Articles tagged with Cancer Treatments
The team identified 21 microRNAs associated with ovarian cancer survival and 838 target genes linked to its progression. The findings suggest a network-based approach can predict cancer survival and recurrence more accurately than individual biomarkers.
A novel drug developed by Gilead Sciences suppresses hepatitis B virus infection by stimulating the immune system and inducing loss of infected liver cells. The therapy targets a receptor on immune cells, reducing both virus levels and number of infected liver cells in chimpanzees chronically infected with HBV.
A recent study found that nearly all children and teenagers with differentiated thyroid cancer due to radiation have responded favorably to treatment, with 64% in complete remission. The findings suggest victims of recent nuclear accidents like Fukushima may face a lower risk of developing advanced-stage thyroid cancer.
Researchers developed phase shift nanoemulsions that produce tiny microbubbles, which accumulate in tumors and amplify the effects of ultrasound. This reduces treatment time and power needed to destroy tumor tissue by over half, showing promise for improving cancer therapy.
A study by Dana-Farber Cancer Institute found that nearly two-thirds of children receiving stem cell transplants were readmitted to the hospital within six months for treatment of unexplained fevers, infections or other problems. Children who received donor cells were twice as likely to be readmitted compared to those with their own st...
A new study shows that chemical shift techniques in MRI can accurately differentiate clear cell renal cell carcinoma from other types of kidney cancer, enabling better treatment planning. The technique achieved an 83% accuracy rate in distinguishing between tumor types.
A new minimally invasive tumor ablation technique called irreversible electroporation (IRE) has shown promising results in treating liver cancer patients who cannot undergo surgery or thermal ablation. The study found that IRE successfully destroyed tumor tissue in 70% of patients, with two major complications reported but neither life...
A new study reveals that cancer survivors are at higher risk of cardiovascular disease due to shared risk factors like smoking and obesity. The research emphasizes the importance of assessing cardiovascular risk as part of a comprehensive survivorship care plan.
The study found that women with more advanced breast cancer at diagnosis, higher body mass index, and more positive lymph nodes were at increased risk of developing lymphedema. Genetic markers associated with the development of lymphedema in breast cancer survivors were also identified.
A new breast imaging algorithm is being implemented in Uganda to diagnose and treat women with palpable breast masses. The program combines a unique diagnostic algorithm with targeted community outreach to combat myths surrounding cancer, aiming for early diagnosis and effective care.
Gossypin, a naturally-occurring substance, has been shown to inhibit the growth of human melanoma cells and reduce tumor volume in mice. The compound may have great therapeutic potential as a dual inhibitor of mutations that occur in the vast majority of melanoma patients.
Triplet-negative breast cancer lacks receptors for progesterone, estrogen, and HER2/neu, making it difficult to treat. Researchers identified key metabolites that could help differentiate among subtypes and point to new treatment targets.
A new study suggests that medical therapy is a viable alternative to angioplasty in treating stable coronary artery disease, reducing the risk of complications and hospitalizations. The study proposes a targeted approach to shared decision-making, considering treatment options, risks, and outcomes for patients.
The American College of Physicians suggests that men between 50-69 discuss potential benefits and harms of the PSA test before screening. The risks include problems interpreting test results, biopsy complications, and treatment side effects. ACP recommends against testing in men younger than 50 or older than 69 with low life expectancy.
Researchers have developed a non-invasive test for metastatic prostate cancer using whole-genome analysis of plasma DNA, which identifies abnormal copy numbers of specific sequences. This breakthrough could aid personalized therapy and target treatment for castration-resistant prostate cancer.
A study published in the New England Journal of Medicine recommends continuous hormone therapy for metastatic prostate cancer, extending lives by months to years. Continuous therapy offers a better alternative to intermittent therapy with fewer side effects.
Researchers at Henry Ford Hospital have discovered a novel approach for treating malignant brain tumors using microvesicles generated from mesenchymal bone marrow cells. The treatment significantly reduced tumor volume in living lab rats, suggesting a potential new therapy for glioma, a common and aggressive type of brain cancer.
Researchers identified a specific cell membrane protein blocking cell death in hormone-therapy-related breast cancers, which could be targeted by new therapies. Progestin, a synthetic hormone used in hormone replacement therapy, affects the protein's activity and increases cancer risk.
The number of cancer survivors in the US is projected to increase from 13.7 million in 2012 to 18 million by 2022, with two-thirds of those over age 65. The report highlights disparities in survival rates across different cancer subtypes.
A review of 21 National Comprehensive Cancer Network member institutions found that only four provided nutritional guidelines, while many linked to external sites with inconsistent information. The analysis highlights the need for evidence-based, standardized guidelines on dietary recommendations for cancer patients.
