Researchers found that changes in occludin and connexin 43 expression are consistent with the development of brain edema, reflecting its pathogenesis. The study's findings may lead to better treatments for intracranial diseases.
Scientists have identified a new species of wild cat living in northeastern and southern Brazil, with distinct habitats and evolutionary histories. The discovery highlights the need for targeted conservation efforts to protect these endangered species.
The WorldPop website provides open access to global demographic data, helping charities, policy-makers, and researchers tackle challenges like poverty and public health. The project combines country-specific data with satellite imagery to create detailed population distribution maps.
The PLOS & DNDi Collection showcases Open Access research on neglected tropical diseases, highlighting the journey from advocacy to scientific innovation. The collection features articles on Chagas disease, leishmaniasis, and human African trypanosomiasis, emphasizing the need for tangible solutions.
Researchers are working on an injectable compound that can block enzymes that further break down the tendon, reducing injury severity or promoting healing. The therapy aims to treat tendon injuries at an early stage, potentially benefiting athletes and industrial workers.
Researchers create handheld, battery-operated device that can rapidly identify harmful bacteria like E. coli O157:H7, which causes 2,000 hospitalizations and 60 deaths in the US each year. The device uses dielectrophoresis to sort microbes based on their unique electrical properties.
Scientists at Vienna University of Technology have discovered a way to couple electricity and magnetism in materials, opening up possibilities for new electronic devices such as amplifiers, transistors and data storage devices. The breakthrough involves switching magnetic excitations with an electric field in a material called DyMnO3.
Researchers have identified two subglacial lakes beneath the Greenland Ice Sheet, which could influence global sea level rise and the future of the ice sheet. The lakes are part of an open system connected to the surface, unlike isolated Antarctic lakes, and their existence has significant implications for understanding ice flow speeds.
Researchers carefully measure Comet ISON's brightness to infer its current state, as it approaches perihelion on November 28, 2013. The comet's behavior over several days suggests it may be disintegrating or intact.
Tropical Cyclone Lehar is expected to bring strong winds, heavy rainfall, and a storm surge of up to 3 meters to northern Andhra Pradesh and southern Odisha. The Joint Typhoon Warning Center predicts the storm will strengthen before making landfall on November 27.
Recent study published in Neural Regeneration Research shows that Chinese medicines used for tonifying the kidney can protect nerve cells by regulating apoptosis-related factors and neurotrophic factors. Herba Epimedii and Herba Cistanches were found to be effective in inhibiting dopaminergic neuron apoptosis.
Research published in Diabetologia shows that pre-existing diabetes in pregnant women significantly increases the risk of fetal and infant death. The study found a four-and-a-half times higher risk of fetal death and an almost doubling of infant mortality compared to women without diabetes.
A team of astronomers has made a surprising finding about smaller black holes, discovering they can eat matter in an orderly fashion. The black hole in question is surprisingly lightweight and swallows its material at close to its theoretical limits, producing high-energy X-rays.
Researchers found that human periodontal ligament stem cells exhibit similar therapeutic effects to autologous Schwann cells in repairing peripheral nerve injuries. The study suggests a potential value for the use of human periodontal ligament stem cells in the repair of mental nerve injury.
Researchers used patient-derived stem cells to show that a genetic mutation in the alpha-synuclein gene increases vulnerability to pesticides, leading to Parkinson's disease. The study identified a molecule that protects neurons from pesticide damage and may have potential clinical implications for treating the disease.
Scientists recorded and identified the sizzling sound of glacier ice as it melts, a phenomenon caused by trapped air bubbles escaping from the disappearing ice. This discovery could help researchers better monitor polar environments and track changes in glacier melt rates using underwater hydrophone recordings.
Researchers have created a way to measure Bose-Einstein condensates, the coldest objects in the universe, by canceling out light damage. This allows for longer imaging and potentially indefinite measurement, enabling further study of BECs.
Studies have shown that laser treatment is effective in reducing scar height and redness, with a high success rate of 70% in treating both hypertrophic scarring and keloids. The use of specific lasers, such as the 585/595 nm pulsed-dye laser, has also been found to be particularly effective.
Brazilian researchers assessed caxirola sound levels and found them comparable to a normal conversation, with only slight differences from vuvuzela noise. They also analyzed instrument vibrations, finding variations in frequency and intensity over time.
