Articles tagged with Drug Studies
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
The RTS,S/AS02A vaccine has been shown to reduce the risk of clinical malaria by 30% and severe malaria by 58% in a trial involving over 2000 Mozambican children. The vaccine's efficacy did not wane after 12 months of follow-up, providing sustained protection against clinical malaria for at least 18 months.
A new study from Johns Hopkins Medicine finds that alagebrium reduces stiffening in arteries by 37% and improves endothelial function by 102%. The drug works by breaking down advanced glycation endproducts, which contribute to arterial aging. The results suggest a potential new therapy for reducing cardiovascular disease in the elderly.
Patients who received left ventricular assistant devices (LVADs) had a significantly longer average survival time of 10.3 months compared to 3.1 months without the device. The study found that 78% of patients died within six months and 90% within a year without LVAD support.
A new study found that left ventricular assist devices (LVADs) can significantly extend the lives of patients with end-stage heart failure. The device reduced mortality risk by 50% at six and 12 months, extending average life span from 3.1 months to over 10 months.
A Phase III clinical trial led by Duke University researchers found that edifoligide, a drug designed to prevent vein clogging in coronary bypass surgery, was no more effective than a placebo. The study showed that edifoligide had no significant impact on preventing neointimal hyperplasia, the process that causes veins to narrow and fail.
A recent study suggests that current medical research methods are flawed and may miss signs of harm or benefit in subgroups of patients. Risk-stratified analysis, which considers multiple factors, can help detect these issues and provide more accurate information for doctors to discuss with patients.
The available evidence on Herceptin for early breast cancer is insufficient to make reliable judgments, states The Lancet. Drug regulatory agencies must consider the totality of available evidence and be free from external influences.
Studies on central and obstructive sleep apnea suggest that current treatments may not be effective in preventing deaths from heart disease. The findings emphasize the importance of finding better treatments and devices for central sleep apnea. Researchers recommend re-examining treatment approaches to improve patient outcomes and redu...
A two-year, open-label trial demonstrated that adults with ADHD experienced significant long-term symptom control when treated with once-daily ADDERALL XR. The treatment showed a good tolerability profile and was significantly associated with improved quality of life.
A study found that ADDERALL XR significantly improved driving safety and performance in patients with ADHD, measured by a 2.5-point reduction in their average Driving Safety Score. The medication also showed significant effects on ADHD symptom control, improving attention and reducing lapses in attention.
A study of 229 individuals at heightened risk for Alzheimer's disease found that more than 90% supported allowing family consent for research participation in low- to moderate-risk studies. The majority also accepted higher-risk studies with caution, highlighting the importance of balancing individual concerns with societal needs.
A recent study found that 90% of adults with Alzheimer's disease would allow a family member to enroll them in studies with mild to medium risks. Surrogate decision-making for more invasive procedures like gene transfers and brain tissue sampling was also widely accepted, but participants were less willing to participate themselves. Th...
A randomized, placebo-controlled trial found that methylphenidate significantly improved symptoms of hyperactivity and impulsiveness in children with pervasive developmental disorders. The study included 58 participants who showed a response rate of around 76 percent to the medication.
The new Clinical Trials Directive has led to differences in the scope of revised legislations across EU member states, with only a few adding provisions for non-commercial trials. The directive also simplifies the conduct of academic clinical trials but poses challenges for future pan-European multi-centre studies.
A new drug developed at UC Davis in collaboration with Finnish researchers shows promise in preventing breast cancer and treating post-menopausal vaginal atrophy. The study found that the drug inhibited breast cancer development by 95% in mice, suggesting a potential benefit for millions of women.
A review of 143 clinical trials that were stopped early due to benefits found many were industry-funded drug trials with high-impact journals. The proportion of such trials increased over time, often with implausibly large treatment effects, suggesting skepticism from physicians.
The PRECiSE 2 study found that patients treated with CIMZIA achieved a higher clinical response and remission rate compared to those receiving placebo. The study demonstrated the efficacy of CIMZIA in maintaining clinical response after induction therapy, with a significant proportion of patients able to achieve remission by week 26.
Experts from Group Health Research Institute outline five principles for making informed decisions on drug coverage, prioritizing true experiments, real health outcomes, and full ranges of alternatives. These evidence-based guidelines aim to protect patients and promote cost-effectiveness.
New therapy Iressa shows no significant survival improvement for NSCLC patients, but offers better outcomes for Asian and non-smoking patients. The study results provide insight into the effectiveness of EGFR inhibitors in specific patient groups.
A retrospective analysis of patients with invasive aspergillosis showed that those who initially received Pfizer's antifungal agent VFEND had better survival rates and were less likely to need salvage therapy than those on amphotericin B. The study found that patients who started on VFEND also had higher success rates in switching to o...
