Articles tagged with Drug Studies
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Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
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A recent study found that nearly half of physicians surveyed believe ADHD stimulant medication diversion is common among teens, while most have never received training on the topic. This lack of knowledge and expertise can lead to ineffective prevention strategies, posing health risks to patients.
Researchers at UH Rainbow will evaluate treatment guidelines for African American children and young adults with asthma, exploring differences in response to asthma therapies compared to Caucasians. The study aims to identify the best add-on therapy based on patient age.
A recent study found that statin therapy lowers LDL cholesterol and reduces the risk of heart disease and stroke in patients with chronic kidney disease, but has no effect on kidney function or progression. The Study of Heart and Renal Protection (SHARP) included 6,245 patients who received a placebo or cholesterol-lowering treatment w...
Researchers found that a new version of an old MS drug reduced patient relapses and lesion development by 36% compared to placebo. The updated formulation allowed for longer injection intervals, potentially increasing compliance and quality of life for MS patients.
A study by Carnegie Mellon researchers found that providing digital feedback after medication taking improved adherence rates, promptness, and correctness. Participants who received ongoing feedback showed significant improvements compared to those who didn't, suggesting a beneficial effect of continuous monitoring.
Type 2 diabetes affects 24 million US citizens, with African Americans facing a 77% greater risk due to genetic, dietary and cultural factors. Culturally tailored healthcare is crucial for improving outcomes.
Studies by Penn neurologists investigate the potential of statin use and estrogen to delay Parkinson's onset, with promising findings. Telemedicine is also shown to improve access to specialty care for patients with Parkinson's disease.
A new UCLA-led study suggests that people taking statins in the 2009-10 year consumed more calories and fat than those who used statins 10 years earlier. Researchers found a significant increase in caloric intake among statin users, with no similar change among non-statin users.
Researchers have identified a new mechanism by which ghrelin works to limit depression, as well as a potentially powerful neuroprotective drug called P7C3 that may provide greater anti-depressant effects.
A study funded by the NIH found that acetazolamide can help preserve and restore vision for women with IIH, when combined with a moderate weight loss plan. The trial involved 161 participants who experienced improved visual field tests, optic nerve swelling reduction, and greater improvements in daily function and quality of life.
A randomized trial involving 273 pediatric patients with convulsive status epilepticus found that lorazepam was not more effective than diazepam in stopping seizures, but did cause more sedation. The study suggests that diazepam remains a suitable first-line treatment for pediatric status epilepticus.
A national survey found that 69% of U.S. adults support requiring coverage of birth control medications in health plans, with women, blacks, and Hispanics more likely to agree. The majority also support other medical services like mammograms and vaccinations.
Two new studies release promising results for migraine prevention, with one study showing a 66% decrease in migraine days and another demonstrating a 63% reduction. The new treatments target calcitonin gene-related peptide (CGRP), a protein thought to be involved in migraine, and are considered safe and well-tolerated.
Researchers at Cedars-Sinai Medical Center will conduct a Phase II clinical trial to evaluate the safety and efficacy of 3K3A-APC, an experimental drug combining with rtPA to treat ischemic strokes. The study aims to reduce risks and improve outcomes for stroke patients.
A study published in Psychiatry Research found that dopamine replacement therapy commonly used to treat motor symptoms of Parkinson's disease was associated with a decline in cognitive performance among depressed Parkinson patients. Mood in depressed Parkinson's patients was also worse while on dopaminergic medications.
A new study found that sprifermin (recombinant human fibroblast growth factor 18) reduces total and lateral femorotibial cartilage thickness and volume in patients with knee osteoarthritis. The treatment was shown to improve joint space width and WOMAC pain score, particularly at a dose of 100µg.
A pioneering clinical trial will test multiple drugs simultaneously in patients with advanced lung cancer based on their genetic profile. The 'National Lung Matrix' trial aims to provide more personalized treatment options for cancer patients.
The Cochrane review found no evidence of reduced hospitalizations or serious influenza complications with Tamiflu. However, the medication increased the risk of nausea and vomiting in adults and children, as well as psychiatric events when used for prevention.
A study led by Purdue University found that medication therapy management by phone reduced hospitalizations by 86% in low-risk Medicare patients, who were three times less likely to be hospitalized. However, the intervention had no significant impact on higher-risk patients, highlighting the need for tailored strategies.
The TOPCAT trial found that spironolactone did not reduce the composite time to death or hospitalization in patients with preserved ejection fraction. However, it significantly reduced hospitalizations for heart failure, providing important insights into its potential efficacy.
