Articles tagged with Drug Studies
Insilico Medicine's lead compound demonstrates strong enzymatic activity, selectivity, and favorable ADME properties, as well as antitumor activity in various animal models. The company's generative AI-powered platform generated over 3,600 candidate molecules before identifying the promising lead compound.
Scientists have recruited over 20,000 volunteers to a resource aimed at accelerating dementia drug development. The cohort will enable healthy individuals with increased genetic risk to participate in clinical trials, allowing researchers to test new treatments before symptoms appear.
Two studies based on the SELECT trial show semaglutide leads to sustained weight loss of 10% body weight and 7cm waist reduction after 4 years, regardless of starting weight or BMI. The medication also delivers cardiovascular benefits, with a lower risk of heart attack, stroke, or death.
Researchers at UC San Francisco found that dispensing abortion pills through the mail is a safe and effective method, with nearly 98% of patients completing their abortions. The study suggests that this model can help increase access to abortion care for clinicians and patients alike.
A new study finds mail-order pharmacy dispensing of mifepristone for medication abortion is effective, acceptable to patients, and feasible. This care model can improve access to medication abortion services and reduce the need for in-person screening.
A clinical trial found that aficamten significantly increased maximum oxygen use in patients with obstructive hypertrophic cardiomyopathy. This improvement enables patients to perform everyday tasks more easily, such as walking and household chores. Researchers believe aficamten has promise as a treatment for this condition.
A new study published in Addiction journal found that high-potency cannabis use between 16 and 18 doubles the risk of psychotic experiences from 19 to 24. Researchers analyzed data from the Children of the 90s study, which tracked over 14,000 individuals from birth to age 24.
A Danish study found that patients who tapered off semaglutide slowly and focused on lifestyle changes maintained their weight loss for at least 6 months. Lower doses of the drug were as effective as higher ones, with a tailored approach minimising side-effects.
A secondary analysis of a randomized clinical trial found that home blood pressure self-monitoring plus medication self-titration reduces BP in the longer term without increasing healthcare use or adverse events. This simple, inexpensive intervention has potential to improve long-term hypertension control in routine clinical practice.
A clinical trial found that adding Radix Salviae decoction to conventional treatment did not change coronary stenosis and restenosis rates after percutaneous coronary intervention. The diagnosis of MI/angina, average stent length, and ALT levels were associated with neostenosis occurrence.
The ECOG-ACRIN Cancer Research Group has launched the ComboMATCH-E5 trial, evaluating the combination of sotorasib and panitumumab in patients with KRAS G12C-mutated advanced solid tumors. The study aims to assess the efficacy and safety of the combination in this patient population.
A new Cochrane review suggests that taking zinc may reduce the duration of common cold symptoms by around two days, but the evidence is not conclusive. Common side-effects include bowel problems, nausea, and unpleasant taste.
A study by Duke University researchers found that combining a low-carb, high-fat keto diet with fluconazole significantly improved treatment outcomes against fungal meningitis. The keto diet increased the effectiveness of fluconazole by reducing fungal levels by up to ten thousandfold.
Astragalus polysaccharide regulates VRC metabolism by increasing Bifidobacterium bifidum abundance and reducing inflammation in the liver. This leads to improved VRC metabolism, with high-dose APS showing stronger effects.
Scientists have found an effective treatment for spitting cobra snakebites by blocking one of the major dermonecrosis-causing toxins with varespladib. The study suggests that this repurposed drug can prevent tissue damage and may become a valuable treatment against black-necked and red spitting cobra venoms.
A recent study in Saudi Arabia assessed the effectiveness of an educational program improving epilepsy care among caregivers. The intervention showed a significant decrease in knowledge gaps, with 23.2% having sufficient knowledge post-intervention compared to 60% before.
A new study by Boston University School of Public Health found that less than 15% of US college students can administer naloxone, a life-saving medication for opioid overdoses. Despite this, nearly 62% of students can identify signs of an overdose and nearly 67% feel comfortable calling emergency services.
A new study from the University of Texas MD Anderson Cancer Center found that increasing treatment plan doses or altering regimens significantly improves cessation success for persistent smokers who previously tried to quit and failed. Varenicline was more effective than combined nicotine replacement therapy in aiding smokers to quit.
Researchers found that metformin decreases the amount of COVID-19 virus in the body and lowers the chances of viral rebound. The study showed a significant reduction in long COVID cases and hospitalizations among adults treated with metformin.
Researchers at the University of Toronto have found a way to better control the preclinical generation of key neurons depleted in Parkinson's disease. They developed an efficient method for stimulating stem cell differentiation to produce neural cells in the midbrain, which closely resemble dopaminergic neurons of natural origin.
