Articles tagged with Drug Studies
A new drug nerinetide has shown promising results in preserving brain cells for a time after stroke. The study found that combining nerinetide with endovascular therapy improved patient outcomes as compared to those who received only the clot-busting drug alteplase.
A meta-analysis of 24 trials involving over 17,500 older patients found that support with medication for three months after discharge significantly reduces hospital admissions. The study identified transitional support and medicines reconciliation as effective strategies in reducing readmissions.
A Kaiser Permanente study found that diabetes patients who used the patient portal and mobile phone app showed significant improvements in health outcomes. The use of these online tools was associated with increased medication adherence and lower blood glucose levels, particularly among patients with higher baseline HbA1c levels.
A study of 217 adults found no difference in the effectiveness of morning versus evening warfarin dosing. The researchers concluded that patients should take warfarin at a time when compliance is easiest, regardless of day or night.
Researchers found elevated risks of skin cancer, gastrointestinal and blood side effects, as well as liver test abnormalities and cirrhosis in participants taking low-dose methotrexate. The study provides a detailed side-effect profile that may inform more informed prescribing practices.
A new study has found that the guideline-recommended diuretic chlorthalidone causes more serious side effects, including hypokalemia and kidney problems, compared to hydrochlorothiazide. The study analyzed data from over 730,000 individuals treated for hypertension.
Researchers at University of Queensland found certain immune cells linked to distinct MND features, including impaired swallowing, speech, and breathing. The study suggests immune-blocking drugs could be personalized to treat each patient's unique disease symptoms and stages.
Scientists have created a protein drug composed of angiotensin converting enzyme-2 (ACE2) and its product angiotensin (1-7) that can be taken orally to treat pulmonary arterial hypertension. The drug has shown promise in animal models, reducing pulmonary artery pressure and improving cardiac function.
A new study found that Prescription Drug List (PDL) coverage for preventive asthma medications can reduce financial burden and increase medication adherence. However, barriers to PDL use include lack of awareness, exclusions, and inconsistent benefits.
A coalition of health workforce researchers advocates for revising antiquated state laws limiting nurse, PA, and pharmacist practice. Relaxing restrictions could expand access to care at lower cost, with expanded medication management services.
Researchers found that a new stimulation treatment increased blood flow to the brain and improved hand strength in patients with minor strokes. The treatment also showed promise in decreasing disability in patients with severe stroke, regardless of age, sex, or severity of symptoms.
A new Yale study found rosiglitazone, a type 2 diabetes drug, is associated with a higher risk of heart problems, especially heart failure. The research analyzed over 48,000 patients and found a 33% increased risk of cardiovascular events compared to controls.
Researchers conducted a large trial of MRSA blood infections and found that combining two antibiotics was not more effective than using one alone, but led to more kidney injuries. The study's findings aim to guide best management for patients worldwide.
Patients with lupus who take their medications consistently have a 39% lower risk of developing type 2 diabetes. The study found that antimalarial drugs like hydroxychloroquine significantly protect patients against the complication if taken as prescribed for at least 90% of the time.
A systematic review of 23 studies on pharmacological migraine prophylaxis in children and adolescents found that none of the tested medications had a significant long-term effect compared to placebo. Short-term improvements were seen for propranolol and topiramate, but these effects were not sustained.
Researchers at Stanford Medicine have developed a brain-wave signature that can predict which individuals with depression are most likely to respond to sertraline, an antidepressant. The study used electroencephalography and AI to identify the pattern in participants before treatment, allowing clinicians to make informed decisions abou...
A new study led by the University of Sydney has found that common medication can reduce the risk of heart attack during early bereavement. The research used a low daily dose of beta blockers and aspirin to mitigate cardiac risks without affecting grief, with reduced levels of anxiety persisting even after stopping treatment.
The DELIVER trial examines the safety of PrEP and a dapivirine vaginal ring in pregnant women, providing critical data for HIV prevention choices. The study will enroll 750 healthy, HIV-negative women aged 18-40 years and assess the acceptability and feasibility of these tools.
A phase 2/3 clinical trial evaluating two investigational drugs for their ability to slow memory loss and cognitive decline in people with a rare, inherited form of Alzheimer's disease did not meet its primary outcome. Despite disappointing results, the researchers continue to explore data from the trial's cognitive and clinical outcomes.
A national trial has produced a computer that can accurately predict which antidepressant will work for patients based on their brain activity. This breakthrough may lead to personalized depression treatments using AI and brain imaging.
