The COVID-19 pandemic has accelerated the development of vaccines using advanced technologies like reverse vaccinology and synthetic biology. These innovations could help address other pressing health challenges such as antimicrobial resistance and cancer.
Researchers found that exposure to acrolein, a chemical produced by tobacco combustion, increases cardiovascular disease risk; Higher levels of toxic chemicals were detected in tobacco smokers than marijuana only smokers. The study suggests reducing acrolein exposure could lower risk.
A team of specialists developed an award-winning 4D simulator technology to train neurosurgeons and reduce complications during brain aneurysm surgery. The simulator accurately models blood vessels, pulse, and flow, enabling enhanced planning and pre-op practice.
Mutations in the ARID1A gene increase glutamine metabolism in ovarian cancer cells, which can be blocked to target ARID1A-mutant tumors. Glutaminase inhibitors like CB-839 show promise as a standalone or combination therapy for clear cell ovarian carcinoma.
Scientists have created a new method for combating non-Hodgkin's lymphomas by equipping immune cells with an antenna that targets the CXCR5 receptor on cancer cells. In laboratory experiments and mouse models, this approach showed promising results in fighting follicular lymphoma and chronic lymphocytic leukemia.
A new study by FAO and University of Twente reveals that small cities and towns play a significant role in shaping food systems, social development, and economic growth. The research highlights the need for greater coordination between urban and rural administrative authorities to address unequal access to services and employment oppor...
Researchers found that high cortisol concentrations in newborn fawns were associated with lower survival rates. Cortisol levels varied between study areas, suggesting other environmental factors may influence mortality rates.
A new study from Beth Israel Deaconess Medical Center finds that COVID-19 has led to a significant increase in cardiac deaths in the US, with a 11% rise in ischemic heart diseases and a 17% rise in hypertensive diseases compared to the previous year
A new design concept aims to increase laser peak power by compressing pulse duration instead of increasing energy, pushing the record to the Exawatt class. The design uses a two-beam pumped WNOPCPA and carefully optimized phase-matching to avoid pump interference.
Researchers have identified and characterised a new strain of Leishmania parasite to form the basis of a controlled human infection model. The study aims to accelerate vaccine development for this life-threatening disease, which causes slow-to-heal skin ulcers and has no current vaccines or effective treatments.
A study investigated the correlation between ADC parameters, Ki-67 expression, and clinical outcomes in PCNSL patients. In immunocompetent patients, ADC histogram analysis predicted tumor proliferation and survival. However, in HIV-positive patients, ADC values showed limited utility in predicting clinical outcomes.
Rutgers-led research found coral reef fish larvae dispersal varies significantly over time and seasonally. This variability affects population estimates and conservation strategies, highlighting the need for more nuanced studies on dispersal patterns.
A new approach involving specially trained nurses increased ACP discussions with patients, documenting it in 42% of visits compared to 3.7% in normal care groups. The nurse-led group used an electronic health record tool to guide the conversation and document patient goals.
Research reveals a strong relationship between anthropogenic heat flux and extreme temperature events, including both heat and cold extremes. The study, conducted in Beijing, China, uses advanced modeling techniques to analyze the impact of urbanization on temperature records.
A massive community-based testing blitz in San Francisco found that COVID-19 infections disproportionately affect the city's Latinx low-income workforce, with 79% of positive results coming from this demographic. The study emphasizes the need for targeted strategies to address the ongoing pandemic and support vulnerable communities.
Researchers found that osteoporosis drug denosumab can protect patients from osteolysis, reduce the need for re-operations and decrease the health burden of this disease. This could lead to a significant reduction in the number of repeat hip replacement operations.
Recent research suggests that traditional entrepreneurship education may not be effective in motivating students to pursue entrepreneurial careers. A new study by two researchers found that students' life goals play a crucial role in their decision-making process regarding entrepreneurship. By facilitating an understanding of these lif...
Researchers discovered that invasive brown tree snakes on Guam can use a novel, lasso-like locomotion to climb smooth vertical cylinders. This new mode of locomotion has important implications for understanding the snakes and conservation practices aimed at protecting birds from them.
Researchers at NC State University developed a framework to predict organic solar cell stability using elastic modulus and glass transition temperature. The most stable cells contain highly rigid materials with low miscibility, resulting in reduced diffusion and increased stability.
Researchers found that individuals who enjoyed zombie and apocalyptic movies before the pandemic were better equipped to deal with it. Immersing oneself in fiction can serve as mental rehearsal for real-life events, according to the study published in Personality and Individual Differences.
