Articles tagged with Drug Studies
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A new treatment, anti-LINGO-1, has been found to be safe and tolerable in phase I clinical trials for multiple sclerosis. The treatment blocks a protein that prevents myelination, potentially repairing damaged nerves.
A new study from Johns Hopkins Medicine suggests that nearly half of African-Americans may not receive effective doses of the HIV drug maraviroc due to their genetic makeup. Researchers developed a simple genetic test to determine individual dosage needs, which could help improve treatment outcomes.
A study found that a self-monitoring and self-titration program for hypertension significantly reduced systolic and diastolic blood pressure in high-risk patients. The results showed lower blood pressure at 12 months compared to usual care, with no adverse events.
Renal artery stenting may benefit patients with kidney artery blockages who were excluded from clinical trials. Expert panel recommendations suggest patients with cardiac disturbance or severe high blood pressure are good candidates for the procedure, while others may not be suitable due to mild or moderate blockages.
A randomized clinical trial found that patients with severe, nonchronic depression had better recovery rates when treated with combined therapy of cognitive therapy and antidepressant medication compared to antidepressant medication alone. Patients who received combined treatment also reported fewer serious adverse events.
Two experts denounce clinical trials of highly implausible treatments, citing dubious science and lack of evidence. They advocate for science-based medicine, urging patients to exercise critical thinking when evaluating treatment options.
A randomized clinical trial found that combining cognitive therapy with antidepressant medicine increases the odds of recovery by up to 30% for patients with severe, nonchronic depression. In contrast, chronic or mild cases do not benefit from this combination.
A study published in JAMA found that a program providing extended support to hospitalized smokers increased the six-month success rate of quitting by over 70%. The program used interactive voice response technology and stop-smoking medication to provide sustained care after discharge.
A postdischarge intervention that included automated telephone calls and free medication resulted in higher sustained smoking cessation rates at six months than standard advice. The study found that more participants achieved biochemically confirmed past 7-day tobacco abstinence and reported continuous abstinence for 6 months.
A new study published in Diabetologia found that fenofibrate is as effective in treating type 2 diabetes in women as it is in men. The research showed that fenofibrate reduced levels of adverse blood fats and cardiovascular events by 30% in women, compared to 13% in men.
Researchers discovered that naked mole rats maintain youthful heart function until age 90, offering insights into preventing debilitating cardiovascular disease. The rodents' natural habitat and stress resistance may hold the key to understanding these protective mechanisms.
Researchers found that clinical practice guidelines for beta-blockers were adopted quickly despite later studies showing no difference in postoperative outcomes. The case study highlights the importance of critically evaluating guideline development processes to ensure reliable and safe medical practices.
Research highlights the effectiveness of blood pressure-lowering treatment based on cardiovascular risk, as well as the importance of predicted baseline risk equations. Additionally, studies investigate the use of bivalirudin versus heparin in percutaneous coronary intervention and implant-based multiparameter telemonitoring for heart ...
A Phase II trial is being conducted to test fexinidazole, a 'rediscovered' drug, for its safety and efficacy in treating Chagas disease. The study aims to determine if the drug is safer and more effective than placebo in clearing the parasite that causes the disease.
Researchers found that digoxin increases the risk of death in patients with atrial fibrillation, regardless of age or other factors. The study, published in the Journal of the American College of Cardiology, suggests alternative treatments may be safer and more effective.
Researchers found triheptanoin oil to be an efficient treatment for Glut 1 deficiency, reducing seizure frequency and improving brain metabolism. The oil has been shown to have a positive impact on neuropsychological performance in patients with the rare disease.
Researchers have discovered how a drug that starves cancer cells of an essential amino acid kills them. The study's findings suggest using this approach may spare patients from chemotherapy toxicity.
Researchers found that mindfulness-based stress reduction (MBSR) resulted in significant reductions in systolic and diastolic blood pressure. MBSR was more effective than progressive muscle relaxation (PMR) in reducing blood pressure levels, suggesting it could be a valuable adjunct to traditional treatment plans for hypertension.
A study found that storing medication in the bathroom and incorporating it into daily routines can improve adherence to prescribed inhalers. The research identified six strategies that aid elderly asthmatics in managing their condition, providing clinicians and care coaches with useful ideas to support patients.
A meta-analysis of 6,700 stroke patients shows that alteplase treatment significantly improves chances of good outcome and reduces disability. Prompt administration within 4-5 hours of symptoms onset yields the best results.