A UK study found that children with ADHD in poorer areas are more likely to receive medication compared to those in affluent areas. The research suggests that social deprivation can impact access to non-medication treatments for ADHD.
A new study by Rutgers University and colleagues highlights the need for more research on rural opioid crisis treatment, citing barriers to access and inadequate resources. The researchers recommend expanded telemedicine, low-cost technology-assisted treatment, transportation subsidies, and pharmacy legislation changes.
A Finnish study found that patients taking cholesterol or blood pressure-lowering medications were more likely to become obese and reduce their physical activity levels. The research highlights the importance of maintaining healthy habits even when starting prescription medications.
A new study finds that rosiglitazone increases the risk of heart failure and cardiovascular events by 33% compared to controls. The research highlights the importance of access to raw clinical trial data for accurate drug safety assessments.
Studies funded by the tanning industry are more likely to downplay risks and highlight perceived benefits of indoor tanning. Researchers analyzed 691 articles on indoor tanning and found that studies with financial ties to the industry were significantly more favorable, highlighting the need for independent scientific data.
Recent clinical trials of Prolonged Exposure Therapy and Cognitive Processing Therapy show limited effectiveness in treating active duty military personnel and veterans with PTSD. The studies suggest that emotionally demanding therapies may not be beneficial for all patients, and more personalized treatment approaches are needed to acc...
A study of 3,537 children found that 40% go without treatment for 60% of the time, with lower socio-economic families more likely to drop off medication. The research suggests that consistent treatment is crucial for managing ADHD, a chronic condition affecting around 1 in 20 Australian children.
A new Ohio law allowing pharmacists to dispense naloxone without a prescription has been linked to an increase in naloxone dispensing rates. The study found that the law resulted in more naloxone being made available to patients, potentially saving lives in opioid overdose situations.
A University of Georgia psychologist's study confirms that treating avolition, a motivation-related symptom, improves other negative symptoms of schizophrenia. The results suggest targeting this domain could improve overall negative symptoms and reduce functional disability.
Researchers developed a comprehensive multi-Organ-on-a-Chip platform to bridge the gap in current limitations in drug development. The system enabled accurate modeling of human pharmacokinetic and pharmacodynamic parameters for tested drugs, mimicking real-world human responses.
A new study found that amlodipine lowered long-term gout risk compared to two other commonly prescribed blood pressure medications. The study, conducted by physician-researchers at Beth Israel Deaconess Medical Center, demonstrated the antihypertensive drug's association with a lower risk of gout.
A new oral pill, elagolix, has been shown to effectively reduce heavy menstrual bleeding in women with uterine fibroids. The study found that 80.4% of women treated with elagolix alone experienced a 50% reduction in bleeding, compared to 9.6% in the placebo group.
Breakthrough research presents five major advances in inflammatory bowel disease (IBD) treatment, including a new drug pipeline, a diet that improves symptoms, and a fecal microbiota transplantation approach. These studies offer hope for patients with Crohn's disease and ulcerative colitis.
A randomized controlled trial found that the ACE method was as effective as a specialist stop smoking service in quitting smoking. The study's results suggest that ACE may offer a viable cost-effective alternative for public-funded healthcare settings.
A Texas policy reducing anti-psychotic medications for foster children showed a 5-8% decrease in non-FDA indicated prescriptions while preserving medication use for those with approved indications.
A randomized clinical trial evaluated the absorption of six sunscreen active ingredients in four formulations, with all ingredients surpassing FDA thresholds for potentially waiving additional safety studies. The study highlights the need for further research on sunscreen ingredient exposure and its effects.
Research links proton pump inhibitors to poorer concentration and memory in breast cancer patients. Cognitive problems reported by PPI users were 20-29% more severe than those in non-users. The study suggests an association between PPI use and cognitive decline in breast cancer survivors.
A study found that fewer than half of US clinical trials comply with the law on reporting results, with non-industry sponsored trials most likely to breach. Trials with industry sponsors are more likely to report results on time, but progress has stalled since July 2018.
Researchers at UC Riverside are targeting cancer-causing genes Mcl-1 and Bfl-1 for novel therapies in melanoma and lung cancers. They aim to develop potent agents that can help tackle chemotherapy-resistant cancers.
Clinical trials suggest that psychedelic-assisted psychotherapy is more effective than traditional therapy alone in treating PTSD. The combination of MDMA and traditional psychotherapy has shown promising results, with patients experiencing temporary adverse reactions not requiring additional medical intervention.