A survey of healthcare providers in the Middle East reveals a good understanding of halal pharmaceuticals, but gaps in knowledge, particularly about ingredients and aligning with Islamic principles. Personalized education and culturally sensitive care can address patient concerns and improve healthcare outcomes for all patients.
A study of 15 brand-name drugs found that competition from 'skinny label' generics saved Medicare nearly $15 billion from 2015 to 2021. The largest savings were seen for rosuvastatin, pregabalin, and imatinib, with actual spending being $16.8 billion versus projected spending of $31.5 billion.
A new study on aspirin's role in breast cancer treatment highlights critical issues related to health equity and aging, with implications for future disease intervention trials. The study found that aspirin did not decrease the risk of cancer recurrence or improve survival among breast cancer survivors.
A honey-containing nanoemulsion was developed and characterized for stability, maintaining normal pH values corresponding to skin pH throughout a 90-day testing period. The emulsion showed non-Newtonian flow and pseudo-plastic behaviour required for ideal topical formulation.
A multicenter study found that dapagliflozin improves diuresis and reduces hospital stays in patients with acute heart failure. The drug was shown to be safe and effective when initiated during early hospitalization, leading to faster discharge times.
A new study found that better heart health in middle-aged Black women is linked to reduced cognitive decline and preserved brain function. However, this benefit was not observed among white women. The study suggests that taking care of one's heart may have a positive impact on brain function and overall well-being.
Researchers identified elevated MALAT1 levels in various blood cancers, correlating with adverse outcomes. MALAT1 promotes cancer cell proliferation, migration, invasion, and metastasis through multiple mechanisms.
The Alzheimer's disease treatment landscape is experiencing a significant shift, with numerous potential drugs making their way through clinical trials. Biomarkers have also emerged as a key area of focus, providing valuable information on the drug's impact and allowing for more precise guidance in future trials.
Researchers at the University of Pennsylvania are working on a decision-support system to help clinicians navigate conflicting clinical trials. The system will use artificial intelligence to analyze study results and provide recommendations, aiming to improve patient outcomes and inform treatment decisions.
A study suggests that a strong therapeutic alliance is key to successful psychedelic-assisted therapy in reducing depression. Participants who had stronger relationships with their therapists experienced lower depression scores one year later.
A phase 3 trial shows that pembrolizumab significantly prolongs overall survival in high-risk kidney cancer patients. The treatment delays recurrences and helps patients live longer, with a 38% reduction in risk of death compared to placebo.
A study found that social stress during adolescence in female mice leads to prolonged cortisol elevation after giving birth, similar to women exposed to adverse early life experiences. The researchers suggest alternative treatments may be more effective for postpartum depression.
Researchers found that riociguat significantly improved blood pressure and reduced the risk of serious adverse events compared to a placebo treatment. The study showed promising results for this potential new treatment to manage complications from sickle cell disease, paving the way for larger clinical trials.
A new study shows that a massive effort to reduce the overuse of proton pump inhibitors (PPIs) led to a nearly 30% reduction in prescriptions, but also resulted in some veterans missing out on protective use. The intervention, which imposed limits on PPI prescription size and refills, was carried out in one region of the Veterans Healt...
A comprehensive Scandinavian study has found no evidence that popular diabetes medications GLP-1 analogues increase the risk of thyroid cancer. The research analysed data from over 145,000 patients treated with these drugs and compared them to other patient groups.
A clinical trial found that a nasal spray called etripamil effectively and safely treated recurrent episodes of paroxysmal supraventricular tachycardia (PSVT) in patients. The study showed that two-thirds of participants experienced relief within an hour, with an average time needed for symptom relief being 17 minutes.
A comprehensive review examines the impact of osteoporosis on fracture healing and the effects of osteoporosis medications. The study concludes that there is no deleterious effect of osteoporosis medications on fracture healing, and prompt treatment can reduce the risk of secondary fractures.
Saruparib, a selective PARP1 inhibitor, demonstrates clinical benefit in patients with HRR-deficient breast cancers. The objective response rate was 48.4%, and progression-free survival was 9.1 months. The drug's favorable safety profile enables patients to stay on treatment for longer durations.
A new study published in the New England Journal of Medicine found that half of patients discharged from hospital after a heart attack are treated with beta-blockers unnecessarily. The study shows that these patients have suffered a small heart attack and have retained heart function afterwards.
The study, presented at AACR Annual Meeting 2024, found the combination therapy to be effective with an objective response rate of 34% and a disease control rate of 85.1%. The regimen performed favorably compared to historical data for similar cohorts, indicating potential as a new standard of care.
