Research on new and better ways to treat cancer. Covers radiotherapy, targeted microdroplets, nerve-injury protection, drug combinations, and tumor models.
A new study published in the British Journal of Surgery found that breath analyses can identify pancreatic cancer compounds. Researchers detected 12 specific volatile organic compounds indicative of pancreatic cancer, offering potential for early detection and treatment.
Football training has been linked to improved bone mineral density in elderly men with prostate cancer, particularly in those undergoing androgen deprivation therapy. The study found no association with body composition or physical functioning.
Research highlights the physiological and pathophysiological functions of olfactory receptors in human tissues, including their potential applications in cancer diagnosis and therapy. The receptors also regulate skin regeneration, intestinal digestion, and hair growth.
A study published in the Journal of Thoracic Oncology found that active surveillance of lung subsolid nodules can reduce unnecessary surgery and overtreatment. Lung cancers arising from these nodules rarely led to death, suggesting they can be a biomarker for cancer risk.
Scientists have discovered that CRISPR/Cas9 gene editing can cause extensive mutations, including DNA deletions and insertions, leading to major implications for its use in gene therapies. The study highlights the need for specific testing and caution when using CRISPR/Cas9 in therapeutic applications.
The American Cancer Society and NFL have awarded $3.2 million in grant funding to address breast cancer disparities among women of color. The grants will support timely access to follow-up care and high-quality breast cancer screening for underserved women.
Researchers found at least one rhesus gammaherpesvirus in all but one tumor, with RLCV associated with cancer risk and RFHV levels increasing over time. The study suggests that gammaherpesviruses contribute to tumor development in SIV/SHIV-infected macaques.
A class of enzymes, DYRK3, has been found to promote mixing of phases in cells during division, ensuring correct distribution of genetic material, organelles, and cell contents. This process is crucial for preventing errors like those seen in cancer and neurodegenerative diseases.
A study of over 250,000 British women found no overall increased risk of invasive breast or womb cancer after assisted reproduction. However, small increased risks of non-invasive breast and ovarian tumours were detected, with the former linked to a greater number of treatment cycles.
Researchers at Cincinnati Children's Hospital Medical Center have found a potential therapeutic target for acute myeloid leukemia (AML), a deadly blood cancer with a dismal survival rate. By targeting the F-box protein Skp2, they were able to kill AML cells and induce healthy white blood cell regeneration in preclinical tests.
Researchers at Kumamoto University identified optimal PEF conditions for increasing cell membrane permeability to calcium. The study found that larger electric fields produced high calcium intake rates, while smaller fields showed undetectable intake rates initially followed by increased rates.
A new study by IRB Barcelona researchers reveals that myeloid cells use p38 protein signalling to support inflammation-associated colon cancer. The study suggests IGF-1 as a potential therapeutic target in combination with prior detection of inflammatory infiltration in biopsies.
The American Cancer Society is outlining its vision for cancer control in the decades ahead, aiming to eliminate socioeconomic disparity to prevent one in four cancer deaths in the US. The blueprint identifies key areas such as prevention, screening, and early detection, and emphasizes the need to address disparities in cancer outcomes.
Researchers found that activating a specific type of neuron in the hypothalamus can trigger hot-flash-like symptoms in mice, regardless of gender. This discovery validates previous research on hot flashes and suggests a neurological target for preventing them.
The American Society of Human Genetics (ASHG) recognizes Dr. Andrew Adey's contributions to cancer development and progression research. His novel single-cell technologies are being used worldwide to understand epigenetics and disease models.
Researchers from UAB successfully used gene therapy to treat type 2 diabetes and obesity in mice by inducing the production of FGF21, a hormone that maintains correct energy metabolism. The treatment led to weight loss and improved insulin sensitivity, reducing the risk of related comorbidities.
New Zealand scientists have developed a revolutionary 3D colour medical scanner that provides far greater detail of the body's chemical components. The MARS spectral x-ray scanner will revolutionise medical imaging globally, enabling more accurate diagnosis and personalisation of treatment for diseases like cancer and heart disease.
Extended tamoxifen therapy for 10 years increases the risk of developing endometrial cancer by two-fold compared to standard 5-year treatment. Screening for endometrial cancer may be necessary in patients receiving extended tamoxifen therapy.
The University of Hawai'i Cancer Center has been awarded a $6 million Cancer Center Support Grant to fund research at the Center. The renewal of its National Cancer Institute (NCI) designation recognizes the Center's unique contributions to cancer research and care in Hawaii, particularly for diverse ethnic populations.