A Penn Medicine study found that an automated prediction tool can accurately identify patients at risk of being readmitted within 30 days of discharge. The tool, developed by researchers, uses prior hospital admissions as a key predictor, and has been shown to reduce readmissions by 31% compared to those without the flag.
Research suggests that age-adjusted rates of dementia have declined for people born later, particularly those at higher risk. Lifestyle factors such as exercise and diet are being studied as potential contributors to this trend.
Researchers have developed nanoparticles that can be delivered orally and absorbed through the digestive tract, allowing patients to take a pill instead of receiving injections. The particles are coated with antibodies that act as a key to unlock receptors found on cells lining the intestine.
Researchers at the University of Bristol discovered that a specific protein called RIM1α is modified by SUMO, acting as a 'molecular switch' to regulate neurotransmitter release. This finding has implications for understanding neurological disorders such as epilepsy and schizophrenia.
A global survey by the European Society for Medical Oncology found that over half of the world's population lives in countries with regulations limiting access to opioid medicines for managing cancer pain. The study highlights the need for regulatory reform and education to improve access to these medicines.
A novel study reveals a severe shortage of rheumatologists in smaller micropolitan US regions, where patients often have to travel over 200 miles for care. The research highlights the need for interventions to increase the supply of rheumatologists in underserved areas.
Researchers have discovered a promising new treatment that can help people with spinal cord injuries walk better. The study involved 19 participants who received short periods of breathing low oxygen levels, resulting in improved walking speed and endurance.
The article discusses the evolution of ethical debates surrounding face transplantation, with early concerns fading as experience shows benefits in helping patients return to normal life. The procedure is expected to become more common, raising new questions about patient selection, costs, and allocation of donor tissues.
A new clinical study shows that a tongue-controlled wheelchair can access computers and execute commands faster than sip-and-puff systems, with equal accuracy. The Tongue Drive System enables people with tetraplegia to maneuver their wheelchairs better than those using traditional assistive technologies.
Researchers have identified phosphatidylinositol 4-kinase (PI4K) as a potential malaria drug target, essential throughout the Plasmodium life cycle. Imidazopyrazines inhibit PI4K activity, blocking parasite development in both liver and bloodstream stages.
Older patients with traumatic injuries can regain more daily activities with geriatric care, according to a new study. Geriatric interventions helped them take better care of themselves and be more independent.
Astronomers Alice Quillen and her team developed a mathematical model to understand the movement of stars in the galactic bulge, finding that peanut-shell shaped orbits are consistent with observed effects. The new research aims to improve our understanding of galaxy formation and evolution.
A new study examines the geological legacy of Hurricane Irene, shedding light on the long-term record of storm frequency and impact. The researchers found that the lack of definitive signatures from the hurricane in paleostorm records highlights concerns about current understanding of hurricane deposition and preservation.
New research suggests that 55% of bilateral adrenal Cushing's syndrome patients have genetic mutations predisposing to adrenal tumors. Genetic screening may help identify affected family members, potentially preventing disease progression and eliminating current treatment practices.
Researchers discovered a potential new treatment for malaria by targeting the parasite's vulnerability to oxytocin, a naturally occurring hormone. Oxytocin has been shown to enhance brain activity while processing social information in children with autism spectrum disorders.
Tropical Storm Alessia reclaimed her title after being tracked by NASA's TRMM satellite on November 27. Heavy rainfall was observed around the storm's center, with rain rates reaching up to 50 mm/hour.
A new analysis of NFL results suggests that West Coast teams perform better at night when playing East Coast teams, likely due to their natural circadian peak. In 106 night games, West Coast teams beat the point spread in 66% of matches by an average of 5.26 points.
Researchers found that persimmon leaf flavonoid mitigates pathological injury of brain tissue following cerebral ischemia/reperfusion in rats, elevating brain ischemic tolerance. High-dose persimmon leaf flavonoid showed an identical effect to ginaton, providing a potential basis for drug development.
A new aggressive HIV strain, A3/02, has been identified in West Africa and is associated with a shorter period of five years from infection to AIDS development. The study also highlights the increasing global spread of recombinant HIV forms, which can be more vigorous and aggressive than traditional strains.
Research suggests that women who test negative for BRCA2 mutations but have a family history are still at higher risk of developing breast cancer, with a fourfold increased risk compared to the general population. The study found that genetic factors other than BRCA-related genes may contribute to this increased risk.
