Articles tagged with Cancer Treatments
The National Cancer Institute has granted $2.5 million to Van Andel Research Institute and Cedars-Sinai to develop better diagnostic and treatment strategies for cancer. The project aims to uncover the underpinnings of cancer by analyzing epigenetic data from thousands of samples.
VA researchers found certain HLA gene alleles offer protection from Gulf War illness, while lacking them makes veterans vulnerable to symptoms. The studies used MEG brain scans to track differences and found that such protection is manifested in the brain.
A study of 101 advanced lung cancer patients found that hybrid capture-based next-generation sequencing (HC-based NGS) identified clinically actionable genomic alterations (GAs) in 50% of patients, leading to changes in treatment strategy. The overall response rate to targeted therapies was 65%, with median survival not yet reached.
Researchers at University of California San Diego School of Medicine found that ustekinumab induces response and remission in patients with Crohn's disease. The study showed high remission rates among patients treated with intravenous or subcutaneous ustekinumab.
New research suggests that food restriction increases levels of tumor-suppressing molecule p53 in mice and human hepatocytes. This p53-induction is required for fasting-induced adaptation of nutrient metabolism, offering new therapeutic concepts for metabolic diseases and cancer.
Researchers at UC San Diego School of Medicine developed a bioinformatics framework that identified key proteins significantly altered in patients with diabetic kidney disease. The 'MetBridge Generator' framework revealed the protein MDM2 played a key role in disease progression, and its potential as a therapeutic target was discovered.
Testing for HPV types 16 and 18 in women with minor cervical lesions may help determine which patients should be referred to colposcopy. This approach could lead to more precise patient management and reduced healthcare burden.
The project aims to improve diagnosis and tailor treatment by analyzing the genome and expressed genes of tumour cells from 250 breast cancer patients. This personalized approach will help doctors choose the best treatment for individual patients, potentially increasing survival rates and reducing side effects.
Researchers have discovered how heat shock factor 1 (HSF1), a master transcriptional regulator, is activated and controlled by the on/off switch HSP70 and phosphorylation. This finding could lead to treatments for cancer and neurodegenerative diseases.
The American Society of Hematology has partnered with several organizations to create a specialized curriculum for acute myeloid leukemia (AML) care. The program aims to address knowledge gaps in the entire multidisciplinary team involved in AML management, including accurate diagnosis, risk stratification, and treatment options.
A team of scientists, led by prof. Savvas Savvides, used integrative structural biology to study how GIF, a protein secreted by the Orf virus, inactivates key cytokines of the host immune system. The research reveals unique strategies that viruses use to counter antiviral responses and highlights great potential for innovative therapies.
A study of over 2,000 people in the UK found that two thirds worry about emotional impact and cancer treatments, while ethnic minorities are more likely to worry about social consequences.
A new procedure using a 22-gauge needle improves the diagnosis of autoimmune pancreatitis (AIP) through microscopic examination of tissue samples. Researchers successfully diagnosed AIP in 58% of patients using this method, offering a solution for distinguishing AIP from pancreatic cancer.
The study highlights the importance of understanding the risks of obesity and its effects on overall health. Americans perceive diet and exercise as the most effective long-term weight loss method, despite medical professionals recommending a range of treatments.
The Cell Press has partnered with The American Society of Gene and Cell Therapy (ASGCT) to publish its four journals, including Molecular Therapy, starting January 2017. This partnership aims to improve the dissemination of research breakthroughs in gene and cell therapies.
Researchers used Stampede supercomputer to simulate largest atomic level system of p53 protein, identifying new 'pockets' to reactivate the tumor suppression protein. The simulations revealed complex dynamics between p53 and DNA sequences, offering insights into a potential anticancer therapeutic strategy.
Researchers at University of Granada found telerehabilitation through Skype reduces pain, fatigue, and improves strength in women with breast cancer. An 8-week exercise program led to significant benefits that lasted 6 months after completion.
A Mayo Clinic study found that patients with multiple myeloma treated at centers seeing more cases of the disease live longer. The researchers analyzed data from over 94,000 patients and discovered a significant correlation between treatment center volume and patient outcomes.
A pediatric otolaryngologist is developing a mouse model to identify the most effective treatment for respiratory papillomatosis, a rare condition that can cause chronic hoarseness and breathing problems in children. The goal is to provide personalized medicine and reduce the need for frequent surgeries.
A new report suggests that well over half of American men with non-aggressive prostate cancer could choose to monitor their disease instead of seeking immediate radiation treatment or surgery. Active surveillance relies on regular blood tests, physical exams, and periodic biopsies to screen for tumor growth before therapy is considered.
