Articles tagged with Drug Therapy
A new study found that patients who prefer a highly active role in their treatment do not necessarily have better luck managing chronic health conditions. Those who preferred an active role had higher blood pressure and cholesterol levels over a 12-month period compared to those with a less active approach.
A new study by Buck Institute researchers finds that high levels of MAO-B enzyme in mice lead to Parkinson-like symptoms. The findings suggest that humans with high MAO-B levels may be at risk for the disease and could benefit from preventive treatment.
A 13-year study found significant changes in Onchocerca volvulus populations' genetic structure, indicating adaptation to repeated ivermectin treatments. The parasite's resistance to the drug threatens the current control strategy against onchocerciasis.
Researchers identify nerve that transmits signals of chemotherapy-associated illness from small intestine to brain, offering new approach to reduce debilitating side effects. Anorexia and cachexia often accompany chemotherapy symptoms, compromising patient's nutritional status.
A team of researchers has identified pancreatic stem cells with the capacity to generate new insulin-producing beta cells in adult mice. These findings represent a significant breakthrough in understanding the pancreas's ability to regenerate beta cells, a crucial step towards developing effective treatments for diabetes.
A recent study by Beth Israel Deaconess Medical Center found that the majority of adverse events and device malfunctions associated with biliary stents occur during off-label use. Over 1 million patients received these devices for 'off-label' treatments between 2003 and 2006.
Researchers discovered significant changes in brain activity with intensive cognitive-behavioral therapy, leading to improved symptoms and reduced anxiety. The study suggests that this type of therapy may be more effective than previously thought, with potential implications for treatment.
Experts warn that psychotherapies like CBT can have serious adverse effects, including worsening of conditions, psychological dependency, and exploitation. They call for rigorous regulation and monitoring to ensure patient safety and effectiveness.
The use of medications in psychoanalysis is a topic of debate among professionals, with some advocating for cautious approach while others see its potential benefits. The American Psychoanalytic Association hosts a panel discussion to explore the uses of medications in analysis.
A randomized controlled trial suggests that combining lifestyle intervention with metformin is the most effective treatment for antipsychotic-induced weight gain. Participants who received this combination therapy experienced significant reductions in body mass index, waist circumference, and insulin resistance. In contrast, those who ...
Researchers have discovered new treatment mechanisms for schizophrenia, targeting the dopamine D2 receptor and novel neurotransmitters like N-acetylaspartylglutamate (NAAG) and serotonin. These approaches aim to complement existing treatments and offer new hope for patients with schizophrenia.
A study published in Biological Psychiatry found that genetic variants of the RGS4 gene predict antipsychotic treatment response in schizophrenia patients, with varying predictive power across different ethnic groups. The research highlights the potential for pharmacogenomics to guide treatment decisions and improve patient outcomes.
A study found that bright light therapy can ease symptoms of bipolar depression in some patients, with optimal response observed at midday. Six out of nine women treated achieved full recovery from depressive symptoms, highlighting the potential of light therapy as an augmentation strategy for improving treatment response.
Researchers aim to identify effective ways to disseminate research-based treatments and foster dialogue between treatment providers and innovators. The grants will examine barriers to adoption of promising practices and support partnerships between treatment organizations and states.
The International Osteoporosis Foundation (IOF) applauds the National Osteoporosis Society's (NOS) success in appealing the National Institute for Health and Clinical Excellence's (NICE) Guidance on osteoporotic fracture prevention. IOF calls for continued efforts to ensure clinically appropriate treatments are made available.
The American College of Physicians has issued new clinical guidelines that recommend against routine screening for carotid artery stenosis. Meanwhile, the use of vitamin D as a standard treatment for chronic kidney disease remains unchanged despite concerns over its effectiveness. Additionally, experts have called for revisions to orga...
Two drugs, dasatinib and nilotinib, are showing promising results as frontline therapy for newly diagnosed CML patients with high complete cytogenetic response rates of approximately 90% at 6 months. The treatments target a greater variety of genetic variations than imatinib, which has increased the 5-year survival rate for CML patient...
Researchers found that 71% of patients taking baclofen achieved and maintained alcohol abstinence, compared to 29% of those receiving placebo. Baclofen reduced clinical markers of liver injury associated with significant reductions in self-reported alcohol use.
Bioengineers at Yale have created a new method of drug delivery that effectively targets and treats brain tumors by adding a water-soluble polymer to the anti-cancer drug. This approach has the potential to increase treatment distances, potentially preventing recurrence and improving treatment outcomes.
TB drug resistance is a growing concern, with millions of cases worldwide each year. Doctors Without Borders advocates for increased funding and collaboration to develop new treatments.