A comprehensive study reveals that poor mothers and fathers from ethnic minority groups experience high levels of chronic stress, affecting their mental and physical health. The research also found that certain ethnic groups, such as recent immigrants, tend to have lower stress levels despite facing similar socioeconomic challenges.
Javad Nazarian, a Children's Research Institute researcher, has received a $99,979 grant to study pediatric diffuse intrinsic pontine glioma (DIPG) using proteomics and RNA sequencing. The goal is to understand the molecular biology of this lethal childhood cancer.
Researchers at MD Anderson Cancer Center have identified USP13, an enzyme that stabilizes the tumor-suppressor protein PTEN, preventing its destruction by the cell's proteasome machinery. This discovery provides a new avenue for treating cancers with low levels of PTEN.
A Northwestern University research team successfully built near-perfect single crystals out of nanoparticles and DNA, transforming disordered materials into orderly crystal structures. The technique, developed by Chad Mirkin and Monica Olvera de la Cruz, holds promise for novel technologies and new industries.
Researchers successfully created artificial magnets using quantum matter waves of Rubidium atoms. The team's innovative method mimics the behavior of traditional magnets, allowing for clearer understanding and potential applications in fields like data storage and medical instrumentation.
New Australian research reveals that non-hip, non-vertebral fractures can significantly increase the risk of premature death, with some fractures potentially shortening life expectancy. The study analyzed data from a large-scale epidemiological study and found that all fractures are serious, with varying levels of severity.
Researchers Hanna, Guven, and Müller used patterns on whirling dervish skirts to create mathematical equations governing cone-shaped structures in rotation. Their work enhances understanding of flexible object dynamics and pattern formation in rotating systems.
Researchers found EU governments pay 75% of annual access fees, which account for just 1.5% of revenue generated from selling catch. The industry benefits more than developing countries, perpetuating overfishing and contradicting the EU's development goals.
A study by Aarhus University researchers reveals that labor mobility is essential for small European countries to match China's export growth rates. Companies can hire employees with experience in and knowledge about new export destinations to gain a competitive edge.
The study found that perinatal exposure to estrogen-like compounds may be associated with a host of health problems. The researchers aim to review the latest advances in morphological definition, developmental mechanisms, and environmental factors that can influence the development of the sexually dimorphic nucleus.
Researchers at UH have discovered that a specific protein inhibits gamma lobe neurons, which are involved in forming memories. This finding has implications for treating dementia by understanding how memories form.
A study by The University of Manchester shows that improved safety measures and specialist community services can reduce suicide rates among patients at risk. Implementing key recommendations, such as crisis resolution and information sharing with criminal justice agencies, is crucial in preventing suicide deaths.
The University of Pittsburgh's Project Tycho has digitized all weekly surveillance reports for reportable diseases in the US since 1888, revealing patterns and insights into vaccine effectiveness. The database contains data on eight vaccine-preventable diseases, showing a resurgence of some diseases despite vaccination efforts.
A new analysis suggests that economic development can only buy happiness up to a certain level of wealth. Once income reaches around $36,000 GDP per capita, life satisfaction levels peak before dipping slightly in the very rich countries. This finding contradicts previous studies that showed a flat relationship between GDP and happiness.
Researchers at Brigham and Women's Hospital have successfully developed nanoparticles that can be absorbed through the digestive tract, enabling targeted and convenient drug delivery. This breakthrough could one day allow patients to take a pill instead of receiving injections for conditions such as cancer and high cholesterol.
Scientists have identified a key metabolic enzyme used by Plasmodium species at each stage of infection, paving the way for more effective drugs and potentially eradicating malaria. The discovery could lead to radical cures and prevent infections, blocking transmission back to mosquitoes.
Researchers found that higher doses of testosterone improved sexual function, muscle mass, and physical performance in postmenopausal women who had undergone hysterectomy. However, side effects such as unwanted hair growth and acne were rare in the study.
Researchers found that combining modafinil with antidepressants improved depression symptoms and reduced fatigue, which are common relapse triggers. The study suggests modafinil may be a useful supplement for those struggling with depression.
5-hydroxymethylfurfural, extracted from wine-processed Fructus corni, protects against H2O2-induced rat hippocampal neuron apoptosis by regulating apoptosis-related genes. This finding provides evidence for the clinical prevention and treatment of oxidative injury-related diseases in the brain.
Researchers found that over half of subarctic lakes show signs of desiccation, with some drying up completely in summer 2013. The decline in meltwater is linked to dry summers and less snowy winters, which could lead to significant ecological consequences.