Articles tagged with Cancer Treatments
A new study found that HPV vaccination rates are significantly lower among childhood cancer survivors compared to the general population. Most participants lacked a healthcare provider's recommendation, highlighting the need for increased communication and awareness about HPV vaccination.
The 'Programme for Translational Hematology' aims to strengthen cooperation between basic and clinical research to gain new knowledge on leukaemia. The programme will focus on identifying new treatment forms for AML and MDS, using DNA sequencing, pre-clinical models, and international research capacities.
A clinical trial demonstrates the safety and efficacy of magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) for treating osteoid osteoma, a benign but painful bone tumor in children. The procedure eliminates incisions and ionizing radiation exposure, offering a faster treatment option with improved outcomes.
A compound has been identified that enhances tumor-targeting viruses' ability to selectively kill liver cancer cells while sparing healthy ones. The oncolytic virus M1 was boosted by combining it with Eeyarestatin I, increasing its potency 3,600-fold against cancer cells in culture and animal models.
A new research study reveals that a nanolaser called spaser can detect and kill circulating tumor cells in the bloodstream, preventing cancer metastases. The spaser is biocompatible and selectively targets cancer cells with high folate receptor expression.
Many young cancer patients are not receiving adequate fertility information and support, according to a new Psycho-Oncology review of published literature. The analysis found that clinicians' lack of knowledge and unclear roles hinder the provision of fertility preservation services.
A recent study found that tumor-infiltrating immune cells, specifically regulatory T cells (Tregs), can interfere with immune-targeting therapies in aggressive breast cancers. Depleting Tregs delayed tumor growth in mouse models, suggesting a potential strategy to improve targeted treatments.
The University of Houston has received a $2 million grant to recruit cancer researcher Rohith Reddy, who will focus on next-generation technologies for detecting gynecological cancers. The institution also received a $1.3 million grant to expand tobacco cessation programs in substance abuse treatment centers.
A new study published in Menopause found that vaginal estrogen therapy does not increase the risk of cardiovascular disease, cancer, or other health issues in post-menopausal women. The research suggests that vaginal estrogen is a safe treatment for genitourinary symptoms associated with menopause.
Researchers developed a genome sequencing method that can detect clinically relevant mutations using just 5 circulating tumor cells. The technique, known as long fragment read (LFR), is more comprehensive than gene panels and can analyze the entire genomic content of small numbers of cells.
Researchers have discovered that cancer-fighting T cells can recognize infected cells with much less evidence of cancer than previously believed. The study, which used optical tweezers to apply a tiny amount of force to the T cells, found that they can bind to just two peptides for activation
Women diagnosed with cancer experience diverse sexual health concerns that change over time and stages of cancer. Their unique values, goals, and needs must be addressed during treatment and survivorship.
A study by Fumiko Chino and colleagues found that nearly all insured cancer patients experience financial burden, with those underinsured paying up to 31% of their income on healthcare costs. The research highlights the need for interventions to improve patient health care cost literacy and mitigate future treatment-related expenses.
A study found that a next-generation probiotic, Lactobacillus reuteri, produces an antibacterial compound that selectively kills C. difficile. This could lead to a preventative strategy for reducing the risk of C. difficile infections in patients taking antibiotics.
The Pacific Northwest Research Institute (PNRI) is partnering with Merck to develop a comprehensive plan to bring a promising antifungal agent from the laboratory to clinical practice. The compound has potential to reduce the burden of opportunistic infections in people living with HIV in developing countries.
A clinical trial at the University of Cincinnati is investigating a drug combination therapy using sirolimus and resveratrol to induce disease remission in patients with lymphangioleiomyomatosis (LAM). The study aims to identify a regimen that will eliminate LAM cells, which currently only suppress growth.
A new study found that cancer survivors have a higher rate of opioid prescription use compared to non-survivors. The study analyzed data from over 8,600 adults and found an average of 7.7 opioid prescriptions filled over 36 months among survivors.
A collection of articles on hereditary cancer syndromes, including Li-Fraumeni and Lynch syndromes, has been published in JAMA Oncology. The studies focus on the effectiveness of intensive cancer surveillance programs for individuals with these rare syndromes.
A team of researchers from UCR developed a ceramic skull implant that allows doctors to deliver therapeutic sound waves into the brain. The material, made of Yttria Stabilized Zirconia, is biocompatible and shatter-resistant, making it ideal for implants.