A new study by Stanford researchers reveals that climate change has substantially contributed to the growing cost of flooding in the US. The analysis, published in Proceedings of the National Academy of Sciences, found that changes in precipitation accounted for 36% of actual flood damages from 1988 to 2017.
Research suggests that COVID-19 severity may be influenced by the composition of the gut microbiome, with certain bacteria contributing to inflammatory responses. The study found that patients with COVID-19 had altered gut microbiota compared to healthy individuals, including lower levels of beneficial species.
Researchers developed a novel, patient-derived model of ulcerative colitis to identify promising targets for new treatments. The model showed that inhibiting CXCL8 expression slowed disease progression.
Scientists at TU Graz have identified a bacterium inside the seed of rice plants that can lead to complete resistance to a particular pathogen. The bacterium, Sphingomonas melonis, produces an organic acid that inhibits the pathogen and renders it harmless.
The American Academy of Arts & Sciences and The MIT Press have announced that Daedalus, Journal of the American Academy, will now be an open access publication. This move makes hundreds of previously inaccessible essays freely available to audiences worldwide.
Astronauts on long-duration missions face nutrient deficiencies from dehydrated food; Ying Diao's research uses wearable sensors to monitor plant stress and optimize growth conditions. The technology has potential applications beyond space exploration, including addressing climate change by helping plants adapt to changing environments.
Researchers developed saliva-based testing as a sensitive alternative to nasal swabs. High demand for PPE revealed society's dependence on forced labor during the pandemic. No association was found between COVID-19 mitigation strategies and risk of preterm births or stillbirths. A new case report suggests a potential link between SARS-...
Researchers at the University of Bath developed a sustainable polymer using xylose, with applications in polyurethane, bio-medicine, and batteries. The polymer's properties can be easily controlled to make it flexible or crystalline.
Researchers at Rice University have successfully created metastable metallic nanoparticles from dichalcogenides, which can be used in electronics and optics. The process involves applying a high electrical charge to rapidly raise the material's temperature, producing a new class of highly valued materials.
A new study suggests that Dense Breast Notifications (DBNs) have achieved partial success in informing women about their breast density, with higher rates of notification and discussions with providers in states with mandated DBN laws. However, the study also found disparities in knowledge and awareness among women of different race/et...
The American College of Physicians (ACP) has released a comprehensive framework to address disparities and discrimination in healthcare, proposing policy recommendations to enhance quality and effectiveness for all patients. The framework also discusses specific contributors to health disparities and steps to improve them.
A large-scale international study found strong associations between specific gut microbes, dietary habits, and cardiometabolic disease risk. Participants who consumed a healthy, plant-based diet had higher levels of beneficial gut microbes.
Researchers have discovered how Staphylococcus aureus binds to human corneocytes in atopic dermatitis, providing new insights into the development of targeted treatments.
A team of UT Southwestern researchers has identified the gene ZMYND8 as being increased in breast cancer conditions and correlating with poor survival rates. The gene regulates DNA stability and inhibits antitumor immunity, but removing or inhibiting it allows lymphocytes to invade tumors and prevent growth.
A study found that nonnative birds in Oahu, Hawaii, dominate seed dispersal networks, with most seeds coming from nonnative plants. This shift has significant implications for the island's ecosystems and biodiversity.
Researchers analyzed COVID-19 hospitalization trends in 22 states to assess severity and spread of the virus in pediatric population. The study found significant variations in hospitalization rates across states, highlighting the need for targeted interventions to prevent further transmission.
Researchers have developed a new optical neural network that can process large-scale data and images at incredible speeds, surpassing electronic computing hardware. This innovation has the potential to transform artificial intelligence in applications such as image recognition, medical diagnosis, and real-time video analysis.
This special issue of Acta Pharmaceutica Sinica B investigates the impact of tumor microenvironment on drug delivery systems for cancer treatment. Featured papers discuss various strategies to enhance specificity, target tumor-associated macrophages and manipulate immune-vascular crosstalk.
A study of potential jurors found they are more favorable towards physicians who accept standard AI medical recommendations. The study suggests the threat of legal liability may be smaller than commonly thought, influencing physician behavior and AI adoption.
Researchers at Northwestern University identified critical targets to treat severe COVID-19 pneumonia and lessen its damage. The study suggests macrophages can be infected by SARS-CoV-2, contributing to the infection's spread.