The MND-SMART trial is a comprehensive clinical study that seeks to find treatments for motor neurone disease (MND), a progressive condition affecting the nervous system. The trial will involve over 1,500 participants and test multiple treatments against a shared placebo group.
A systematic review found that albendazole (ALB) and praziquantel (PZQ) are effective in treating taeniasis caused by the pork tapeworm. The study analyzed 20 studies, including before-after designs and controlled trials, and reported cure rates ranging from 52% to 99.5%.
As demographics change, spina bifida patients' needs are evolving, highlighting the need for research on quality of life and social determinants. The article discusses emerging trends in spina bifida care and the importance of addressing health disparities among minority populations.
A recent investigation by Science found that companies, universities, and institutions are often non-compliant with the requirement to report clinical trial results in a federal database. More than 55% of trials violated this law, yet regulatory agencies have failed to enforce penalties or actions against violators.
A 20-year study found that long-term antipsychotic treatment significantly reduced mortality in people with schizophrenia compared to those without medication. The study also showed no increased risk of hospitalization for cardiovascular disease among those receiving antipsychotic therapy.
Researchers analyzed 20 years of research on intention deactivation and found that completed intentions can sometimes continue to affect people, particularly when reminders or stimuli trigger their retrieval. This effect is often rare but can play a role in learning new routines.
A UK-wide trial has started recruiting patients for a three-year study on preventing falls in people with Parkinson's disease, led by the Royal United Hospitals Bath NHS Foundation Trust and the University of Bristol. The trial will test whether a commonly prescribed dementia drug can prevent debilitating falls and improve patients' qu...
A nationwide Finnish study found that individuals with Alzheimer's disease who took antipsychotic medications had a 29% higher risk of head injuries compared to those who didn't. This is particularly concerning as these patients already have a higher risk of falling and traumatic brain injuries.
A physically and mentally active lifestyle can slow FTD symptoms by providing cognitive resilience to brain degeneration. Research participants with dominant genetic mutations showed slower functional decline in the most active group compared to the least active group.
The study found significant tumor shrinkage in two out of three patients with salivary gland tumors treated with T-DM1. The benefit lasted for at least two years in one patient, suggesting a promising activity for this rare cancer type.
Researchers identified five practices: prepare with intention, listen intently and completely, agree on priorities, connect with the patient's story, and explore emotional cues. These practices aim to improve patient experiences and clinician satisfaction in medicine. The team is now evaluating their effectiveness in clinical settings.
Antipsychotic medications may increase death or cardiopulmonary arrest risk in older hospital patients, particularly those taking first-generation antipsychotics. The study highlights the need for cautious use of these medications to treat delirium and protect patients.
A new set of guidelines for Complex Innovative Trials (CID) aims to improve the quality and efficiency of clinical trials. The recommendations cover stages from trial planning to patient-facing documentation, with the goal of accelerating the development and approval of innovative treatments.
A study by Penn Medicine found that residents of Hispanic neighborhoods are less likely to receive CPR from a bystander and have a lower chance of survival following cardiac arrest. The study analyzed over 27,000 cardiac arrest events and showed a significant disparity in CPR delivery rates between Hispanic and non-Hispanic neighborhoods.
A University of Michigan study found that prompt disposal of leftover medications improved when parents received a disposal packet and tailored online messages. The study suggests that easy disposal and risk education can significantly reduce the number of parents keeping leftover opioids for their children.
A systematic review and meta-analysis found insufficient evidence to determine whether serotonin reuptake inhibitors or trauma-focused psychotherapy are more effective in treating PTSD. The study concludes that clinicians should make shared decisions with patients based on patient preferences regarding treatment characteristics.
A new study published in the Journal of the American Heart Association finds that heavy drinking can cause subclinical heart damage, increasing levels of blood biomarkers associated with inflammation and cardiac wall stretch. Heavy drinkers are more likely to experience cardiovascular disease than non-problem drinkers.
A new drug trial by Monash University Professor Eric Morand shows a statistically-significant reduction in disease activity versus placebo in lupus patients. The TULIP 2 trial found a significant effect in global disease activity measures, including improved skin disease and reduced steroid doses.
A new study shows that blocking the neonatal crystallizable fragment receptor (FcRn) can reduce levels of immunoglobulin G (IgG) and IgG immune complexes, potentially treating autoimmune diseases. The therapy, SYNT001, was well-tolerated in a Phase 1 clinical study.
Researchers found that fenfluramine significantly reduced convulsive seizures in Dravet syndrome patients, with a 62% decrease in seizures per month. The study also showed improvements in seizure-free intervals and parental assessments of child improvement.