'Smart bomb' drug delivery may increase effectiveness
Researchers developed a smart bomb-like drug delivery system that combines imaging with chemotherapy for prostate cancer treatment, showing promise in reducing tumor cells.
Drug Therapy
Articles tagged with Drug Therapy
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OptiNose presents new data on highly effective treatment for chronic rhinosinusitis
Patients in the active treatment group experienced significant improvements in nasal symptoms, sense of smell, and a reduction in nasal swelling. The study showed a highly significant improvement to a normal state in the nasal mucosa, with peak nasal inspiratory flow and rhinosinusitis outcome measures also significantly improved.
Annual dose of zoledronic acid better than daily bisphosphonates at improving bone density
A randomised controlled trial found that a single annual infusion of zoledronic acid improved bone mineral density by 4.1% compared to daily risedronate's 2.7%. This increase in BMD is associated with reduced fracture risk and acceptable safety and tolerability profiles.
Nicotine may have more profound impact than previously thought
New Brown University research suggests nicotine interferes with multiple cellular interactions, potentially developing new treatments for various diseases. The study identified 55 proteins interacting with the alpha-7 nicotinic receptor, which may have broader roles in the body than previously thought.
Targeted drug therapy prevents exercise-induced arrhythmias
Researchers at Vanderbilt University Medical Center discovered that the clinically available drug flecainide prevents potentially lethal arrhythmias in patients with CPVT. In two patients, flecainide prevented exercise-induced ventricular arrhythmias and allowed them to live normal lives.
Discovery of tuberculosis bacterium enzyme paves way for new TB drugs
Researchers at the University of Maryland have discovered an enzyme in Mycobacterium tuberculosis that is essential for its survival, paving the way for new TB drugs. The study identified NAD+ synthetase as a key target for developing structure-based inhibitors to combat latent and active TB infections.
Combating weight gain caused by antipsychotic treatments
A new study published in Biological Psychiatry found that modafinil can reduce weight gain associated with olanzapine treatment. The study showed that subjects receiving olanzapine and modafinil experienced less weight gain than those receiving only olanzapine.
Latent tuberculosis: An international project to fight a worldwide disease
A team of researchers from the McGill University Health Centre has received a $4.9 million CIHR grant to study a new, four-month treatment for latent tuberculosis that could help eradicate TB worldwide. The current nine-month treatment causes many side effects, and this new regimen has already shown fewer unwanted side effects.
Acitretin therapy may help reduce nail psoriasis
Low-dose acitretin therapy shows promise in reducing nail psoriasis symptoms, with 25-33% of patients experiencing complete or near-complete clearing. The treatment also demonstrates safety and effectiveness in improving quality of life for patients suffering from severe nail psoriasis.
Motivational readiness for alcohol/drug treatment is more about self-evaluation than consequences
New research on the University of Rhode Island Change Assessment Scale (URICA) finds that motivational readiness is more about individual self-reflection than avoiding negative consequences. The study, published in Alcoholism: Clinical & Experimental Research, suggests that motivation and readiness to change are influenced by personal ...
Ecstasy could help patients with post-traumatic stress disorder
A study published in Journal of Psychopharmacology found that MDMA, a pharmaceutical version of Ecstasy, can enhance the effectiveness of exposure therapy for PTSD. By increasing oxytocin levels and reducing fear responses, ecstasy may help patients overcome traumatic memories and reduce stress.
Long-term effects of early Parkinson's treatments similar
A study compared two common drugs used to treat early-stage Parkinson's disease and found that their long-term impact is similar. The research showed that patients on different treatment regimens experience roughly the same level of disability and quality of life over time.
Number of cardiovascular risk factors could determine safety of intravenous gammaglobulin treatment
Research identifies elderly patients with multiple cardiovascular risk factors as higher risk for stroke and heart attack after IVIg treatment, while those with fewer risk factors have lower likelihood. The study provides guidance for physicians counseling patients on IVIg treatment risks.
Support for adjunctive vitamin C treatment in cancer
A recent study on vitamin C treatment in cancer has been disputed by a nutrition expert due to the use of oxidized form of vitamin C and toxic doses. Contrasting findings suggest that high-dose vitamin C may have beneficial effects on cancer cells, tumor cell death, and postsurgical healing.
Lowering blood pressure prevents cardiovascular events and deaths in dialysis patients
A systematic review of eight trials found that lowering blood pressure with medication reduced cardiovascular complications, all-cause mortality, and cardiovascular deaths among dialysis patients. The protective effects were similar across different drug classes and were well-tolerated.