The randomized clinical trial demonstrates plozasiran's potential to reduce triglyceride levels in patients with severe hypertriglyceridemia. Additional studies are needed to determine its impact on complications associated with the condition.
A meta-analysis of 11 trials involving 78,607 patients found a 9% reduction in major adverse cardiovascular events (MACE) and a 14% reduction in cardiovascular death with SGLT2 inhibitors. The analysis showed consistent effects across patient groups and subgroups.
A study found that only 43% of accelerated approval drugs demonstrated a clinical benefit in confirmatory trials after five years. The study analyzed 129 cancer drugs approved between 2013-2023 and found that 63% were converted to regular approvals, but 22% were withdrawn due to lack of efficacy.
A pilot study by UCLA Health investigators suggests that treating patients with immunotherapy and chemotherapy before surgery may improve long-term outcomes for those with borderline resectable pancreatic cancer. The study found a higher rate of successful tumor removal and increased overall survival when compared to historical controls.
Recent trials have shown that testing for tumour DNA in the blood can identify advanced bladder cancer patients who are less likely to relapse after surgery, allowing doctors to target treatments more effectively.
Researchers from China conducted a nationwide study to assess optimal treatment strategies for CSDH. The study found that multimodality management and personalized treatment plans significantly reduced recurrence rates.
Researchers identified four weight-gain trajectories and factors associated with rapid or gradual weight gain, including age, sex, ethnicity, and baseline body mass index scores.
New research from Cedars-Sinai found that glucagon-like peptide-1 receptor agonists (GLP-1RAs) used to treat diabetes and obesity increase the risk of aspiration pneumonia following endoscopy. The study recommends patients taking these medications stop their medication in advance of procedures to avoid complications.
The University of Cincinnati Cancer Center team has opened a Phase 2 clinical trial to test a new combination treatment for glioblastomas, a deadly form of brain tumors. The treatment uses letrozole, a drug that targets an enzyme present in breast cancer cells, and temozolomide, a chemotherapy drug already approved as a GBM treatment.
Dr. Chana Sacks is the new Editor-in-Chief of NEJM Evidence, focusing on providing high-quality, practice-changing evidence for medical professionals. The journal aims to change how medical professionals think about generating evidence while making clinical learning engaging and fun.
A comparative study of four major type 2 diabetes medications reveals differences in medication acceptance, quality of life, insulin secretion, and mortality. The GRADE Study found that younger age and higher blood sugar levels at baseline were associated with poor blood sugar control over time.
Researchers from USC's Keck School of Medicine synthesized over 23,000 studies to inform updated clinical practice guidelines for ADHD. The comprehensive literature review found that both medications and psychosocial treatments work for treating ADHD and that children can and do get better.
Young adults in Korea with ideal cardiovascular health had significantly lower risks of developing heart disease, stroke, and kidney disease. The study highlights the importance of achieving and maintaining ideal heart health during young adulthood to prevent these diseases.
Researchers have discovered a new immunotherapy approach to overcome resistant leukemia by targeting the mutated TP53 gene. Combining pharmacological therapies with genetically engineered CAR T-cells increases effectiveness against cancer cells, offering promising strategies for patients with resistant disease.
Researchers at Xi'an Jiaotong-Liverpool University developed a new method that enables the efficient production of cysteine-rich peptides and microproteins in their naturally folded 3D structure. The approach uses organic solvents to mimic nature's oxidative folding process, resulting in speeds of over 100,000 times faster than aqueous...
Researchers at WVU are developing an AI tool to reduce medication errors that lead to hospital readmissions, aiming to improve patient safety and reduce healthcare costs. The tool will analyze patient records and identify high-risk patients, alerting pharmacists to potential issues.
A study published in Genome Medicine uses digital twins to computationally treat thousands of medications in individual patients with autoimmune diseases, finding promising results in mice and human tissue samples. The technology has the potential to revolutionize precision medicine by providing tailored medication for each patient.
Adding ribociclib to hormone therapy improves invasive disease-free survival by 90.4% at three years, distant disease-free survival by 90.8%, and recurrence-free survival by 91.7%. The study found a 25% relative reduction in recurrence rate for patients with stage 2 or 3 HR-positive, HER2-negative early breast cancer.
Researchers have developed a vascularized organoid model (VOM) that accurately replicates the actual vasculature and environment of gastric cancer, enabling patient-specific predictions of response to anticancer drugs. The VOM demonstrates high cell viability rates and similarity to actual gastric cancer conditions.
A new study from Harvard T.H. Chan School of Public Health finds that prenatal exposure to antiseizure medication topiramate does not increase the risk of autism spectrum disorder (ASD) among children. In contrast, valproate has been linked to a heightened risk of ASD.