Research on opioids, addiction, and treatment. Covers traditional care practices, opioid treatment in pregnancy, illicit fentanyl, and treatment disparities.
Andrew Subica, a UC Riverside researcher, has been awarded two NIH grants to develop culturally tailored interventions for Pacific Islanders' mental health treatment and engagement in opioid use disorder treatment. The studies aim to address the significant research gap on opioid use disorders in Pacific Islander populations.
A new study found that opioid prescription rates for outpatient knee surgery vary greatly across the US, with some states prescribing up to 85% of patients opioids. The average strength of prescriptions is also high, often exceeding the CDC's threshold for increased risk of overdose death.
Researchers found that patients who received daily text messages from an automated chatbot experienced a significant decrease in opioid use, averaging 26 pills compared to 41 for non-participants. This low-effort approach aims to reduce opioid dependence and is potentially transferable to other patient populations.
Researchers at the University of Wisconsin-Madison discovered that patients taking opioid painkillers produce anti-opioid antibodies, which may limit the benefit of an anti-opioid vaccine. The study found a correlation between recent opioid dose exposure and antibody production.
Two new evidence reviews from McMaster University suggest that alternative treatments are as effective as opioids in managing acute musculoskeletal injuries like strains and sprains. The studies found that opioids have a higher risk of harms to patients, particularly those with past or current substance use disorders.
A pilot study found that long-term opioid users develop chronic inflammation and heightened pain sensitivity, which could be influenced by their immune system producing antibodies against the drugs. The researchers are now working on isolating key opioid antigenic intermediates in the body that prompt antibody production.
The American College of Physicians and the American Academy of Family Physicians recommend treating acute pain from non-low back musculoskeletal injuries with topical NSAIDs, with or without menthol gel, as the first line of treatment. Topical NSAIDs were shown to be effective for pain reduction, physical function, treatment satisfacti...
Adult cancer survivors are more likely to misuse prescription opioids compared to those without cancer. The study found a significant association between cancer diagnosis and increased opioid misuse.
A new AI algorithm can identify environmental and psychological factors that contribute to substance abuse among homeless youth, allowing for personalized rehabilitation programs. The model, developed by Penn State researchers, found adverse childhood experiences and PTSD to be strong predictors of substance use disorder.
A new study reveals that women often receive excessive opioid prescriptions after childbirth, leading to a higher risk of addiction and misuse within communities. The research emphasizes the need for revised prescribing practices to prioritize patient health and safety.
Research from Oregon State University shows that hospital patients discharged to skilled nursing facilities often receive high-dose opioid prescriptions, posing significant risk to older patients. The study found that 70% of patients received an opioid prescription, with 68% being for oxycodone, a potent medication.
A new study published in Annals of Internal Medicine found that a substantial number of overdose deaths were misclassified as sudden cardiac deaths, leading to grossly underestimated national estimates of the opioid overdose burden. Meanwhile, another study provides real-world recommendations for overcoming telemedicine challenges with...
The Studies To Advance Recovery Support (STARS) Network will focus on Central Appalachia's urgent need for recovery support services. Researchers aim to advance understanding of treatment services, particularly those using medication-assisted treatment and counseling.
A new study published in JAMA Pediatrics found that young adults and adolescents prescribed opioids for the first time are at a slightly greater risk of developing a substance-related problem, but not as high as previously thought. The risk was found to be around 1-2% higher than those who were not prescribed an opioid.
A new study finds that providers participating in an intervention with education and resources are more likely to adhere to national chronic opioid therapy guidelines compared to those who do not take part. The intervention includes access to a nurse care manager, addiction specialists, and monitoring of prescription usage.
The study found that patients following the ERAS protocol had significantly lower rates of opioid use at one, three, and six months after surgery compared to those receiving standard care. Additionally, the ERAS group experienced shorter hospital stays, fewer postoperative complications, and improved patient outcomes.
Researchers found a significant decrease in opioid prescribing rates and improved pain control following hip and knee replacement surgeries in the US between 2014 and 2017.
Researchers at Johns Hopkins Medicine have demonstrated that behavior therapy exposing people to memories of their trauma does not cause relapses of opioid or other drug use. Following the first therapy session, PTSD severity and emotional problems decrease significantly.
A novel study by Keck Medicine of USC researchers reveals a potential new opioid medication that can slow the progression of osteoarthritis while easing pain. The medication, which activates the kappa opioid receptor, has been shown to preserve cartilage in joints and alleviate pain with reduced risk of addiction.
