Researchers at CNIO's Cell Division & Cancer Group have discovered that the protein Greatwall is essential for preventing mitotic collapse in mammals. By inhibiting Greatwall, cells can no longer divide properly, which may lead to slowed-down cancer growth and potentially reactivated tumour suppressor PP2A
A new study by the University of North Carolina School of Medicine has identified low preoperative albumin levels as an independent risk factor for surgical-related health problems after radical cystectomy. Patients with a low albumin level before surgery are 2.1 times more likely to experience complications within 30 days.
The grant aims to investigate the effects of HIV-related changes on oral bacterial communities and their relationship to various oral infections in HIV disease. Researchers will explore how these changes affect conditions like oral candidiasis, periodontal disease, and cavities.
A study published in Cancer Epidemiology, Biomarkers & Prevention found that walking for at least seven hours a week reduced breast cancer risk by 14% in postmenopausal women. Women who engaged in vigorous physical activity daily had a 25% lower risk of breast cancer.
A new study published in Menopause found that a specific bacterial mix may contribute to vaginal dryness and pain after menopause. The researchers suggest that personalized probiotics could prevent or treat vulvovaginal atrophy (VVA), a common cause of sexual pain, offering an alternative to traditional therapies.
Researchers at Emory University discovered that hemin injection causes labored breathing and rapid death in sickle mice, but not in control mice. Hemopexin treatment was effective in preventing hemin-induced lung injury. These findings suggest targeting hemin and TLR4 signaling may be a valuable approach for treating acute chest syndrome.
Lihong Wang has received a $3.5 million NIH grant to translate his single-cell label-free photoacoustic microscopy technology into the clinic for cancer screening, detection, prognosis, and monitoring.
A new report from ECCO highlights the growing burden of cancer worldwide, with India, China, and Nigeria expected to see dramatic increases in cases due to population growth and lifestyle changes. The report calls for a major public-private partnership to improve cancer care and outcomes globally.
Researchers estimate that routine PSA testing can lead to increased impotence and incontinence cases, as well as additional prostate cancer diagnoses. However, the difference in death rates between screened and unscreened men is relatively small, with only 0.07 more deaths attributed to screening.
Researchers at IMIM discovered that intestinal mucus prevents inflammatory reactions against commensal bacteria and dietary antigens, offering a promising complementary way to treat ulcerative colitis and Crohn's disease. The study also suggests potential applications in cancer therapy due to mucus' anti-inflammatory properties.
A clinical study found that stem-cell enriched fat grafts retained 80.9% of their initial volume, compared to 16.3% for non-enriched grafts, after 121 days. The treated grafts showed significantly higher amounts of adipose tissue and newly formed connective tissue.
The Pan-Cancer Initiative has identified common genetic patterns across various tumor types, enabling researchers to extend therapies effective in one cancer type to others with a similar genomic profile. This breakthrough has the potential to revolutionize cancer treatment by recognizing similarities between seemingly distinct tumors.
Cancer researchers at UC San Diego isolated and characterized early-stage prostate cancer cells, which may drive recurrent disease. The study suggests that these cells could be targeted for new treatments, potentially reducing cancer progression.
A study published in the Journal of Clinical Oncology found that married patients with cancer live longer than unmarried patients, with cancers diagnosed at an earlier stage. Social support from spouses is thought to be driving this improvement in survival rates.
Researchers at The Wistar Institute have discovered a protein motif, TFLY, crucial to telomerase function, which can be disrupted to block enzyme activity. This finding offers new insights into developing drugs to inhibit telomerase and its potential role in cancer therapy.
Researchers have developed a novel treatment for gonorrhea that works like a live vaccine, reversing immunosuppression and preventing reinfection. The treatment, administered intravaginally, uses microsphere technology to stimulate an immune response against the bacterium.
A new marker called isocitrate dehydrogenase (IDH1) has been identified as a non-invasive diagnostic marker for lung cancer, with high sensitivity and specificity in detecting non-small cell lung cancers (NSCLC). IDH1 levels were found to be significantly higher in patients with lung cancer compared to healthy controls.
A new study found that microRNA-486 (miR-486) is a potent tumor-suppressor molecule in lung cancer. It regulates the proliferation and migration of lung-cancer cells and induces programmed cell death.
The EORTC trial found that vaccination with GM2/KLH-QS-21 did not improve relapse-free or overall survival rates for patients with stage II melanoma. The vaccine was expected to stimulate antibodies against the GM2 ganglioside, but instead, it led to a higher risk of death and decreased survival rates.
Researchers at Massachusetts General Hospital identify fibroblast growth factor 18 (FGF18) as a predictive marker for poor overall survival in ovarian cancer patients. Overexpression of the gene encoding FGF18 was associated with enhanced tumor blood vessel formation and expression of cancer-promoting cytokines.
