Articles tagged with Cancer Treatments
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers at the University of Copenhagen have discovered a new mechanism by which cancer-inhibiting proteins regulate signaling molecules. The study found that primary cilia, or cellular antennae, play a crucial role in balancing PDGFRα signaling, preventing excessive receptor activation that can lead to brain and gastrointestinal t...
A new study found that person-to-person genetic differences can impact the efficacy of gene editing technologies like CRISPR-Cas9. The researchers analyzed 7,444 whole-genome sequences and discovered that about 50% of guide RNAs could be affected by variants at their target sites.
Researchers found that socio-demographic factors such as income level, education, and insurance status significantly impact access to stem cell transplants for patients with multiple myeloma. Higher-income Whites and Blacks, and those with private insurance, were more likely to receive the treatment.
Researchers developed a genetic model that predicts outcomes in primary myelofibrosis patients under 70 using gene mutations and clinical variables. The model improves on previous predictive models, which only used clinical variables.
Researchers at Thomas Jefferson University discovered how losing a gene leads to large-scale genetic changes that make cancer more aggressive and resistant to treatment. The study shows promise for personalized therapy using liquid biopsies to track RB status in prostate cancer patients.
Researchers at NUS Cancer Science Institute discovered a molecular pathway in which TIP60 inhibits cancer cell growth by targeting telomerase. This finding offers a new approach to treating various types of cancer triggered by high telomerase levels.
A new gene therapy transplantation technique could improve treatment of neurodegenerative diseases by generating genetically engineered microglia-like cells in the brain. This technique has been tested on an experimental model for a metabolic disease and may have future therapeutic applications for other neurodegenerative diseases.
Scientists have made a breakthrough in treating neurodegenerative disorders and lysosomal storage diseases by transplanting hematopoietic stem cells directly into the brain, achieving therapeutic benefits faster than traditional methods. This innovative technique could pave the way for new treatments for Parkinson's, Alzheimer's, and o...
Large racial disparities were found in the survival of patients with ovarian, colon, and breast cancers in the United States. Black women had consistently worse survival compared to white women, despite similar stage distributions. The five-year net survival for black women was lower than for white women in all three types of cancer.
Researchers at Tufts University have developed a new approach to analyzing complex genomic rearrangements (CGRs), enabling rapid and precise identification of their causes and impact on DNA and cellular formation. This breakthrough could lead to significant advances in diagnosing and treating genetic disorders and certain cancers.
A recent study examined the intubation decision-making process of 73 hospital-based doctors from three academic medical centers. The researchers found that mental models of doctors who deviated from patient preferences focused on reversibility, inferred consent, and comfort levels. This variation highlights the need for well-structured...
D'Angelo will investigate the role of altered nuclear pore complexes in blood cell malignant transformation and cancer. His research may lead to better treatments and potentially cures for leukemia.
Researchers have imaged ATR kinase protein at unprecedented resolution using electron microscopy, revealing regulatory sites poised to activate in response to DNA damage. The high-resolution structural information may aid in developing new therapeutics for cancer treatments and improving cellular health.
A study found that microRNA-31 accelerates intestinal stem cell growth, potentially leading to bowel cancer. The molecule's levels increased after radiation exposure, suggesting a role in regeneration, while also promoting tumor growth.
Researchers investigate pretreatment with etanercept to manage post-treatment inflammation in neurocysticercosis, a major cause of epilepsy worldwide. Etanercept suppresses inflammatory pathways involved in treatment-induced inflammation.
The study found that urban American-Indian and Alaskan Native individuals had a higher risk of mortality from prostate and breast cancer, with AIANs facing an 87% increased risk for prostate cancer-specific mortality. The community's unique history of social and environmental injustices may be contributing to these disparities.
A recent study published in Cancer journal shows that communities with strong smoke-free workplace laws have lower rates of new lung cancer diagnoses. The study found an eight percent reduction in lung cancer incidence in communities with strong smoke-free laws compared to those without such laws.
Researchers have discovered a molecular commonality between two progeroid syndromes and introduced a method for disease recognition that could lead to breakthroughs in therapy. By characterizing disruptions in DNA replication timing, the team identified a shared abnormality in the gene TP63.
A team of scientists led by Johns Hopkins University biologist Vincent Hilser has cracked the mystery of proteins that emerged as a distinct type less than 30 years ago. They discovered how these 'intrinsically disordered proteins' regulate their activities and interact with other proteins, constituting the majority of proteins involve...
Researchers at UVA Cancer Center are developing a tool to assist patients in making treatment decisions based on their tumor's genomic information. The tool aims to provide personalized comparisons of treatment options, incorporating factors like age, personal priorities, and health conditions.
