes to influence results. Two-thirds of trials with serious side-effects under-reported them, particularly when the treatment showed a positive outcome. The authors call for improved reporting guidelines.
A recent study published in PLOS Biology has discovered the role of ELF5 in aggressive breast cancer subtypes and its potential to overcome anti-estrogen therapies. The research suggests that manipulating ELF5 levels could lead to new treatment strategies for breast cancer patients.
A preclinical study found that androgen deprivation therapies may have adverse effects on prostate cancer growth and survival in men with precancerous conditions. The study's results suggest that reducing testosterone levels may encourage indolent tumors to become more aggressive as men age.
Researchers report on the therapeutic potential of microRNAs in cancer therapy and their role as potential biomarkers for early cancer detection. The stability of miRNAs in body fluids makes them suitable for non-invasive malignancy detection methods, offering exciting opportunities for revolutionizing diagnostics and screening.
A new study published in the Journal of Urology found that robotic-assisted laparoscopic radical cystectomy (RARC) resulted in decreased estimated blood loss and shorter hospital stays compared to open radical cystectomy (ORC) for patients with muscle-invasive bladder cancer. RARC also showed a trend towards faster return of bowel func...
Researchers found ID proteins essential for retaining glioma-initiating cells in a specific extracellular niche, maintaining their cancer-promoting properties. The study's results suggest ID proteins as potential therapeutic targets for glioma treatment.
Scientists are harnessing big data analytics and genomics to tailor fertility treatments to individual women. Dr. Piraye Yurttas Beim's work at Celmatix Inc. aims to develop non-invasive diagnostic tests to identify genetic drivers of infertility, enabling personalized recommendations for effective treatments.
A recent study found immunohistochemistry to be a reliable and accurate method for detecting ALK rearrangement in non-small cell lung cancer. The technique outperformed fluorescence in situ hybridization, which is currently the standard but time-consuming method.
The conference, organized by IRB Barcelona and the BBVA Foundation, brings together experts to discuss the virtues of statistics for biomedical applications and present current state of the discipline. Biostatistics is applied to clinical assays, scrutinizing huge amounts of data and integrating information from diverse sources.
Researchers found that patients with a family history of colorectal cancer are more likely to develop tumors with low-level methylation of LINE-1, a molecular sign associated with an aggressive form of the disease. Testing for this sign may help identify patients in need of aggressive treatment and inform familial cancer-risk assessments.
Researchers have developed a novel method for screening ALK fusions in non-small cell lung carcinoma (NSCLC) that is sensitive, specific, and economical. The new test offers a high-throughput and cost-effective screening modality compared to existing tests.
A phase 3 trial by Dana-Farber Cancer Institute found an experimental drug combination for preventing graft-versus-host disease (GVHD) did not significantly improve outcomes compared to the standard regimen. The treatment had some benefits, including reduced mucositis and faster engraftment, but also increased veno-occlusive disease risk.
The study found that 71% of previously untreated older patients experienced a complete or partial response to ibrutinib treatment. After 22 months of follow-up, the disease had not progressed in 96% of previously untreated patients. Ibrutinib's potential as a highly active, well-tolerated first-line therapy for CLL is promising.
Researchers have found that nanoparticles produced by fungus A. oligospora stimulate the immune system and kill tumors, offering a potential new approach to cancer treatment. The discovery could lead to the development of novel materials for therapeutic applications.
The University of Kentucky has developed a pioneering electronic health record (EHR) reporting system for cancer cases to the state's cancer registry. This innovation enables real-time data transmission, facilitating faster trend analysis and informed statewide cancer control efforts.
A survey of over 6,200 Finns found that there is substantial disagreement about whether certain states of being should be considered diseases, influencing public funding and policy decisions. The results highlight the complexities of defining disease and its impact on social debates.
Researchers have discovered two related genes, ARID1A and ARID1B, involved in the most aggressive form of childhood cancer neuroblastoma. These findings identify a novel pathway that scientists can now study to develop potential new therapies for children with tumors having these mutations.
Researchers found ARID1A and ARID1B gene mutations in 8 patients, associated with worse survival outcomes. The discovery could lead to early identification of high-risk patients requiring additional treatments.
Women with advanced breast cancer who wait over 60 days for treatment face significantly higher risks of dying. Early detection and timely treatment can increase five-year survival rates to as high as 98 percent.