Laser treatment clinical trial misses primary endpoint
A clinical trial of laser therapy for stroke patients found that those with moderate to moderately severe strokes experienced significant improvement, with a 9.7% absolute gain in treated patients. However, the treatment did not significantly reduce overall stroke disability, missing its primary endpoint.
Knowledge of genetics improves uncertain medication
Researchers at Uppsala University have developed a model to calculate the appropriate dose of Waran before treatment starts. The study used data from 5,700 subjects across four regions to identify two genes, VKORC1 and CYP2C9, which can predict dosage needs for patients of European, African, and Asian origin.
Study shows ultrasound and tPA effective for stroke
A new experimental therapy combining ultrasound and tissue plasminogen activator (tPA) has shown to be more effective than tPA alone in treating ischemic stroke, according to a recent study. The treatment, which involves tiny gas-filled microspheres activated by ultrasound waves, helped restore blood flow and improve patient outcomes.
Young adult stroke patients may be misdiagnosed in ER
A study found that 14% of young adults (16-50 years old) with stroke symptoms were misdiagnosed in ERs, leading to delayed treatment and potential paralysis and speech problems. Accurate diagnosis is critical to reduce disability and improve outcomes.
Robotic therapy may reduce stroke physical disability years later
A small randomized study found that robotic therapy improved physical ability in stroke patients, with more significant gains in those with lower disability at the start of rehabilitation. The study suggests that robotic therapy may be useful in reducing physical disability years after a stroke.
Experimental antiarrhythmic drug reduces death rate in patients with atrial fibrillation
The ATHENA trial found that dronedarone reduced the incidence of cardiovascular-related hospitalisation or death by 24% compared to placebo. The study also showed a significant reduction in cardiovascular death, with no difference in overall mortality.
Synthetic steroid increases risk of recurrence in breast cancer survivors
A study found that women with a history of breast cancer who use synthetic steroid tibolone are at a 40% increased risk of recurrence. The drug was linked to distant metastases, which are often fatal. Tibolone should not be prescribed to breast cancer patients.
Estrogen found to increase growth of the most common childhood brain tumor
Researchers at University of Cincinnati discovered that estrogen receptors are present in medulloblastoma, the most common type of pediatric brain tumor. This finding suggests that anti-estrogen drug treatments may be beneficial in limiting tumor progression and improving patient outcomes.
New method to monitor disease status of patients with advanced prostate cancer
A new method uses circulating tumour cells to monitor disease status and predict survival in patients with advanced prostate cancer. Changes in CTC number before and after treatment are strongly associated with risk, making it a more predictive biomarker than PSA.
Immunosuppressant medication may be cost-effective for dry eye syndrome
A topical cyclosporine emulsion has been found to improve quality of life by 4.3 percent and reduce net cost by $598 per patient, making it a cost-effective treatment option for moderate to severe dry eye syndrome that does not respond to conventional therapy.
Alternative and complementary medicine should have role in new era of health care reform
The article highlights the importance of alternative and complementary medicine (CAM) in healthcare reform, advocating for universal coverage and evidence-based methods. CAM encourages a holistic view of health, promoting whole-systems approaches and multifactorial integrative therapies.
Controversial medication may decrease spasms for infants with epilepsy
A new study published in Epilepsia found that vigabatrin treatment in infancy may be effective in reducing infantile spasms with a lower risk of permanent visual field defects compared to adults. The study used kinetic perimetry to detect peripheral field defects and found normal visual fields in 15 out of 16 children.
Patients starting Parkinson's drug rasagiline earlier do better
A new study found that patients starting rasagiline earlier experienced less progression of Parkinson's disease symptoms and signs, including rigidity and activities of daily living. The long-term study showed a 16% less progression in the early-start group compared to those who delayed treatment for six months.
More than 1 in 5 lifetime risk of men developing alcohol dependence disorder
Lifetime risk of alcohol-use disorders for men exceeds 20% and women less than half that, with 15% at risk for abuse and 10% for dependence. Effective recovery strategies exist and can begin with doctor visits.
New treatment option for latent tuberculosis
Researchers at McGill University Health Centre have developed a new four-month treatment for latent TB, which causes less liver damage and improves patient adherence. The study found that this shorter treatment is better tolerated than the traditional nine-month treatment with isoniazid.