A recent study published in BJU International found that despite growing trends towards kidney-preservation treatments, patients with chronic kidney insufficiency are more likely to undergo total nephrectomy. The researchers emphasize the need for further investigation into treatment selection factors.
Researchers have discovered a new mechanism contributing to tumour development, including Chronic Lymphocytic Leukaemia, by identifying mutations in the POT1 gene that affect chromosome protection. This is the first time an essential gene has appeared mutated in human cancer.
A new study has identified CA9, CD31, CD34 and VEGFR1/2 as potential biomarkers for predicting a good response to sunitinib treatment in patients with metastatic clear cell renal cell carcinoma. Patients with low Fuhrman grade tumors and high CA9 expression exhibited improved progression-free and overall survival.
A recent study published in the Journal of Family Planning and Reproductive Health Care analyzed data from three major studies on hormone replacement therapy (HRT) and found no clear evidence linking its decline to a decrease in breast cancer rates. The authors point out methodological flaws in the original studies, including detection...
Researchers develop a gene therapy technique to increase enkephalin, an opioid compound, in the bladder wall, reducing pain signals. The treatment approach shows promise for severe chronic pain conditions like bladder pain syndrome/interstitial cystitis.
A Danish study found that men in same-sex marriages have lower mortality rates than unmarried or divorced men since the 1990s. In contrast, women in same-sex marriages have higher mortality rates, particularly from suicide and cancer, compared to married women of opposite sex.
The Life Sciences Discovery Fund has awarded nearly $750,000 in Proof of Concept grants to three Washington organizations to develop and test new diagnostic and therapeutic products. These grants will help accelerate the transition of promising technologies from concept to commercial product.
Scientists have identified enzymes that can reverse a key protein modification involved in breast cancer, cellular stress reactions, and gene regulation. The discovery enables selective manipulation of ADP-ribosylation, which could lead to new treatments for inflammasions and cancers.
A new software tool, COCPIT, will aid healthcare professionals in identifying at-risk patients and investigating data quality issues. By analyzing patient journeys and electronic health records, the tool aims to improve patient care and public health by reducing hospital admissions for conditions like strokes.
University of Central Florida chemist Kevin Belfield uses acid reflux to kill certain cancer cells by making them more acidic when exposed to specific wavelengths of light. This technique could provide a way to target cancer cells deep within human tissue with minimal side effects.
A UCLA study found that financial hardship, lack of doctor continuity and care coordination, and communication issues significantly hinder access to prostate cancer care among Latino men. The study highlights the need for a multi-faceted approach to improve access, increase health literacy, and enhance care coordination.
A new virtual reconstruction of human metabolism, Recon 2, has been built to identify causes of diseases and develop new treatments. The model provides a detailed map of metabolic pathways, allowing researchers to pinpoint specific gene expressions and their effects on disease progression.
Researchers have discovered a chemical probe, UNC1215, to investigate the role of malignant brain tumor domains in biology and disease. The probe targets L3MBTL3 methyl-lysine reader domain proteins, which play a fundamental role in gene expression and cancer development.
Scientists identified nitric oxide's role in degrading a protein that attenuates cardiac growth, linking vascular changes to heart size. A nanogel-based treatment targeting an immunosuppressive drug directly to tissues associated with immune cells may help treat systemic lupus erythematosus.
Researchers at Fox Chase Cancer Center found that two antagonistic proteins help keep leukemia at bay by maintaining balance in stem cell production. The study suggests that new compounds could fight cancer by targeting the pathways responsible for regulating these proteins.
Research found that obesity increases the risk of colorectal cancer with a specific molecular characteristic, known as CTNNB1-positive cancer. Physical activity, on the other hand, was linked to a lower risk for this type of cancer.
A recent study by Professor Hermann Brenner and colleagues found that smoking cessation in older adults significantly reduces the risk of heart attacks and strokes. Within five years of quitting, smokers experience a reduction of over 40% in cardiovascular disease risk compared to non-smokers.
Researchers discovered a novel use of a fish oil component that reduced brain trauma in newborn mice by about 50%. The study found that injecting docosahexaenoic acid (DHA) within two hours of ischemic stroke significantly decreased neonatal brain damage. DHA provided protection while other omega-3 fatty acids did not.
A new study by researchers at the University of Pennsylvania School of Medicine found that minimally invasive therapies can effectively remove damaged cells from patients with Barrett's esophagus, reducing cancer progression. In over two-thirds of cases, patients had no signs of disease return for years.
Moffitt researchers found that silencing the retinoblastoma gene can regulate the differentiation of myeloid-derived suppressor cells into a more aggressive form. This discovery may lead to new therapeutic strategies targeting these cells in cancer treatment.