A phase II trial of efatutazone with erlotinib failed to improve efficacy in patients with refractory non-small cell lung cancer, but researchers hope to refine future treatments by identifying the right biomarker for individual patients. The study found that fluid retention was a key factor contributing to the lack of success.
Researchers at Newcastle University are investigating Google Glass as an assistive aid to help people with Parkinson's retain their independence. The technology is voice-operated and linked to the internet, providing discreet prompts to support key behaviours typical of Parkinson's.
The I-SPY 2 trial found that neratinib-based treatment improved outcomes for women with newly diagnosed, high-risk breast cancer. The adaptive randomization algorithm successfully identified patient subgroups likely to benefit from the regimen.
Researchers from Universidad Carlos III de Madrid find that price controls can increase efficiency and lower prices for generic medicines. The study suggests alternative instruments to direct regulation, promoting competition and transparency.
A third of ICU survivors develop depression manifesting as physical symptoms, such as weakness and fatigue, rather than psychological symptoms. Depression is four times more common than PTSD after critical illness, highlighting the need for new treatment approaches focusing on physical rehabilitation.
Researchers have found several molecular alterations that drive the cancer, including mutations and epigenetic changes. The study identifies potential new targets for drug treatments, including existing drugs that could block specific mutations.
Despite promises of personalized medicine, pharmacogenomics research has focused mostly on common diseases, neglecting tropical infections and rare diseases prevalent in developing countries. Researchers from low-income countries also conducted few studies on these topics.
Researchers at Penn Medicine have found that the drug baclofen can help block the impact of the brain's response to 'unconscious' drug triggers, potentially preventing cocaine relapse. The study used fMRI scans to measure neural responses to subliminal cocaine cues in patients treated with baclofen.
The app uses data from peer-reviewed research studies to show people if there is scientific evidence linking acne to foods like chocolate, fat, sugar and whey protein. Research displayed in the app shows that dairy, whey protein, omega-6 fatty acids and foods high in sugar are associated with acne.
The POISE-2 trial found that clonidine increased rates of clinically concerning hypotension and non-fatal cardiac arrest in patients undergoing non-cardiac surgery. The study showed higher risks from clonidine without counterbalancing benefits, contradicting earlier findings that suggested it would improve outcomes.
Bariatric surgery patients report better quality of life, reduced need for cardiovascular medications, and improved blood sugar control without insulin or most diabetic medications. The STAMPEDE trial shows gastric bypass surgery is more effective than medical therapy in treating type 2 diabetes in obese patients.
A recent study found that clinical trials often report adverse events less frequently on government websites compared to peer-reviewed medical journals. Inconsistent reporting of primary outcomes and deaths also occurred, highlighting the need for more comprehensive information on ClinicalTrials.gov.
A study comparing heparin and bivalirudin found that patients treated with heparin had significantly fewer major cardiovascular events at 28 days compared to those receiving bivalirudin. Heparin was also shown to reduce repeat heart attacks caused by stent thrombosis.
A JAMA study finds that biodegradable polymer biolimus-eluting stents (BP-BES) have similar safety outcomes to durable polymer everolimus-eluting stents (DP-EES) after two years, with noninferiority found for death and heart attack rates. The rates of target-lesion revascularization were also noninferior between the groups.
Patients with uncontrolled high blood pressure treated with renal denervation had low rates of adverse events, including five procedural complications and nine hospitalizations. The procedure also showed significant lowering of office systolic blood pressure by 11.9mmHg at six months.
A multicenter study found colchicine significantly reduced the rate of disease recurrence, improved symptoms, and hospitalization rates in patients with recurrent pericarditis. The medication was also associated with higher remission rates compared to placebo.
Researchers measured fruit fly food consumption using radioisotope labeling and paired it with the capillary feeder assay to achieve the most accurate measurements. The team's findings provide a best practices guide for nutrition measurement in studies of metabolism and disease.
The AleCardio trial was ended early after patients treated with aleglitazar showed higher rates of heart failure, kidney events, and gastrointestinal bleeding. The study found no cardiovascular benefits despite dual-action on PPAR receptors, leading researchers to consider the class of drug being tested clinically.
A study found that self-expanding TAVR significantly lowers death rates compared to traditional surgical valve replacement in high-risk patients with severe aortic stenosis. The treatment resulted in lower all-cause mortality and heart attack/stroke-related deaths at one year.