A North Carolina team of doctors and nurses has created a model to provide faster treatment for heart attack patients. The RACE project uses caregivers from 65 hospitals and emergency medical teams throughout the state to diagnose and treat heart attacks more quickly, with median times improving by 22%.
Dexamethasone treatment disrupts sleep and causes profound fatigue in children with ALL, according to a new St. Jude study. The research suggests that altering timing or dosing of the drug could lessen these side effects and improve quality of life.
A Buck Institute study found that lithium increases lifespan in nematode worms by reducing the activity of a gene that modulates chromosome structure. The research highlights the potential for using C. elegans as a model organism to study drug toxicity and genetic impacts of compounds.
Researchers identified 7 anti-hypertensive drugs that significantly prevent beta-amyloid production, a key mechanism in Alzheimer's disease. These drugs, including Valsartan and Propranolol HCI, showed promise in preventing cognitive deterioration and memory loss in mice with Alzheimer's disease.
Researchers have discovered blood plasma proteins that rise and fall after treatment with antiangiogenic drugs, which may be used as surrogate biomarkers to predict the optimal dose. The study also found molecular changes in normal mice, suggesting that the body's response is not solely tumor-dependent.
The Juvenile Diabetes Research Foundation (JDRF) has partnered with Housey Pharmaceutical Research Laboratories to develop small molecule compounds promoting beta cell growth and survival. This research aims to identify new therapeutics targeting key scientific pathways, accelerating drug discovery and development.
A new study suggests that a long-acting erythropoiesis-stimulating agent variant of epoetin could be an effective alternative to conventional therapy for treating anaemia in haemodialysis patients. The treatment involves giving the drug every 2 or 4 weeks, which may reduce errors and improve patient quality of life.
A new study by Louisiana State University Health Sciences Center researchers found that hyperbaric oxygen therapy improved spatial learning and memory in a model of chronic traumatic brain injury. The therapy increased vascular density in the brain and was associated with an improvement in cognitive function.
A study found that individuals with a specific genetic variant (CYP2B6*6 allele) benefit from bupropion treatment and maintain abstinence longer than those without the variant. The study provides insight into personalized medicine for smoking cessation.
A study found tadalafil improved erectile function in men with spinal cord injuries, with average scores indicating mild to moderate dysfunction. The medication was safe and well-tolerated, with common side effects including headache and urinary tract infection.
A study found that UK children with asthma are being treated inappropriately, with over 121,000 prescriptions for bronchodilator syrups still issued in 2006 despite guidance discouraging their use. The number of combination inhaler prescriptions also increased significantly.
A study by St. Jude Children's Research Hospital reveals the loss of Arf gene and BCR-ABL mutation leaves cells vulnerable to growth-enhancing environment of bone marrow, promoting immunity to anti-leukemia drug imatinib.
Researchers at the University of Leeds have discovered a naturally occurring protein preventing 57 genes from operating normally in Huntington's sufferers' brains. Cancer drugs targeting this protein could halt its destructive nature.
A study published in PLOS ONE found that all eukaryotic kinases share a common set of substrates, suggesting that despite their diversity, these enzymes have similar functions. This discovery may improve the testing of drugs targeting protein kinases for various diseases.
A new oral treatment, EN101 antisense, has been shown to significantly reduce muscle weakness in people with myasthenia gravis. The study found that patients experienced improved muscle function, swallowing time, and disappearance of symptoms such as drooping eyelids.
The Hypertension in the Very Elderly Trial (HYVET) found that lowering blood pressure significantly reduces both stroke and mortality in patients aged 80 and over. The trial, which began in 2001, involved 3,845 patients from across the world and stopped early due to significant reductions in overall mortality.
A study published in The American Journal of Medicine found that emergency angioplasty use has increased, but 10% of eligible patients are still going untreated for life-saving treatment after a heart attack. Patients without typical symptoms or from underrepresented groups are most likely to miss out on this critical care.
A study at the University of Granada found that daily stress exacerbates lupus symptoms, but controlling stress reduces negative effects, including weight loss and joint pain. Psychological therapy significantly improved patients' quality of life and reduced stress, anxiety, and depression.
The clinical effectiveness of topical negative pressure therapy for wound healing is unclear, according to a review by the BMJ Specialty Journals. The technique has been used to treat various types of wounds, but many studies have been flawed, casting doubt on its validity and reliability.
Biologics may be a valuable treatment option for inflammatory bowel disease (IBD), offering new hope for patients. However, gastroenterologists must carefully weigh the potential benefits against significant side effects and costs. Research is ongoing to better understand the role of biologics in IBD treatment.
Researchers found that adherence to TB treatment is influenced by structural factors such as poverty and gender discrimination, highlighting the need for tailored support systems. A separate study on ventilatory control reveals evidence of central plasticity in humans, providing insight into the complexities of human physiology.