A research team has used an integrated structural biological approach to elucidate the maturation of a cancer-causing microRNA in gene regulation. Understanding this process may help develop new therapies for cancer treatment.
Men treated with ICSI for infertility have a significantly higher risk of developing early-onset prostate cancer, which is considered more aggressive. The study found that this risk is associated with male sub-fertility, not the ICSI procedure itself.
Researchers at BIDMC developed the BE3A score to predict improvement in liver function after DAA therapy for patients with decompensated cirrhosis. The online scoring system assesses 5 baseline factors to provide a shared decision-making tool for physicians and patients.
A team of researchers from CSIRO Australia has identified a new gene called C6 that regulates the body's immune response to infection and disease. The discovery could lead to targeted therapies for various diseases, including cancer, diabetes, and inflammatory disorders.
A study of over 32,000 cancer survivors found an increased risk of endocrine diseases such as thyroid disease and diabetes. Researchers examined the long-term consequences of cancer treatment in adolescents and young adults.
Researchers have identified a new gene-activation pathway caused by lipids associated with coronary artery disease, which could help identify new directions in research and drug development. The study found that exposure to lipids activates the MTHFD2 gene in the walls of blood vessels.
A new potential combined treatment for Hepatocellular Carcinoma (HCC) has shown positive results, increasing overall survival in tumor-bearing mice. Researchers found that the combination of mTOR inhibitors and Phenformin causes a metabolic shift to glycolysis, sensitizing liver tumors to dual inhibition of mTOR.
A new long-lasting type of radionuclide therapy has been proven effective in treating advanced neuroendocrine tumors, with the treatment lasting up to 4 times longer than previous options. The therapy, Lutathera-177 (Lu-DOTA-EB-TATE), was well-tolerated and showed promising results in a Phase I trial.
A significant portion of adult childhood cancer survivors are unconcerned about their future health and developing new cancers. Despite increased risk, many survivors underestimate their risks due to lack of understanding or awareness.
Researchers developed a novel PSMA-targeting agent by conjugating MCG with an albumin-binding Evans blue derivative, improving tumor delivery and increasing the therapeutic effect. The agent showed significant tumor growth inhibition and complete eradication of tumors in mice, suggesting a promising strategy for cancer management.
A new study from UT Southwestern researchers highlights the importance of diagnosing and treating stress urinary incontinence in men, who often wait years before seeking help. The study recommends a standing cough test as a routine part of male patients' physicals to accurately diagnose and treat this condition.
The International Association for the Study of Lung Cancer (IASLC) has issued a statement paper on liquid biopsy for advanced non-small cell lung cancer, recommending its use for molecular analysis in guiding clinical management. The paper aims to provide general oncologists and clinicians with access to the latest information on liqui...
A MSU chemistry professor has been awarded a $356,598 grant to develop new methods for gathering rare medical isotopes. The goal is to enable targeted alpha therapy for metastatic cancer and advance research in fields like astrophysics and biochemistry.
Scientists at the German Cancer Research Center have discovered a protein called TXNIP that controls the aging process. TXNIP inhibits thioredoxin-1, an enzyme that protects DNA from oxidative stress and slows down aging processes.
A team of researchers has identified a new family of enzymes that modify transfer RNAs in malignant melanoma, leading to addiction and resistance. Inhibiting these enzymes synergizes with targeted therapies to produce a strong anti-tumoral effect.
The Hong Kong University (HKU) team designed the world's first intra-operative MRI-guided robot for bilateral stereotactic neurosurgery. This innovation enables accurate and safe brain surgery, targeting tiny nucleus structures with minimal damage to surrounding tissue.
A new decision-making tool called the BE3A score assesses 5 factors to predict improvement in liver function for patients with decompensated cirrhosis. The scoring system will aid physicians in shared decision-making about HCV treatment, particularly for those awaiting liver transplantation.
A study examining the rate of incident malignancy in patients with RA who newly started on tocilizumab or a TNFi found no significant differences. The incidence of malignancy per 100 person-years ranged from 0.83 to 2.32 in TCZ patients and from 0.96 to 2.15 in TNFi patients.
The Synodos for NF2 consortium published its first set of results, showing that drug combination therapies are effective in treating schwannomas and meningiomas. The team integrated innovative research approaches to analyze gene and protein expression, finding that different drugs are likely needed to treat these two tumor types.