The drug treatment of heart failure is influenced by the gender of the patient and of the physician
A recent study found that female patients are less frequently treated with evidence-based treatments for heart failure, including ACE inhibitors and beta-blockers. However, the gender of the physician plays a significant role in adherence to treatment recommendations, with male physicians prescribing more complete treatment for female ...
Studies point to novel target for treating arrhythmias
Researchers at Vanderbilt University Medical Center have discovered a new molecular mechanism that increases the risk of arrhythmias. They found that calcium-sensitizing drugs can cause arrhythmias by making heart muscle cells more prone to irregular rhythms.
Study compares 2 nonsurgical treatments for reflux disease
Two non-surgical treatments for gastroesophageal reflux disease (GERD) have been found to be effective in reducing medication use and improving symptoms, according to a recent study. Radiofrequency therapy appears effective for reducing heartburn and cough, while full-thickness plication may be beneficial for patients with regurgitation.
How to treat fevers in African children up for debate
Two experts disagree on whether all African children with fever should be treated presumptively with antimalarial drugs. Blaise Genton and colleagues argue that declining malarial transmission rates support changing the policy, while Mike English and colleagues claim there is not enough evidence to abandon presumptive treatment.
Anti-fungal drug offers great benefits to some with severe asthma
A study by The University of Manchester found that patients with severe asthma and allergic sensitivity to certain fungi experience significant improvements in quality of life and lung function after taking an antifungal drug. However, symptoms often return after treatment is stopped.
Study shows optimal dose management of warfarin improves anticoagulation control
Researchers found that adjusting warfarin doses only when the international normalized ratio is between 1.7 and 3.3 improves patient outcomes. The study used a model to predict optimal dose changes based on clinic visits and anticoagulation control, revealing that patients deviating from predicted changes had worse control.
GPs 'could do more' to help obese avoid surgery
Researchers say that GPs could do more to help obese individuals avoid surgery by implementing early stage weight management programs and using anti-obesity drugs. Patients face a post-code lottery when seeking access to specialist care, highlighting the need for improved obesity management strategies.
Hospitals using quality improvement program increase compliance to stroke treatment guidelines
Researchers found that hospitals participating in the Get With The Guidelines–Stroke program increased adherence to national recommendations, with a significant increase in guideline-based care. The study showed that all hospitals improved, regardless of size or geography, and there is still room for improvement.
Group in lymphoma research chooses revlimid for study in disease's largest patient population
A phase III study will evaluate Revlimid as a maintenance therapy for elderly patients with diffuse large B-cell lymphoma. The study aims to determine progression-free survival and overall survival associated with Revlimid compared to placebo.
Drug-resistant tuberculosis rife in China
Levels of drug-resistant TB in China are nearly twice the global average, with 10% resistant to first-line drugs. The prevalence varied greatly between provinces, with an average weighted mean of 9.3% among all cases.
Potential breakthrough for T-Cell lymphoma patients with drug that mimics folic acid
A Phase 2 clinical trial of pralatrexate found a complete or partial response in 27 percent of patients with recurrent or resistant peripheral T-cell lymphoma. The treatment, which mimics folic acid, showed durable responses in patients who had failed multiple prior treatments.
Study reports REVLIMID activity in patients with relapsed/refractory mantle-cell lymphoma
The study found an ORR of 53% and CR/CRu of 20% in evaluable patients, while pooled data showed a 57% ORR and 21% CR. REVLIMID is being evaluated as a treatment option for heavily pretreated MCL patients.
UK kidney cancer patients face toxic, out-dated treatments with little hope of change
New treatments for advanced kidney cancer have shown promising results but are unlikely to be adopted in the UK due to high costs. The National Institute for Health and Clinical Excellence has provisionally ruled out using four new drugs, citing cost-effectiveness concerns.
Extended-release naltrexone, treatment for alcohol dependence, improves quality-of-life measures
A study found that extended-release naltrexone improves mental health, social functioning, general health, and physical functioning in alcohol-dependent patients. The medication reduces drinking and increases quality of life, making it a cost-effective treatment option.
NICE approves lung-cancer drug provided manufacturer Roche offers discounted price for NHS
The National Institute for Health and Clinical Excellence (NICE) has approved erlotinib as an alternative to docetaxel for NSCLC patients, with the manufacturer Roche offering a discounted price. This approval is part of a collaboration between NICE and manufacturers to reduce drug costs within the NHS.