A Phase 1 clinical trial demonstrated the long-term safety of gene transfer in treating neovascular age-related macular degeneration. The therapy produced therapeutic proteins encoded by genes for at least 2.5 years in patients with advanced NVAMD.
A recent study reveals that blood-based genomic and proteomic testing can rapidly identify genetic mutations in patients with lung cancer, enabling personalized treatment. This approach significantly reduces the wait period between diagnosis and treatment, improving patient outcomes.
The Endocrine Society recommends treating hypopituitarism by replacing hormones at natural patterns, with accurate hormone measurements crucial for diagnosis and treatment monitoring. The guideline also addresses special circumstances like pregnancy care and post-surgical care.
A new study found that androgen deprivation therapy for prostate cancer may be associated with an increased risk of dementia, particularly among older men. The study analyzed electronic medical records data and found a significant association between ADT use and dementia development.
Researchers discovered that pancreatic cancer develops rapidly through a 'big bang' process, where key alterations occur simultaneously. This finding provides new insights into the disease's aggressiveness and may lead to improved diagnostic and therapeutic strategies.
Researchers pinpoint a unique metabolic reprogramming in cancer cells that enables their ability to biosynthesize and replicate, and may provide new treatment opportunities. By blocking specific enzymes involved in this process, tumor growth can be slowed or stopped in preclinical tests.
Patients diagnosed with cancer at emergency presentation have poorer survival rates compared to those diagnosed electively. The review highlights inequalities in socioeconomic groups and ethnicity, emphasizing the need for new screening methods and improved participation in existing screening programs to reduce emergency presentations.
Researchers at the University of Texas at Arlington have developed a novel microwave-induced photodynamic therapy that can target deeply situated tumors. The treatment uses microwaves to activate photosensitive nanoparticles, producing tissue-heating effects that ultimately lead to cell death.
Forty percent of people in Great Britain express concerns about talking through symptoms with GP receptionists, hindering GP visits. Women and those from lower socio-economic backgrounds are more likely to report these barriers. Cancer Research UK emphasizes the need for better training of front desk staff and addressing the GP shortag...
A phase III trial found that MEK inhibition with selumetinib plus docetaxel did not improve progression-free or overall survival in KRAS-mutant non-small-cell lung cancer patients. The study concluded that there is a desperate need for new treatments for this subset of NSCLC patients.
Researchers from UHN describe the genomic landscape of schwannomas, identifying novel mutations and a fusion protein driving tumor development. The study provides insight into personalized medicine approaches for diagnosis and treatment.
Cabozantinib significantly improves progression-free survival and response rate in patients with intermediate or poor-risk clear-cell metastatic renal cell carcinoma compared to sunitinib. The study also found a higher objective response rate in the cabozantinib arm.
University of Groningen scientists discovered that tumor necrosis factor receptor 2 (TNFR2) is essential for preventing neuronal death in neurodegenerative diseases like multiple sclerosis and Alzheimer's. A specific TNFR2 agonist may prevent cell death, offering a new treatment direction.
A research team at UHN has identified new mutations in genes associated with schwannoma development, providing insights into the growth drivers of these tumors. The study's findings have significant implications for personalized medicine and potentially change treatment approaches for some patients with treatment-refractory schwannomas.
A study of over 7,500 patients with invasive breast cancer found that tamoxifen therapy significantly reduced the risk of developing contralateral breast cancer. The risk was highest among those using tamoxifen for four years or more, with a 66% relative reduction in CBC risk.
The University of Warwick is conducting a breakthrough research project to improve the diagnosis and treatment of oral cancers in Pakistan, using digital pathology. The project will generate a repository of information about different types of cancer cells found in oral cancers, enabling pathologists to analyze samples more accurately.
A clinical trial found that ruxolitinib, a JAK inhibitor, significantly restored hair growth in 75% of patients with moderate to severe alopecia areata. The treatment was well-tolerated and showed promise for treating other forms of hair loss.
Researchers develop a portable biological factory platform that can produce pharmaceuticals, specialized therapies, and experimental biomolecules using freeze-dried molecular components. The technology is applied in various fields, including vaccine production and designer antibody development.
A study published in JAMA compared five-year survival rates after endosonography and mediastinoscopy for mediastinal nodal staging of lung cancer. The endosonographic strategy was found to be more sensitive for diagnosing mediastinal nodal metastases.
A set of microRNAs, known as C19MC, was found to be specific to infantile hemangiomas and detectable in patient plasma. These microRNAs may serve as biomarkers for IH diagnosis and treatment monitoring, with levels decreasing before tumor regression but rebounding upon re-growth.
