Research on the tests that detect and monitor disease. Covers blood tests, cancer monitoring, emergency diagnostics, and new patent-pending assays.
A new blood test measures the rate of nicotine metabolism to predict quitting success, distinguishing smokers who need higher doses of nicotine or alternative therapies. The study used saliva samples from 480 smokers and found a link between rapid metabolism and increased craving.
Researchers have created a heat-stable antibody that can detect caffeine in various drinks, including coffee, tea, and cola. The test has shown accuracy comparable to sophisticated equipment, with potential applications for consumers who want to avoid caffeine due to health or personal reasons.
A new treatment using fosfomycin has shown promise in treating Listeria infections, which cause severe food-borne diseases. The drug was ineffective in laboratory tests but proved effective in the body, highlighting the need to revise testing methods.
A new point-of-care assay for C trachomatis has shown higher specificity and sensitivity than the standard TF technique, allowing for more targeted treatment of trachoma. The study's findings suggest a major re-think in how trachoma control is conducted in Africa.
Researchers have made significant advancements in stroke treatment, improving functional use of arms and hands through robotics and neuromuscular stimulation. Additionally, a multidisciplinary program for Parkinson's disease patients has shown long-term improvements in motor function scores.
University of Florida scientists develop tiny test tubes that can be easily opened and closed to deliver targeted chemotherapy drugs to cancer cells. By using biodegradable materials and amino-modified nanotubes, the researchers aim to improve the effectiveness of cancer treatment while minimizing side effects.
A new home testing kit could help identify 'hidden' caffeine in coffee, tea, and soda by detecting the stimulant in hot beverages. The test strips use an unusual antibody derived from llamas that is resistant to high temperatures, allowing for accurate detection of caffeine content.
The Biodesign Institute developed a mobile, rapid assessment device to respond to potential bioterror threats using automated miniaturized lab-on-a-chip cartridges. A portable biodosimetry system was also designed for identifying radiation exposure in 'dirty bomb' victims.
A UK trial of TeGenero's TGN1412 biological agent resulted in six healthy volunteers developing serious adverse events, highlighting the need for urgent changes to phase I trial authorisation processes. Regulatory bodies must now consider the unique risks associated with activating antibodies compared to conventional drugs.
A team of researchers has created a miniaturized blood-counting machine that can analyze blood samples using minute amounts, reducing the need for bulky equipment and large blood draws. The device will enable astronauts to perform simple blood tests on the moon and Mars, as well as improve neonatal care with infants.
A study of 2,946 patients with age-related macular degeneration (AMD) found that those with more severe AMD had poorer cognitive function and lower brain reserve. This association remained even after controlling for other factors, suggesting a link between vision and cognitive impairment.
Researchers at UC Davis and Lawrence Livermore National Laboratory have developed a new test that can diagnose vitamin B12 absorption problems with a single drop of blood. This simple test could help identify patients at risk for dementia and anemia, allowing for early treatment and prevention of permanent damage. The breakthrough uses...
A study found that only three-quarters of men attended their eight-week sperm test, highlighting a significant issue with post-vasectomy follow-up care. Despite counselling, many patients failed to return for additional tests, leading to concerns about the true vasectomy failure rate.
The new test measures minimal residual disease and helps identify patients who can be cured with milder treatment. It has been implemented in Brazil to treat children with lower MRD levels, reducing the risk of fatal infections.
A study of 186 cognitively normal adults aged 70+ found that performance on cognitive tests of executive control and memory predicted walking speed without interference. Gait velocity with interference was also affected by executive control and memory, highlighting the importance of these functions in navigating busy environments.
A study published in Archives of Neurology found that cognitive impairment is common in ALS patients, affecting 30% of those studied. Nearly a quarter (23%) of these patients met criteria for dementia, with no significant differences in demographic or disease severity observed.
Frequent marijuana use leads to deteriorated cognitive functions, particularly in remembering new information. Long-term users showed significant impairment in cognitive abilities compared to non-users, with more severe decline over time.
Dr. Larry Kricka's work on chemiluminescence, bioluminescence, and analytical microchips has revolutionized clinical analysis, enabling point-of-care testing and bio-terrorism detection. His research also led to the development of miniaturization techniques for DNA analysis, fertility testing, and immunoassay analysis.
Researchers developed a new method to measure EPC levels in blood samples using ALDH activity, which correlates with the degree of coronary artery disease. Patients with lower EPC levels are more likely to have greater disease and increased risk for cardiac events.
