Articles tagged with Drug Studies
A novel low-dose 3-in-1 blood pressure pill (GMRx2) significantly reduces blood pressure in patients with uncontrolled hypertension. After six months treatment, the GMRx2 group achieved a 5.8mmHg lower systolic blood pressure compared to standard care.
New studies show semaglutide reduces all-cause death, CV death, and non-CV death in people with overweight or obesity and established cardiovascular disease. The medication also improves heart failure symptoms and physical limitations in those with obesity-related HFpEF, regardless of sex.
A study emulated a clinical trial using real-world UK healthcare data to explore treatment effects in patients with atrial fibrillation. The method found similar outcomes between apixaban and warfarin, but with differences linked to ethnicity and medication use.
A new study published in Alzheimer's & Dementia found that cholinesterase inhibitors (ChEIs) may slow down cognitive decline in dementia with Lewy bodies over five years. ChEIs were also associated with a reduced risk of death in the first year after diagnosis.
A new non-hormonal hot flash treatment has been shown to significantly reduce symptom frequency and severity within weeks, while also improving sleep quality and overall well-being. The investigational drug elinzanetant was found to have a favorable safety profile with mild side effects.
A new study found that semaglutide significantly reduces major adverse cardiac events, including heart attacks and strokes, among overweight individuals with cardiovascular disease. The medication also shows similar benefits for people with pre-existing heart failure, regardless of type or severity.
A team of neuroscientists at Stanford University discovered that blocking the kynurenine pathway can improve cognitive function in lab mice with Alzheimer’s disease. The study found that drugs that block this pathway improved glucose metabolism, corrected astrocytic performance, and enhanced spatial memory in the mice.
A WVU researcher argues that more validation is needed for the increasing number of gallbladder surgeries performed for biliary dyskinesia, a functional gallbladder disorder. The researcher suggests that a combination of factors must come together to diagnose and select patients who would benefit from surgery.
A clinical study confirmed the safety of aceneuramic acid in treating distal myopathy with rimmed vacuoles (GNE myopathy), a rare disease causing progressive muscle weakness. The treatment, developed for an ultra-orphan drug, showed efficacy and was approved by Japan's Ministry of Health, Labour and Welfare.
A disproportionality analysis of World Health Organization data revealed a signal of semaglutide-associated suicidal ideation, particularly among patients with co-reported antidepressant use. This finding warrants urgent clarification and highlights the need for further research on the safety profile of semaglutide.
Researchers at UCSF have developed intelligent brain pacemakers that use AI to monitor and adjust brain activity in real-time, providing personalized treatment for Parkinson's patients. The approach, called adaptive deep brain stimulation, has shown promise in reducing symptoms such as movement problems and insomnia.
A new study by Northwestern University found that PrEP users frequently perceive others using the medication as promiscuous, despite knowing those who use it. The authors suggest sex-positive messaging to address this stigma and encourage a broader understanding of PrEP's benefits among vulnerable populations.
A study examining tecovirimat's effectiveness on mpox in the DRC found the drug safe but showed no significant impact on lesion duration. The trial, sponsored by the NIH and co-led with the DRC, resulted in lower mortality rates among participants compared to reported cases.
Scientists discovered a way to kill pancreatic cancer in mice by combining a ketogenic diet with an existing cancer drug. The diet blocks the cancer's only source of fuel, allowing the drug to take effect and shrink tumors. This finding opens a new vulnerability for treating cancer with diet and personalized therapies.
A new study provides first-of-its-kind data on the pharmacokinetics and safety of intravenous remdesivir in treating SARS-CoV-2 coronavirus in pregnant women. The research reveals that no dose adjustments are necessary for remdesivir when used in pregnant women, with no safety concerns or adverse pregnancy outcomes identified.
A study by researchers at São Paulo State University found that dopaminergic medication levodopa improves sleep quality in Parkinson's disease patients. The number of times patients woke up during the night fell by 25% and the amount of time they remained awake fell 30% on average.
A trial at UT Health San Antonio found that Sacituzumab Govitecan was well-tolerated and showed signs of effectiveness for patients with breast cancer who had progressed to brain tumors. The drug has been shown to deliver a topoisomerase inhibitor into tumors, providing promising clinical signals of efficacy.
Research by University of Southampton finds medications improve ADHD quality of life, but core symptoms targeting alone is insufficient; combining medication with other approaches may lead to further improvements in well-being.
A clinical study in Birmingham has found that nipocalimab can improve the survival rate of unborn babies with rare fetal anaemia. The majority of pregnant patients who received nipocalimab gave birth at or after 32 weeks without needing an intrauterine transfusion, resulting in a perinatal survival rate of 92%.