Researchers developed tiny robots measuring a few millionths of a metre long that can diagnose and treat illness in hard-to-reach areas. The robots could track chemical changes linked to illness onset and deliver targeted drugs with high precision, potentially paving the way for new diagnostic and therapeutic approaches.
Researchers at NIST developed a novel method for measuring tumor growth using disposable diapers as 'phantoms' with water. Volumetric measurement proved more accurate than the traditional RECIST approach, potentially enabling earlier and more effective cancer screenings.
A recent study found that approximately one-fifth of cancer patients develop PTSD several months after diagnosis. Researchers emphasize the need for early identification and treatment to improve psychological well-being and quality of life.
A subset analysis of the FLAURA trial found that osimertinib improved progression-free survival by 16.5 months compared to 11.0 months with standard therapy in Asian patients with EGFR-mutated non-small-cell lung cancer, resulting in a hazard ratio of 0.54.
A new project led by Queen Mary University of London aims to develop and test a talking-based therapy for cancer survivors, addressing issues such as fatigue, fear of recurrence, and concerns about returning to work. The therapy, Acceptance and Commitment Therapy (ACT), will be assessed in a full trial involving 344 participants.
Ludwig Cancer Research researchers will present findings on cancer cell metabolism, tumor microenvironment, and potential therapeutic targets. They will also discuss the use of immunotherapy to treat brain cancer, including results from a Phase 2 clinical trial.
A high dose of hydroxyurea significantly increased fetal hemoglobin levels and reduced hospitalizations among young sickle cell anemia patients. The study found that maximizing the dose resulted in a substantial reduction in hospitalizations, with nearly all patients experiencing improved health outcomes.
The summit brought together experts to define endoscopic therapies in obesity management and reframe the debate around obesity as a chronic disease. Key findings include the need for public health measures, reduced stigma, and increased collaboration among medical specialties.
Cristina Lo Celso, a rising star in biomedical research, has been awarded the Foulkes Foundation Medal for her groundbreaking work on leukemia. Her research focuses on understanding how leukaemia cells develop and relapse, with the ultimate goal of improving treatments and preventing disease recurrence.
A new study found significant disparities in survival rates for patients with different types of human papillomavirus (HPV)-associated cancers. The findings highlight the need for improved HPV vaccination, cancer screening, and treatment access to address these disparities.
A new study found that antidepressants are ineffective in treating depressed patients with chronic kidney disease, prompting experts to reconsider treatment approaches. Alternative therapies such as ketamine, electroconvulsive therapy, and psychotherapy may be more effective for these patients.
The European Society for Medical Oncology advocates for a unified and comprehensive cancer research program across Europe. Key findings include the urgent need for integrated cancer research, diagnosis, and treatment targets.
Chronic hepatitis B and C cause life-threatening liver damage, cancer, and premature death, with 300 million infected worldwide. Donors are essential to deliver results in the next 13 years, as domestic funding is unlikely to meet the challenge.
A new article proposes a virtual European Cancer Institute to combine innovative prevention and treatment strategies, achieving high survival rates in countries with well-developed healthcare systems. The initiative aims to address economic and social inequalities in less developed systems
A recent study by UNC Lineberger Comprehensive Cancer Center researchers found that more than half of men with prostate cancer prefer preserving sexual function, but this preference was not strongly linked to the choice of treatment strategy. Active surveillance is widely recognized as the best option for preserving sexual function, ye...
Scientists have developed intelligent nanoparticles that can heat cancer cells to a high temperature, but then self-regulate and lose heat before causing harm to healthy tissue. This breakthrough could lead to a more effective treatment method for cancer patients.
The Society of Nuclear Medicine and Molecular Imaging (SNMMI) has published appropriate use criteria (AUC) for FDG PET/CT imaging in cancer patients. The AUC aims to improve the utilization of this technology and provide guidance for providers across specialties.
Gender disparities are identified in lung cancer screening and care, with more female patients meeting high-risk criteria but not completing low-dose CT scans. Language barriers do not delay initiation of lung cancer care, according to a second study.
The study found that the uninsured rate for adults with new cancer diagnoses decreased from 5.73% to 3.81% in 2014, a gain of 1.92 percentage points across multiple cancers and demographic groups. Coverage gains were particularly significant for Hispanic individuals and those with early- or late-stage disease.
Researchers at UC San Diego found mutant p53 amplifies inflammatory responses in cancer cells, increasing invasive behavior and tumor growth. Chronic inflammation plays a crucial role in predisposition and progression of human cancers like colon and breast cancers.