A study found that higher-than-normal levels of IL-1-beta in saliva are associated with increased bone loss. Osteonectin levels inversely correlate with bone loss, suggesting this marker may measure periodontal health. The researchers hope to develop a biomarker test for early detection and monitoring.
A recent study found that elevated lactate dehydrogenase (LDH) levels can define a subgroup of sickle cell patients at risk for serious complications such as pulmonary hypertension and leg ulcerations. Patients with high LDH values had reduced survival rates compared to those with lower LDH values.
David Vanderbilt's work simplifies computer calculations to understand material atomic structure and create new materials. His methods have broad applications in physics, chemistry, and engineering.
A new saliva test detects changes in alpha amylase levels, offering a more comprehensive understanding of the body's response to caffeine and stress. The study found that moderate doses of caffeine improve task performance but excessive amounts can lead to decreased performance.
Mount Sinai School of Medicine researchers identified three proteins found in lower concentration in ALS patients' cerebral spinal fluid, showing 95% accuracy in diagnosing the disease. Early testing may provide relief from symptoms years earlier than current methods.
A study published in JAMA found that individuals with lower socioeconomic status have poorer physical fitness levels, which can lead to a higher risk of cardiovascular death. The researchers discovered that functional capacity and heart rate recovery were strongly associated with SES and accounted for 47% of the association.
Scientists at Georgia Tech have developed reusable hydrogel microlenses that can detect trace amounts of biological or chemical agents in a matter of seconds. These tiny lenses use antibody-antigen binding to change their focus when exposed to the target substance, enabling rapid detection and identification.
A recent study found that low-income minority patients are underrepresented in colon cancer screenings, with only 7% receiving correct screenings. The study highlights the need for organizational interventions to support physicians in underserved areas and promote recommended screening practices.
A recent study found that older women are more susceptible to hip fractures, with over half experiencing significant decline in functioning. Unfortunately, many women in this age group do not undergo bone density screenings, which can help prevent fractures through osteoporosis therapy.
A new clinical prediction rule for estimating the probability of PE significantly reduces adverse outcomes by identifying patients at low or high risk. The revised Geneva score provides a standardized, easy-to-compute tool for diagnosing and managing PE.
A new screening method, qMRSA, was tested on 1,053 patients in Geneva University Hospital. The study found that qMRSA significantly reduced the time to get MRSA test results from 87 hours to 21 hours, and isolated infected patients immediately after detection, which substantially decreased MRSA infections in the medical ICU.
A study found that only 25% of high-risk black men aged 60-69 are screened for prostate cancer, compared to 81% of white men. This disparity highlights a need for increased awareness and targeted screening efforts among black males with positive family histories.
Pooled data from 14 randomized trials reveals a 55% relative reduction in thromboembolic events, 39% reduction in all-cause mortality, and 35% reduction in major hemorrhage with self-monitoring. Patients who can self-manage also show improved outcomes.
A new proteomic profiling test can detect preterm birth risk in 20-30 minutes, predicting delivery times of four days or less. The test uses fresh amniotic fluid samples and is faster than current methods.
A text messaging service reduced the average number of days to diagnosis from 11 to under 8, saving staff time and costs. The study found that a text messaging service minimizes the risks of missed results and is often more acceptable for patients with limited access to landlines.
A study found that more sensitive Chlamydia testing led to a significant increase in reported cases, with a 62% jump in female infections and a 56% rise in male infections between 1992 and 2003. The shift from culture tests to nucleic acid amplification testing (NAAT) is believed to be the primary cause of this increase.
A recent study published in the Canadian Medical Association Journal found that over 63,000 Ontario patients with diabetes had inadequate blood sugar control, with testing rates decreasing among younger adults. The research highlights concerns about unequal access to care and its impact on health outcomes for this vulnerable population.
A new test developed by Ohio State University researchers helps identify the best algorithms for specific applications, reducing errors and improving results. The test rates algorithms on a scale from zero to one, providing a quick way to determine which methods are most effective.
A recent study compared neurocognitive recovery in NFL and high school athletes after concussion. The results showed that NFL players returned to pre-injury baseline performance in just one week, while high school athletes took longer to recover. The study used computerized neurocognitive testing tool ImPACT to evaluate the athletes.
A non-invasive urine test, NMP22, can detect recurrent bladder cancer more effectively than traditional cytology methods. This assay detected 99% of malignancies when combined with cystoscopy, improving patient surveillance and outcomes. Cystoscopy alone identified only 91.3% of cancers.
