Articles tagged with Cancer Treatments
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Researchers found HPV16 antibodies develop in body between 6-40 years prior to throat cancer diagnosis, increasing risk significantly. The presence of these antibodies indicates a strong increased risk of disease, particularly among white people, with an estimated 100-fold increase compared to black people.
The number of cancer survivors in the US is projected to increase to over 22 million by 2030 due to a growing and aging population. The American Cancer Society reports that 68% of cancer survivors were diagnosed five or more years ago, highlighting the need for proactive assessment and management of their unique medical needs.
A prospective study found that higher levels of abdominal and thigh fat are associated with an increased risk of aggressive prostate cancer. Men with a lower BMI showed a stronger association between visceral fat and advanced prostate cancer. Lifestyle interventions, such as diet and exercise, may also reduce the risk of prostate cancer.
The use of mini-organs from tumors and healthy tissue in cancer research has been explored, revealing their potential in studying tumor development and testing existing and new therapies. This innovative approach holds promise for improving cancer treatment outcomes and advancing personalized medicine.
A study published in Blood found that slower walking pace is strongly associated with poorer outcomes in older adults with blood cancers. Gait speed was found to be an independent predictor of death even after adjusting for other factors, highlighting its potential as a tool to tailor care.
Berkeley Lab scientists develop faster technique to purify elements, opening door to faster discovery of new elements and easier nuclear fuel reprocessing. The method achieves separation factors many orders of magnitude higher than current state-of-the-art methods, reducing contaminants and increasing efficiency.
A molecule called LL-37 has been found to boost the function of dendritic cells, which are used in cancer therapy. This improvement could lead to more effective treatments by increasing the success rate of dendritic cell-based therapies.
SORLA promotes HER2 receptor recycling and cancer cell proliferation. Removing SORLA from HER2 positive cancer cells inhibits tumor growth and formation.
A new laser-based method can double the energy of a proton beam produced by particle accelerators, enabling more compact and affordable equipment for cancer treatment. The technique involves colliding two less intense laser pulses to create highly charged protons with higher energy levels.
A study published in JNCI has identified hnRNP K as an oncogene that may cause B-cell lymphomas. The overexpression of this tumour suppressor gene was found to promote the development of cancer, leading to poor recovery and low survival rates for patients.
York University researchers have identified novel genes that play a crucial role in regulating muscle cell differentiation and growth. The study found that Smad7 and β-catenin proteins work together to control the pathway for normal gene expression, resulting in normal skeletal muscle cells.
A study found that female mice replace their entire set of hormone-producing cells within 3 months, while it takes male mice 9 months. This sex-specific difference could lead to sex-specific treatments for diseases like adrenal cancer.
A study published in CANCER journal found that sexual minority cancer survivors, especially female survivors, experience poor access to medical care and lower quality of life. This disparity is linked to poorer physical and mental well-being, as well as decreased survival rates compared to heterosexual counterparts.
A new clinical trial has shown that partial breast irradiation produces similar long-term survival rates and risk for recurrence compared to whole breast irradiation for many women with low-risk, early stage breast cancer. The study found a 4.6% recurrence rate for partial breast irradiation and a 3.9% rate for whole breast irradiation.
Graduates can expect to earn nearly £670,000 more over their working life due to SES education. SES research is vital to tackling global health challenges like obesity, diabetes, and cancer.
Researchers have developed a novel compound that specifically targets the endoplasmic reticulum stress response in cancer cells, promoting apoptosis and inhibiting tumor growth. The compound can be precisely activated by UV irradiation and emits fluorescence, allowing real-time tracking of its activity.
Researchers developed cell membrane-coated nanocarriers to overcome immune clearance and biotoxicity issues. These biomimetic hybrids achieve improved biocompatibility, circulation time, and therapeutic efficiency.
Abnormal chromosome number abnormalities are linked to increased risk of lethal disease in prostate cancer patients. Patients with five or more predicted aneuploidy alterations had a 5.3 times higher odds of lethal cancer during follow-up.
A new study found that children with inflammatory bowel disease, including ulcerative colitis and Crohn's disease, have a higher risk of developing cancer and dying early compared to the general population. The study suggests that cancer surveillance and mental health assessment are crucial for young patients with these conditions.
Researchers at Uppsala University found that inhibiting ribosome biogenesis can revert aggressive tumors to a non-invasive state, potentially regaining sensitivity to hormonal therapy. The study also showed a marked reduction in lung metastases.
A large study found that HER2 expression can predict DCIS recurrence and progression, enabling targeted treatments for high-risk patients. By screening DCIS patients for HER2, doctors can minimize the chance of recurrence or spread in lower-risk patients.
