Research on new and better ways to treat cancer. Covers radiotherapy, targeted microdroplets, nerve-injury protection, drug combinations, and tumor models.
Researchers identified rural Georgia counties with high mortality rates from breast, prostate, colorectal, and lung cancer. These hotspots were concentrated in the eastern Piedmont to southern Coastal Plain regions, as well as southwestern and northern rural areas.
Pediatric cancer patients from lower- and middle-income countries faced a higher risk of all-cause mortality than those in high-income countries during the COVID-19 pandemic. The study found that patients in LMICs had 35.7 times the risk of all-cause mortality compared to those in HICs.
Researchers developed a virus that infects cancer cells, killing them while sending signals to nearby uninfected cells for viral attack. This approach shrinks tumors and enhances cancer-killing efficacy in various models, including pancreatic and ovarian cancers.
A study by University of Helsinki researchers found that the immune system attacks itself in rare type of blood cancer. The immune system plays a role in the development and growth of cancer cells, making current therapies less effective.
A new CAR T-cell product targeting CLDN6 showed acceptable safety and early signs of efficacy in a phase I/II clinical trial. The therapy combined with an mRNA vaccine expanded transferred CAR T cells and improved tumor cell killing.
A new study reveals funding for fertility preservation policies varies across the UK, with Scotland offering the most inclusive approach. The study highlights the need for standardization of policies to ensure equal access to care for patients.
A study found that 12% of recurrent ductal carcinoma in situ (DCIS) cases were new primary lesions unrelated to the original tumor. These findings suggest that genetic biomarkers for predicting recurrence may not be effective for all patients.
Recent progress in targeted nanomedicine for managing resistance and toxicity of cisplatin in cancer therapy is reviewed. The article highlights strategies to increase cisplatin sensitivity through improved intracellular concentration and combination therapy, as well as novel approaches targeting tumor microenvironment and immunotherapy.
Researchers developed a gel that temporarily houses cytokines and CAR-T cells near tumors, enhancing their attack power. The gel enables continuous release of activated CAR-T cells, effectively treating solid tumors.
Researchers have identified a critical vulnerability in high-risk multiple myeloma patients with co-occurrence of chromosome abnormalities. The study reveals that cells lacking p53 and NEIL1 genes are reliant on the Chk1 pathway, suggesting a synthetic lethal relationship.
Recent studies published in the Journal of Pharmaceutical Analysis have found applications of nanotechnology in medicine, drug research, and environmental protection. Researchers developed nanodots made of carbon using natural polysaccharides from mushrooms to detect chromium, and created nanozymes that could be used to detect drug con...
Researchers have identified a process to study circulating tumor cells responsible for cancer recurrence in patients with non-small cell lung cancer. The study models showed that these cells correlated with cancer recurrence, and blocking a protein called MYC made the tumor cells more vulnerable to chemotherapy.
A new study suggests that cardamonin, a compound from the cardamom spice, can kill triple-negative breast cancer cells and reduce PD-L1 expression. The findings hold promise for improving cancer therapy without severe side effects.
A new study found that exercising before developing cancer reduced tumor growth and cachexia symptoms in mice. Regular exercise improved cardiac structure and function, and helped slow tumor growth even after cancer was induced.
The study reveals a narrowing gap between cancer profiles in China and the USA, with converging trends in lung, breast, and colorectal cancers. China's cancer burden is expected to rise, while the US has seen reduced rates since the 1990s due to effective prevention strategies.
The NCCN Annual Conference focuses on the cancer patient journey, featuring state-of-the-art practice algorithms, updates to clinical guidelines, and new therapies. Leading experts present treatment recommendations for various cancer types, including breast, colorectal, and lung cancer.
Researchers at Okayama University have created a new method to kill cancer cells using light-activated protein AR3, reducing the risk of adverse reactions. The approach uses green light to trigger apoptosis in targeted cells, offering a promising alternative to conventional treatments.
A new study shows that a potential treatment for Alzheimer's disease, sargramostim, improves cognitive function in people with Down syndrome and normal aging mice. The drug reverses learning and memory deficits, nerve cell loss, and brain abnormalities in mouse models of Down syndrome and aging.
A new study from the University of Eastern Finland shows that liquid biopsy can detect cancer mutations months before recurrent breast cancer is detected. This method uses biomarkers released by cancer cells in serum samples to assess changes in intratumoural heterogeneity and provide a more accurate clinical picture.
Researchers develop innovative non-contact agitation technology to assess motility and invasive capacity of cancer cells in tissue sections. The study reveals significant increases in Rac/Cdc42 activity in tumor areas, with stronger correlations found in advanced cancer stages.
