Articles tagged with Cancer Treatments
A new study by NYUAD researchers demonstrates a small molecule protein mimetic can reactivate the tumor suppressor protein p53, which is often mutated and deactivated in cancer. The treatment effectively shrinks tumors and prolongs survival with no noticeable toxicity to healthy tissue.
A new multiplex technique developed at Goethe University Frankfurt allows simulating millions of genetic defect combinations and studying their effects in cell culture. This enables the identification of genes involved in cancer and other complex diseases suitable as targets for therapies.
A recent EULAR study found that treatment with tumor necrosis factor inhibitors can slow the progression of radiographic sacroiliitis in patients with axSpA. This effect becomes apparent 2-4 years after treatment initiation, according to the research.
Foresight Diagnostics is presenting its proprietary PhasED-Seq technology at ICML for improved minimal residual disease (MRD) detection rates in diffuse large B-cell lymphoma (DLBCL) patients. The technology has been shown to detect relapsing disease 200 days earlier than current methods.
A team of researchers has developed a combined imaging and machine learning technique that can measure glycolysis in single endothelial cells, revealing a new mechanism of glucose transport. This breakthrough could lead to better treatments for cancer, vascular diseases, and COVID-19.
Researchers engineered NK cells to resist immune suppression and eliminated glioblastoma stem cells using inhibitors targeting TGF-β receptors. The study suggests a combinatorial approach of NK cell-based immunotherapy with disruption of the TGF-β signaling axis for treating glioblastoma.
A new therapy has been shown to reduce amyloid beta plaque deposits and toxic tau levels in elderly monkeys' brains, slowing neurodegeneration. The treatment also improved cognitive function in the monkeys, suggesting its potential as a therapeutic approach for Alzheimer's disease.
Researchers discovered that cancer cells hijack an ageing gene to block environmental factors and gain a competitive advantage over healthy stem cells. The study's findings suggest that blocking the function of this enzyme could lead to new therapies for patients predisposed to intestinal cancers.
Andrea Ablasser is awarded the EMBO Gold Medal 2021 for her groundbreaking research on how cells recognize double-stranded DNA as a danger signal. Her work may pave the way for therapeutic opportunities for inflammatory conditions and cancer treatment.
A convolutional neural network-based algorithm predicts tumor mutational burden-high (TMB-H) colorectal cancer response to immunotherapy. The model uses histopathological characteristics, particularly tumor-infiltrating lymphocytes, from hematoxylin and eosin-stained slides.
The National Pharmaceutical Regulatory Agency of Malaysia has granted conditional registration to a new hepatitis C treatment combination developed through public-private partnership. The treatment, ravidasvir, was shown to be effective and well-tolerated in clinical trials, with cure rates of up to 97%.
Researchers at the University of Bradford say naked mole rats' long lifespan and resistance to cancer could lead to new treatments for degenerative diseases like cancer and dementia. The animals' unique DNA repair mechanism may provide insights into preventing these conditions, with potential applications in humans.
A recent study has revealed a wide range of cost variations and transparency levels in the treatment of thyroid cancer. The research, conducted by Brigham and Women's Hospital, found that only half of the cancer centers studied reported payer-negotiated prices for services, with some costs varying by up to 70-fold across institutions.
Researchers analyzed tumor microenvironment of 26 patients with metastatic melanoma to identify patient response in advance of therapy. They found that specific immune cells, such as DC3s, are associated with improved overall survival and active T cell immune response.
Researchers analyzed 430 lung squamous tumors and identified mutations in genes such as TP53, CDKN2A, and FGFR1. The study found that 13.5% of patients with druggable mutations had lower median overall survival.
The Treatabolome project is an EU initiative that seeks to deliver rare disease and gene-specific treatment information to healthcare professionals. Systematic reviews on various rare neurological disorders are now available, providing a foundation for the platform's database.
A Swedish study found a link between HPV infection and increased risk of preterm birth, even in women without previous abnormal cell changes. The study included over 1 million births and suggested that vaccination against HPV may be beneficial for pregnancy outcomes.
A study published in Oncotarget found a distinct global DNA hypermethylation pattern and gene expression signature in liver cancer among patients with Indigenous American ancestry. This molecular subtype of HCC preferentially affects people with Indigenous ancestry, highlighting the importance of considering anthropological background ...
The study reveals that 1B3, a novel synthetic miR-193a-3p mimic, consistently suppresses several pro-tumorigenic phenotypes in vitro, including reduced cell proliferation, viability, and induced apoptosis. The pleiotropic mechanism of 1B3 action supports its development as a novel therapeutic agent for cancer treatment.
Researchers investigated mRNA vaccination response in Israeli cancer patients. Patients with cancer who received the vaccine showed seropositivity, indicating an immune response against SARS-CoV-2. The study aimed to assess the safety and efficacy of mRNA vaccines in this vulnerable population.
