Articles tagged with Gene Therapy
UCLA researchers develop gene therapy approach using modified HIV to target P-glycoproteins on cancer cells, minimizing side effects and maximizing therapeutic effectiveness. The method shows promise for controlling cancer and other diseases.
Scientists prevented brain damage by producing therapeutic levels of GDNF, a protein that helps nourish brain cells, in small monkeys. The gene therapy approach aims to halt Parkinson's disease at its onset and treat devastating side effects.
A study led by William Giannobile at the University of Michigan showed that gene therapy involving BMP-7 can produce nearly 50% more supporting bone around dental implants. This breakthrough has potential to reduce the need for bone grafts in reconstructive surgery.
A phase II clinical research study uses VEGF-2 gene therapy to stimulate growth of new blood vessels, relieving angina symptoms. The study aims to improve quality of life for patients with refractory chest pain.
Researchers discovered a critical 'gatekeeper' function that prevents auto-antibody accumulation in lupus, which can be restored to reverse the disease. Increasing Fc receptor activity by 40% restored health in animal models of lupus.
Researchers found that 50% of c-MYC-induced mammary cancers persisted in mouse models despite c-MYC gene blockage. Residual cancer cells quickly recovered malignant properties after treatment and eventually progressed to independent growth states.
Researchers discovered a jumping gene called Hermes, which creates changes in DNA similar to those created by the process behind antigen recognition. This discovery provides evidence that genetic processes behind antigen diversity may have evolved from the activity of a jumping gene.
Professor Xiaolian Gao's research develops a technology to mass-produce multiple genes on a single chip, reducing costs and time factors by 100 times. This breakthrough has the potential to create complete functioning organisms, produce energy, neutralize toxins and make drugs.
A new study has provided proof of principle for a combined stem cell-gene therapy approach as a potential treatment for cystic fibrosis. The researchers were able to correct the CFTR gene defect using adult stem cells and ex vivo gene therapy, which may offer advantages in screening and long-term function.
A new gene therapy approach has successfully corrected immunodeficiencies in 17 of 18 patients with severe combined immunodeficiency disease. The treatment, which involves introducing a 'good' gene into stem cells, has shown clear and sustained clinical benefits.
Researchers develop gene therapy to treat XP, a devastating disease causing cancerous lesions on exposed skin. The treatment restores DNA repair mechanism, preventing cancerous growth and sunburn-like symptoms in mice.
Researchers at Cedars-Sinai Medical Center found that a genetically engineered virus delivering the protein hsFlt3L slowed tumor growth and increased immune cell production in laboratory rats with glioblastoma multiforme. The study may lead to a new treatment approach for patients with GBM.
Researchers at Thomas Jefferson University used gene therapy to restore heart function in rats with failing hearts, reversing cardiac dysfunction. The study found that delivering the human S100A1 gene improved heart muscle efficiency and reversed cardiac dysfunction.
ALS researchers found that continuous administration of VEGF protein into the cerebrospinal fluid increases life expectancy in ALS rats. The treatment has shown promising results with a patient-oriented approach, allowing controlled doses to be easily administered.
Researchers found that viral delivery of a parkin gene protected dopamine-producing neurons from degeneration, offering new hope for treating Parkinson's disease. The study demonstrates the feasibility of gene therapy in a genetic model of the disease.
A new gene therapy has successfully corrected the genetic defect responsible for Fabry disease in mice, producing a sustained level of enzyme activity and reducing fat buildup in target organs. The treatment, administered shortly after birth, could potentially lead to a one-time treatment option for humans.
Researchers identified a complete deficiency in the CD3 epsilon chain of the T cell receptor causing SCID, leading to normal B cells but no T cells. Early diagnosis via bone marrow stem cell transplantation can result in a survival rate as high as 97% for patients with this mutation.
A new gene therapy technique has successfully treated irregular heart rhythms in pigs, using a 'painting' method to deliver the therapy. The technique, which uses a plastic, gel-like substance to contain the gene therapy, shows promise for treating atrial fibrillation, a common heart condition.
Researchers at the University of Pennsylvania School of Veterinary Medicine have identified key growth factors essential for sustaining spermatogonial stem cells in culture. By understanding these factors, scientists hope to develop new fertility therapies and create sperm in vitro.
Researchers at Pitt University successfully reversed peripheral neuropathy in diabetic mice using gene therapy based on HSV vectors, delivering neurotrophic factors to affected neurons. The approach restores lost nerve endings and prevents progression of neuropathy, with promising results for potential human treatment.