Researchers found that state-level opioid-reduction policies led to a decrease in opioid poisonings among children and teens. The study suggests that targeted policy interventions can help mitigate the devastating impact of the opioid crisis on young people.
A recent study published in the Journal of the American Board of Family Medicine found that older adults taking opioids are at a higher risk of crashing, with a 5.4% increase in reported crashes compared to non-users. However, they also tend to self-regulate their driving habits and report lower self-rated driving ability.
A pilot program trained Nurse Practitioners and Physician Assistants to prescribe Medication for Opioid Use Disorders, increasing availability of services by 10-fold in two rural counties. The project led to the expansion of Medication-Assisted Treatment into 17 counties, addressing a critical need in Colorado's opioid crisis.
A new study by Johns Hopkins Bloomberg School of Public Health found that hospital visits, release from prison, and patterns of medication use can predict both fatal and nonfatal opioid overdoses. The researchers used linked databases to analyze over 2.29 million records and identified groups at highest risk.
A new study has found that tanezumab provides relief in patients with chronic low back pain, one of the leading causes of disability worldwide. The therapy, which inhibits nerve activity, shows promise as a non-opioid treatment option for chronic pain.
Researchers developed LIH383, a novel molecule targeting ACKR3, which modulates natural painkilling and antidepressant properties by reducing opioid peptide levels. This discovery offers an alternative therapeutic strategy for chronic pain, stress, anxiety, and depression, as well as cancer treatment.
Researchers found that 45% of patients had low levels of pain effectively managed by a non-opioid regimen, with no reported side effects. Patients who required opioids were more likely to have anxiety/depression and higher pain scores, highlighting the potential for reduced opioid use in surgical settings.
A large national database found that nearly 40% of patients who didn't use opioids before undergoing coronary artery bypass grafting or heart valve procedures developed persistent opioid use afterwards. The study suggests that cardiac surgery may be a contributing factor to the development of opioid dependence in some individuals
A new study found that nearly 10% of patients prescribed opioid medications following heart surgery will continue to use them more than 90 days after the procedure. The study also revealed a direct link between the dosage of opioids first prescribed and the likelihood of persistent opioid use.
A new study found that depressive and anxious symptoms are linked to reduced opioid receptors in the brain, which can be an important mechanism in treating depression. The study, conducted with Positron Emission Tomography (PET) scans, suggests that drugs affecting the opioid system may help treat depression.
A new study by Vanderbilt University Medical Center researchers found that opioid prescriptions after childbirth are associated with a higher risk of overdose and persistent use. Over 160,000 pregnant women were followed for their opioid prescription filling rates after delivery.
A study of 1,201 patients found that pre-surgery use of opioids, sedatives, or antidepressants increased complications after colorectal surgery. Regular opioid users faced higher risks of infections, respiratory failure, and mortality.
A team of UTHSC researchers will study genetic differences in stress response, oxycodone consumption and stress-induced drug seeking in rats. The findings have great potential to translate to human conditions of opioid addiction.
A growing number of patients in Europe are taking opioids for pain related to rheumatic and musculoskeletal diseases, with risks of addiction and dependency identified. Experts warn that measures must be taken to use these analgesics more safely.
The study found that prescriptions for buprenorphine treatment increased significantly among adults, particularly those prescribed by primary care providers. However, access to treatment decreased among young adults and teens, primarily due to a decline in prescriptions from psychiatrists and addiction medicine specialists.
Research reveals that age, sex and smoking impact μ-opioid receptor density in brain. Dysfunctions of the brain's opioid system are linked to disorders like addiction and chronic pain.
A health system implemented a three-pronged public health strategy to address the opioid epidemic, reducing opioid use by 19% and shortening duration of use. The strategy included primary prevention, safe prescribing guidelines, and access to treatment for Opioid Use Disorder.
A study found that taking short-acting benzodiazepines and opioids together increases the risk of premature death in patients with kidney failure. The analysis of over 69,000 US adults with kidney disease who initiated hemodialysis revealed a 1.9-fold higher risk of dying among those taking both medications.
A new study analyzed four years' worth of data from two million patients and found that those having dental procedures on Fridays or before holidays were more likely to fill opioid prescriptions. Non-opioid painkillers are equally effective at controlling pain with lower risks.
Researchers analyzed deaths following nonfatal opioid overdoses in California from 2009 to 2011, finding that patients with intentional overdoses were more likely to die by suicide than those with unintentional overdoses. The study sheds light on the complex relationship between opioid use and suicidal behavior.
Rates of neonatal abstinence syndrome have plateaued, with NAS per 1,000 live births stabilizing in 2016 after peaking in 2014. The study found significantly higher rates than 20 years ago, highlighting the need for continued action to improve outcomes.