Scientists at the Gladstone Institutes have discovered a method to reprogram specific T cells, turning pro-inflammatory cells into anti-inflammatory ones. This breakthrough could lead to improved treatments for autoimmune diseases and therapies using stem cells.
The Damon Runyon Cancer Research Foundation has awarded four young pediatric cancer researchers with nearly $1 million in funding. The award supports innovative research into prevention, diagnosis, and treatment of one or more pediatric cancers.
Lorenz Studer, a renowned stem cell biologist, has been awarded the prestigious Ogawa-Yamanaka Stem Cell Prize for his groundbreaking research on cellular reprogramming and human induced pluripotent stem cells. His work has advanced the therapeutic potential of stem cell-based therapies in Parkinson's disease.
Researchers have identified a wide genetic variety in medulloblastoma, the most common type of childhood brain cancer. This discovery could lead to more precise subgroups and individualized treatments, improving curative chances and reducing side effects.
Researchers have patented a mobile device that can detect cancer quickly, cheaply, effectively, and noninvasively. The device uses two systems: a flow system to align blood cells and an optical system to analyze and count tumor cells.
A study published in Cell Reports found that altering the levels of microRNA miR-128 can induce a more homogeneous subtype of glioblastoma cells, making them more responsive to treatment. This discovery opens the door for using miR-128 as a therapeutic agent.
A Western diet high in fat and sugar has been shown to cause hepatic inflammation in mice, especially in males, with FXR-deficient mice being more susceptible. The study found that probiotics and bile acid receptor agonists may hold promise for preventing and treating hepatic inflammation and progression into advanced liver diseases.
Researchers used mathematical modeling to examine patterns in lung cancer metastases, revealing a preferential pattern for brain spread in patients with EGFR mutations. The findings suggest that Markov modeling could help predict metastatic spread and personalize treatment for non-small cell lung cancer patients.
A new sub-population of immune cells plays a key role in the development of pulmonary fibrosis. Targeting these cells could lead to new treatments with fewer adverse effects.
Researchers have developed novel secreted reporter proteins that can be detected for several months after infusion into the liver, demonstrating potential for monitoring therapeutic gene delivery and ongoing expression. The findings show promise for scaling up this method to humans.
A team of researchers at Brigham and Women's Hospital developed a potential therapy using stem cells loaded with oncolytic viruses to target skin cancer metastases in the brain. The study found that this approach led to the elimination of metastatic skin cancer cells from the brain, resulting in prolonged survival.
A new study indicates that Holocaust survivors have a small but consistent increase in cancer risk, linked to extreme population-level tragedies. Survivors exposed to starvation, overcrowding, and psychological stress had higher risks of developing certain types of cancer, including colorectal and lung cancers.
A recent study found that nearly 10% of terminal cancer patients are unwilling to face their prognosis, hindering them from making informed end-of-life plans. Healthcare professionals should assess patients' readiness for prognostic information and provide sensitive coaching to cultivate accurate awareness.
Researchers from McGill University Health Centre cracked the code to understanding regulatory T cell function, a key component of our immune system. The study's findings have significant implications for treating autoimmune diseases such as arthritis and Crohn's disease.
Researchers have developed a nanolock-nanopore sensor to detect a specific cancer mutation with single-molecule resolution. The approach can accurately identify disease-causing mutations in various types of cancer.
A Berkeley Lab-led study reveals phosphate steering, an electrostatic force, guides key enzyme used by both healthy and diseased cells. This finding provides new directions for cancer treatment research.
Women living in lower-income areas were more likely to be diagnosed with late-stage breast cancer after a substantial rollback of Medicaid coverage, according to a new analysis. The study found a significant shift towards later stage diagnosis in low-income areas compared to higher-income areas.
A recent study published by The BMJ found that cancer control measures have led to rising life expectancy in rich populations but not in poorer ones. Urgent global action is needed to develop effective and affordable cancer control measures for countries undergoing socioeconomic transitions.
A survey of 102 young cancer patients aged 13-24 found that digital resources could enhance their experience and engagement. The study's lead author believes digital support resources can address unmet needs and improve patient outcomes.
Researchers at Scripps Florida and collaborators have won a $7.2 million grant to develop new RNA-based treatments for ALS and frontotemporal dementia. The project aims to create small-molecule drug candidates that target the root cause of these diseases.
A study found that PD-L2 protein expression was associated with clinical response to pembrolizumab in patients with HNSCC, independent of PD-L1 expression. Clinical response rates were higher among patients whose tumors expressed both PD-L1 and PD-L2.