Researchers have identified specific cortisol production levels linked to increased mortality risk in patients with benign adrenal tumors. This breakthrough enables healthcare providers to concentrate efforts on high-risk patients and optimize public healthcare resources.
A Ludwig Cancer Research study has discovered how to revive terminally exhausted T lymphocytes, found within tumors, for cancer therapy by using an immune factor called interleukin-10. This revival restores their potent anti-cancer activity, leading to tumor regression and cures in mouse models of melanoma and colon cancer.
Researchers evaluate expression of TAZ and YAP, the p53-MDM2 axis, and RABL6A in sarcomas, finding that elevated YAP and TAZ independently predict worse overall and progression-free survival. Network analysis reveals a possible functional relationship between biomarkers.
Researchers discovered a sub-set of CAR T-cells called 'stem cell memory T-cells' that play a key role in destroying cancer and maintaining immune surveillance. These cells are critical to the long-term success of CAR T-cell therapy, which could improve treatment outcomes for patients with high-risk relapse.
A new study reveals that small uveal melanomas have molecular genetic alterations, making them highly metastatic tumours. Prompt treatment can significantly increase the chances of cure for these patients.
A study by Virginia Commonwealth University researchers found that secondhand smoke exposure during pregnancy is associated with epigenetic changes in babies, which can increase the risk of developmental disorders and cancer. The study analyzed data from over 100 pregnant women and found correlations between low levels of cotinine, a n...
The USPSTF has recommended lowering the age for colorectal cancer screening to 45 years of age, aligning with the American Cancer Society's 2018 guideline. This change aims to catch more early deaths and preventions due to increasing cases in younger individuals. Further research is needed to identify underlying causes and risk factors.
Researchers at The University of Hong Kong have developed synthetic biotherapeutics with anti-tumor, insulin-sensitizing, and hepatoprotective activities, offering potential treatments for obesity-related diseases such as type 2 diabetes, hypertension, and cancer.
The study created a comprehensive catalog of healthy breast tissue cells, enabling scientists to pinpoint the origin of abnormal changes. By tracking gene activity in over 15,000 cells, the team redefined healthy breast tissue and identified subpopulations with different responses to therapies.
Researchers found that obesity-related cancer deaths improved at a slower rate than non-obesity related cancer deaths, with declines of 2.29% and .83%, respectively. Obesity contributes to both cancer risk and heart disease risk, but the study suggests that maintaining a healthy weight can improve overall health.
A machine learning algorithm, FARDEEP, has been developed to assess an individual patient's risk of regenerative outcomes after surgical treatments of peri-implantitis. The study found that immune cell types central to microbial control are strongly correlated with superior clinical outcomes.
A team of Oregon State University scientists discovered a new class of anti-cancer compounds, SMAhRTs, that activate AhR signaling and kill liver and breast cancer cells. These compounds provide exciting new leads for drug development, targeting the AhR pathway to induce anti-cancer effects.
A new form of gene therapy has successfully treated 48 out of 50 children born with a rare and deadly inherited disorder. The treatment, developed by an international team, involves delivering a corrected copy of the ADA gene into stem cells, which are then returned to the child's body to produce healthy immune cells.
A new study by Brigham and Women's Hospital found that Medicaid expansion did not significantly improve receipt of definitive treatment and timeliness of care for cancer patients treated at minority-serving hospitals. Despite increased access to insurance, these hospitals continued to face significant disparities in care.
Researchers identify key protein MavQ that helps Legionella bacteria set up house in human cells, remodeling endoplasmic reticulum to create protective dwellings. This discovery could lead to new treatments for various infections.
Researchers rationally designed a new monoclonal antibody HA98 with improved affinity for CD146, a key adhesion molecule in angiogenesis and cancer metastasis. The study revealed superior inhibitory effects on tumor growth compared to the original AA98 antibody.
Researchers enrolled 50 Black and 50 white men with advanced prostate cancer to test hormone therapy abiraterone acetate plus prednisone. They found that Black men's PSA levels dropped further and more frequently, but disease progression and survival times were similar.
Scientists have discovered nano-scaled apoptotic bodies as a new brain-targeting drug carrier, overcoming the blood-brain barrier challenge. The small apoptotic bodies (sABs) are stable in serum, have a long circulating time, and high drug loading efficiency, making them a promising candidate for drug delivery.
Researchers found that decreased neuronal complexity may be a feature of chronic migraine and propose restoring this complexity as a treatment. HDAC6 inhibition restored cytoskeletal flexibility and relieved migraine-associated pain.
A new study has identified 16 quality measures for end-of-life care in children with cancer, covering topics such as avoiding medically intensive care and assessing sibling needs. The measures aim to standardize care and identify disparities in quality of care received by different groups of children.
