Articles tagged with Drug Studies
A study of 3,537 children found that 40% go without treatment for 60% of the time, with lower socio-economic families more likely to drop off medication. The research suggests that consistent treatment is crucial for managing ADHD, a chronic condition affecting around 1 in 20 Australian children.
A new Ohio law allowing pharmacists to dispense naloxone without a prescription has been linked to an increase in naloxone dispensing rates. The study found that the law resulted in more naloxone being made available to patients, potentially saving lives in opioid overdose situations.
A University of Georgia psychologist's study confirms that treating avolition, a motivation-related symptom, improves other negative symptoms of schizophrenia. The results suggest targeting this domain could improve overall negative symptoms and reduce functional disability.
Researchers developed a comprehensive multi-Organ-on-a-Chip platform to bridge the gap in current limitations in drug development. The system enabled accurate modeling of human pharmacokinetic and pharmacodynamic parameters for tested drugs, mimicking real-world human responses.
A new study found that amlodipine lowered long-term gout risk compared to two other commonly prescribed blood pressure medications. The study, conducted by physician-researchers at Beth Israel Deaconess Medical Center, demonstrated the antihypertensive drug's association with a lower risk of gout.
A new oral pill, elagolix, has been shown to effectively reduce heavy menstrual bleeding in women with uterine fibroids. The study found that 80.4% of women treated with elagolix alone experienced a 50% reduction in bleeding, compared to 9.6% in the placebo group.
Breakthrough research presents five major advances in inflammatory bowel disease (IBD) treatment, including a new drug pipeline, a diet that improves symptoms, and a fecal microbiota transplantation approach. These studies offer hope for patients with Crohn's disease and ulcerative colitis.
A randomized controlled trial found that the ACE method was as effective as a specialist stop smoking service in quitting smoking. The study's results suggest that ACE may offer a viable cost-effective alternative for public-funded healthcare settings.
A Texas policy reducing anti-psychotic medications for foster children showed a 5-8% decrease in non-FDA indicated prescriptions while preserving medication use for those with approved indications.
A randomized clinical trial evaluated the absorption of six sunscreen active ingredients in four formulations, with all ingredients surpassing FDA thresholds for potentially waiving additional safety studies. The study highlights the need for further research on sunscreen ingredient exposure and its effects.
Research links proton pump inhibitors to poorer concentration and memory in breast cancer patients. Cognitive problems reported by PPI users were 20-29% more severe than those in non-users. The study suggests an association between PPI use and cognitive decline in breast cancer survivors.
A study found that fewer than half of US clinical trials comply with the law on reporting results, with non-industry sponsored trials most likely to breach. Trials with industry sponsors are more likely to report results on time, but progress has stalled since July 2018.
Researchers at UC Riverside are targeting cancer-causing genes Mcl-1 and Bfl-1 for novel therapies in melanoma and lung cancers. They aim to develop potent agents that can help tackle chemotherapy-resistant cancers.
Clinical trials suggest that psychedelic-assisted psychotherapy is more effective than traditional therapy alone in treating PTSD. The combination of MDMA and traditional psychotherapy has shown promising results, with patients experiencing temporary adverse reactions not requiring additional medical intervention.
The MND-SMART trial is a comprehensive clinical study that seeks to find treatments for motor neurone disease (MND), a progressive condition affecting the nervous system. The trial will involve over 1,500 participants and test multiple treatments against a shared placebo group.
A systematic review found that albendazole (ALB) and praziquantel (PZQ) are effective in treating taeniasis caused by the pork tapeworm. The study analyzed 20 studies, including before-after designs and controlled trials, and reported cure rates ranging from 52% to 99.5%.
As demographics change, spina bifida patients' needs are evolving, highlighting the need for research on quality of life and social determinants. The article discusses emerging trends in spina bifida care and the importance of addressing health disparities among minority populations.
A recent investigation by Science found that companies, universities, and institutions are often non-compliant with the requirement to report clinical trial results in a federal database. More than 55% of trials violated this law, yet regulatory agencies have failed to enforce penalties or actions against violators.
A 20-year study found that long-term antipsychotic treatment significantly reduced mortality in people with schizophrenia compared to those without medication. The study also showed no increased risk of hospitalization for cardiovascular disease among those receiving antipsychotic therapy.
Researchers analyzed 20 years of research on intention deactivation and found that completed intentions can sometimes continue to affect people, particularly when reminders or stimuli trigger their retrieval. This effect is often rare but can play a role in learning new routines.
