Articles tagged with Drug Studies
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Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
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A new study by Yale University researchers found that buprenorphine maintenance therapy is more effective than detoxification in treating patients with prescription opioid dependence. Patients who received ongoing buprenorphine were less likely to use illicit opiates and had better treatment outcomes.
Researchers have successfully transplanted human intestinal organoids into mice, creating a model to study intestinal diseases and potentially treat conditions like Crohn's disease. The findings could lead to bioengineering personalized human intestinal tissue for treatment.
A recent study suggests that long-term daily treatment of Viagra can provide protection for the heart at different stages of heart disease, with few side effects. The phosphodiesterase-5 inhibitor improved heart performance in all patients with various heart conditions and showed no negative effect on blood pressure.
The study will evaluate the benefits of genetic testing to guide medication decisions for patients with depression or schizophrenia, including clinical outcomes and cost benefits. The research aims to provide personalized treatment recommendations tailored to individual patient genetics.
A new study published by The Endocrine Society reveals that resveratrol increased spinal bone density in men with metabolic syndrome and improved levels of the bone formation marker BAP. This finding suggests the compound's potential as an anti-osteoporosis drug, stimulating bone-forming cells within the body.
A study by Cornell Food & Brand Lab found that trivial elements like graphs and formulas can lead consumers to believe products are more effective. The researchers concluded that presenting consumers with 'scientific looking' information increases product confidence because individuals trust the appearance of scientific validity.
A study found that an outpatient antimicrobial stewardship intervention lost its initial benefits after discontinuing audit and feedback to clinicians. The program reduced broad-spectrum antibiotic prescribing rates by nearly 50 percent initially, but saw a significant increase in prescriptions after termination of the feedback component.
Researchers found that a combination of specialist behavioral support and medication significantly increases the odds of smoking cessation success, with a 23% quit rate among study participants. The approach outperformed unaided quitting and nicotine replacement therapy alone.
A new clinical trial found that drug combinations not including efavirenz are effective as first-line antiretroviral therapy for HIV patients who cannot tolerate efavirenz. The study showed high rates of HIV control and immune system restoration with these regimens, but noted differences in tolerability.
A CTRC doctor has been awarded a $1.6 million FDA orphan grant to study the efficacy of TH-302 in treating glioblastoma, a devastating brain tumor with a median survival time of four months. The drug, combined with Avastin, aims to slow tumor growth by creating a low-oxygen environment, sparing healthy cells from chemotherapy damage.
Scientists simulate nano-bearings made of C60 flake to study friction reduction. However, results show no significant decrease in friction when the flake is attached in a way that prevents rotation.
Researchers warn that sildenafil, used to treat erectile dysfunction, can cause visual responses in people with a common mutation for eye disease. Studies on mice found heightened effects and signs of cell death in those with the mutation, raising concerns about long-term vision impact.
Research reveals that young men and women who had a heart attack have poorer health and quality of life if they have limited social support, including friends, family, and emotional connections. This study provides new insights into the importance of social support for younger patients after a heart attack.
A phase 3 trial found that combining dabrafenib with trametinib significantly reduces disease progression and death risk in metastatic melanoma patients. The therapy results in a 67% complete or partial response rate compared to 51% on monotherapy.
Alpha-synuclein regulates neuronal communication by self-association, clustering synaptic vesicles and restricting neurotransmission to manage communication. This newfound understanding may be critical for therapeutic interventions targeting alpha-synuclein levels and activity in Parkinson's disease.
The Canadian Medical Association Journal refutes criticisms of the BART trial that showed a substantially increased risk of death associated with aprotinin. The authors argue that regulatory bodies should have mandated a second large trial to confirm or refute the results.
The VCU Center for Medication Development for Cocaine Use Disorder aims to develop safe and effective treatments for cocaine addiction. The center will conduct preclinical and early clinical trials, and provide educational resources to train the next generation of translational scientists.
A phase III trial showed that Rolapitant significantly reduced nausea and vomiting in patients receiving cisplatin-based chemotherapy. The study found that 72.7% of patients experienced complete response, with improved quality of life outcomes.
A phase III trial demonstrated that afatinib significantly improved progression-free survival compared to methotrexate in patients with recurrent or metastatic squamous cell carcinoma of the head and neck. The study showed a 20% reduction in risk of progression or death, with patients experiencing less pain over time.
Australian researchers successfully treated 12 participants with celiac disease using hookworms, increasing gluten tolerance by a factor of 60. The study suggests a potential new treatment for inflammatory diseases, including asthma and Crohn's disease.
The NCI/FDA workshop resulted in the development of two innovative clinical trials, Lung-MAP and ALCHEMIST, which employ a 'Master Protocol' approach to improve patient outcomes. These trials aim to accelerate the development of targeted therapies for lung cancer by integrating multiple sub-studies based on genomic profiles.