Researchers developed an AI system, TOAD, that accurately predicts the origin of tumors in cancer cases with unknown primary sites. The model, trained on gigapixel pathology images, correctly identified cancer types and listed diagnoses as top predictions 96% of the time.
Research has expanded hyaluronic acid's uses beyond cosmetics, exploring its potential in wound healing, nerve and muscle pain treatments, and cancer therapy. The ingredient is being combined with other proven ingredients to create optimized products with tangible results.
A new neuroimaging technique using diffuse optical tomography studied brain stimulation for depression, finding reduced brain activation in response to rTMS. The study suggests that treatment parameters may need adjusting for patients with severe depression.
Petco Love and Blue Buffalo have partnered with Morris Animal Foundation to support pet cancer research, investing over $16 million in the fight against pet cancer. The $100,000 grant will be used to match donor gifts and raise awareness for animal cancer research.
A team of researchers, including Saket Navlakha and Dr. Sejal Morjaria, developed a computational tool to predict COVID-19 severity in cancer patients. The tool has an accuracy rate of 70-85% and prevents unnecessary expensive testing, improving patient care.
A Phase II trial found that BKV-specific T cells from healthy donors are safe and effective in treating debilitating complications after stem cell transplants. Patients experienced rapid responses, with 81.6% showing improvement after 28 days, and no cases of severe GVHD or toxicities.
A new treatment has shown promising results in reducing the severity of acute respiratory distress syndrome caused by the flu in mice. The therapy, based on natural molecules, improves lung function and prevents progression of disease in infected animals.
Researchers discovered that distinct Notch family members are modified differently by phosphorylation, leading to opposite effects on transcriptional activity and oncogenic behavior. The study suggests that targeting PIM or Notch proteins may provide new treatment options for hormone-dependent breast cancer with poor prognosis.
Researchers developed a predictive model to estimate the age of natural menopause in middle-aged women based on hormone levels, menstrual cycle irregularities, and lifestyle factors. The study demonstrated adequate prediction accuracy, suggesting potential benefits for health promotion and family planning decisions.
A new study by Massachusetts General Hospital researchers finds that a proposed law to regulate high-risk diagnostic tests could increase US healthcare costs by $565 million to $1.1 billion over a three-year period, depending on stringency of enforcement.
A new mathematical model developed by Chalmers University of Technology can predict how different bacteria interact and affect the intestinal microbiome. The model was tested on two clinical studies, one involving Swedish infants and another adults in Finland, showing high accuracy in predicting multiple variables.
A new study from the University of Bergen reveals that targeted therapy using PARP inhibitors can be effective in treating early-stage triple negative breast cancers. The study found a significant response rate among patients not harboring germline mutations, highlighting a potential for improved personalized treatment.
This issue of APSB features studies on protecting against doxorubicin-induced cardiotoxicity via increasing YAP1 expression, as well as investigating alternative strategies to downregulate PD-L1 in gastric cancer cells. The journal also publishes research on a novel injectable micelle-hydrogel hybrid for localized drug delivery and tar...
A recent study found that banning tanning beds among U.S. minors would significantly reduce the number of melanoma cases in adolescents, with estimates suggesting up to 15,101 cases prevented over the lifetime of 17.1 million minors. The study also estimated that such a ban would save millions of dollars in healthcare costs.
A recent study by Yale Cancer Center reveals that young patients with early-onset colorectal cancer (under age 50) have a better survival rate than those diagnosed at older ages. After adjusting for stage at diagnosis, these patients had a 5% lower risk of death compared to those diagnosed between 51-55 years old.
Tumor gene profiling decreases patient acceptance of active surveillance among men with clinically similar prostate cancers and low health literacy, a new study found. The study suggests that education on prostate cancer treatment options is needed for this population.
Researchers designed and synthesized acrylamide-based DHODH inhibitors for treating rheumatoid arthritis. The lead compound showed encouraging in vivo anti-arthritic effects in a dose-dependent manner.
A newly released position paper from ESMO and SIOPE defines a common vision for improving outcomes for AYAs with cancer in Europe. The paper highlights the key challenges of AYA care, including limited awareness of cancer biology, availability of specialist centres, and access to clinical trials.
The Vilcek Foundation has launched a digital celebration to recognize the 2021 Vilcek Foundation Prizewinners. Four scientists from diverse backgrounds are being honored for their groundbreaking contributions to biomedical science and creative promise in filmmaking.
A new study published in JCI Insights found that COVID-19 convalescent plasma treatment with high levels of antibodies is safe and significantly improves clinical outcomes. The treatment was effective in non-mechanically ventilated patients, with a survival rate of 88.9% at the 30-day mark.