A Melbourne-based research team has discovered a genetic defect that can halt cell growth and force cells into a death-evading survival state. The finding reveals an important mechanism controlling rapidly-dividing cells, which may lead to the development of new treatments for diseases including cancer.
A recent study published in The Lancet Oncology reveals that patients with low-grade serous carcinoma of the ovary or peritoneum can experience tumor stabilization or shrinkage after taking a regular dose of selumetinib. This breakthrough discovery offers new possibilities for treating previously chemoresistant tumors.
Researchers have discovered a vast potential for noncoding RNAs to be used as therapeutic and diagnostic tools. Long noncoding RNAs play significant roles in various diseases, including cancer, diabetes, and other conditions. The emerging concept of microRNAs functioning as hormones has also led to new avenues for disease treatment.
Research suggests that happy marriages improve both partners' spirits and well-being, while lower stress levels. Health professionals are advised to consider patients' personal relationships when designing health promotion programs or treatment plans.
A study from researchers at the Hospital of the University of Pennsylvania reports that endoluminal therapies combining resection and ablation techniques have a high success rate in eradicating Barrett's esophagus, with durable results. Persistent vigilant surveillance is required due to recurrence risks.
Researchers found that geographic site, demographic factors, and adherence to initial therapy are crucial for successful H pylori eradication. The study suggests a 'one size fits all' approach may not be optimal, highlighting the need for tailored interventions.
A large study of nearly 60,000 patients found that stage at diagnosis only partly explains the wide variation in lung cancer survival rates among different developed countries. Treatment differences also played a key role, with some countries experiencing lower survival rates due to delays in diagnosis or suboptimal staging.
Experts recommend physicians engage in gun policy dialogue, leveraging their skills in managing fears and providing mental health treatment. They can influence Congress through collective advocacy and lead by example.
Researchers from University of Copenhagen identify Fbxl10 as crucial for embryonic stem cell differentiation and suggest it as a potential target for cancer therapy. The protein recruits Polycomb complexes to silence genes, maintaining cellular identity.
Researchers have designed a guideline for physicians and patients with Androgen Insensitivity Syndrome (AIS), a rare condition that prevents tissues from responding to male hormones. The guideline includes follow-up protocols from birth to adulthood, therapy options such as hormone replacement therapy, and more.
The discovery of the Mcl-1 gene's critical role in keeping antibody-producing cells alive could lead to better treatments for diseases like myeloma and chronic immune disorders. Without this gene, plasma cells die within two days.
Researchers found that breast cancer tissue has a mix of stiff and soft zones, whereas healthy tissue has uniform stiffness. This discovery may help improve breast cancer diagnosis and therapy by identifying potential for cancer spread. The study used advanced microscopy techniques to analyze tissue properties at the nanoscale.
A new study suggests that early diagnosis and treatment of Hepatitis C in intravenous drug users can prevent many transmissions by identifying 'super-spreaders' who are highly infectious. By understanding how the virus spreads in these individuals, researchers hope to develop targeted interventions to stop its spread.
A genetically reprogrammed Herpes simplex virus has been engineered to target and kill cancer cells expressing the HER-2 oncogene, specifically breast and ovarian cancer metastases. This breakthrough oncolytic herpesvirus has shown promising results in treating experimental metastasis, holding promise for a novel type of cancer treatment.
Researchers have identified how two genes, Ipl1 and Mps1, work together to correct mistakes in chromosome distribution during cell division. This understanding could lead to targeted cancer treatments by controlling these master regulator genes.
A pioneering study published in The Lancet Oncology found that local volunteers increased early breast cancer detection rates in a low-income rural area. The study showed that 70% of women screened were diagnosed with benign lesions or successfully treated for breast cancer, significantly improving long-term survival chances.
Researchers discovered XPD protein's role in locating damaged DNA, which aids cancer treatment development. The protein works like a scanner that glides along the DNA double helix, marking damaged spots for repair.
A meta-analysis of large randomised trials found no significant increase in cancer risk among those taking daily folic acid for 5 years or less. The study provides reassurance about the safety of folic acid intake, particularly in countries where fortification is mandatory.
Researchers discovered a novel class of early replicating fragile sites contributing to genome instability in B cell lymphomas. These sites, uncovered through genome-wide sequencing, overlap with mutations associated with the disease and suggest a major feature of its mutational landscape.
The new book, Navigating Life with a Brain Tumor, offers comprehensive guidance on managing brain tumors, including treatment options, side effects, and coping strategies. Written by neuro-oncologists from Mayo Clinic and Tufts Medical Center, the book aims to empower patients to be active participants in their care.