A new analysis confirms the importance of regular mammography screening in reducing breast cancer deaths, especially among younger women. The study found that 71% of confirmed breast cancer deaths occurred in the 20% of patients who did not receive annual mammograms.
A team of researchers has discovered a genetic mutation specific to risk of childhood leukemia, providing a potential window into inherited causes. The PAX5 gene mutation was found in several family members with childhood acute lymphoblastic leukemia (ALL), increasing the risk of developing the disease.
Researchers extended mouse lifespan by 20% through gene manipulation, with some organs aging better than others. This increase is equivalent to a 16-year boost in human lifespan, offering insights into aging and potential therapies for age-related diseases.
The North American Menopause Society (NAMS) has published new guidance for diagnosing and treating vulvovaginal atrophy (VVA), a condition affecting up to 45% of women after menopause. The guidance emphasizes the importance of effective treatments, including simple vaginal lubricants, estrogen therapy, and nonhormonal options.
A combination of sofosbuvir and ribavirin achieved high sustained virologic response rates in patients with unfavorable treatment characteristics, including advanced liver disease and high baseline HCV RNA levels. The regimen was well-tolerated and safe, with a lower relapse rate compared to traditional interferon-based therapy.
Mayo Clinic researchers found that high-tech imaging technologies are leading to the overdiagnosis and overtreatment of low-risk papillary thyroid cancer. This is exposing patients to unnecessary treatments with potential complications such as nerve injury. The study calls for more research on care for these patients.
A study found wait times for colorectal cancer operations at VA hospitals rose to 32 days, but researchers believe longer waits may be due to improved care and outcomes. The study suggests that more careful care is worth the wait, even if it means delayed treatment.
Researchers have developed a novel treatment for stroke using exosomes containing genetic material from bone marrow stem cells, which significantly improved neurological function in lab rats. The treatment, tested on lab rats with induced stroke, showed gradual and eventually significant improvement over four weeks.
A new study found that poor oral health is associated with an increased risk of oral human papillomavirus (HPV) infection, which can cause oropharyngeal cancers. Good oral hygiene practices can help prevent HPV infection and its related cancers.
Researchers found that a combination of calorie restriction and targeted therapy may increase cancer survival. Calorie restriction decreased Mcl-1 protein activity, sensitizing lymphoma cells to treatment. This study suggests a potential new approach to improve cancer treatment efficacy.
A new biomarker, PROVAR, predicts time to ovarian cancer recurrence and distinguishes between high-risk patients. Analysis of protein biomarkers may help determine treatment plans for ovarian cancer patients.
Researchers evolved hyperswarmable Pseudomonas aeruginosa bacteria, which formed less dense biofilms than their non-hyperswarmable counterparts. This could lead to the development of new anti-biofilm therapies.
The CEO Cancer Gold Standard program, developed by Johnson & Johnson, promotes workplace health promotion and industry practices that support cancer prevention and treatment. Employers can influence healthcare policies and reimbursement through data-driven decision making and the '5 Pillars' framework.
Cervical cancer is a significant burden on women of reproductive age in low- and middle-income countries, with reduced reproductive capacity and associated health risks. Experts argue that cervical cancer screening and treatment should be included in the post-2015 development agenda for improving reproductive health outcomes.
A UCLA study found that women diagnosed with breast cancer who created personal websites experienced reduced depressive symptoms, improved mood, and increased appreciation for life. The project, Project Connect Online, provided a platform for breast cancer patients to share their experiences and connect with friends and family online.
Metabolic fingerprinting looks at metabolite levels in blood, urine, or tissue to analyze tumor development and growth. This technique can improve diagnosis accuracy alongside existing imaging methods.
Using surface-enhanced Raman spectroscopy (SERS), scientists can distinguish between adult stem cells, enabling the use of healthy ones in therapies. This technique holds promise for advancing stem cell and other cell-based therapies to treat diseases like Parkinson's.
Researchers at Ohio State University Comprehensive Cancer Center discovered that the tumor-suppressor gene A20 is silenced due to the loss of microRNA-29, leading to increased levels of NF-kB and tumor progression. This finding could guide the development of more effective therapies for soft-tissue sarcomas.
A new study reveals that certain patient groups feel unmet needs for greater involvement in cancer treatment decisions. Younger patients and those with specific rare types of cancer want more input in the decision-making process. The research emphasizes the importance of shared-decision making policies to address these disparities.
The Louisiana Tumor Registry has been awarded a contract to continue its work as a SEER Program-designated cancer registry, collecting cancer incidence and survival data from 28% of the US population. The funding will support cancer research, including prevention, early detection, treatment, and survivorship studies.