A study published in PLOS Medicine found that TB patients often take their medications under difficult conditions, highlighting the need for support systems tailored to their needs. Patient involvement in decision-making is crucial to improve treatment adherence and reduce the global disease burden of tuberculosis.
Researchers found that a drug originally developed to fight tuberculosis can help people with OCD make more progress in therapy, with participants reporting less distress and anxiety. The drug, D-Cycloserine, is believed to accelerate extinction learning and will be studied on smokers who want to quit.
Non-compliance with dermatologic treatment is a widespread issue, and physicians can improve compliance by establishing strong patient-physician relations, choosing suitable medications, and using effective education materials. Research shows that addressing non-adherence can lead to better success for patients with psoriasis and other...
A study by University of Illinois Chicago researchers found that young adults who want to quit smoking are less likely to use evidence-based behavioral treatment. Only 4-5% of young adult smokers use any form of treatment, compared to 32% of older smokers.
Nepalese researchers have identified Gatifloxacin as a more effective and affordable treatment option for drug-resistant typhoid fever. The study, funded by the Wellcome Trust, has significant implications for treating enteric fever in areas with high levels of drug resistance.
Researchers in Nepal have found a cost-effective treatment for drug-resistant typhoid fever using Gatifloxacin, a fluoroquinolone drug. The study shows that Gatifloxacin is effective against two common bacteria causing enteric fever and is relatively inexpensive at $1 per seven-day course.
Two new vaccines have been designed to combat cocaine and methamphetamine dependencies, stimulating the body to produce antibodies that attack the drugs. These therapeutic vaccines minimize withdrawal symptoms and relieve addiction, but do not necessarily curb relapse.
A retrospective study found that trabectedin response rates were significantly higher than previous studies, with an overall response rate of 51% and a progression-free survival rate of 88%. This suggests that myxoid sarcoma may be a uniquely sensitive subgroup to trabectedin treatment.
Researchers at St. Jude Children's Research Hospital found no association between the UGT1A1*28 gene variation and neutropenia or diarrhea in children treated with low-dose irinotecan. This allows clinicians to begin treatment sooner and eliminate costly genetic testing.
A preliminary study suggests that administering a blood clot-dissolving medication within 24 hours of severe frostbite injury can significantly reduce the risk of amputation. The treatment, tissue plasminogen activator (tPA), has been shown to improve blood flow and prevent cell death in affected limbs.
Motor neurone disease is a degenerative disorder that causes loss of basic motor functions, with symptoms including bulbar-onset, cervical-onset, and lumbar-onset patients. The disease has been reported in certain populations, such as the Chamorro population on Guam, and may be linked to genetic and environmental factors.
Researchers at the University of Maryland have defined the difference between near-cognate and non-cognate codons in messenger RNA, enabling more accurate design of drug therapies. This discovery could lead to improved treatment options for diseases caused by mutations in genes.
A multi-center team has discovered a 'signature' of proteins in the blood that predicts which non-small-cell lung cancer patients will live longer when treated with targeted therapies. The findings could help physicians decide which patients to treat with drugs known as EGF receptor tyrosine kinase inhibitors.
Two research teams developed models to predict NSCLC patient outcomes based on protein patterns. The new models, validated in independent groups, could help physicians decide treatment options for patients with NSCLC. Researchers identified a 25-signature proteomic signature associated with increased survival among NSCLC patients.
The study demonstrated that genotyping can optimize Quinamed dosing for improved tolerance and antitumor activity. Patients with slow acetylator genotypes showed evidence of anticancer activity in various tumor types, including prostate, ovarian, and gastrointestinal stromal tumors.
A University of Michigan study found that 86% of patients with follicular lymphoma survived after 8 years of treatment with Bexxar, a radioimmunotherapy drug. This success rate compares favorably to state-of-the-art chemotherapy regimens, making Bexxar an attractive option for patients.
A Phase II clinical trial at M.D. Anderson Cancer Center found dasatinib achieves complete cytogenetic response in 77-95% of newly diagnosed CML patients, compared to historical data on imatinib. The rapid response rate suggests dasatinib may be more effective as a first-line treatment for CML.
A clinical trial evaluated three leading combination therapies for uncomplicated falciparum malaria and found artemether-lumefantrine to be the most effective. The study included 601 healthy children from Uganda and demonstrated significant reductions in treatment failure, anemia, and asymptomatic parasitemia.
A study of 149 patients with low-grade gliomas found that temozolomide reduced tumor size in 53% and stabilized it in 37%, while increasing it in 10%. Genetic testing revealed that missing the 1p/19q gene was associated with better treatment outcomes.