Arthritis research shows better management more important than new drugs
A recent study published in Arthritis Research & Therapy found that more effective use of existing arthritis treatments is crucial for achieving better patient outcomes. The research, led by Isidoro González-Alvaro, suggests that disease activity and disability have improved independently of new therapies.
Cases of extensively drug-resistant TB declining each year in the US, but new cases still
A decline in US XDR-TB cases has been observed over the past 15 years, coinciding with improved TB and HIV/AIDS control. However, new cases continue to emerge, highlighting the ongoing need for vigilance regarding drug resistance.
New pulmonary hypertension research presented at CHEST 2008
New research shows tadalafil, an erectile dysfunction drug, effectively treats pulmonary arterial hypertension (PAH) by improving six of eight short form-36 domains and reducing pulmonary artery pressures. The study also reveals PAH diagnosis has increased by 10 months and affects women more in middle age.
3-substituted indolones as novel therapeutic compounds for neurodegenerative conditions
Researchers have discovered 3-substituted indolones with neuroprotective properties, offering promising therapeutic agents for neurodegenerative conditions. The compounds are more efficacious than existing treatments and display no cytotoxicity at high doses.
Elderly fare better when included in decisions on treatment trade-offs
A study by Yale University researchers found that elderly patients with multiple medical conditions can make more informed treatment decisions when involved in the process. By prioritizing global outcomes such as length of life and symptom relief, these patients can maximize their desired outcome and minimize potential harm from medica...
Breakthrough in treatment for E. coli toxin
A polymeric drug developed by University of Alberta researcher David Bundle binds to the E. coli toxin, preventing it from affecting the kidneys and causing life-threatening damage.
AGA releases evidence-based GERD guidelines
The AGA Institute published evidence-based guidelines for the management and treatment of suspected GERD, highlighting the need for high-quality clinical trials. The guidelines recommend various treatments, including proton pump inhibitors and antireflux surgery, to improve patient outcomes.
Older renal cancer patients appear to benefit from sorafenib treatment
A subset analysis of a randomized trial found that older patients with renal cell carcinoma derive similar clinical benefits from sorafenib therapy as younger patients, including improved progression-free survival and quality of life. The treatment was well-tolerated regardless of age, with manageable side effects.
A new 10-year vision for glaucoma
The article discusses a global summit of leading glaucoma specialists who gathered to discuss key needs and opportunities in advancing therapies for patients. The summit highlighted the need to advance beyond traditional IOP-lowering therapies and explore new approaches, including innovative drug delivery systems and novel biomarkers.
Not a moment to lose in therapy for acute stroke
Recent study findings suggest expanding thrombolysis window to up to 4.5 hours after acute ischemic stroke may lead to worsening outcomes due to irreversible tissue damage. The UCSD Stroke Center emphasizes the importance of timely treatment, highlighting the critical need for door-to-needle time during a stroke.
How to treat abdominal compartment syndrome in acute pancreatitis?
Researchers found that administering a traditional Chinese medicine Dachengqi Decoction combined with Glauber's salt improved treatment outcomes for patients with severe acute pancreatitis and abdominal compartment syndrome. The study suggested that this therapeutic protocol can lower IAP, relax symptoms of ACS, slow disease progressio...
What is the best strategy for treating Helicobacter pylori?
Researchers found that quadruple therapy is effective in treating H. pylori-related diseases, but side effects can compromise patient compliance. Modifying the regimen or educating patients about side effects can improve treatment outcomes.
OptiNose presents data on highly effective nasal polyp treatment
A Phase II trial of OptiNose's novel nasal drug delivery device showed a significant reduction in nasal polyp size and associated symptoms, with almost 80% of patients experiencing overall improvement. The treatment achieved a 57.4% reduction in polyp size and improved sense of smell, nasal obstruction, and nasal comfort.
ACP issues guideline for drug treatment of men and women with osteoporosis or low bone density
The American College of Physicians (ACP) issues a guideline for the drug treatment of osteoporosis in men and women, recommending bisphosphonates as a first-line therapy. The guideline emphasizes individualized treatment decisions based on risks and benefits.
First generation antipsychotic drugs as effective as newer ones in some children
A study from UNC School of Medicine suggests molindone, a first-generation antipsychotic, is as effective as newer drugs like olanzapine and risperidone in treating childhood schizophrenia. The medication may offer benefits due to fewer side effects, including weight gain and increased risk of heart disease.