A new urine test, BladderChek, detected nearly all recurrences of bladder cancers with a higher accuracy rate than conventional tests. The test, used in conjunction with a diagnostic scope, detected 99 percent of recurring bladder cancers.
A recent study found that nearly a third of patients on commonly prescribed diuretics have their electrolyte levels tested, despite the risk of severe health problems. Low sodium levels were more common than low potassium levels, with 21% of tested patients having reduced sodium levels.
A new CU-Boulder study found that morning grogginess can cause diminished short-term memory, counting skills, and cognitive abilities. Cognitive deficiencies following 24 hours of sleep deprivation have previously been shown to be comparable to the effects of alcohol intoxication.
A study of over 1,000 male veterans found that prostate cancer screening with PSA testing did not prolong survival. Researchers compared men who died from prostate cancer to those living with the disease and found no difference in screening rates.
A new study verifies Namenda's effectiveness in slowing cognitive decline and improving daily activities in patients with severe Alzheimer's disease. The medication maintained its benefits when continued treatment was added to the original 28-week study.
A recent study suggests that individuals with a family history of lung cancer are at increased risk, with approximately a two-to-threefold higher chance of developing the illness. Researchers recommend identifying high-risk populations through data collection on family history and genetic susceptibility to facilitate targeted screening...
Researchers have discovered new synthetic compounds that inhibit inducible nitric oxide synthase (iNOS), an enzyme involved in brain cell death. These compounds, including a melatonin metabolite, prevent NO-induced brain damage by suppressing iNOS production.
A new study published online by Vision Research documented a 70 percent improvement in eye chart performance in 19-year-old subjects with lazy eye. The training program involved detection of a small "gabor" exercise that generalized to marked improvement in standard vision tests.
A study of 80 medical school applicants found that assessors couldn't accurately predict happiness with a career in medicine from application forms. Higher educational qualifications were associated with perceived happiness, but didn't actually predict it.
Researchers found that patients with severe periodontitis have elevated levels of small-dense LDL in their blood, which increases the risk of heart disease. The study also suggests that platelet activating factor acetylhydrolase may play a role in this increased risk.
A study published in the BMC Neurology Journal found that patients with chronic fatigue syndrome have a set of proteins in their spinal cord fluid not detected in healthy individuals. These proteins could serve as a 'biosignature' for the disease and may help diagnose CFS in the future.
The shift in commonly used PTH assay has led to inconsistent results, potentially causing increased parathyroidectomy rates, unnecessary medication use, and adynamic bone disease among dialysis patients. Researchers have developed a more specific assay for PTH to address these concerns.
A new blood test has been developed to identify individuals at high risk for ischemic stroke in middle-aged adults. The PLAC test measures Lp-PLA2 and CRP levels, finding an 11-fold increased risk of stroke associated with elevated lipoprotein-associated phospholipase A2 and C-Reactive Protein.
Researchers found that watching violent scenes can impair cognitive flexibility, while a beta-blocker medication can promote flexible thinking under stress. The study used propranolol to block the brain's normal response to stress and improve performance on word association tasks.
Researchers at Ohio State University found that hamsters exposed to limited daylight before birth exhibited increased depressive symptoms as adults. The study suggests a link between seasonal light exposure, sex, and depression in hamsters, providing potential insight into human seasonal affective disorder.
Researchers investigate which nanomaterial sizes, shapes, compounds, and coatings harm or kill cells. The aim is to develop non-toxic types using 'green' nanomaterials, addressing growing concerns about nanoparticle health impacts.
Researchers at Johns Hopkins Medicine conducted a non-randomized study to assess the impact of CABG surgery on higher-level mental functions. The results showed that on-pump CABG patients had no significant differences in their cognitive abilities compared to other groups.
The study reveals a sharp decline in sperm donor applications, with only 3.63% of applicants accepted as suitable donors. The researchers call for urgent action to attract more volunteers, particularly from older men and minority ethnic groups.
A study found that ADDERALL XR significantly improved driving safety and performance in patients with ADHD, measured by a 2.5-point reduction in their average Driving Safety Score. The medication also showed significant effects on ADHD symptom control, improving attention and reducing lapses in attention.
Researchers at UCLA found that reflecting on personal values can significantly lower cortisol levels after stressful events, providing a potential new method to combat stress. The study involved 80 undergraduates who underwent stressful tasks, with those reflecting on meaningful values showing reduced cortisol responses.
A large series of patients surveyed by Mayo Clinic found that those with chronic cough experience significant social, psychological, and physical sufferings. The top problems reported include interference with lifestyle and leisure, frequent physician visits, and frustration.