Researchers seek to reduce inflammation in kidney transplants by increasing regulatory T cells, either through infusions or pharmacologically. The goal is to maximize long-term organ survival and improve graft success rates, which have remained unchanged at 4% loss annually.
Scientists at the Salk Institute have discovered a compound in the Voacanga africana plant that protects cells from altered molecular pathways linked to neurodegenerative diseases. The compound, voacamine, has shown anti-inflammatory and neuroprotective effects, suggesting potential as a treatment for Alzheimer's, Parkinson's, and stroke.
A systematic review of over a decade of studies on anticholinergic medications found significant adverse effects on both cognitive and physical functioning in older adults. The review suggests that these medications may negatively impact their ability to feed, dress, and engage in daily activities.
Researchers found that naltrexone reduced symptoms of compulsive gambling and other behaviors in PD patients. The medication may help alleviate these issues due to dopamine agonist treatment, not necessarily a result of the disease itself.
A new study has shown that Celgosivir, a naturally occurring compound, is generally safe and well-tolerated in patients with dengue virus. The treatment regimen will be tested in the next phase to evaluate its therapeutic effect.
A groundbreaking study in Tanzania successfully infects volunteers with malaria in a controlled laboratory setting, paving the way for accelerated development of new treatments. The innovative PfSPZ Challenge method eliminates the need for live mosquitoes, reducing costs and increasing accessibility to malaria research and treatment.
Researchers report recovery of injured corticospinal tracts in a patient with subfalcine herniation, suggesting neurological remodeling under rehabilitation intervention. Diffusion tensor tractography results show narrowed and then thickened tracts indicating recovery.
A medication called ferric citrate may reduce the need for dialysis patients to take multiple drugs that treat complications related to kidney disease. Ferric citrate binds phosphorus, increases iron stores, and decreases the need for iron and anemia medications, leading to fewer hospitalizations.
The Zerenex PERFECTED study demonstrated a highly statistically significant change in serum phosphorus, increases in serum ferritin and transferrin saturation, and significant reductions in IV iron and ESA usage. This could lead to significant pharmaco-economic benefits and improved patient care.
A large randomized trial found paracetamol to be no better than placebo in treating acute lower back pain, challenging universal recommendations. The study suggests advice and reassurance may be more effective than pharmacological strategies for acute episodes of low-back pain.
A new investigation by The BMJ raises concerns about the top-selling blood-thinning drug dabigatran, citing withheld company information and potential flaws in regulatory decisions. Key findings suggest that monitoring blood levels could reduce major bleeding risks by up to 30-40%.
Researchers found that bioidentical hormone treatments reduced tumor recurrence and improved cardiovascular and bone health, while also increasing physical activity and cognition. The study's results are promising but require further validation, providing a new direction in the search for alternative hormone therapies.
A systematic review of 10 studies confirms ketamine's safety in critically ill patients, providing analgesia, sedation, and amnesia without significant increases in intracranial pressure or neurological outcomes. The findings support the use of ketamine as a routine treatment for life-threatening infections and unconscious patients.
A six-month treatment with tesamorelin lowered liver fat modestly but significantly in HIV patients. The drug's impact on glucose metabolism was temporary, and reduced liver inflammation may result from lower fat levels.
A clinical trial found that high-dose fluticasone induced remission in 65% of patients with eosinophilic esophagitis, while 25% remained resistant to steroid treatment. Gene expression analysis identified a cluster of genes associated with steroid responsiveness.
A new analysis compares various anticoagulants after different types of orthopedic surgery. Aspirin may be a suitable option for preventing blood clots in patients undergoing hip or knee replacements, but anticoagulation therapy is more beneficial for those who have undergone hip fracture repairs.
Researchers extracted chemical compounds and microfossils from ancient teeth to study prehistoric diets. The analysis suggests that purple nut sedge was a staple food source with medicinal and aromatic qualities.
A recent study found that nearly 30% of completed clinical trials in the US remained unpublished after four years, threatening the validity of medical research literature. The lack of transparency was particularly pronounced among industry-funded studies and those with smaller sample sizes.
A new study published in JAMA found that patients enrolled in a 12-month telecare program experienced significant improvement in chronic pain management, with twice the likelihood of pain reduction compared to usual care. The program also showed increased patient satisfaction.
A telephone-delivered telecare intervention improved chronic musculoskeletal pain compared to usual care, with nearly twice as many patients experiencing a 30% reduction in pain score. The intervention was associated with clinically meaningful improvements in pain and treatment satisfaction.