Children's Hospital Boston geneticist Dr. Kunkel has made significant contributions to understanding muscular dystrophy, from identifying genes to developing new therapies. His work aims to find patterns common to all muscular dystrophies and those distinct to specific forms of the disease.
A recent study found that demethylation agents not only restart cancer-suppressing genes but also knock methyl groups off other genes, turning hundreds more off. The research raises concerns about the impact of these agents on gene expression and their potential to exacerbate cancer development.
Researchers at St. Jude Children's Research Hospital developed a gene vector that allows hematopoietic stem cells to produce fetal hemoglobin, reversing beta-thalassemia in mice. The technique uses a new vector with added regulatory elements to improve the expression of the gamma-globin gene.
Researchers have identified a new region on the bcl-2 gene that regulates its expression and stability. This discovery may lead to the development of new cancer therapies by targeting the CA-repeated Region (CAR) to reduce bcl-2 levels in cancer cells.
NIST has awarded up to $80.1 million in funding for 32 new advanced technology program (ATP) projects, spanning various key technology areas including energy, medical diagnostics, electronics, and computer interfaces. The projects aim to improve productivity, facilitate trade, and enhance quality of life.
Researchers have developed a novel gene regulation strategy using ribozymes, which can be controlled with virtually any drug, offering a safer alternative to existing methods. The technique enables the easy turn on and off of genes, allowing for potential applications in therapeutic and research settings.
A study funded by the Christopher Reeve Paralysis Foundation has identified novel potential therapeutic targets for spinal cord repair using microarray technology. The study analyzed 108 genes and found patterns of gene expression that could help researchers identify new treatments.
A study has identified two distinct subclasses of liver cancer with differing survival rates, providing new molecular insight into the pathogenesis of hepatocellular carcinoma. The findings suggest that gene expression profiles can accurately predict patient survival and may lead to the development of more targeted therapies.
Researchers will study 120 patients with chronic and aggressive periodontitis to identify molecular basis of disease and develop targeted therapies. The goal is to reduce risk of periodontitis and improve treatment outcomes for the leading cause of adult tooth loss.
A recent study found that genetic variations in the HLA and TNF gene regions are associated with response to treatment in early rheumatoid arthritis patients. Patients with two copies of the shared epitope were four times more likely to achieve significant improvement in disease activity compared to those with one or no copies.
Scientists uncover vital role of Periaxin gene in causing CMT, a disabling disease affecting 23,000 people in the UK. The new research provides insight into how nerves work and may lead to development of gene therapies to correct faulty genes.
Researchers developed a novel gene-based therapy that substantially decreased tumor size and eliminated cancer cells in experimental mice. The treatment, which uses recombinant adenoviruses encoding interferon-alpha, showed promise in responding to even resistant bladder cancer cell lines.
A gene associated with lupus has been identified, suggesting a potential breakthrough in diagnosing and treating the disease. The discovery could lead to earlier intervention and more effective therapies.
Researchers found that different retroviral vectors from ASLV, HIV, and MLV integrate into human chromosomes at varying sites. The study suggests ASLV may be a promising candidate for human gene therapy due to its distinct integration preferences.
Researchers at Jefferson Lab are adapting detector technology to develop a new gene therapy technique for cystic fibrosis, which affects 30,000 Americans. The technology allows for successful imaging of gene transfer in mice, paving the way for clinical trials.
Researchers at UCSD and VA San Diego Healthcare System have developed a novel method of transcriptional gene silencing in the nucleus, utilizing short interfering RNA (siRNA). This approach may provide a long-lasting solution for gene regulation, with potential applications in treating diseases such as cancer and HIV.
Researchers have developed a novel gene therapy that combines a therapeutic gene with a genetic sensor to protect the heart from damage caused by reduced blood flow. The therapy, which was tested in rats, showed a significant reduction in tissue death and damage compared to untreated animals.
Researchers have identified nearly 100 genes linked to cancer, shedding light on the processes driving disease progression. The study highlights the potential of targeted therapies and early detection methods to manage cancer.
Researchers have successfully delivered a mini-dystrophin gene to all skeletal and cardiac muscles of an adult mouse with muscular dystrophy, reversing the disease. The breakthrough uses a safe and simple method to target muscle cells without triggering an immune response.
Researchers found genetic mutations in fibulin genes, specifically FBLN5, that could contribute to AMD. However, these changes were not statistically significant, and the study highlights the importance of precise search methods for genetic causes.