A large randomized trial found that renal denervation did not significantly lower systolic blood pressure in patients with severe resistant hypertension. Despite rigorous design and blinding, the treatment failed to meet primary efficacy goals, highlighting the need for further research.
A systematic review and meta-analysis of published studies on antidepressants in pregnancy found a strong association between their use and increased preterm birth rates. The study suggests that antidepressant medications may be contributing to the rising trend of preterm births, which can lead to significant health problems and costs.
A phase 1 trial found ceritinib to be highly effective against both crizotinib-sensitive and resistant tumors with manageable side effects. The study enrolled 130 participants and showed dramatic shrinkage in tumor size and number in around 60% of patients.
A study published in Journal of the American Medical Informatics Association found that redesigned electronic medication alerts reduced prescribing errors and increased efficiency among healthcare providers. The redesign incorporated concise language, a table-like format, and presented more detail to help providers scan for information...
A new vertebral augmentation implant showed promise in reducing pain and improving function in patients with compression fractures caused by osteoporosis. The study, involving 300 patients, found the implant to be effective in providing similar pain relief as current treatments and improving quality of life.
A preclinical study suggests that AHCC supplement can eliminate HPV infections and may have a role in preventing HPV-related cancers. The study found durable responses after treatment with AHCC for up to 90 days, with no side effects observed.
A recent study found that obese women may require a higher or adjusted dose of GnRH antagonist medication for successful IVF egg harvesting due to faster clearance rates and rebound hormone responses. This could improve fertility treatment outcomes for overweight and obese women.
Researchers have identified a subclass of antibodies associated with an effective immune response to an HIV vaccine. The study provides key insights that could aid the development of new vaccines, focusing on understanding the underlying quality of the immune response.
A multidisciplinary research team has developed a new approach, E2E Clinical Trials, which aims to improve the accuracy of treatment selection by seamlessly transitioning from controlled efficacy trials to real-world effectiveness trials. This continuum will provide better understanding of treatment effects on diverse patient populations.
The Miriam Hospital will continue to conduct HIV/AIDS research and provide treatments under the NIH grant, which has supported studies since 2000. The grant renewal allows for further investigation into novel therapeutic interventions and reduced pill burden for treatment-experienced patients.
A new class of BTK inhibiting drugs has shown significant improvements in patients with terminal forms of leukemia and lymphoma. The treatment has virtually no side effects and improves a patient's life expectancy and quality of life.
A recent systematic review of clinical trials found that vitamin D supplementation had little to no effect on depression. However, additional analyses suggested that vitamin D supplements may help patients with clinically significant depression when combined with traditional antidepressant medication.
A phase 2 study found that simvastatin slowed brain atrophy by 43% over two years compared to placebo. The medication was well-tolerated and showed small but significant improvements in disability scales.
A proof-of-concept study led by TGen used genomic analysis of canine tumors to identify potential new therapies for human cancers. The study successfully analyzed dog tumor samples in under 5 days, fitting within a clinical window for human medical advancements.
A study found that critically ill patients with mechanical ventilation had a higher prevalence of prior psychiatric diagnoses and an increased risk of new psychiatric diagnoses and medication use after hospital discharge. The risk was particularly high among those with no previous psychiatric history.
A study published in Medical Care found that patient requests for specific medications, including brand-name drugs, have a substantial impact on doctors' prescribing decisions. The results suggest that these requests can lead to suboptimal care and increased medication costs.
A study found that 22.6% of older Americans take medications that worsen coexisting conditions, such as hypertension and osteoarthritis. Experts call for more research and awareness to address this issue, which can lead to increased healthcare waste and harm to patients.
Researchers at North Carolina State University have developed a new trial design to counter the caregiver placebo effect in veterinary medicine. The study found that a low-dose pain medication was effective in cats with degenerative joint disease, despite owners' initial perceptions of improvement due to the placebo effect.
A recent study analyzing over 80,000 patients found that only a small minority of reported side effects from statin use were actually caused by the medication. In contrast, many common side effects like muscle pain and fatigue were equally common in both treatment and placebo arms.
Researchers at Sanford-Burnham and Icahn School of Medicine at Mount Sinai have discovered a key cellular process leading to heart failure, which can be halted with a therapeutic approach. Blocking the effects of miR-25 has improved cardiac function and survival in mice.
Researchers found that higher cerebrospinal fluid alpha-synuclein levels predict faster cognitive loss in Parkinson's disease, but not motor symptoms. The study, published in the American Journal of Pathology, offers new insights into PD pathology and potential management strategies.