Research shows that pill appearance can affect how patients take their medications, with a study finding that 30% of heart patients who stopped taking their medication had changed pill color or shape beforehand. In contrast, having strong social ties is associated with lower rates of suicide death among men, according to another study.
Researchers found that variation in generic drug appearance is associated with a greater risk of patients stopping their essential post-heart attack medications. Changes in pill color and shape are linked to increased odds of non-adherence, highlighting the need for healthcare professionals to warn patients about potential changes.
Using an expensive agent to prevent blood clots in kidney failure patients' dialysis catheters may reduce overall medical complications and lower healthcare costs. A recent clinical trial found that the increased cost of this medication was partially offset by lower costs for managing complications.
Researchers at SLAC and Stanford have found a way to estimate uncertainties in computer calculations used to speed the search for new materials, improving confidence in discoveries. This technique can be applied to thousands of computational studies across various fields.
A new medication called dupilumab has shown promising results in treating atopic dermatitis, a chronic and debilitating skin disease. Dupilumab blocks the action of two proteins involved in inflammation, leading to a marked improvement in disease activity and itch.
Researchers found that only five trials were focused specifically on drug safety, and 14 drugs were approved without condition-specific trials or trials in children. The study calls for increased regulatory emphasis on long-term safety and efficacy, particularly for chronic use medications.
A recent study by the University of Waterloo found that most prescription labels in Canada do not follow recommended guidelines for legibility. The researchers suggest that improving label appearance can be achieved without new technologies or larger labels, and recommends a patient-centered approach to labelling standards.
The National Institute of Allergy and Infectious Diseases (NIAID) has launched a Phase I clinical trial of CRS3123, an investigational oral antibiotic aimed at treating Clostridium difficile infection. The study aims to evaluate the safety and tolerability of the medication in healthy adults.
A study published in Diabetologia suggests that consuming whey protein before a regular breakfast can reduce post-meal blood sugar spikes and improve insulin responses. The researchers found that the early insulin response was significantly higher after whey protein, which could be beneficial for individuals with diabetes.
A new study published in The Lancet compares two drugs used to prevent blood clot formation during emergency heart attack treatment. The results suggest that systematic use of heparin rather than bivalirudin after primary percutaneous coronary intervention (PPCI) could save health services substantial sums of money while potentially im...
A nationwide clinical trial is being conducted to determine whether a commonly used probiotic can safely and effectively treat infants and toddlers with acute gastroenteritis. The five-year study will involve approximately 900 children at various medical centers, assessing symptoms and health outcomes over multiple months.
A UT Southwestern Medical Center study found that combining cognitive behavioral therapy with medication improves long-term success of depression treatment in children and adolescents. Relapse rates were significantly lower for those who received both forms of treatment compared to those on medication alone.
A study published in JAMA Dermatology found that women with long-term hypertension are at a higher risk of developing psoriasis. Long-term use of beta-blocker medication also increases the risk of psoriasis. The study analyzed data from 77,728 women and found a significant association between hypertension and psoriasis risk.
A clinical trial found that patients with psychogenic nonepileptic seizures (PNES) experienced a significant reduction in seizures and improvements in related symptoms, including depression and anxiety, when treated with cognitive behavioral therapy informed psychotherapy (CBT-ip) alone or in combination with the medication sertraline....
The EORTC presents a European solution for effective cancer drug development through collaborative molecular screening platforms. These platforms enable efficient access to new therapeutic agents and adapt clinical research to individual patient needs.
A recent study shows that half of patients with severe sickle cell disease have safely stopped immunosuppressant medication after a modified blood stem-cell transplant. The trial reversed the condition in nearly all patients and allowed them to achieve stable mixed donor chimerism.
A new clinical trial aims to remove the need for immunosuppressive drugs in organ transplant patients by increasing their regulatory T cells. The TRACT study uses a therapeutic approach that isolates and expands T-regs from participants prior to kidney transplantation.
A study found that lab monitoring tests are not always ordered as recommended, with factors such as specialist status, age, and general health influencing the use of these tests. The research suggests that interventions to improve laboratory monitoring should focus on areas with the greatest potential for improvement.
The ASPIRE trial is testing a vaginal ring containing the antiretroviral drug dapivirine for HIV prevention in women. The study has completed enrollment with 2,629 participants and is expected to conclude by late 2015 or early 2016.
The US Food and Drug Administration (FDA) has found that failure to monitor progress according to the stated schedule was the most common concern among clinical trial sponsors, followed by failure to obtain the agreement of the principal investigator. Poor record keeping was also a significant issue, with 40% of warnings related to it.