A study of 429 men with metastatic castration-resistant prostate cancer found correlations between specific genetic alterations and clinical outcomes. The loss of the RB1 tumor suppressor gene was significantly correlated with poor survival in patients treated with androgen receptor signaling inhibitors.
A new nomogram developed by researchers can accurately predict the likelihood of occult lymph node metastases in esophageal cancer. This tool may help clinicians identify high-risk patients who would benefit from neoadjuvant therapy, leading to more informed treatment discussions and potentially improved patient outcomes.
A study by Johns Hopkins Medicine and partners found that a simple performance evaluation letter can reduce unnecessary tissue removal in Mohs micrographic surgery for skin cancer. The intervention led to an improvement in surgical behavior, sustained for one year, with 83% of notified physicians reducing their practice.
Researchers found a truncated variant of the p53 protein, Δ40p53, forming amyloid aggregates in endometrial cancer cells. This finding promises new perspectives for treating Type 2 endometrial cancer, the most aggressive form of the disease.
Researchers have identified four hallmarks of cancer metastasis: motility, modulation of the microenvironment, plasticity, and ability to colonize. This understanding could lead to the development of new therapeutic interventions for this complex process, which is responsible for up to 90% of cancer deaths.
Researchers found that repeated detection of HPV DNA in oral rinses after cancer treatment was associated with a higher risk of cancer recurrence and death. The study suggests HPV DNA may be a promising biomarker for understanding cancer treatment response and future risk of progression.
Researchers at CNIO describe the RUVBL1-RUVBL2 ATPases as the 'energy engine' in the co-chaperone R2TP, regulating access to ATP for energy production. The study found a gate-like structure in RUVBL2 that controls energy exchange, coupled to the assembly of mTOR complexes.
The number of cardiologists trained in cardio-oncology is not meeting the growing needs of cancer survivors, who are aging and developing co-morbid cardiovascular disease. Limited training programs and resources are emerging to address this need, highlighting the importance of collaboration between cardiologists and oncologists.
A pilot program investigates human-animal interactions (HAIs) in reducing suffering of children with cancer undergoing debilitating treatments. Children are randomly assigned to a group receiving usual care or a group receiving HAI plus therapy dog visits.
Researchers at H. Lee Moffitt Cancer Center discovered a signaling pathway between cytokines and BRAF that promotes tumor growth. Blocking ITCH activity or BRAF ubiquitination may be an effective treatment approach to slow tumor growth in melanoma.
A deep-learning model developed using serial image scans of tumors from patients with non-small cell lung cancer (NSCLC) predicted treatment response and survival outcomes better than standard clinical parameters. The model's performance improved with the addition of each follow-up scan, predicting two-year survival with an accuracy of...
The article discusses the potential of liquid biopsy in cancer diagnosis, focusing on targeted disease diagnosis and detection of cancer biomarkers. Researchers have successfully detected specific genetic mutations using digital PCR, identifying promising biomarkers for various cancers, including melanoma and lung squamous cell carcinoma.
Researchers identified UNC45A as a key player in cancer cell proliferation and tumor growth. Inhibiting UNC45A was found to decrease cancer cell proliferation and cause mitotic catastrophe, leading to cell death.
Researchers have discovered that amplifying the amount of VGLL3 in skin cells pushes the immune system into overdrive, leading to autoimmune responses. This finding may help explain why women are more likely to develop autoimmune diseases like lupus and could lead to new treatments.
Scientists identified a molecular driver of glioblastoma, a highly aggressive and treatment-resistant brain cancer, by analyzing cell-by-cell genetic data. Researchers found that reprogramming primitive oligodendrocyte progenitors into stem-like cells plays a key role in glioma initiation and progression.
A new study investigates the Auger effect in aromatic hydrocarbons, revealing that molecules with pi electrons have a lower double ionization threshold. This finding favors Auger decay over saturated hydrocarbons, with potential applications in cancer treatment and atomic identification.
Research shows that branched actin transmits information to cells about their environment and regulates growth, a mechanism that can be targeted to fight certain types of cancer. Inhibiting branched actin formation prevents the growth of melanoma cells, offering new therapeutic options.
Researchers have developed a gene editing approach that corrects over 80% of patient cells, targeting the COL7A1 gene mutation responsible for recessive dystrophic epidermolysis bullosa. The technique shows promise for treating this rare disease with high efficiency and safety.
A new study has revealed a previously unknown interaction between proteins that causes certain types of cancer called sarcoma. The research, led by Pierre Åman, found that tumor-altered FET proteins bind to the SWI/SNF complex, leading to misregulation and disruptions in genetic programming.