Researchers at Monash University have developed a therapeutic approach that promotes muscle mass growth by inhibiting three proteins responsible for muscle wasting. The approach, combining molecules to target activin A, activin B, and myostatin, resulted in a 150% increase in skeletal muscle mass in preclinical models.
A recent study published in CANCER found that Asian women are less likely to receive timely follow-up tests after an abnormal mammogram compared to non-Hispanic White women. The study highlights disparities in breast cancer screening and outcomes among Asian ethnic groups, with Vietnamese and Filipino women facing the longest delays.
Researchers at the American Society of Hematology report on the effectiveness of enasidenib in treating a rare form of leukemia. Enasidenib demonstrates significant benefits as a targeted treatment for this aggressive disease, offering new hope for patients with limited options.
A study published in Journal of Clinical Oncology found that patients undergoing androgen deprivation therapy experience significant changes in physical function and skills of daily living. After treatment, most patients show improvement in overall geriatric health, with some even experiencing increases in daily function.
A study analyzing SWOG treatment trials from 1965 to 2012 found positive trials resulted in substantial gains in patient survival, with estimates suggesting over 3.34 million life-years were saved through these trials.
A new study by Cleveland Clinic researchers found that delays in initiating cancer therapy are associated with a substantially increased risk of death. Patients who wait more than six weeks for treatment have significantly worse survival rates, with some cancers experiencing declines of up to 40% in five-year survival rates.
A new study found that generous health insurance plans with low deductibles and copays can lead to unnecessary treatments for chronically ill patients. The study suggests that personalized medicine interventions, providing more information about treatment effectiveness, can reduce healthcare costs and improve patient outcomes.
A study of 23,600 childhood cancer survivors found a decline in severe health problems occurring five or more years after diagnosis, with the largest decreases seen in Wilms' tumor and Hodgkin lymphoma. Advances in treatment have improved five-year survival rates from 58% to 84% today.
A phase II randomized clinical trial found that the Conquer Fear psychological intervention significantly reduced fear of cancer recurrence in survivors. The intervention lowered general anxiety, cancer-specific distress, and improved quality of life compared to relaxation training.
A randomized clinical trial of 305 patients with advanced cancer found that a brief psychological intervention called Managing Cancer And Living Meaningfully (CALM) significantly reduced depressive symptoms. CALM also improved psychological well-being and preparedness for the end of life, with greater benefits at six months.
A web-based stress management program improved quality of life and reduced distress in patients with cancer, according to a prospective study. The STREAM intervention showed significant clinical improvements after two months, with a greater improvement in quality of life compared to the control group.
The AACR Project GENIE initiative has published its first analysis of nearly 19,000 de-identified genomic records, showing that over 30% of samples had clinically actionable mutations. The data can be used to facilitate clinical research and improve patient care.
Scientists have found a biocompatible material in silicon that can heat up quickly and signal its temperature through Raman scattering. The nanoparticles are more efficient than gold at converting laser radiation into heat, making them a potential cheaper alternative to metal-based treatments.
A new study suggests that CT scans can be used to detect core muscle frailty in elderly patients with hip fractures, predicting survival rates and guiding treatment decisions. The research found that patients with better core muscle had significantly better survival rates over a 10-year period.
The omentum, a layer of fat over intestines, liver, and stomach, has immune functions and secretes hormones related to obesity. It also plays a role in cancer development, serving as a breeding ground for aggressive tumors.
Researchers have developed a new drug delivery strategy to block pain within nerve cells, offering a major breakthrough in treating chronic pain. The target protein, NK1 receptor, is controlled once it enters the cell, allowing for more effective pain suppression.
Scientists at Trinity College Dublin discovered that dendritic cells become better at stimulating T lymphocytes when starved of glucose. This finding opens the door to developing new therapies for debilitating immune-related diseases.
The Affordable Care Act has improved access to and affordability of cancer-related care, but critical gaps remain. The ACA has expanded insurance coverage, led to earlier diagnoses, and ensured access to cancer treatments.
A new treatment modality called PPCA has been discovered that targets the DNA damage in rapidly expanding T cells, reducing autoimmune damage in mouse models of hemophagocytic lymphohistiocytosis (HLH) and multiple sclerosis (MS). The therapy, which leverages p53 potentiation with checkpoint abrogation, selectively interrupts DNA damag...
A recent study found that approximately 22.1 percent of adult patients prescribed antibiotics for community-acquired pneumonia do not respond to treatment, highlighting the need for updated guidelines and more aggressive antibiotic therapy for vulnerable populations such as older adults. The study also revealed regional variations in t...