A UK-wide trial has started recruiting patients for a three-year study on preventing falls in people with Parkinson's disease, led by the Royal United Hospitals Bath NHS Foundation Trust and the University of Bristol. The trial will test whether a commonly prescribed dementia drug can prevent debilitating falls and improve patients' qu...
A nationwide Finnish study found that individuals with Alzheimer's disease who took antipsychotic medications had a 29% higher risk of head injuries compared to those who didn't. This is particularly concerning as these patients already have a higher risk of falling and traumatic brain injuries.
A physically and mentally active lifestyle can slow FTD symptoms by providing cognitive resilience to brain degeneration. Research participants with dominant genetic mutations showed slower functional decline in the most active group compared to the least active group.
The study found significant tumor shrinkage in two out of three patients with salivary gland tumors treated with T-DM1. The benefit lasted for at least two years in one patient, suggesting a promising activity for this rare cancer type.
Researchers identified five practices: prepare with intention, listen intently and completely, agree on priorities, connect with the patient's story, and explore emotional cues. These practices aim to improve patient experiences and clinician satisfaction in medicine. The team is now evaluating their effectiveness in clinical settings.
Antipsychotic medications may increase death or cardiopulmonary arrest risk in older hospital patients, particularly those taking first-generation antipsychotics. The study highlights the need for cautious use of these medications to treat delirium and protect patients.
A new set of guidelines for Complex Innovative Trials (CID) aims to improve the quality and efficiency of clinical trials. The recommendations cover stages from trial planning to patient-facing documentation, with the goal of accelerating the development and approval of innovative treatments.
A study by Penn Medicine found that residents of Hispanic neighborhoods are less likely to receive CPR from a bystander and have a lower chance of survival following cardiac arrest. The study analyzed over 27,000 cardiac arrest events and showed a significant disparity in CPR delivery rates between Hispanic and non-Hispanic neighborhoods.
A University of Michigan study found that prompt disposal of leftover medications improved when parents received a disposal packet and tailored online messages. The study suggests that easy disposal and risk education can significantly reduce the number of parents keeping leftover opioids for their children.
A systematic review and meta-analysis found insufficient evidence to determine whether serotonin reuptake inhibitors or trauma-focused psychotherapy are more effective in treating PTSD. The study concludes that clinicians should make shared decisions with patients based on patient preferences regarding treatment characteristics.
A new study published in the Journal of the American Heart Association finds that heavy drinking can cause subclinical heart damage, increasing levels of blood biomarkers associated with inflammation and cardiac wall stretch. Heavy drinkers are more likely to experience cardiovascular disease than non-problem drinkers.
A new drug trial by Monash University Professor Eric Morand shows a statistically-significant reduction in disease activity versus placebo in lupus patients. The TULIP 2 trial found a significant effect in global disease activity measures, including improved skin disease and reduced steroid doses.
A new study shows that blocking the neonatal crystallizable fragment receptor (FcRn) can reduce levels of immunoglobulin G (IgG) and IgG immune complexes, potentially treating autoimmune diseases. The therapy, SYNT001, was well-tolerated in a Phase 1 clinical study.
Researchers found that fenfluramine significantly reduced convulsive seizures in Dravet syndrome patients, with a 62% decrease in seizures per month. The study also showed improvements in seizure-free intervals and parental assessments of child improvement.
A working group of medical organizations analyzed 29 pivotal phase III trials for disease-modifying drugs in MS, finding that patient symptoms and quality of life were often not considered. They suggest improving studies by focusing on patient-reported outcomes and long-term treatment effects.
A randomized controlled trial found that fenfluramine reduced convulsive seizures by 62% in patients with Dravet Syndrome. Low-dose fenfluramine also showed significant reductions in seizure frequency, while side effects were manageable.
A national study found a significant rise in teens taking and overdosing on benzodiazepines, commonly prescribed anxiety medications. The rate of exposure among adolescents increased by 54% between 2000 and 2015, with nearly half of all reported exposures documented as intentional abuse or misuse.
A recent clinical trial found that nilotinib increases dopamine levels and reduces neurotoxic proteins in people with Parkinson's disease. The study also showed potential in halting motor and non-motor decline, making it a promising treatment option.
Researchers found that children with mild to moderate asthma who experienced worsening symptoms had distinct bacterial groups in their upper airways, while those with well-controlled asthma had different bacteria. Altering the airway microbiome could potentially help patients with asthma.
Researchers found that women with poorer quality of life, higher pain and endocrine symptoms, and negative beliefs about medication effectiveness are more likely to stop taking aromatase inhibitors. Patient-reported outcomes can act as biomarkers, predicting non-adherence and informing personalized treatment strategies.