A new study found that children with neuroblastoma have an elevated risk of developing anxiety, depression, and attention deficits. The study also showed that survivors who experience psychological impairment are more likely to require special education services and not attend college.
Researchers develop flexible vaccine platform for single-dose protection against a range of infectious diseases. The technology offers rapid, large-scale production and is suitable for repeated use.
Developing cancer was associated with an increased risk of new type 2 diabetes, even after accounting for precancer risk factors. The risk was highest in the first two years after diagnosis.
New research funded by Cancer Research UK found that people using high nicotine e-liquid puffed less deeply and often than those using low nicotine liquid. The study also showed that high nicotine vapers had lower levels of toxic chemicals in their vapour compared to low nicotine users.
Breast cancer patients aged 70 and over in England have a higher risk of mortality due to reduced surgical intervention compared to other countries. Patients with stage three breast cancer in England are also more likely to not receive surgery, which has been linked to poorer survival rates.
The NCI-MATCH trial has released findings from three treatment arms, offering hope for targeted therapies in patients with specific gene abnormalities. The trial's results could aid in identifying effective treatments for various cancers, paving the way for future research.
The UKPID registry has provided valuable information on PID in the UK, especially regarding delays to diagnosis. The data show that longer diagnostic delays can lead to poorer long-term outcomes for patients.
The University of Surrey has created a mathematical model that more accurately details how hepatitis C (HCV) infection develops and behaves. This new model could lead to improved treatment for the infection affecting 215,000 people in the UK.
Breakthrough lab-on-a-chip technology allows scientists to isolate single cells, analyse them in real time and observe their complex signalling behaviour. This technology holds great promise for developing new treatments for diseases.
Researchers from EPFL have created an optofluidic device that allows them to observe cells in real-time without disrupting their environment. This technology enables the monitoring of chemical secretions and offers a powerful tool for studying individual cell behavior, which can inform new treatments for cancer and autoimmune diseases.
The DFG is supporting top-level research at German universities with 14 new CRCs, covering topics like life emergence and hearing acoustics. The programme aims to improve understanding of diseases through innovative research projects.
A lower-fat diet was linked to increased breast cancer overall survival among postmenopausal women, although the increase may be partly due to better survival from other causes. The study found modest increases in vegetable, fruit, and grain intake in the lower-fat group.
A population-based registry study confirms that secondary surgery can delay recurrence by two years and improve median overall survival by at least six years. The treatment model is centralized in Norway, which led to the favorable results, and may be adopted by other countries.
Two studies found that more frequent follow-up testing did not significantly impact mortality rates from any cause or colorectal cancer over five years. However, a related editorial suggests that current guidelines should be reevaluated in the context of these findings and potential harms associated with more frequent testing.
Dr. Michel Sadelain shares his role in advancing CAR T-cell therapy, a rapidly evolving field that targets cancer cells. He describes the FDA approval of the first CAR T-cell therapy and predicts next-generation technology advancements.
A new study reveals declines in prostate cancer screening and diagnoses in the US between 2008-2014, with significant decreases in definitive treatments. The findings suggest that men are choosing active surveillance for low-risk prostate cancer, avoiding treatment-related harms.
Researchers developed an algorithm to predict treatment effectiveness in individual patients using a molecular communication pathway. The study found that repurposing ruxolitinib, a drug approved for malignant blood disorders, can overcome resistance to measles virotherapy by increasing its effectiveness by a factor of 1,000.
A new special issue of the Journal of Dental Research brings together leaders in the field to discuss the state-of-the-science in head and neck cancer, presenting new early diagnostic tools and mechanism-based therapies.
Researchers developed a novel inertial cell focusing and sorting microfluidic device with a wavy channel structure, achieving size-based separation of target cells. The device offers high-throughput, low-energy consumption, and simplified setup, making it suitable for practical biomedical applications.
Researchers found that continued treatment of muscle wasting with a soluble growth factor receptor protein improved survival in a pre-clinical cancer model. The study suggests a possible causal link between preserving muscle mass and improved survival, but notes that other factors may also play a role.
A study by Duke University Medical Center researchers has identified early cell movement as a potential indicator of malignant tumors in colorectal cancer. The team analyzed 19 human colorectal tumors, finding that invasive samples exhibited signatures of abnormal cell movement more frequently than benign tumors.
Researchers have developed criteria for routine genetic screening of patients with medulloblastoma, a rare and malignant tumor predominantly affecting children. This analysis of 1022 patients identified six genes frequently affected by genetic alterations, increasing cancer risk in up to 20% of the patient population.