A recent study found that mefloquine, an antimalarial drug, was not effective as an alternative to sulfadoxine-pyrimethamine (SP) for malaria prevention during pregnancy. Despite its safety profile, the drug showed poor tolerability and limited benefits for fetal health in HIV-positive women.
A new survey of over 70 people with bipolar disorder suggests that yoga can have a substantial impact on reducing anxiety, promoting calm, and improving emotional well-being. However, some respondents also reported potential risks, such as physical injury or pain, and the need for caution in certain practice styles.
A new randomized trial demonstrated that optical coherence tomography (OCT) guidance during stent implantation in primary PCI for ST-elevation myocardial infarction (STEMI) improves patient outcomes. The OCT STEMI trial found lower area stenosis and fewer uncovered struts after nine months, indicating better long-term results.
A randomized trial found that IVUS-guidance significantly improved 12-month clinical outcomes after new-generation drug-eluting stent implantation, compared to conventional angiography-guided CTO intervention. The IVUS-CTO study showed lower rates of cardiac death, myocardial infarction, and target-vessel revascularization in the IVUS-...
A study by WHO and University of Toronto researchers found that implementing essential medicines policies is associated with improved quality use of medicines. Countries with higher per capita wealth levels showed weaker correlation, highlighting the importance of these policies in low-income nations.
A 19-year study found that children who received early interventions for aggressive behavior had fewer convictions for violent crimes, lower rates of serious substance abuse, and fewer psychiatric problems. The program's positive effects held true across four different sites and among both males and females.
Researchers have developed a new compound for treating spinal muscular atrophy (SMA), a neurodegenerative disease that causes muscles to weaken. The compound, an antisense oligonucleotide, repairs the expression of the SMN2 gene and improves survival rate in mice studies.
A study analyzing reanalysis of RCT data found that about one-third led to changes in findings, with some altering patient groups or treatment effects. The results underscore the importance of standardizing data sharing and reanalysis practices for individual and public health.
A new study by Stanford researchers found that re-analysis of clinical trial data can change conclusions, particularly when data is not shared. The study identified 37 published re-analyses, with 13 concluding that different patient populations or treatment protocols could benefit from the tested medication.
A recent study found that more than 60% of people with dementia have three or more other conditions, but these are often not adequately described in clinical trials. The combined effects of co-morbidities like diabetes and chronic heart failure can lead to worsening symptoms and increased risk of preventable dementia admissions.
A study published in JAMA Neurology found that immunosuppressant MMF treatment significantly reduced relapse rates and improved disability scores in patients with neuromyelitis optica spectrum disorder (NMOSD). The results suggest MMF may be an effective treatment option for preventing attacks and resulting disabilities in these patients.
A multicenter trial of 1358 children found intermittent montelukast reduced wheezing episodes only in those with the specific genetic subtype. The treatment was ineffective in children without this genotype, highlighting the need for targeted research.
A recent study published in JAMA Internal Medicine found that patients with advanced dementia are still being prescribed medications with little to no proven benefit. The study analyzed data from over 5,400 nursing home residents and found that nearly 54% received at least one questionable medication.
A phase II clinical trial combining Sorafenib and Selective Internal Radiation Therapy (SIRT) achieved improved patient survival, with median overall survival of 20.3 months for intermediate stage HCC patients. The treatment also showed promise in downstaging locally advanced HCC to potentially curative treatment.
A phase III trial found that continuous REVLIMID (lenalidomide) with dexamethasone improved progression-free survival and reduced risk of disease progression compared to standard treatment. Patients treated with continuous REVLIMID plus dexamethasone showed a significant reduction in risk of progression or death.
A recent study found that postmenopausal women who consume higher amounts of potassium are less likely to experience strokes and die. Fruits and vegetables are rich sources of potassium and may help lower blood pressure and reduce the risk of stroke and death among older women.
A recent study found a significant increase in liver injury caused by herbals and dietary supplements in the US population over a ten-year period. Non-bodybuilding supplements were more likely to result in death or liver transplantation compared to conventional medications.
Dr. Rowan Chlebowski, a leading expert in women's health, has been recognized by the North American Menopause Society for his groundbreaking research on estrogen alone and joint symptoms. His work has significantly impacted clinical use of menopausal hormone therapy worldwide.
A survey of over two million people found that lesbian, gay, and bisexual individuals in England are more likely to experience poor health and negative interactions with the National Health Service. These individuals were also up to 50% more likely to report dissatisfaction with primary care services.