A study reveals systemic gender and racial inequities in US chemistry graduate programs, leading to lower retention and completion rates for underrepresented groups. Inadequate financial support and poor peer interactions also hinder career aspirations.
Researchers developed a new way to generate tough, functional materials using a mixture of bacteria and yeast, producing cellulose embedded with enzymes that can sense environmental pollutants. They also incorporated yeast directly into the material, creating 'living materials' for purifying water or detecting damage.
Researchers at Washington State University have identified biomarkers in fathers' sperm that are linked to an increased risk of their children developing autism. These epigenetic markers can be detected with high accuracy and may help diagnose the condition, as well as identify environmental factors that contribute to its development.
The study found PD-1 lymphocytes more frequent in high-grade anal dysplastic lesions and CD8 lymphocytes in HSIL versus LSIL. The presence of PD-L1 epithelial cells showed no difference between high and low-grade lesions.
A study published in PLOS ONE found that people who pursue meaningful activities during lockdown feel more satisfied, while those who engage in mindless busywork experience increased frustration and less fulfillment. Researchers suggest that substituting enjoyable activities for the pre-lockdown routine can be a more rewarding experience.
A team-based approach to treating opioid use disorder with community pharmacists shows promise in improving medication adherence and participant satisfaction. The study found nearly 90% of participants remained in the program and 95.3% adhered to their daily medication regimen.
Engineered living materials (ELMs) are created using a symbiotic combination of yeast and bacteria, similar to those found in kombucha SCOBY. These ELMs can detect and filter contaminants in water, packaging, and act as 'living photographs' displaying projected images.
A UMass Lowell researcher has received a $700,000 NIH grant to explore the effectiveness of virtual reality-based rehabilitation for young people with traumatic brain injuries. The therapy aims to improve cognitive functioning and enhance quality of life for these patients.
Researchers at the University of Houston have developed a new 3D zinc-manganese nano-alloy anode that allows for fast charging and is stable without degrading. The anode uses seawater as an electrolyte, lowering battery cost, and has been tested to last up to 1,000 hours under high current density.
Researchers discovered that face-sensitive neurons in humans reactivate with the same unique pattern when viewing and remembering a face. This finding has significant implications for understanding human facial recognition and processing.
Researchers improved understanding of intestinal stem cells' renewal and differentiation into specialized cell types. They identified a specific Wnt/planar cell polarity pathway regulating intestinal stem cell self-renewal and lineage decisions, crucial for treating diseases like diabetes and colorectal cancer.
A study published in JAMA Network Open found that associate clinicians performed inguinal hernia operations safely and effectively, with fewer cases of recurrence compared to medical doctors. The research suggests task sharing as an attractive option to expand surgical services in low-income countries.
A recent study published in Cancer reveals that having multiple oral sex partners and engaging in high-intensity sex at a younger age significantly increase the likelihood of developing HPV-related oropharyngeal cancer. The research also found that older sexual partners and extramarital relationships are associated with higher risk.
A team of Virginia Tech scientists has identified a new link between seizures and connexin 36 deficiency in zebrafish models. The study found that connexin 36 deficiency altered the susceptibility to neuronal hyperactivity, which may contribute to the onset of subsequent seizures.
Researchers from NANOGrav used Arecibo Observatory and Green Bank Telescope to study pulsar signals, detecting minute changes in Earth's position possibly due to gravitational waves. The findings provide new insights into the universe and expand knowledge of gravity beyond current limits.
Research reveals that aerosol-generating procedures like fillings and root canal treatment can spray aerosol particles large distances, contaminating areas up to 5 meters away. The study found that dental suction decreases contamination, making it a suitable time to clean surgeries after procedures.
Recent studies document striking patterns of insect biodiversity loss, with many populations decreasing at annual rates of 1-2% a year due to human activities such as agriculture. However, some species are increasing in abundance and geographic distribution in temperate and Arctic areas.
Researchers on the North American Nanohertz Observatory for Gravitational Waves (NANOGrav) project have detected a strong signal in their dataset, but cannot yet confirm it as the gravitational wave background. The team is hoping to pinpoint the source of the signal and gain insights into the universe through this discovery.
A large-scale international study found a panel of 15 gut microbes associated with lower risks of common conditions. Diets rich in healthy foods encourage the presence of these beneficial microbes, which are linked to improved health outcomes.
Physicists at Princeton University have observed quantum oscillation in an insulator, a phenomenon typically seen in metals. The discovery hints at the existence of neutral fermions and challenges the long-held distinction between metals and insulators.