Results of a Phase 2 clinical trial show that nipocalimab can delay or prevent anemia and intrauterine blood transfusions in babies at high risk for Hemolytic Disease of the Fetus and Newborn (HDFN). The study involved 13 pregnant women who received intravenous nipocalimab between 14 and 35 weeks of gestation.
Researchers question the effectiveness of new amyloid immunotherapy drugs in reducing Alzheimer's disease impact, citing limited eligibility and high costs. The drugs showed small effect sizes that may not outweigh the risk of adverse events.
A nationwide study found that brentuximab vendotin significantly improved the quality of life for young patients with high-risk pediatric Hodgkin lymphoma. Nearly 44% of patients reported poor quality of life before treatment, but researchers saw significant improvement as treatment progressed.
A major new study by Karolinska Institutet has found that women with epilepsy are four times more likely to die during pregnancy and their babies have a 50 percent higher risk of illness or death. Despite the high relative risks, most pregnancies for women with epilepsy go well.
Researchers at WashU Medicine have developed a novel compound that effectively clears bacterial infections in mice, including those causing rare and potentially fatal 'flesh-eating' illnesses. The compound targets gram-positive bacteria, reducing virulence and speeding up post-infection healing.
A new study found that Cannabigerol (CBG) significantly reduced feelings of anxiety at 20, 45 and 60 minutes after ingestion, with stress ratings also decreasing. CBG's effect on memory was unexpectedly positive, enhancing the ability to recall lists of words.
Terasaki Institute scientists have created a novel bioink derived from egg whites, offering abundant proteins and excellent biocompatibility. This breakthrough technology has the potential to create more accurate tissue models for drug testing and develop functional tissue replacements for regenerative medicine applications.
US adolescents have reported decreases in both medical and nonmedical use of prescription medications between 2009 and 2022. The study attributes these changes to factors such as revised prescribing guidelines and COVID-related school closures.
Researchers study T cells and monocytes interaction in the meninges before they attack the brain and spinal cord, potentially leading to new disease progression targets. The findings could provide a pathway to treating other neurological diseases like Alzheimer's and Parkinson's.
The A4 study, a large clinical trial of pre-symptomatic Alzheimer’s disease, has yielded key insights into the condition. Researchers have collected extensive data on brain scans, blood samples, genetic information and cognitive tests from over 7,500 participants.
A study of nearly half a million women found that endometriosis was associated with a higher risk of ovarian cancer. The risk was particularly elevated among women with ovarian endometriomas or deep infiltrating endometriosis, with a 19-fold increased risk for certain types of ovarian cancer.
A new study published in Neurology found that ofatumumab is more effective than teriflunomide at helping people with relapsing-remitting MS reach a period of no disease activity across racial and ethnic groups. The medication showed consistent results among diverse populations, including Black, Hispanic, and Asian individuals.
Researchers created a new cell model to study the effects of senescence on lung fibroblasts. Senescent alveolar epithelial cells triggered fibrotic activation in lung fibroblasts, which was attenuated by senolytic therapy.
A new study published in Hypertension journal suggests that both 30-year and 10-year risk predictions should be considered when making high blood pressure treatment decisions. The researchers compared two risk prediction tools and found that long-term, 30-year risk may be more important than short-term, 10-year risk for informing medic...
TAS-303 reduces SUI episode frequency by 58% compared to placebo, while also improving urinary incontinence amount and health-related quality of life. The medication may offer a safer alternative for SUI treatment without adverse effects associated with existing medications.
Researchers analyzed over 1.5 million patient records to find that metformin and SGLT-2 inhibitors lowered dementia and Alzheimer's disease risks compared to other antidiabetic drugs. The study suggests individualized treatment approaches considering patient-specific factors for optimal diabetes management.
Researchers at the University of Plymouth have discovered that administering a HDAC6 inhibitor prior to radiotherapy can inhibit cellular growth and increase cell death in meningioma samples. This promising approach could lead to improved treatment outcomes for malignant meningioma patients.
Researchers found that combining sodium glucose co-transporter 2 inhibitors and glucagon-like peptide-1 receptor agonists reduces the risk of major adverse cardiovascular events and chronic kidney disease progression by 11% and 33%, respectively. The study suggests using this combination to further improve outcomes in patients with typ...
A Phase 2 clinical trial demonstrated the effectiveness of OXO-001 in increasing embryo implantation, pregnancy and live birth rates among infertile women. The study showed significant improvements in biochemical, clinical and ongoing pregnancy rates, with a notable increase in live birth rates.
A new study by the University of Toronto Nursing found that over one million industry-sponsored events took place in the US in 2022, with a focus on physician and nurse practitioner interactions. These events were linked to specific pharmaceutical products, indicating their potential impact on prescribing practices.