A randomized controlled trial found that melatonin supplementation had no effect on reducing delirium in elderly patients undergoing hip fracture surgery. The study suggests that melatonin may not be effective in preventing postoperative delirium, and further research is needed to compare its effects with antipsychotics.
The ROCKET AF trial found that digoxin use was associated with a 22% increased risk of death due to any cause and a 22% increased risk of death due to cardiovascular events. In complex atrial fibrillation patients, doctors should proceed with caution when using digoxin.
A new study found that treating only the pulmonary veins with a procedure called ablation resulted in reasonable outcomes without the need to treat other areas of the heart. The study, which included 589 patients, showed that adding further ablation increased treatment time but did not reduce AF recurrence rates.
A novel polypill with a fixed-dose combination of blood thinner, cholesterol-lowering drug, and angiotensin-converting-enzyme inhibitor shows promise in increasing patient adherence to treatment following a myocardial infarction. The study found that patients were more likely to take their medication when given as a polypill compared t...
The SYMPLICITY HTN-3 trial found renal denervation to be safe, with no significant clinical benefit for lowering blood pressure in patients with resistant hypertension. The procedure resulted in similar blood pressure reductions as a sham procedure, casting doubt on its effectiveness.
A new generation of coronary artery stent combining a biodegradable component with an ultrathin scaffold showed promising results compared to the current gold standard. The trial demonstrated non-inferiority of the experimental stent, but superiority in patients presenting heart attack.
The FOCUS Study found that patients taking a polypill had higher adherence rates compared to those receiving individual medications. The study identified factors contributing to non-adherence, including age, depression, and complexity of treatment.
A new diagnostic technique using Fractional Flow Reserve (FFR) measurement has shown that it can help avoid stents or surgery in over one-fifth of heart attack patients. The study found that patients with FFR values above 0.80 can be safely treated medically, without the need for coronary revascularisation surgery.
The RELAX-AHF trial found that serelaxin reduced the occurrence of worsening heart failure within the first 5 days of admission by 12.2% compared to 6.7% in placebo groups, resulting in a significant reduction in repeated episodes of worsening heart failure and hospitalization length.
The FAME 2 trial found that FFR-guided drug-eluting stenting significantly reduced major adverse cardiac events compared to medical therapy in patients with stable coronary artery disease. The rate of death, MI, or urgent revascularisation was lower with PCI than MT.
Investigational alirocumab produced superior results compared to placebo in reducing low-density lipoprotein-cholesterol (LDL-C) levels. The study found that 72.2% of patients treated with alirocumab reached an LDL-C goal, significantly higher than the 11.3% on placebo.
The ODYSSEY LONG TERM trial demonstrates alirocumab's efficacy in lowering LDL-C and reducing cardiovascular events. The study showed a significant reduction in major cardiovascular events and improved lipid profiles, suggesting a useful addition to statin therapy for high-risk patients.
The ODYSSEY COMBO II trial shows that alirocumab, a PCSK9 inhibitor, lowers LDL-C levels significantly more than ezetimibe when added to regular statin therapy. By week 24 and 52, alirocumab achieved 50.6% and 49.5% reductions in LDL-C, respectively.
A new study suggests rosuvastatin has an initially more favourable effect on glucose levels compared to atorvastatin in type 2 diabetes patients. This makes rosuvastatin a wiser choice, especially for those struggling to control their glucose levels.
A new trial found that darapladib did not reduce the risk of major coronary events or cardiovascular death in patients with an acute coronary syndrome. The study's findings challenge the notion that inhibition of lipoprotein-associated phospholipase A2 is a worthwhile approach for patients with coronary heart disease.
The PARADIGM-HF trial found LCZ696 to be superior to enalapril in reducing cardiovascular mortality and hospitalization for heart failure. The study showed a 20% reduction in death from cardiovascular causes and a 21% reduction in hospitalization for heart failure.
A new study found that pre-surgical colchicine administration reduced post-pericardiotomy syndrome (PPS) in cardiac surgery patients, but was associated with high gastrointestinal side effects.
The 2014 ESC/EACTS revascularisation guidelines emphasize the therapeutic benefit of revascularisation in coronary artery disease (CAD) for patients with stable CAD. Coronary artery bypass grafting (CABG) reduces the risk of death, myocardial infarction, and repeat revascularisation compared to medical treatment. DES are favored over b...
A study of 360 cardiac surgery patients found that colchicine reduced postpericardiotomy syndrome, but not postoperative atrial fibrillation or pericardial/pleural effusions. Colchicine also increased the risk of gastrointestinal adverse effects.
A clinical trial has shown that the infection caused by RSV can be effectively reduced after it has started, paving the way for a new treatment. The study found that the oral drug GS-5806 reduced viral load and improved symptoms in healthy adult volunteers infected with RSV.