In an animal study, researchers created an implantable biotechnology called MASTER that produces and releases CAR-T cells for attacking cancerous tumors. This technology reduces the manufacturing time from weeks to hours, increasing efficiency and effectiveness.
Researchers collected hundreds of cerebrospinal fluid samples from patients with Diffuse Midline Glioma, tracking changes in cell-free tumor DNA over time. The findings suggest that this method could provide data about tumors sooner than MRIs alone, allowing clinicians to address aggressive brain cancer more effectively.
Researchers at Duke University have developed a device that manipulates particles and cells using complex sound waves, enabling selective pairing of individual cells to measure adhesion forces. This technology could lead to personalized medicine by allowing doctors to determine treatment for individual cancer patients.
Scientists have identified diagnostic features of circulating tumour DNA (ctDNA) in blood samples, which can predict treatment response and patient outcome in aggressive lymphoma. The study reveals significant heterogeneity among patients, with high ctDNA levels associated with poorer survival rates.
Researchers at Karolinska Institutet identified a novel protein mechanism that inhibits tumour growth in ER-negative breast cancer, leading to improved prognosis. High levels of GIT1 were associated with reduced tumour growth and better outcomes in ER-negative patients.
The NCI has launched a program to provide molecular characterization of childhood cancers, allowing for accurate diagnoses and personalized treatment. The program will expand to include soft tissue sarcomas and other rare tumors, and data collected will be shared among researchers to accelerate the development of new treatments.
Researchers at ChristianaCare's Gene Editing Institute describe a new process for evaluating the impacts of gene edits that alter rather than completely disabling DNA code. The study validates the safety and efficacy of their novel approach for using CRISPR to improve lung cancer treatments.
A team of engineers and scientists has developed a proof-of-concept for a magnetic tentacle robot that can navigate the narrow tubes of the lung, enabling doctors to take tissue samples or deliver cancer therapy. The device measures just 2 millimeters in diameter and uses an autonomous magnetic guidance system to guide it into place.
Researchers developed a computational approach called CellTrek to combine parallel gene-expression profiling methods, creating spatial maps at single-cell resolution. The tool provides detailed information on individual cell types' location within tissues, enabling unique biological insights.
Research led by Adam Green, MD, shows that the youngest patients with brain tumors (ages 0-3 months) have about half the five-year survival rate as children ages 1-19. The study analyzed population-based data for almost 14,500 children and found significantly poorer outcomes among the youngest patients.
A study published in Cell Reports Medicine reveals the oncometabolite role of progesterone in advanced prostate cancer and strategies to eliminate its oncogenic effect. Biochanin-A, an isoflavone found in soy, inhibits the enzyme 3βHSD1, which generates progesterone.
A meta-analysis of over 3,000 studies found that women with one ovary have a 30% lower chance of becoming pregnant and giving birth after IVF. The study suggests that surgical removal of an ovary has an adverse effect on fertility.
A study published in eLife reveals that cancer cells undergoing confined migration become more resistant to anoikis and exhibit increased invasiveness. This process may boost survival in cancer cells and make them more prone to forming deadly metastases.
Researchers created implantable beads that produce high concentrations of interleukin-2, a natural compound activating white blood cells to fight cancer. The treatment eradicated ovarian and colorectal cancer in mice within six days, paving the way for human clinical trials later this year.
The study found that White people are more than twice as likely to get some types of cancer, including melanoma skin cancer and oesophageal bladder cancers, compared to Black, Asian or Mixed ethnic backgrounds. Black people are also more likely to get certain types of cancer, such as myeloma and prostate cancer.
A study published in Nature Cancer has found that tissue damage caused by radiation can facilitate the spread of cancer, with neutrophils playing a key role. The researchers used mice to test the effect of high doses of radiation on healthy lung tissue and found that secondary tumours formed more easily in damaged lungs.
The American Gastroenterological Association (AGA) has issued new clinical practice guidelines on systemic therapy for HCC, emphasizing the importance of consulting a multidisciplinary team of healthcare professionals. The guidelines provide specific patient scenarios and treatment options to help hepatologists make informed decisions.
Researchers investigated COVID-19 mortality in adult cancer patients, finding that systemic treatments and comorbidities played a role in increased risk. The study analyzed 2,500 patients and identified specific tumor subtypes associated with higher mortality rates.
Researchers found that MYC inhibition by Omomyc exerts a dramatic effect on the metastatic process, reducing primary tumor and metastatic growth. The study suggests that MYC inhibition is anti-metastatic in breast cancer, offering promise as an anti-metastatic therapy.