The Lancet review highlights the importance of statin therapy in preventing cardiovascular disease. Lowering cholesterol by 2 mmol/L with a low-cost statin can prevent major cardiovascular events in patients with pre-existing vascular disease or those at increased risk.
The new technique, called 'Chirped-Standing-Wave Acceleration', could enable compact and inexpensive ion treatment facilities, increasing access to advanced cancer therapy. Researchers have developed a novel method to accelerate ions using lasers, promising a paradigm shift in the field.
The European Society for Medical Oncology (ESMO) has awarded four distinguished recipients for their outstanding contributions to cancer treatment and research. Alberto Sobrero received the ESMO Award for his world-renowned research on gastrointestinal cancer, while Sir Richard Peto was recognized for his important contributions to bre...
A new study from Uppsala University found that biobank storage time is a crucial factor in medical research, rivalling the importance of blood donor age. The researchers analyzed 380 samples from 106 women, isolating the impact of storage time to show its significant influence on test results.
Researchers present cutting-edge studies on healthcare economics, sleep apnea, and 3-D printed tissue engineering, showcasing potential breakthroughs for obstructive sleep apnea and head and neck cancer treatments. The findings have significant implications for the future of otolaryngology.
A large single-center study found that EUS-FNA is beneficial for diagnosing malignant BD-IPMNs, particularly those with suspicious features missed by CT/MRI. The procedure also improved long-term outcomes for patients with malignant lesions, reducing recurrence risk.
Researchers found that a 40% reduction in sepsis deaths was achieved through simple steps, including increased training and a special observation chart. Standardized treatment plans can increase survival rates and reduce mortality from serious infections.
Researchers have developed a method to utilize CRISPR/Cas9 technology to diagnose and inactivate cancer mutations. The study found that over 80% of reported cancer mutations can be targeted with the CRISPR/Cas9 system, enabling the rapid separation of driver from passenger mutations.
Researchers at Sanford Burnham Prebys Medical Discovery Institute have discovered a previously unknown protein, SETDB2, that helps the liver adapt to fasting states. This protein is increased during times of fasting and alters the genome to turn on genes needed for energy storage.
Researchers created novel scaffolds with aligned ceramic nanofibers to control stem cell development and cancer cell behavior. The unique hybrid nano-network selectively guides stem cells towards specific lineages while suppressing inflammatory factors in cancer cells.
A new study reveals that socioeconomic differences between white and ethnic minority patients are the main factor affecting their chances of survival. Patients with higher income, insurance status, and marital status tend to have better outcomes.
Researchers have developed a gene therapy approach using ultrasound energy and microbubbles to selectively open cells, allowing delivery of therapeutic agents. The study's findings will help refine this technique as a clinical tool and translate it into an effective gene or drug delivery tool for patients.
A study published in the American Journal of Roentgenology suggests that nephron-sparing treatment for small renal masses can improve life expectancy in patients with mild or moderate chronic kidney disease. The study developed a framework for incorporating tumor imaging features and renal function into treatment selection, providing a...
A new regenerative bandage heals diabetic foot ulcers faster and promotes healing without cancer risk, according to Northwestern University researchers. The bandage delivers a protein that recruits stem cells and creates new blood vessels, improving wound repair.
A new study reveals that chromosomal changes in breast cancer occur in short, punctuated 'bursts' at the earliest stages of tumor growth, contradicting the traditional gradual acquisition model. This finding has significant implications for diagnosis and treatment, suggesting a potential new approach to clinical management.
Researchers found that angiogenin promotes hematopoietic regeneration by dichotomously regulating quiescence of stem and progenitor cells. ANG simultaneously reduces proliferation of stem cells and promotes proliferation of myeloid progenitor cells, which give rise to mature myeloid cells.
A study from Michigan Medicine found that women who engaged on social media after a breast cancer diagnosis expressed more deliberation about their treatment decision and more satisfaction with the path they chose. However, the researchers also identified significant barriers to social media use among certain groups of patients.
Drexel researchers create chains of microscopic magnetic bead-based robots that can swim at impressive speeds through a microfluidic environment. The team demonstrates their ability to link and unlink the beads using a rotating magnetic field, paving the way for targeted medicine delivery and minimally invasive surgery.
The UK Lung Cancer Screening randomized controlled trial found that CT screening did not cause unnecessary anxiety, despite fear and stigma being barriers to participation. The trial recruited over 4,000 participants aged 50-75 at high risk of lung cancer, with a significant reduction in deaths for those who received screening.
Scientists at Newcastle University have identified a group of molecules that can be targeted to slow tumor growth in prostate cancer patients. The research found that testosterone changes these molecules, making cancer cells more likely to survive and spread.