A LSU vet school professor has successfully treated a dog with cancerous tumors using gene therapy, which helps the body develop an anti-tumor memory. The treatment involves electroporation and cytokine gene therapy, resulting in the elimination of smaller tumors and reducing the size of larger ones.
OHSU researchers are studying vaccination methods for seniors and children, with a focus on developing protection against infectious diseases. The study aims to understand immune system changes that occur with aging and develop methods to manipulate the system for better protection.
Using guinea pigs, researchers increased production of G-protein Gem, which decreased calcium current densities by 30-90% and helped steady irregular heartbeats. Gene therapy shows promise as an alternative to calcium channel blockers with fewer side effects.
Researchers at UNC have developed a high-throughput technique to rapidly analyze gene functions, resolving two bottlenecks in the process. This method has the potential to accelerate the development of new drugs by quickly identifying and testing candidate genes.
Scientists used gene therapy to deliver RNA that silenced the disease-causing SCA1 gene in mice with spinocerebellar ataxia 1, preventing neurodegeneration. The approach also protected brain cells from destruction and prevented protein clump buildup.
Research shows that children who survive ALL have a higher rate of genetic mutations, which can lead to increased risk of developing secondary malignant neoplasms and other complications. The study found that the number of genetic mutations accumulated over the course of treatment and remained elevated after completion.
A study found two common genetic polymorphisms associated with reduced statin effectiveness, affecting total and LDL cholesterol levels. The findings suggest personalized medicine and genetic screening could improve treatment outcomes.
Researchers have developed a gene therapy that protects bone marrow cells from chemotherapy's debilitating effects. The study found up to 41% transfer of the protective gene to blood stem cells in patients with advanced cancer, offering new hope for improved treatments.
Researchers found that women with a specific gene mutation in the CYP2D6 gene had lower levels of endoxifen, a byproduct of tamoxifen metabolism. This suggests that the gene mutation may affect the potency of tamoxifen when combined with certain antidepressants like paroxetine and sertraline.
Researchers developed a regulatable gene therapy that can be turned on and off using doxycycline, offering potential for treating Parkinson's disease. The treatment uses the glial cell line-derived neurotrophic factor (GDNF) protein to promote survival and differentiation of dopamine neurons.
Researchers at the University of Wisconsin-Madison have developed a groundbreaking gene therapy technique that safely delivers therapeutic DNA to muscle cells. The innovative approach, which uses a non-viral method to inject genes into limb veins, has exciting implications for treating muscle and blood vessel disorders.
Researchers have discovered that a gene therapy using growth factor VEGF can slow down the onset and progression of ALS in mice, increasing life expectancy by 30%. This treatment has shown promising results without toxic side effects, offering new hope for patients with this incurable disease.
Researchers from USC provide a new perspective on treating genetic disorders by switching genes back on using epigenetic therapy. Several chemical compounds have been found to affect epigenetic gene changes and are being tested in clinical trials, including one recently approved for myelodysplastic syndrome.
A gene mutation may cause misrouting of proteins in retinal cells, leading to macular degeneration. Research aims to understand the biological function of the gene and its role in fatty acid metabolism.
Researchers used gene therapy to increase dopamine D2 receptor levels, reducing preference for alcohol and consumption by half in genetically predisposed rats. The treatment showed significant reductions in drinking preference and consumption in both groups, with the greatest effects observed within days of treatment.
Researchers at UCLA successfully deliver gene therapy agents directly into tumor cells with minimal complications, improving effectiveness and reducing side effects of existing treatments. The study demonstrates the feasibility and safety of CT-guided injection for gene therapy delivery.
A study of 160 pregnant women with genetic risk factors for thrombophilia found that enoxaparin significantly reduced pregnancy loss compared to low-dose aspirin. Women taking enoxaparin had a normal live birth rate of 86% and healthy newborns, while those on aspirin suffered more pregnancy losses.
A new gene-based screen developed by Stanford researchers can accurately predict a person's response to treatment and identify patients who may benefit from novel therapies. The screen uses a technique called RT-PCR to analyze genes associated with cancer survival, offering a more accessible alternative to existing microarray technology.
A study by Johns Hopkins Medicine found that a gene defect, PASG, is linked to premature aging in mice. The researchers discovered that the mutated gene causes cells to age and die prematurely, leading to growth problems and early death.
Recent studies have identified key molecular markers of cognitive decline in Alzheimer's disease, revealing a complex role of amyloid proteins in the condition. These findings have significant implications for developing new treatments that target the underlying processes driving the disease.