A cost-effectiveness analysis found that KRAS testing is cost-saving, while BRAF testing offers additional savings. The study suggests that molecular testing primarily generates cost savings by identifying nonresponders, rather than improving survival.
Researchers have discovered a novel mechanism by which normal stromal cells around ovarian cancer cells are converted into cancer-promoting cells. Altering microRNA expression in these cells enhances tumor growth and metastasis, providing new potential therapeutic targets.
A new discovery reveals that chromatin remodeling complexes (CRCs) are intrinsically turned on, requiring specific instructions to turn them off. This finding has significant implications for understanding how CRC mutations contribute to cancer development.
Aerobic exercise can help relieve fatigue associated with cancer and treatment, balancing rest with physical activity may reduce fatigue. The new review adds 28 studies, including those in breast cancer patients, showing that aerobic exercise benefits those with solid tumours during and after treatment.
The 2012 Collegiate Inventors Competition awarded over $100,000 to students for their groundbreaking inventions in medical devices, cancer therapies, and more. Inanc Ortac's Nano-Wiffle-Balls for Cancer Therapy and Leslie Myint's FastStitch suturing device were among the top winners.
A drug originally developed to prevent organ rejection has been shown to dramatically reduce a particular kind of brain tumor in patients with tuberous sclerosis complex (TSC). The study found that 35% of patients experienced at least a 50% reduction in tumor volume after treatment with everolimus.
Researchers found that a protein called TGFβig-h3 is impaired in patients with gastric cancer, allowing cancer to spread. This discovery could lead to the development of new therapies restoring the functions of this protein.
A new study found that black patients with kidney cancer have a survival disadvantage compared to white patients, even when diagnosed at early stages or receiving less aggressive treatment. The study analyzed nearly 40,000 renal cell carcinoma patients and confirmed poorer survival rates for blacks.
The UT Arlington physics team has developed a novel thermoelectric generator using copper sulfide nanoparticles and single-walled carbon nanotubes. The technology, which can convert both light and thermal energy into electrical current, shows increases of up to 80% in light absorption compared to earlier methods.
Moffitt Cancer Center researchers have identified novel metabolic signatures in glioma, a type of tumor that starts in the brain. These findings may pave the way for personalized therapy and prognostic value.
Researchers use antisense technology to target cancer cell metabolic process, killing cancer cells by blocking production of pyruvate kinase splice-variant. The approach shows therapeutic promise in treating various types of cancer.
Researchers have identified a new molecular marker, β2-syntrophin, which can help differentiate between low-risk and high-risk types of prostate cancer. This breakthrough discovery could lead to more accurate diagnoses and personalized treatment plans, ultimately improving patient outcomes.
Researchers found oxidative stress in an animal model of alpha-1-antitrypsin deficiency, which may benefit from antioxidant treatment. The study identifies potential alterations in gene expression pathways that could modify disease development.
Researchers have identified three novel genes - CHD4, FBXW7 and SPOP - that are frequently altered in serous endometrial cancer, a rare and aggressive form of uterine cancer. These findings may lead to new therapeutic targets for this devastating disease.
A recent study has found that non-Hispanic black women diagnosed with estrogen receptor-positive tumors have a significantly increased risk for breast cancer death, particularly within the first three years after diagnosis. This risk is more pronounced among black women compared to non-Hispanic white women.
Claudia R. Baquet, M.D., M.P.H., is being honored for her contributions to cancer health disparities research. She will deliver the third annual AACR Distinguished Lecture on The Science of Cancer Health Disparities.
Palliative care discussions can improve symptoms, stress, and survival time for patients with terminal illnesses. Physicians should discuss palliative care with patients during initial talks about prognosis and at subsequent visits to help them plan their remaining lives.
A recent study published in Menopause found that about one-third of women who stopped taking the SSRI antidepressant escitalopram experienced a relapse of hot flashes and night sweats. Women with insomnia and those who responded less well to the medication were more likely to experience a relapse.
Scientists at CU-Boulder have discovered the cellular targets of the Hepatitis B virus, including proteins Bcl-2 and Bcl-xL. This breakthrough could lead to new treatments for liver disease in millions of people infected with the virus, many of whom lack access to effective treatment.