The University of Texas at Arlington's Junha Jeon is developing transition metal-free cross-coupling technologies using arynes to deliver medications safely and effectively. This project aims to improve the production of drugs, particularly for cancer treatment, by reducing impurities left behind by metals.
A study of over 183,000 adults found that certain antidepressants can cause significant weight gain or loss, while others have little to no effect. Bupropion was consistently associated with the least weight gain among 8 first-line antidepressants, which may impact medication adherence and patient treatment decisions.
A new study found that bupropion is associated with the least amount of weight gain among common antidepressant medications, with users being 15-20% less likely to gain clinically significant weight. The research also highlights the varying weight gain effects of different antidepressants.
Researchers at UCSF have discovered a way to turn ordinary white fat cells into beige fat cells that burn calories, opening the door to developing new weight-loss drugs. The approach uses a protein called KLF-15 and may avoid side effects associated with current treatments.
The NIH is sponsoring a Phase 1 trial of an experimental nasal COVID-19 vaccine that may offer enhanced protection against emerging variants. The trial will enroll 60 adult participants and assess the safety and immune response of the vaccine candidate, MPV/S-2P.
A study published in Trends in Urology and Men's Health found that several treatments have been effective in treating delayed ejaculation, including vibration stimulation therapy and psychotherapy. The research highlights the need for health professionals to be aware of a patient's full medical and sexual history and offers hope for mi...
Researchers have identified three new variants of MDMA as promising alternatives for controlled psychotherapeutic use, retaining therapeutic potential while reducing side effects. The new compounds show a similar effect on clinical target structures in the brain and are broken down more favorably, resulting in fewer toxic products.
A University of Otago-led trial found that extended-release ketamine tablets significantly improved depressive symptoms in adults with treatment-resistant depression. The tablets showed good tolerability and minimal side effects compared to traditional injection or nasal spray methods.
A new study by UC San Francisco's ANSIRH program found that patients who received care remotely for medication abortion had similar outcomes to those who got ultrasounds and in-person care. The researchers analyzed the experiences of over 500 patients and found a high success rate for the
A new ketamine tablet form has shown promise in treating severe depression with negligible side effects and convenience. The study found that patients on the strongest dose of ketamine had the best results compared to placebo.
A new study led by researchers from the University of Pennsylvania School of Medicine developed a novel approach to assess medication-related liver injury. By analyzing real-world health care data, they found that some medications' levels of danger to the liver are being misclassified.
Researchers have developed a novel drug therapy for obstructive sleep apnea (OSA), which has shown significant improvements in reducing breathing interruptions and improving overall health. The treatment targets both respiratory and metabolic complications, providing a promising alternative to existing therapies.
Researchers at MD Anderson Cancer Center have identified a small molecule compound that restores physiological levels of telomerase reverse transcriptase (TERT), reducing cellular senescence and tissue inflammation. TERT restoration also spurred new neuron formation with improved memory and enhanced neuromuscular function.
A study by TUM researchers discovered four subtypes of Amyotrophic Lateral Sclerosis (ALS) with different molecular processes, including sex differences. The findings suggest repurposing an approved cancer drug targeting the MAPK pathway as a promising therapeutic approach for ALS.
A landmark clinical trial collaboration has reported significant improvements in neurobehavioral and functional outcomes for children with moderate to advanced stages of Sanfilippo syndrome. The study found anakinra, a recombinant interleukin-1 receptor antagonist, to be safe and effective in reducing disease symptoms.
A new study published in PLOS ONE found that lifetime LSD use is associated with a higher likelihood of severe psychological distress after losing one's job. The study analyzed data from over 15,000 adults and found that prior LSD use was linked to greater symptoms of psychological distress.
A preliminary clinical trial found that nicotinamide riboside, a form of vitamin B3, increased the walking endurance of patients with peripheral artery disease by over 57 feet. The study suggests that nicotinamide riboside may be a new option for treating chronic leg disease.
Scientists have created mirror-image cyclodextrins in the laboratory, which could make it easier to formulate and deliver complex medications. These discoveries may also lead to improved treatment of cardiovascular diseases caused by atherosclerotic plaques.
A study of 450 community outpatient mental health facilities found that approximately one-third offered medications for opioid use disorder. The availability of these medications highlights the need for further research on uptake and effective referral models.
The number of US individuals with chronic hypertension in pregnancy increased significantly, while medication treatment remained low, according to a new study. The findings highlight the need for improved maternal health strategies to address high blood pressure and cardiovascular complications.
A global study and meta-analysis confirm pantoprazole's effectiveness in preventing upper GI bleeding in critically ill adults on a breathing machine. The research, led by McMaster University, shows that pantoprazole reduces the risk of clinically important upper GI bleeding but has no significant impact on mortality.