The study found that loss of PTEN leads to high levels of PI(3,4)P2, which could result in hyperactivation of AKT, a key regulator of cell growth. This discovery may help identify patients who will benefit from targeted therapies.
A new gene expression profiling assay has been developed to enhance the diagnosis and treatment of non-Hodgkin lymphoma, particularly diffuse large B-cell lymphoma. The assay can differentiate between three major subtypes associated with different outcomes, including germinal center B-cell-like and activated B-cell-like subtypes.
Dr. Michael Keidar, a George Washington University professor, received the award for his groundbreaking research on cold plasma application in cancer therapy. His work demonstrated progress in creating cold plasmas and their applications to cancer therapy procedures.
A new Cleveland Clinic study emphasizes the significance of prompt treatment in stage I melanoma, with patients treated within 30 days showing better survival rates. Delayed treatment beyond 90 days led to significantly worse outcomes, especially among older patients and those with comorbidities.
Researchers confirmed IASLC's proposed criteria for uncertain resection margin status (R(un)) have a prognostic value between R0 and R1. The study analyzed data from 14,712 patients and evaluated the impact of various factors on survival.
A study published at the International Association for the Study of Lung Cancer (IASLC) conference found that biopsy specimens are a reliable material for evaluating DLL3 expression in small cell lung cancer. High levels of DLL3 expression were correlated with poor survival trends, smoking history, and neuroendocrine differentiation.
A new study found that insurance disparities account for a substantial proportion of the excess risk of death from breast cancer faced by black women. Improving access to care could address much of the existing black/white disparity in breast cancer mortality.
Researchers at RIKEN discovered a way to prevent liver cancer spread by treating with a modified fucose sugar. The treatment disrupts biological pathways, blocking hepatoma cells from invading healthy liver cells and suppressing migration, but not proliferation.
A clinical trial led by Medical University of South Carolina is investigating frankincense as a possible treatment for breast and colon cancer. The study aims to assess whether boswellic acid, an extract from Indian frankincense, can reduce inflammation and slow tumor growth.
Significant declines in sperm counts among men in Western countries are alarming, with a 52% fall between 1973 and 2011. The research highlights the need for further investigation into the causes of these trends, which may be linked to exposure to endocrine-disrupting chemicals.
A University of Texas at Arlington bioengineering professor and her team will integrate a portable brain imaging system with an advanced signal-processing technique for newborns. This project aims to provide real-time analysis needed to treat encephalopathy or brain swelling more quickly, saving the lives of sick babies.
Two new studies evaluate the safety and effectiveness of endoscopic submucosal dissection (ESD) and liquid nitrogen spray cryotherapy (LNSCT) in treating Barrett's esophagus. ESD was found to have high en-bloc and curative resection rates, while LNSCT showed long-term efficacy in eliminating dysplasia and intestinal metaplasia.
UC Davis researcher Sean Collins receives $1.5M NIH award to develop smart immune cells that can control their recruitment and response to tumors without amplifying attack signals, reducing potential side effects. The goal is to create targeted therapies with controlled responses.
A recent study has identified 150 genetic drivers of diffuse large B cell lymphoma, a common form of blood cancer. The research, led by Duke Cancer Institute scientists, found correlations between specific genes and treatment responses, opening up new avenues for targeted therapies.
Researchers found that cancer cells 'recharge' by transferring power-generating mitochondria from healthy bone marrow cells, supporting leukaemia growth. Inhibiting a specific enzyme reduced mitochondrial transfer and slowed cancer growth.
Researchers at Lund University have identified a new class of fusion genes that primarily affect microRNA activity, which may help in developing cancer treatment and diagnostics. The study re-analyses existing data and highlights the importance of studying non-coding gene components.
A new study found that delays in melanoma surgery are common among Medicaid and privately insured patients, highlighting the need for better access to specialty care. The likelihood of surgical delay decreased when dermatologists performed operations or made diagnoses.
Researchers report on a new dosing regimen for actinium-225 labeled targeted alpha therapy, showing promising anti-tumor response in patients with PSMA-positive tumors. The treatment protocol balances treatment response with toxicity concerns to provide effective therapy with minimal side effects.
The Hastings Center Report examines ethical dilemmas in global health, including resource sensitivity, physician-assisted death and parental authority. The case for providing cheaper, less effective treatments to promote health and realize ethical values is presented.
Plastic surgeons at Maastricht University Medical Center used the Microsure robotic device to perform a super-microsurgical intervention on a patient's lymphedema, the world's first of its kind.