Patricia Resick, PhD, ABPP, received the American Psychological Association's Division of Trauma Psychology Award for Lifetime Achievement in trauma psychology. She has made outstanding contributions to science, practice, advocacy, and education, developing Cognitive Processing Therapy (CPT) for PTSD treatment.
Researchers at the University of Kentucky Markey Cancer Center have made significant discoveries about the Par-4 gene and its role in cancer recurrence. The study found that low levels of Par-4 protein may predict breast cancer relapse, while high levels can eliminate cancer cells through apoptosis.
Researchers at the National Human Genome Research Institute identified biomarkers of kidney damage and demonstrated that antioxidant therapy protected kidney function in mice. These findings offer new tools for monitoring disease progression and may pave the way for clinical trials for patients with methylmalonic acidemia.
New study reveals stable survival rates for HIV-associated lymphoma patients during the antiretroviral therapy era. Despite increased incidence and changing demographics, recent diagnosis years are not associated with decreased mortality. The study highlights an ongoing need to improve treatments for this challenging population.
Undergraduate students at University of Houston are conducting research on Alzheimer's diagnostics, breast cancer treatment, and fruit fly courtship patterns. Their projects aim to develop new diagnostic methods and treatments, while exploring adaptations to environmental changes.
Researchers have characterised the binding of IFNβ proteins to cells, providing a breakthrough in understanding immune response mechanisms. This study offers new avenues for developing treatments with reduced side effects and improved effectiveness.
Women who survive cancer have more frequent, severe, and troubling hot flashes than other women with menopausal symptoms. However, the study also found that the cancer survivors reported better psychological and social well-being, similar levels of sexual activity and function compared to women without cancer.
A study of over 10,000 men with nonmetastatic prostate cancer found that use of androgen deprivation therapy (ADT) was associated with a significantly increased risk of acute kidney injury. The association remained consistently elevated across different types of ADTs, particularly in the first year of treatment.
Gay men are more than 15 times as likely to develop genital cancer as straight men due to HPV infection. Targeted vaccination is recommended for those aged up to 26 years, with sexual health clinics ideal for offering the vaccine.
Older African-American and Hispanic male cancer survivors are more likely to miss specialist visits and preventive care, such as vaccinations, compared to their white counterparts. The study found that disparities persist despite access to Medicare and adjustments for factors like education and insurance.
Chemists from North Carolina State University have successfully performed a DNA-based logic-gate operation within a human cell. The researchers used a DNA-based Boolean logic gate that was activated only when two specific microRNAs were present in cells, generating an output by releasing a fluorescent molecule.
A large UK cohort study found that children born through assisted reproduction have no higher cancer risk than naturally conceived children. However, rare cancer types were associated with low birth weight and small absolute excess risks.
A study found that biological tumor necrosis factor inhibitors did not significantly reduce work loss compared to conventional treatment in patients with early rheumatoid arthritis. Early and aggressive treatment can help reverse increasing work loss days, but the cost of infliximab outweighs its benefits.
Research published in the Journal of Leukocyte Biology found that excessive mast cells lead to delayed wound healing due to overproduction of IL-10. The study provides a potential therapeutic target for future drug development.
Researchers have developed two new methodologies to determine ALK status in non–small-cell lung cancer (NSCLC) patients. The first method improves IHC assay sensitivity using a novel hapten and tyramide amplification, detecting low levels of ALK protein expression. The second method combines brightfield IHC with in situ hybridization f...
Researchers will study pediatric sarcomas, a rare and aggressive form of cancer affecting 11% of all childhood cancers, with the goal of developing new therapies. The project aims to improve outcomes for children with advanced or metastatic disease, who have limited success with current treatments.
Researchers evaluate immunohistochemistry for detecting ALK rearrangement in lung adenocarcinoma, finding it a reliable and cost-effective method. The study suggests that IHC can effectively detect ALK rearrangement and identify suitable candidates for targeted therapy.
A recent study published in the Journal of the American College of Cardiology found that heart failure patients are more likely to develop cancer, with a significant increase in mortality rates. The study suggests that side effects of cardiovascular treatments and inflammation may be contributing factors.
A study finds a link between prenatal ICP and postnatal obesity in offspring, while another investigation reveals genetic changes in preeclampsia and brain inflammation caused by chronic cannabis use. These findings may have implications for understanding and treating metabolic diseases and pregnancy complications.
Researchers at Max Planck Institute discover Chlamydia promotes gene mutations, impairing DNA damage response and leading to uncontrolled cell growth. The infection can cause chronic damage, increasing risk of cervical and ovarian cancer.