A double-blind, placebo-controlled study found that COLD-fX significantly reduced upper respiratory infections by 25% and recurrent infections by 56%. The treatment also showed a significant effect in reducing symptom scores and infection duration.
A new class of drug has been shown to reduce post-operative vomiting in 95% of patients, with no significant difference in nausea reduction compared to existing anti-emetic drugs. The NK-1 receptor antagonist was found to be well-tolerated and effective in preventing vomiting after surgery.
A meta-analysis of seven head-to-head drug-eluting stent trials found that the CYPHER Stent reduces the need for re-treatment by about 30% compared to Taxus Stent-treated patients, regardless of patient and lesion types. The CYPHER Stent's strong clinical performance is established through rigorous analysis.
A study of Norwegian medical students found that nearly 70% self-prescribed medication in their first year after graduation, a trend that continued into their fourth and ninth years. The most commonly self-prescribed medications were antibiotics, contraceptives, and analgesics.
A meta-analysis of atypical antipsychotic drug trials found that patients randomized to these medications had a significantly increased risk of death compared to placebo, with an odds ratio of 1.54. This suggests that antipsychotic drugs should be used with caution in elderly patients with dementia.
A meta-analysis of 15 trials found that atypical antipsychotics increased the risk of death in dementia patients by 1.54 times compared to placebo. The study suggests that clinicians should use antipsychotics cautiously and consider alternative treatments.
A study found that second-generation antipsychotics increase the risk of death in elderly Alzheimer's patients. Alternative treatments, such as behavioral interventions and antidepressants, have proven effective in some cases.
A large multicenter randomized study involving 384 patients found the CYPHER Stent to have a superior safety profile compared to intravascular brachytherapy. The study showed lower incidence of target vessel failure and major adverse cardiac events with the CYPHER Stent at nine-month follow-up.
Moxifloxacin could be the first new treatment for TB in over 40 years, shortening treatment period by nearly two months. Researchers aim to assess ability of antibiotic to cure disease more effectively and with better patient tolerance.
The European Infliximab for Psoriasis Efficacy and Safety Study (EXPRESS) found that 80% of patients achieved at least a 75% improvement in symptoms after ten weeks treatment with the drug. The study showed significant skin clearance and nail psoriasis response in moderate to severe psoriasis sufferers.
A new trial demonstrates the effectiveness of infliximab against psoriasis, with 80% of patients experiencing at least a 75% improvement in skin symptoms. The drug also showed promise in treating nail psoriasis, with significant reductions in severity and complete clearing of skin psoriasis in some cases.
Researchers at the University of Manchester have shown that IL-1ra protects brain cells from injury and death in laboratory studies. The first small trial of IL-1ra in patients has demonstrated promising results, which may lead to a full trial next year to test its effectiveness.
A University of Michigan Health System study found that pharmacies in predominantly minority and low-income areas have lower availability of opioid analgesic pain medications. The gap is pronounced, with 86.9% of white ZIP code pharmacies carrying sufficient supplies compared to 54.2% in minority ZIP codes.
GSK's salmeterol was approved despite concerns over negative side effects and asthma-related deaths. The company allegedly submitted manipulated data to the FDA, suggesting lower risk values than initially reported. This has raised questions about the safety of the drug.
The PROactive study found that Takeda's ACTOS (pioglitazone HCl) significantly reduced the combined risk of non-fatal heart attacks, strokes, and deaths by 16% in high-risk patients with type-2 diabetes. This led to a 10% reduction in the primary combination endpoint of seven different macrovascular events.
Researchers at Yale School of Medicine found that expanded physician and residency training in telephone medicine is necessary to prevent medical mishaps. The lack of visual cues indicating emotions may lead physicians to assume patients take news better than they actually do.
A meta-analysis of 13 randomized clinical trials found that pulmonary artery catheter (PAC) use did not improve clinical outcomes in patients with advanced heart failure or those awaiting major surgery. The study suggests that PACs should only be used in specific situations where they can provide valuable guidance for treatment.
A double-blind trial found that buprenorphine combined with behavioral interventions was significantly more efficacious in treating opioid-dependent adolescents than clonidine. The study also showed that 72% of teens who received buprenorphine were retained in treatment, compared to 39% of those given clonidine.
A two-year study by Massachusetts General Hospital found that extended-release stimulant medications continue to be effective in controlling ADHD symptoms with minimal tolerance. The study involved over 400 children and showed no clinically significant effects on growth, weight, or cardiovascular health.
The Phase II study showed that FTY720 reduced annualized relapse rates by at least 50% during the first six months and maintained this rate for an additional six-month extension. Patients who switched to FTY720 after six months experienced a reduction of at least 70% in their annualized relapse rate compared to placebo.