A study by Yale researchers found that only 21% of emergency department clinicians indicated readiness to offer buprenorphine to patients with opioid use disorder. Barriers included lack of formal training, time limitations, and perceptions that initiating therapy falls outside the scope of emergency medicine.
Researchers discovered that inhibiting heat shock protein 90 in the spinal cord enhances opioid efficacy and decreases side effects. Hsp90 inhibitors could enable dose-reduction strategies for patients while maintaining pain relief.
A new study shows that financial incentives can increase the number of emergency department physicians trained to prescribe buprenorphine, a potentially life-saving medication for opioid overdose. By offering reimbursement and a $750 incentive, 89% of physicians were fully trained in six weeks.
Long-term buprenorphine treatment is associated with improved health care outcomes, including lower prescription opioid use and opioid-related events. Patients with continuous treatment had significantly lower rates of overdose events, inpatient and emergency department services, and prescription opioids use compared to those who disco...
A new study found that pharmacies in Appalachian Kentucky are limiting buprenorphine dispensing due to concerns about DEA caps, distrust of pharmaceutical companies, and stigma against people who use drugs. This limits access to effective treatment for opioid use disorder, which affects fewer than two in ten individuals.
Taking antibiotics with opioids may exacerbate addiction by altering brain responses to opioids, according to research on rats depleted of their gut microbiome. The study found that a weakened microbiome intensified opioid intoxication while reducing withdrawal effects.
A study published in eNeuro found that gut microbes significantly impact the brain's response to opioids in rats, altering the pattern of neuron recruitment during addiction and withdrawal. This discovery may lead to new prevention and treatment strategies for drug abuse.
The Rural Opioid Telehealth Project will connect underserved communities in Virginia and West Virginia to life-saving services through rapid response remote care. The project aims to address opioid dependency and provide other telehealth services to low-income residents.
A new study found that almost 4 out of 5 patients with moderate pain intensity considered it tolerable, and 30-40% of those with severe pain also described it as tolerable. This suggests an alternative to traditional 0-10 rating scales could help doctors better understand patient needs.
A study published in JAMA Network Open found that more than half of Americans starting highly regulated opioids may be receiving inappropriate treatment. The research team used pharmacy and medical claims data to identify nearly 300,000 instances of prescriptions for medications reserved for people with opioid tolerance. However, less ...
Researchers at the University of Queensland have designed a novel tarantula venom mini-protein that can relieve severe pain without addiction. The mini-protein, Huwentoxin-IV, binds to specific pain receptors and has been tested in mouse models with promising results.
A new measure of patient frailty could improve accuracy, fairness, and equity in Medicare value-based payment models. Researchers found that incorporating this measure into cost prediction improved performance, especially among frail patients.
Two studies from Boston University School of Public Health found that patients with higher BMIs were up to 158% more likely to use prescription opioids long-term. Osteoarthritis, other joint disorders, and back pain accounted for most opioid prescriptions linked to obesity.
A study of 72,000 adolescents and young adults found that exposure to family members with opioid prescriptions increases the youth's own risk of overdose. Higher rates of opioid prescription among young people also contribute to their increased risk of overdose.
A pair of new studies indicate parents are more reluctant to have opioids prescribed for their children than doctors, citing fears of addiction and side-effects. Pediatricians emphasize the importance of treating children's pain while acknowledging the unknown risks of opioid treatment.
Researchers are studying gene transcription in blood of patients undergoing buprenorphine treatment to understand its therapeutic effects. The study aims to identify key genes and their association with clinical results, potentially leading to new treatments for opioid use disorder.
A new study published in Drug and Alcohol Dependence reveals that experiencing opioid withdrawal increases the likelihood of needle sharing and non-fatal overdose among individuals who inject drugs. The research also highlights the urgent need for medication-assisted treatment to address this public health issue.
Life expectancy in the US has stagnated since 2010, with cardiovascular diseases having a greater impact than drug deaths from the opioid crisis. The number of drug-related deaths had a small influence on life expectancy, rising by just 0.4 years between 2010 and 2017.
Nonmedical opioid prescription use is common among transgender girls and young women, linked to history of trauma and mental health struggles. The study highlights the need for targeted interventions and support services to address this critical public health issue.
Researchers have found a new mechanism for long-lasting pain relief through the production of endogenous opioids by immune cells. The discovery uses cytokine interleukin-4 to induce M2 macrophages, which produce opioids and reduce pain, offering potential alternative pain management options.