The Physicians Committee awarded Mihael H. Polymeropoulos the Trailblazer Award for his efforts to replace animal tests with human-relevant science. He challenged the FDA's utility of dog studies in drug development and advocated for modern, human-based scientific methods to advance human drug safety.
A new analysis confirms human genomic data can predict success in clinical trials, with genetically supported drug targets twice as likely to be approved. Historically, drugs targeting proteins with amino acid sequence changes linked to the disease have the best chance of approval.
A new study has confirmed that bovine kobuvirus is the causative agent for calf diarrhea in US cattle. The virus was found in four of nine samples tested at the University of Illinois Veterinary Diagnostic Laboratory.
A systematic review and meta-analysis found no conclusive evidence supporting the safety of ivermectin administration among pregnant women. The studies included in the analysis reported some adverse events, but the number of cases was too low to be conclusive.
A phase III clinical trial shows tucatinib significantly improves survival rates in women with HER2+ breast cancer, especially those with brain metastases. The study found nearly tripled one-year progression-free survival and doubled two-year overall survivor compared to standard treatment.
A study found that pharmacy-based transition-of-care models can improve patient satisfaction by educating patients about their medications as they transition out of hospital care. The model also led to a significant drop in hospital readmission rates.
The trial showed that adding tucatinib to capecitabine and trastuzumab improved progression-free and overall survival in advanced HER2-positive breast cancer patients, regardless of whether they had brain metastasis. The treatment combination also increased the overall response rate compared to standard care.
A study by University of Cincinnati researchers found that certain antidepressant medications cause more side effects in children and adolescents with OCD and anxiety disorders. SSRIs were associated with increased rates of agitation, while SNRIs showed no significant link to suicidality.
A study found that more than 25% of lung cancer patients are prescribed medications with potential cardiac risk, and almost 10% take multiple such medications. The researchers argue that these criteria may be excessive and could be too strict, excluding patients who don't pose a cardiac risk.
A new study found that Huntington's disease patients are at risk of therapeutic misconception due to a lack of understanding about clinical trial risks and benefits. Investigators recommend improving patient-doctor communication to address this issue.
Cinnarizine and sodium valproate show promise as preventive agents for pediatric migraine, reducing headache frequency by over 50% compared to placebo. The study suggests these medications may be a new option for children and adolescents with migraine, but long-term safety concerns need further investigation.
A new study found that varenicline tartrate is effective in quitting smoking among adolescents, with a higher rate of long-term success compared to the placebo group. However, it did not prevent relapse. The researchers suggest pairing medication with therapy and behavioral treatments for better results.
A recent review found that aspirin no longer provides a net benefit for primary prevention of cardiovascular disease and cancer, despite its long history of reducing heart attack risk. Aspirin use has decreased in recent years due to the emergence of statins and improved cancer screening technology.
A recent study found that a combination of chemotherapy and immunotherapy caused serious side effects in 32% of older patients enrolled on a leukemia trial. The findings highlight the need for caution when enrolling vulnerable populations in clinical trials.
A study by University of Utah Health found that people with chronic illnesses turn to underground exchanges for medicines and supplies due to affordability and accessibility issues. Many participants donated or traded goods with family, friends, or strangers who couldn't get them through traditional channels.
A pilot study found that limiting food consumption to a 10-hour window per day improved health outcomes in participants with metabolic syndrome. Participants experienced significant weight loss, reduced abdominal fat, and stable blood sugar and insulin levels.
A global clinical trial has demonstrated the safety and effectiveness of an oral medication to treat nonalcoholic steatohepatitis (NASH), a chronic liver disease. The treatment, obeticholic acid, showed the ability to reverse liver scarring in patients most at risk for irreversible liver damage.
A pilot study found that restricting eating to 10 hours a day for 12 weeks improved weight loss and reduced symptoms of metabolic syndrome in individuals at high risk for diabetes. Participants also experienced increased sleep satisfaction and some were able to lower or discontinue medications.
A clinical trial found nilotinib to be safe and tolerable for patients with moderate to advanced Parkinson's disease, but did not show a clinically meaningful benefit. The study, led by Northwestern University, involved 76 participants and tested three doses of the medication over six months.
A new field study in Nepal shows the typhoid vaccine is safe, immunogenic and effective against the disease, with results showing 7 cases out of 20,000 children vaccinated. The study's findings are significant, especially with the recent spread of drug-resistant typhoid, which threatens child health in affected regions.