The two-year study found that patients treated with Starlix plus metformin had a 50% lower incidence of hypoglycemia compared to those taking glyburide and metformin. This combination therapy resulted in equally effective glycemic control and sustained reductions in post-meal glucose levels.
The University of Cincinnati will lead a randomized trial comparing new interventional treatments for acute ischemic stroke against the standard approach. The study aims to improve outcomes by quickly opening clogged brain arteries and reducing long-lasting brain damage.
A pharmacist has been awarded a $500,000 MacArthur grant to develop and implement safe medication practices, potentially saving up to 98,000 lives per year. The project aims to educate the healthcare community on medication safety, following a range of successful initiatives.
The CATIE study found that while newer medications have no substantial advantage over older antipsychotics, individual differences in patient response to these drugs remain crucial. Patients on olanzapine tended to stay on the medication longer but experienced increased side effects such as weight gain and metabolic changes.
Researchers found abatacept to be effective in treating rheumatoid arthritis, improving at least 20% of patients' condition compared to placebo. The drug reduces immune system attack on joints, providing significant pain relief and improving functionality.
A study found that heart failure patients with high predicted risk of death within a year are less likely to receive appropriate medications, including ACE inhibitors and beta-adrenoreceptor antagonists. The researchers suggest underappreciation of therapy benefits and multiple comorbid conditions may contribute to the treatment mismatch.
Researchers demonstrate that reducing trauma to the artery and using anti-clotting drugs are key to successful stent placement. The study's findings suggest an 8.5% true clinical restenosis rate after two years.
The PROactive study shows that ACTOS significantly improves cardiovascular outcomes by reducing heart attacks, strokes, and death in high-risk patients. The study found a 16% reduction in life-threatening events and significant improvements in lipid profiles, blood pressure, and insulin resistance.
Researchers have found that Clioquinol, an old antibiotic, may interrupt the production of mutant huntingtin protein in neurons, reducing its toxic effects and potentially slowing down Huntington's disease progression. The study suggests a new potential treatment for the degenerative brain disorder.
A study found that 69% of meta-analyses in critical care had flaws, leading to concerns about the reliability of medical research. The most common issues were failure to report comprehensive literature searches and methods for avoiding bias.
A comprehensive tobacco cessation plan could help 33 million smokers quit, adding years of life to former smokers and reducing health care costs for all Americans. The plan, which includes free medications and counseling, is based on scientific evidence and has the potential to dramatically reduce the human and financial tolls of tobacco.
A recent study confirms that letrozole treatment can improve the survival of women with node-positive disease and reduce metastasis risk. The study also found a 39% reduction in the risk of metastasis among participants receiving letrozole.
The ACTIVE trial program was designed to evaluate the use of clopidogrel plus aspirin in patients with atrial fibrillation. After an interim analysis, it was recommended to discontinue the ACTIVE W trial but continue the ACTIVE A and I trials.
A new study has shown that fondaparinux, a synthetic drug, is as effective as traditional therapy in preventing heart attacks and ischemia while reducing major bleeding risks. Patients with acute coronary syndromes who received fondaparinux had lower mortality rates at one month and six months compared to those receiving enoxaparin.
Researchers from Norway found that treating patients with high doses of B vitamins after a heart attack does not prevent recurrent heart disease or stroke. In fact, high doses of B vitamins may increase the risk of cardiovascular disease, particularly among those with impaired renal function.
The OASIS-5/MICHELANGELO study found fondaparinux to be as effective as enoxaparin in preventing heart attacks and death at nine days after an event, but demonstrated a dramatic reduction in major bleeding. Patients also had a lower mortality rate at six months.
The Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) found that newer antihypertensive drugs, such as amlodipine and perindopril, were more effective than standard diuretic or ß-blocker therapy in reducing blood pressure and preventing major cardiovascular events. The study showed a significant reduction in stroke events and fewer cas...
A new study published in the JAMA Network found that clopidogrel pretreatment significantly reduced the odds of cardiovascular death, heart attack, or stroke following PCI by 46% compared to treatment at the time of PCI. Pretreatment also resulted in a 41% reduction in cardiovascular death from randomization through 30 days.
VNS therapy has been shown to be effective for some patients with treatment-resistant depression, with up to 20% experiencing total remission. The treatment involves surgical implantation of a device that stimulates the vagus nerve, delivering mild pulses to areas of the brain involved in mood regulation.
The article highlights the need for further research on HIV and aging, citing concerns over delayed diagnoses and inadequate treatment. Older patients with HIV may experience increased mortality rates and unique side effects from HAART treatment due to age-related factors.