Scientists at the Institut Pasteur have identified a cellular protein that can degrade hepatitis B virus DNA, potentially leading to a 'Trojan horse' approach to target infected liver cells. This discovery offers new hope for developing curative treatments for chronic HBV infection.
Rising liver cancer death rates in the US are largely confined to individuals with lower educational attainment, particularly men. The study highlights the need for targeted efforts to address the growing burden of liver cancer in lower socioeconomic groups.
Scientists developed a new imaging technology to visualize what cells eat, such as glucose, which could aid in the diagnosis and treatment of diseases like cancer. The technique uses chemical probes that light up when they attach to specific molecules consumed by cells.
A new study found that continued smoking by patients with cancer adds significant costs to subsequent cancer treatment. The analysis conservatively suggests a total of nearly $11,000 in increased treatment costs for each smoking patient after their initial cancer treatment fails.
A study published in JAMA Network Open found that continued smoking after a cancer diagnosis increases the risk of cancer treatment failure and adds $11,000 to treatment costs per patient. The research estimates $3.4 billion in national additional cancer treatment costs if patients continue to smoke.
A recent commentary suggests that treatment guidelines recommended by medical specialist organizations are more likely to lead to overdiagnosis, overtreatment, and increased healthcare costs. The authors argue that specialty bias and fee-for-service compensation models contribute to this issue.
Researchers have unraveled the three-dimensional structure of ATP citrate lyase (ACLY), a central metabolic enzyme crucial for fatty acid and cholesterol production. The study's findings provide new insights into ACLY's role in metabolism, evolution, and potential therapeutic targeting of cancer and metabolic diseases.
Researchers found that chronic morphine treatment decreased survival in control mice, but not in sickle mice with sickle cell disease. Chronic opioid therapy also caused hyperalgesia, a condition of increased pain sensitivity, in sickle mice. The study suggests that opioids may still be effective for managing pain in SCD patients despi...
Lauren Sciences LLC has received an AU$1 million grant from FightMND to advance its development of LAUR-301, a novel V-Smart Nanomedicine for ALS. The therapy aims to protect motor neurons and induce neuro-restoration, slowing or reversing the disease.
A study of almost 276,000 children found a small association between IVF conception and an increased risk of childhood cancer, mostly rare tumor types. The link was limited to the first decade of life and was found in only a subset of cancers.
The Cancer Control and Survivorship Program at St. Jude Children's Research Hospital has been awarded the 13th annual AACR Team Science Award for its innovative research advancing childhood cancer treatment and long-term survival outcomes. The program's work has significantly contributed to our understanding of pediatric cancer epidemi...
Scientists found that current WHO guidelines for chronic hepatitis B fail to detect 50% of patients in need of treatment in Ethiopia. The guidelines are based on European and American data, highlighting the need for regionalized approaches to identify patients with significant liver disease.
Researchers at the Garvan Institute of Medical Research have developed a new diagnostic method that screens cancer samples for 'fusion genes', which are linked to one in five cancers. The test identifies 20% more fusion genes than current methods, potentially leading to personalized treatments.
A preclinical study found that combining CAR T-cell therapy with photothermal ablation suppressed melanoma tumor growth for up to 20 days in mice. Among the treated mice, 33% remained tumor-free after 20 days.
A new study shows that uterine fibroid embolization (UFE) is as effective as surgical treatment in treating uterine fibroids, with fewer post-procedure complications. UFE preserves the uterus and allows women to return to their normal lives sooner.
The study found that the percentage of younger women initiating bisphosphonate treatment decreased over the 12-year period, while older women and those with osteopenia or osteoporosis increased. The overall percentage of osteoporosis among white and Asian women also rose.
Researchers have developed a more precise gene-editing technique to reduce DNA breaks and prevent cancer in stem cells. This breakthrough could improve the safety of CRISPR treatments for inherited blood disorders.
A recent study by Cancer Research UK reveals that African-American cancer patients with inherited red blood cell conditions are 20% more likely to experience serious adverse events. This disparity may be attributed to the rigors of therapy and the disproportionately higher incidence of these disorders in the African-American population.
A new study found that keeping blood pressure around 130 mm Hg for three years significantly reduced the accumulation of harmful brain lesions compared to maintaining a higher systolic blood pressure. This reduction also led to fewer major cardiovascular events, such as heart attacks and strokes.
Guidelines issued by North American specialty societies recommend health services linked to their specialties, differing from European guidelines. This phenomenon, known as 'specialty bias,' may exacerbate healthcare costs and worsen patient outcomes.