Scientists have discovered a new subtype of relapsed pediatric AML characterized by a specific gene mutation called UBTF exon 13 tandem duplication (UBTF-TD), which is associated with poor outcomes and an increased incidence of minimal residual disease. This mutation can be used to identify high-risk patients and guide treatment.
Researchers identified a novel mutation in 9% of relapsed pediatric AML cases, suggesting a new subtype of the disease. The UBTF tandem duplication is associated with poor survival rates and higher likelihood of minimal residual disease positivity.
Rice University's Gang Bao receives $1 million CPRIT grant to develop a three-pronged strategy combining magnetic nanoparticles, free radical generation, and immune checkpoint blockade to kill cancer cells. The approach aims to increase the efficacy of cancer therapy, potentially leading to a clinical trial.
Researchers developed patient surrogates to evaluate potential prostate cancer treatments, identifying genes that could be targeted with drugs. The models predicted synergistic effects of treatments and identified promising drug combinations.
A new study highlights alternative treatment options that consider a patient's likelihood of recovery and quality of life. Total Definitive Treatment (TDT) is an approach that combines chemotherapy, radiation therapy, and close monitoring to potentially cure patients without surgery.
Researchers at Tokyo University of Science have developed bionanoparticles derived from corn that selectively target and inhibit the growth of cancer cells, inducing tumor necrosis factor-α release. These findings suggest a novel, economical, and safe anti-cancer therapy approach.
A comprehensive analysis of over 2,200 patients in Europe reveals the complexity of cholangiocarcinoma, a rare cancer often diagnosed at an advanced stage. The study highlights the need for education programs to raise awareness and improve early diagnosis, survival, and quality of life.
Researchers have developed a rapid and affordable test to identify specific genetic mutations in cancer cells using SuperSelective PCR primers. This assay can detect rare mutations, enabling targeted therapy and monitoring minimal residual disease. The study demonstrates the potential of this approach for personalized cancer treatment.
A team of researchers has identified over 250 gene activators in human cells, expanding our understanding of transcriptional regulation and its role in cancer. The study also reveals new insights into how proteins interact with each other to regulate gene expression, potentially leading to the development of targeted therapies.
Women treated for cervical neoplasia grade 3 show declining risks of preterm birth, neonatal sepsis, and infant death after treatment. The study suggests that these high-risk pregnancies should be managed with careful consideration.
A new study found nearly 17% of cancer survivors experience moderate or increased housing insecurity, complicating disease management and healthcare navigation. Housing insecurity also correlates with lower household income, educational attainment, and being Black.
Researchers at Children's Hospital of Philadelphia define a 3-tiered molecular classification system for pediatric differentiated thyroid cancer, where fusion oncogenes are associated with more invasive disease and lower remission rates. The study contrasts findings from adults, who have a two-tiered system based on BRAF mutations.
Researchers at Northwestern University have developed a novel microfluidic device that can efficiently harvest and sort tumor-eating immune cells from tumors. This technology has shown dramatic results in shrinking tumors in mice compared to traditional methods.
A study of 1,000 patients found that some recoverees from hepatitis C still face liver cancer risks after treatment. Researchers propose a 2-step strategy combining FIB-4 and transient elastography/ultrasound to predict high-risk cases.
A single genetic test using RNA sequencing has been used for all children with cancer in the Netherlands since 2018, improving diagnosis and treatment in seven cases. The technique picked up 78 fusion genes, 23 of which led to a more accurate diagnosis or possible treatment.
Researchers investigated geographic disparities in initial breast cancer care, finding significant regional variations and unequal distribution of resources. The study suggests that both patient-level factors and regional characteristics contribute to these disparities, affecting treatment outcomes.
Researchers found that magnesium is essential for the functioning of T cells, which can eliminate abnormal or infected cells. Increasing local magnesium concentration in tumors strengthened the immune response against cancer cells.
Researchers at Osaka University have made a breakthrough in understanding the molecular mechanisms behind Intrahepatic cholangiocarcinoma (ICC), a deadly form of liver cancer. By identifying TRAF3 and NIK as key players, they have uncovered potential therapeutic targets for novel ICC treatment.
Researchers found that knocking down LCDR in lung cancer cells promotes apoptosis, providing a potential new target for diagnosis and treatment. Additionally, targeting LCDR shows promise as a therapeutic strategy and has diagnostic value for lung adenocarcinoma.
Researchers at the University of Cologne have identified a new direct link between proteins BAX and DRP1 and apoptosis. The study reveals that DRP1 can serve as a direct cell death activator by binding to BAX, potentially leading to new cancer therapies.
Researchers found that zika virus injections destroyed brain tumors in mice and reduced tumor size in cerebral organoids, with immune cells alerting the system to its existence. This approach opens up prospects for virotherapy treatment of central nervous system tumors.